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Peroxyacetic acid

RTECS #: SD8750000

CAS #: 79-21-0


UPDATE: May 2007 MW: 76.06 MF: C2H4O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetic peroxide
  2. Acetyl hydroperoxide
  3. Acide peracetique (French)
  4. Desoxon 1
  5. Estosteril
  6. Ethaneperoxoic acid
  7. Hydroperoxide, acetyl
  1. Kyselina peroxyoctova (Czech)
  2. Monoperacetic acid
  3. Osbon AC
  4. Peracetic acid
  5. Peroxoacetic acid
  6. Proxitane 4002


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
1 mg severe UCDS** 12/12/1968
skin
rabbit
500 mg open irritation test severe UCDS** 12/12/1968


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA damage human leukocyte 0.5 ppm/1 hour MUTAEX 19,157,2004
DNA damage multiple
other fish
0.61 mg/L/20 day- continuous MUREAV 557,119,2004
mutation in microorganisms Saccharomyes cerevisiae 5 ppm/2 hour MUTAEX 19,157,2004
micronucleus test multiple
other fish
0.2 ppm/72 hour- continuous MUREAV 587,103,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
mouse
lowest published toxic dose: 21 gm/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application
JNCIAM 55,1359,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 450 mg/m3 N/R GISAAA 48(6),28,1983
intravenous
mouse
lethal dose (50 percent kill): 17,860 g/kg N/R YHTPAD 23,345,1988
oral
guinea pig
lethal dose (50 percent kill): 10 mg/kg N/R BSPII* 1/75-19B
oral
mouse
lethal dose (50 percent kill): 210 mg/kg N/R GISAAA 48(6),28,1983
oral
rat
lethal dose (50 percent kill): 1,540 L/kg N/R UCDS** 12/12/1968
skin
rabbit
lethal dose (50 percent kill): 1,410 L/kg N/R UCDS** 12/12/1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 186 mg/m3/1 hour/90 day- intermittent Liver: Fatty liver degeneration

Lung, Thorax, or Respiration: Other changes

Blood: Pigmented or nucleated red blood cells
WZHMAE 33,513,1984
inhalation
mouse
lowest published toxic concentration: 186 mg/m3/1 hour/90 day- intermittent Liver: Fatty liver degeneration

Lung, Thorax, or Respiration: Other changes
WZHMAE 33,513,1984
inhalation
rat
lowest published toxic concentration: 350 mg/m3/30 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
GISAAA 48(6),28,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,331,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84020;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 2;
Total Number of Employees Exposed 1,683
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84020;
Number of Industries 2;
Total Number of Facilities 31;
Number of Occupations 4;
Total Number of Employees Exposed 1,728;
Total Number of Female Employees Exposed 91


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as polymerization initiator, curing agent and cross-linking agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BSPII* SPI Bulletin. (Soc. of the Plastics Industry, 250 Park Ave., New York, NY 10017)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
WZHMAE Wissenschaftliche Zeitschrift der Humboldt-Universitaet zu Berlin, Mathematisch- Naturwissenschaftliche Reihe. (DDR-1004 Berlin, Strasse der Pariser Kommune 3/4, zu richten) V.1-36, 1951/52-87.
YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU.

Used as polymerization initiator, curing agent and cross-linking agent

NIOSH PROFILE (PERACETIC ACID), PRAB, 6/80

NIOSH PROFILE (PEROXIDES, ORGANIC), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Primary Irritant

Click Here for Additional Information about RTECS

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