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Registry of Toxic Effects of Chemical Substances (RTECS)

Permanganic acid, potassium salt

RTECS #

SD6475000

CAS #

7722-64-7

Updated

July 2013

Molecular Weight

158.04

Molecular Formula

MnO4·K

Synonyms

C.I. 77755
Cairox
Chameleon mineral
Condy's crystals
Permanganate de potassium (French)
Permanganate of potash
Potassio (permanganato di) (Italian)
Potassium (permanganate de) (French)
Potassium permanganate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisoral/mouse718 mg/kg/7D-continuousMUREAV 240,159,1990
Cytogenetic Analysismammary gland/mouse1 mmol/L/48HMUREAV 67,221,1979
DNA adduct/Escherichia coli200 µmol/LMUREAV 89,95,1981
DNA repair/Escherichia coli625 µg/wellMUREAV 133,161,1984
DNA repair/Bacillus subtilis17 mg/LWATRAG 14,1613,1980
micronucleus testoral/mouse205 mg/kg/24H-continuousMUREAV 240,159,1990
mutation in microorganisms/Other microorganisms10 ppm (-enzymatic activation step)JOBAAY 54,767,1947
mutation in microorganisms/Salmonella typhimurium10 µL/tube (+enzymatic activation step)MUREAV 260,295,1991
phage inhibition capacity/Escherichia coli200 µmol/LENMUDM 6,59,1984
sperm morphologyoral/mouse513 mg/kg/5D-continuousMUREAV 240,159,1990

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/rat 400 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)FESTAS 24,884,1973
intratesticular/gerbil 25 mg/kg (1D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)IJEBA6 14,617,1976
oral/mouse 513 mg/kg (5D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 240,159,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intravenous/rabbit lowest published lethal dose: 70 mg/kgEQSSDX 1,1,1975
oral/Dog lowest published lethal dose: 400 mg/kgYKYUA6 31,855,1980
oral/guinea pig lethal dose (50 percent kill): 1151 mg/kgBehavioral: Somnolence (general depressed activity)GISAAA 36(9),15,1971
oral/human lowest published lethal dose: 143 mg/kgLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
34ZIAG -,493,1969
oral/human lowest published lethal dose: 71 mg/kgVCVN5* -,411,1989
oral/mouse lethal dose (50 percent kill): 2157 mg/kgBehavioral: Somnolence (general depressed activity)GISAAA 36(9),15,1971
oral/mouse lethal dose (50 percent kill): 750 mg/kgVCVN5* -,410,1989
oral/rabbit lowest published lethal dose: 600 mg/kgYKYUA6 31,855,1980
oral/rat lethal dose (50 percent kill): 750 mg/kgVCVN5* -,410,1989
oral/woman lowest published toxic dose: 2400 µg/kgGastrointestinal: Nausea or vomitingAIPTAK 44,446,1933
oral/woman lowest published lethal dose: 100 mg/kgVascular: BP lowering not characterized in autonomic section

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HETOEA 15,259,1996

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 7851 mg/kg/39W- intermittentBehavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 36(9),15,1971
oral/rat lowest published toxic dose: 910 mg/kg/91D- intermittentBehavioral: Alteration of classical conditioningVCVN5* -,411,1989

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWCREOH* 42,25,2002
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD-airceiling concentration 5 mg(Mn)/m3DTLVS* 3,149,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit-AUSTRALIAtime-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit-GERMANYMAK 0.02 mg(Mn)/m3 (resp), 0.2 mg(Mn)/m3 (inhal), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.2 mg(Mn)/m3, MAY2012
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(Mn)/m3, MAC(C) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit-SWEDENtime-weighted average 0.2 mg(Mn)/m3, (total dust);time-weighted average 0.1 mg(Mn)/m3, (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.5 mg(Mn)/m3, inhal, JAN2011
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)ceiling concentration 5 mg(Mn)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)ceiling concentration 5 mg(Mn)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 60490; Number of Industries 52; Total Number of Facilities 3004; Number of Occupations 64; Total Number of Employees Exposed 91985; Total Number of Female Employees Exposed 28113
National Occupational Hazard Survey 1974Hazard Code 60490; Number of Industries 47; Total Number of Facilities 2685; Number of Occupations 38; Total Number of Employees Exposed 26428

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; N crassa-reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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