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Permanganic acid, potassium salt

RTECS #: SD6475000

CAS #: 7722-64-7


UPDATE: May 2009 MW: 158.04 MF: MnO4K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. C.I. 77755
  2. Cairox
  3. Chameleon mineral
  4. Condy's crystals
  5. Permanganate de potassium (French)
  1. Permanganate of potash
  2. Potassio (permanganato di) (Italian)
  3. Potassium permanganate
  4. Potassium (permanganate de) (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis oral
mouse
718 mg/kg/7 day- continuous MUREAV 240,159,1990
cytogenetic analysis mouse mammary gland 1 mmol/L/48 hour MUREAV 67,221,1979
DNA adduct Escherichia coli 200 mol/L MUREAV 89,95,1981
DNA repair Bacillus subtilis 17 mg/L WATRAG 14,1613,1980
DNA repair Escherichia coli 625 g/well MUREAV 133,161,1984
mutation in microorganisms other microorganisms 10 ppm (-enzymatic activation step) JOBAAY 54,767,1947
mutation in microorganisms Salmonella typhimurium 10 L/tube (+enzymatic activation step) MUREAV 260,295,1991
micronucleus test oral
mouse
205 mg/kg/24 hour- continuous MUREAV 240,159,1990
phage inhibition capacity Escherichia coli 200 mol/L ENMUDM 6,59,1984
sperm morphology oral
mouse
513 mg/kg/5 day- continuous MUREAV 240,159,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratesticular
gerbil
lowest published toxic dose: 25 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) IJEBA6 14,617,1976
intratesticular
rat
lowest published toxic dose: 400 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) FESTAS 24,884,1973
oral
mouse
lowest published toxic dose: 513 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 240,159,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rabbit
lowest published lethal dose: 70 mg/kg N/R EQSSDX 1,1,1975
oral
dog
lowest published lethal dose: 400 mg/kg N/R YKYUA6 31,855,1980
oral
guinea pig
lethal dose (50 percent kill): 1,151 mg/kg Behavioral: Somnolence (general depressed activity) GISAAA 36(9),15,1971
oral
human
lowest published lethal dose: 143 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Other changes
34ZIAG -,493,1969
oral
human
lowest published lethal dose: 71 mg/kg N/R VCVN5* -,411,1989
oral
mouse
lethal dose (50 percent kill): 2,157 mg/kg Behavioral: Somnolence (general depressed activity) GISAAA 36(9),15,1971
oral
mouse
lethal dose (50 percent kill): 750 mg/kg N/R VCVN5* -,410,1989
oral
rat
lethal dose (50 percent kill): 750 mg/kg N/R VCVN5* -,410,1989
oral
rabbit
lowest published lethal dose: 600 mg/kg N/R YKYUA6 31,855,1980
oral
woman
lowest published toxic dose: 2,400 g/kg/ day Gastrointestinal: Nausea or vomiting AIPTAK 44,446,1933
oral
woman
lowest published lethal dose: 100 mg/kg Vascular: BP lowering not characterized in autonomic section

Liver: Hepatitis (hepatocellular necrosis), diffuse

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
HETOEA 15,259,1996


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 7,851 mg/kg/39 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase
GISAAA 36(9),15,1971
oral
rat
lowest published toxic dose: 910 mg/kg/91 day- intermittent Behavioral: Alteration of classical conditioning VCVN5* -,411,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Mn)/m3 DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
CREOH* 42,25,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Mine Safety and Health Administration (MSHA) STANDARD - air ceiling concentration 5 mg(Mn)/m3 DTLVS* 3,149,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 mg(Mn)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 mg(Mn)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3 (dust), JUL2008
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg(Mn)/m3, short term exposure limit 3 mg(Mn)/m3 (fume), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.2 mg(Mn)/m3, MAR2002
Occupational Exposure Limit - FINLAND time-weighted average 0.5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 5 mg(Mn)/m3, short term exposure limit 20 mg(Mn)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.3 mg(Mn)/m3 (respirable dust), APR2007
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(Mn)/m3, MAC( continuous) 5 mg(Mn)/m3, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 0.2 mg(Mn)/m3, (total dust);
time-weighted average 0.1 mg(Mn)/m3, (resp.dust), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg(Mn)/m3, DEC2006
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 mg(Mn)/m3
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 mg(Mn)/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 60490;
Number of Industries 47;
Total Number of Facilities 2,685;
Number of Occupations 38;
Total Number of Employees Exposed 26,428
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 60490;
Number of Industries 52;
Total Number of Facilities 3,004;
Number of Occupations 64;
Total Number of Employees Exposed 91,985;
Total Number of Female Employees Exposed 28,113


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; N crassa-reversion
EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JOBAAY Journal of Bacteriology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1916-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WATRAG Water Research. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1967-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a topical antibacterial agent

NIOSH PROFILE (MANGANESE AND ITS COMPOUNDS), SRC, 4/82

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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