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Perchloric acid, ammonium salt

RTECS #: SC7520000

CAS #: 7790-98-9


UPDATE: May 2008 MW: 117.50 MF: ClO4H4N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Ammonium perchlorate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intravenous
rat
lowest published toxic dose: 0.1 mg/kg (20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 66,341,2002
oral
rat
lowest published toxic dose: 6 mg/kg (7-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 19,155,2004
oral
rat
lowest published toxic dose: 0.57 mg/kg (14 day prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system TOXID9 60,217,2001
oral
rat
lowest published toxic dose: 1,050 mg/kg (14 day prior to copulation-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TOXID9 60,218,2001
oral
rat
lowest published toxic dose: 0.19 mg/kg (2-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 60,434,2001
oral
rat
lowest published toxic dose: 40 mg/kg (2 week prior to copulation-5 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects IJTOFN 24,403,2005
oral
rat
lowest published toxic dose: 0.35 mg/kg (2 week prior to copulation-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic IJTOFN 24,403,2005
oral
rat
lowest published toxic dose: 0.45 mg/kg (2 week prior to copulation-10 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects IJTOFN 24,403,2005
oral
rat
lowest published toxic dose: 3.1 mg/kg (1 day pregnant-10 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects IJTOFN 24,451,2005
oral
rat
lowest published toxic dose: 32 mg/kg (1 day prior to copulation-10 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic IJTOFN 23,191,2004
oral
rat
lowest published toxic dose: 96 mg/kg (1 day prior to copulation-10 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects IJTOFN 23,191,2004
oral
rat
lowest published toxic dose: 1,080 mg/kg (15 day prior to copulation-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system IJTOFN 22,453,2003
oral
rat
lowest published toxic dose: 0.36 mg/kg (15 day prior to copulation-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) IJTOFN 22,453,2003
oral
rat
lowest published toxic dose: 10 mg/kg (1-10 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
IJTOFN 22,87,2003
oral
rat
lowest published toxic dose: 19 mg/kg (2-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
IJTOFN 22,87,2003
unreported route
rat
lowest published toxic dose: 0.22 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,434,2001
unreported route
rat
lowest published toxic dose: 0.21 mg/kg (1-21 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic TOXID9 60,434,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration : >300 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Liver: Liver function tests impaired
STGNBT -,15,1999
inhalation
rat
lethal concentration : >300 mg/m3 Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Liver: Liver function tests impaired
STGNBT -,15,1999
intravenous
rat
lowest published toxic dose: 0.1 mg/kg Endocrine: Evidence of thyroid hypofunction TOXID9 66,341,2002
oral
guinea pig
lethal dose (50 percent kill): 3,310 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral
mouse
lethal dose (50 percent kill): 1,900 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral
mouse
lethal dose (50 percent kill): 1,900 mg/kg N/R ENTOX* -,105,2005
oral
rat
lethal dose (50 percent kill): 4,200 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral
rat
lowest published toxic dose: 3 mg/kg Endocrine: Evidence of thyroid hypofunction TXAPA9 182,148,2002
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg N/R ENTOX* -,105,2005
oral
rabbit
lethal dose (50 percent kill): 1,900 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral
rabbit
lethal dose (50 percent kill): 750 mg/kg N/R ENTOX* -,105,2005
parenteral
mouse
lowest published lethal dose: 2 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
parenteral
rat
lowest published lethal dose: 3,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
parenteral
rabbit
lowest published lethal dose: 750 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
subcutaneous
mouse
lethal dose (50 percent kill): 940 mg/kg N/R STGNBT -,15,1999
subcutaneous
rat
lethal dose (50 percent kill): 1,600 mg/kg N/R STGNBT -,15,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified)
lowest published toxic concentration: 40 g/kg/17 week- intermittent Endocrine: Other changes STGNBT -,15,1999
oral
mammal (species unspecified)
lowest published toxic dose: 18,200 mg/kg/1 year- intermittent Endocrine: Other changes STGNBT -,15,1999
oral
rat
lowest published toxic dose: 140 mg/kg/2 week- continuous Endocrine: Other changes

Endocrine: Changes in thyroid weight
TOSCF2 57,61,2000
oral
rat
lowest published toxic dose: 140 mg/kg/14 day- continuous Endocrine: Changes in thyroid weight

Endocrine: Evidence of thyroid hypofunction
TOSCF2 57,61,2000
oral
rat
lowest published toxic dose: 140 mg/kg/14 day- intermittent Endocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
TXAPA9 182,148,2002
oral
rat
lowest published toxic dose: 1,937.5 mg/kg/31 day- intermittent Endocrine: Other changes TOXID9 44,352,2005
oral
rat
lowest published toxic dose: 1,050 mg/kg/35 day- continuous Endocrine: Evidence of thyroid hyperfunction TOXID9 60,217,2001
oral
rat
lowest published toxic dose: 50 mg/kg/56 day- continuous Endocrine: Evidence of thyroid hyperfunction TOXID9 60,217,2001
oral
rat
lowest published toxic dose: 0.19 mg/kg/19 day- continuous Endocrine: Other changes TOXID9 60,434,2001
oral
rat
lowest published toxic dose: 1,050 mg/kg/35 day- continuous Endocrine: Changes in thyroid weight IJTOFN 24,403,2005
oral
rat
lowest published toxic dose: 0.35 mg/kg/35 day- continuous Endocrine: Other changes IJTOFN 24,403,2005
oral
rat
lowest published toxic dose: 1,080 mg/kg/36 day- continuous Endocrine: Changes in thyroid weight IJTOFN 22,453,2003
oral
rat
lowest published toxic dose: 0.36 mg/kg/36 day- continuous Endocrine: Other changes IJTOFN 22,453,2003
oral
rat
lowest published toxic dose: 8,190 g/kg/7 day- continuous Endocrine: Thyroid weight (goiter)

Endocrine: Other changes
TOPADD 33,776,2005
oral
rabbit
lowest published toxic dose: 17,290 mg/kg/13 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) GISAAA 28(8),8,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
REPTED 22,196,2006
TOXICOLOGY REVIEW
ENTOX* -,105,2005
TOXICOLOGY REVIEW
ENTOX* -,349,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80353;
Number of Industries 2;
Total Number of Facilities 101;
Number of Occupations 3;
Total Number of Employees Exposed 1,062
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80353;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,445;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
STGNBT "Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St., 123182, Moscow, Russia, IzdAT 1999
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in explosives, pyrotechnic compositions and jet and rocket propellants

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector

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