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Registry of Toxic Effects of Chemical Substances (RTECS)

Perchloric acid, ammonium salt

RTECS #

SC7520000

CAS #

7790-98-9

Updated

May 2008

Molecular Weight

117.50

Molecular Formula

ClO4·H4N

Synonyms

Ammonium perchlorate

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intravenous/rat 0.1 mg/kg (20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 66,341,2002
oral/rat 0.57 mg/kg (14D pre-22D after birth)Reproductive: Specific developmental abnormalities: Endocrine systemTOXID9 60,217,2001
oral/rat 1050 mg/kg (14D pre-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTOXID9 60,218,2001
oral/rat 6 mg/kg (7-21D pregnant)Reproductive: Specific developmental abnormalities: Urogenital systemREPTED 19,155,2004
oral/rat 0.19 mg/kg (2-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOXID9 60,434,2001
oral/rat 40 mg/kg (2W pre-5D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsIJTOFN 24,403,2005
oral/rat 0.35 mg/kg (2W pre-21D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicIJTOFN 24,403,2005
oral/rat 0.45 mg/kg (2W pre-10D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsIJTOFN 24,403,2005
oral/rat 3.1 mg/kg (1D preg-10D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsIJTOFN 24,451,2005
oral/rat 32 mg/kg (1D pre-10D after birth)Reproductive: Effects on newborn: Biochemical and metabolicIJTOFN 23,191,2004
oral/rat 96 mg/kg (1D pre-10D after birth)Reproductive: Effects on newborn: Other postnatal measures or effectsIJTOFN 23,191,2004
oral/rat 1080 mg/kg (15D pre-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemIJTOFN 22,453,2003
oral/rat 0.36 mg/kg (15D pre-21D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)IJTOFN 22,453,2003
oral/rat 10 mg/kg (1-10D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
IJTOFN 22,87,2003
oral/rat 19 mg/kg (2-20D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic
IJTOFN 22,87,2003
unreported route/rat 0.22 mg/kg (1-22D pregnant)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 60,434,2001
unreported route/rat 0.21 mg/kg (1-21D after birth)Reproductive: Effects on newborn: Biochemical and metabolicTOXID9 60,434,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lethal concentration: >300 mg/m3Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Liver: Liver function tests impaired
STGNBT -,15,1999
inhalation/rat Lethal concentration: >300 mg/m3Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting

Liver: Liver function tests impaired
STGNBT -,15,1999
intravenous/rat lowest published toxic dose: 0.1 mg/kgEndocrine: Evidence of thyroid hypofunctionTOXID9 66,341,2002
oral/guinea pig lethal dose (50 percent kill): 3310 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral/mouse lethal dose (50 percent kill): 1900 mg/kgENTOX* -,105,2005
oral/mouse lethal dose (50 percent kill): 1900 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral/rabbit lethal dose (50 percent kill): 750 mg/kgENTOX* -,105,2005
oral/rabbit lethal dose (50 percent kill): 1900 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
oral/rat lowest published toxic dose: 3 mg/kgEndocrine: Evidence of thyroid hypofunctionTXAPA9 182,148,2002
oral/rat lethal dose (50 percent kill): 3500 mg/kgENTOX* -,105,2005
oral/rat lethal dose (50 percent kill): 4200 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Behavioral: Coma
GISAAA 28(8),8,1963
parenteral/mouse lowest published lethal dose: 2 gm/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
parenteral/rabbit lowest published lethal dose: 750 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
parenteral/rat lowest published lethal dose: 3500 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Lung, Thorax, or Respiration: Dyspnea
RPTOAN 32,159,1969
subcutaneous/mouse lethal dose (50 percent kill): 940 mg/kgSTGNBT -,15,1999
subcutaneous/rat lethal dose (50 percent kill): 1600 mg/kgSTGNBT -,15,1999

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 40 µg/kg/17W- intermittentEndocrine: Other changesSTGNBT -,15,1999
oral/mammal (species unspecified) lowest published toxic dose: 18200 mg/kg/1Y- intermittentEndocrine: Other changesSTGNBT -,15,1999
oral/rabbit lowest published toxic dose: 17290 mg/kg/13W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)GISAAA 28(8),8,1963
oral/rat lowest published toxic dose: 140 mg/kg/2W- continuousEndocrine: Other changes

Endocrine: Changes in thyroid weight
TOSCF2 57,61,2000
oral/rat lowest published toxic dose: 140 mg/kg/14D- continuousEndocrine: Changes in thyroid weight

Endocrine: Evidence of thyroid hypofunction
TOSCF2 57,61,2000
oral/rat lowest published toxic dose: 140 mg/kg/14D- intermittentEndocrine: Evidence of thyroid hypofunction

Endocrine: Changes in thyroid weight
TXAPA9 182,148,2002
oral/rat lowest published toxic dose: 1937.5 mg/kg/31D- intermittentEndocrine: Other changesTOXID9 44,352,2005
oral/rat lowest published toxic dose: 1050 mg/kg/35D- continuousEndocrine: Evidence of thyroid hyperfunctionTOXID9 60,217,2001
oral/rat lowest published toxic dose: 50 mg/kg/56D- continuousEndocrine: Evidence of thyroid hyperfunctionTOXID9 60,217,2001
oral/rat lowest published toxic dose: 0.19 mg/kg/19D- continuousEndocrine: Other changesTOXID9 60,434,2001
oral/rat lowest published toxic dose: 1050 mg/kg/35D- continuousEndocrine: Changes in thyroid weightIJTOFN 24,403,2005
oral/rat lowest published toxic dose: 0.35 mg/kg/35D- continuousEndocrine: Other changesIJTOFN 24,403,2005
oral/rat lowest published toxic dose: 1080 mg/kg/36D- continuousEndocrine: Changes in thyroid weightIJTOFN 22,453,2003
oral/rat lowest published toxic dose: 0.36 mg/kg/36D- continuousEndocrine: Other changesIJTOFN 22,453,2003
oral/rat lowest published toxic dose: 8190 µg/kg/7D- continuousEndocrine: Thyroid weight (goiter)

Endocrine: Other changes
TOPADD 33,776,2005

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWREPTED 22,196,2006
TOXICOLOGY REVIEWENTOX* -,105,2005
TOXICOLOGY REVIEWENTOX* -,349,2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80353; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 1445; Total Number of Female Employees Exposed 230
National Occupational Hazard Survey 1974Hazard Code 80353; Number of Industries 2; Total Number of Facilities 101; Number of Occupations 3; Total Number of Employees Exposed 1062

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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