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Registry of Toxic Effects of Chemical Substances (RTECS)

Perboric acid, sodium salt, tetrahydrate

RTECS #

SC7350000

CAS #

10486-00-7

Updated

August 2006

Molecular Weight

153.88

Molecular Formula

BO3·Na·4H2O

Synonyms

Sodium perborate tetrahydrate

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 mg moderateGTPZAB 28(6),44,1984

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium625 µg/plate (-enzymatic activation step)MUREAV 412,17,1998
mutation in microorganisms/Escherichia coli1250 µg/plate (-enzymatic activation step)MUREAV 412,17,1998

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3 gm/kg (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
TJADAB 53,26A,1996
oral/rat 3 gm/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TJADAB 53,26A,1996
oral/rat 10 gm/kg (6-15D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
TJADAB 53,26A,1996

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 538 mg/kgCOREAF 257,791,1963
oral/child lowest published lethal dose: 250 mg/kgYKYUA6 31,855,1980
oral/human lowest published lethal dose: 214 mg/kgYKYUA6 31,855,1980
oral/infant lowest published lethal dose: 400 mg/kgYKYUA6 31,855,1980
oral/mouse lethal dose (50 percent kill): 1060 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
GTPZAB 28(6),44,1984
oral/rat lethal dose (50 percent kill): 1200 mg/kgBehavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness
GTPZAB 28(6),44,1984

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X8545; Number of Industries 5; Total Number of Facilities 703; Number of Occupations 6; Total Number of Employees Exposed 3035

Status in Federal Agencies

OrganizationReference
On EPA IRIS database
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