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Registry of Toxic Effects of Chemical Substances (RTECS)

Pentyl alcohol

RTECS #

SB9800000

CAS #

71-41-0

Updated

July 2013

Molecular Weight

88.17

Molecular Formula

C5H12O

Synonyms

1-Pentanol
Alcool amylique (French)
Amyl alcohol
Amyl alcohol, normal
Amylol
n-Amyl alcohol
n-Amylalkohol (Czech)
n-Butylcarbinol
n-Pentanol
Pentan-1-ol
Pentanol
Pentanol-1
Primary amyl alcohol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 81 mg severeAIHAAP 34,493,1973
eye /rabbit 5 µL/24H severeNTIS** OTS0534716
skin /rabbit 3200 mg/24H severeAIHAAP 34,493,1973
skin /rabbit 20 mg/24H moderate85JCAE -,196,1986

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Escherichia coli7000 ppm (-enzymatic activation step)ABMGAJ 23,843,1969
sex chromosome loss and nondisjunctionlung/hamster25 mmol/LMUREAV 182,135,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >36.8 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration Low: >50.6 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 37 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >12.9 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >23.9 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
inhalation/guinea pig Lethal concentration: >14 gm/m3/6HBrain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
AIHAAP 34,493,1973
inhalation/human lowest published toxic concentration: 0.061 mg/m3Brain and Coverings: Changes in surface EEGVCVGK* -,108,1984
inhalation/human lowest published toxic concentration: 0.4 mg/m3Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,108,1984
inhalation/mouse Lowest published lethal concentration: 14000 mg/m3VCVGK* -,107,1984
inhalation/mouse Lowest published lethal concentration: 14000 mg/m3/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
AIHAAP 34,493,1973
inhalation/rat Lowest published lethal concentration: 14000 mg/m3/6HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
AIHAAP 34,493,1973
inhalation/rat Lowest published lethal concentration: 14000 mg/m3VCVGK* -,108,1984
intraperitoneal/guinea pig lethal dose (50 percent kill): 615 mg/kgEVHPAZ 61,321,1985
intraperitoneal/hamster lethal dose (50 percent kill): 626 mg/kgEVHPAZ 61,321,1985
intraperitoneal/mouse lethal dose (50 percent kill): 970 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rabbit lethal dose (50 percent kill): 140 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lethal dose (50 percent kill): 579 mg/kgEVHPAZ 61,321,1985
intraperitoneal/rat lowest published lethal dose: 450 mg/kgVCVGK* -,108,1984
intravenous/cat lowest published lethal dose: 15 mg/kgVCVGK* -,108,1984
intravenous/mouse lethal dose (50 percent kill): 184 mg/kgAIPTAK 135,330,1962
intravenous/rat lethal dose (50 percent kill): 196 mg/kgEVHPAZ 61,321,1985
oral/Dog lowest published lethal dose: 1400 mg/kgGastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
oral/human lowest published lethal dose: 142.8 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,108,1984
oral/mouse lethal dose (50 percent kill): 200 mg/kgBehavioral: General anestheticGISAAA 35(9),88,1970
oral/mouse lethal dose (50 percent kill): 200 mg/kgVCVGK* -,107,1984
oral/rat lethal dose (50 percent kill): 5660 µL/kgBehavioral: Somnolence (general depressed activity)NTIS** OTS0534716
oral/rat lethal dose (50 percent kill): 370 mg/kgVCVGK* -,107,1984
parenteral/frog lowest published lethal dose: 2 gm/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin/rabbit lethal dose (50 percent kill): 2830 µL/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** OTS0534716
skin/rabbit lowest published lethal dose: 4490 mg/kgVCVGK* -,108,1984
subcutaneous/Dog lowest published lethal dose: 1800 mg/kgGastrointestinal: Other changes

Blood: Hemorrhage
COREAF 81,192,1875
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1174 mg/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mammal (species unspecified) lowest published toxic concentration: 10 mg/m3/24H/90D- continuousBrain and Coverings: Other degenerative changes

Liver: Other changes

Lung, Thorax, or Respiration: Other changes
VCVGK* -,108,1994
inhalation/mammal (species unspecified) lowest published toxic concentration: 0.09 mg/m3/60D- intermittentEye: Other eye effectsVCVGK* -,108,1994
inhalation/rat lowest published toxic concentration: 0.08 mg/m3/24H/30D- continuousEye: Optic nerve neuropathy

Olfaction: Change in olfactory nerve
VCVGK* -,108,1994

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 628,67,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 100 ppm (360 mg/m3), MAY2011
Occupational Exposure Limit-GERMANYMAK 20 ppm (73 mg/m3), 2011
Occupational Exposure Limit-ICELANDtime-weighted average 100 ppm (360 mg/m3), NOV2011
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (73 mg/m3), KZG-week 80 ppm (292 mg/m3), JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 100 ppm (525 mg/m3), JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 100 ppm (525 mg/m3), JAN1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0264; Number of Industries 21; Total Number of Facilities 3107; Number of Occupations 31; Total Number of Employees Exposed 23891; Total Number of Female Employees Exposed 10257
National Occupational Hazard Survey 1974Hazard Code M0264; Number of Industries 32; Total Number of Facilities 892; Number of Occupations 42; Total Number of Employees Exposed 17247

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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