3-Penten-2-one, 4-methyl-

RTECS #

SB4200000

CAS #

141-79-7
See: NMAM or OSHA Methods

Updated

September 2013

Molecular Weight

98.16

Molecular Formula

C₆H₁₀O

Synonyms

2,2-Dimethylvinyl methyl ketone
2-Methyl-2-penten-4-one
2-Methyl-2-pentenone-4
4-Methyl-3-penten-2-on (Dutch, German)
4-Methyl-3-penten-2-one
4-Methyl-3-pentene-2-one
4-Metil-3-penten-2-one (Italian)
Acetone, isopropylidene-
Isobutenyl methyl ketone
Isopropylidene acetone
Mesityl oxide
Mesityl oxide (ACGIH:OSHA)
Mesityloxid (German)
Mesityloxyde (Dutch)
Methyl 2,2-dimethylvinyl ketone
Methyl isobutenyl ketone
Ossido di mesitile (Italian)
Oxyde de mesityle (French)

Skin and Eye Irritation and References

Route/Organism	Dose	Effect	Reference
eye /human	25 ppm/15M		JIHTAB 28,262,1946
eye /rabbit	20 mg	severe	AJOPAA 29,1363,1946
skin /rabbit	430 mg open irritation test	mild	UCDS** 11/3/1971

Acute Toxicity Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	Lowest published lethal concentration: 500 ppm/8H	Lung, Thorax, or Respiration: Other changes	JIHTAB 24,46,1942
inhalation/human	lowest published toxic concentration: 100 mg/m³/15M	Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,434,1994
inhalation/human	lowest published toxic concentration: 25 ppm	Eye: Conjunctiva irritation	JIHTAB 28,262,1946
inhalation/mouse	lethal concentration (50 percent kill): 10 gm/m³/2H		85GMAT -,80,1982
inhalation/mouse	lowest published toxic concentration: 20000 mg/m³	Behavioral: General anesthetic	VCVGK* -,434,1994
inhalation/rat	Lowest published lethal concentration: 4000 mg/m³/8H		VCVGK* -,434,1994
inhalation/rat	lethal concentration (50 percent kill): 9 gm/m³/4H		85GMAT -,80,1982
intraperitoneal/mouse	lethal dose (50 percent kill): 354 mg/kg		SCCUR* -,6,1961
oral/mammal (species unspecified)	lethal dose (50 percent kill): 710 mg/kg		GISAAA 39(4),86,1974
oral/mouse	lethal dose (50 percent kill): 710 mg/kg		85GMAT -,80,1982
oral/rabbit	lethal dose (50 percent kill): 1 gm/kg		85INA8 6,896,1991
oral/rat	lethal dose (50 percent kill): 1120 mg/kg		85INA8 6,896,1991
skin/rabbit	lethal dose (50 percent kill): 5150 mg/kg		NPIRI* 1,71,1974
subcutaneous/frog	lowest published lethal dose: 1400 mg/kg		AEXPBL 56,346,1906
subcutaneous/rabbit	lowest published lethal dose: 840 mg/kg		AEXPBL 56,346,1906

Other Multiple Dose Data and References

Route/Organism	Dose	Effect	Reference
inhalation/guinea pig	lowest published toxic concentration: 500 ppm/8H/2W- intermittent	Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 24,46,1942
inhalation/rat	lowest published toxic concentration: 400 mg/m³/38H- intermittent	Liver: Other changes Kidney, Ureter, and Bladder: Other changes	VCVGK* -,435,1994
inhalation/rat	lowest published toxic concentration: 2000 mg/m³/38H- intermittent	Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,435,1994
inhalation/rat	lowest published toxic concentration: 500 ppm/8H/2W- intermittent	Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	JIHTAB 24,46,1942

Reviews

Organization	Standard	Reference
American Conference of Governmental Industrial Hygienists (ACGIH)	Threshold Limit Value-time-weighted average 15 ppm;short term exposure limit 25 ppm	DTLVS* TLV/BEI,2013

Standards and Regulations

Organization	Standard	Reference
Mine Safety and Health Administration (MSHA) STANDARD-air	time-weighted average 25 ppm (100 mg/m³)	DTLVS* 3,152,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIA	time-weighted average 15 ppm (60 mg/m³), short term exposure limit 25 ppm (100 mg/m³), JUL2008
Occupational Exposure Limit-AUSTRIA	MAK-TMW 25 ppm (100 mg/m³), skin, 2007
Occupational Exposure Limit-BELGIUM	time-weighted average 15 ppm (61 mg/m³), short term exposure limit 25 ppm (101 mg/m³), MAR2002
Occupational Exposure Limit-DENMARK	time-weighted average 10 ppm (40 mg/m³), MAY2011
Occupational Exposure Limit-FINLAND	time-weighted average 10 ppm (41 mg/m³), short term exposure limit 25 ppm (100 mg/m³), skin, NOV2011
Occupational Exposure Limit-FRANCE	VME 15 ppm (60 mg/m³), FEB2006
Occupational Exposure Limit-GERMANY	MAK 5 ppm (20 mg/m³), 2011
Occupational Exposure Limit-ICELAND	time-weighted average 10 ppm (40 mg/m³), NOV2011
Occupational Exposure Limit-KOREA	time-weighted average 15 ppm (60 mg/m³), short term exposure limit 25 ppm (100 mg/m³), 2006
Occupational Exposure Limit-NEW ZEALAND	time-weighted average 15 ppm (60 mg/m³); short term exposure limit 25 ppm (100 mg/m³), JAN2002
Occupational Exposure Limit-NORWAY	time-weighted average 10 ppm (40 mg/m³), JAN1999
Occupational Exposure Limit-PERU	time-weighted average 15 ppm (60 mg/m³); short term exposure limit 25 ppm (100 mg/m³), JUL2005
Occupational Exposure Limit-POLAND	MAC(time-weighted average) 20 mg/m³, MAC(short term exposure limit) 100 mg/m³, JAN1999
Occupational Exposure Limit-RUSSIA	short term exposure limit 1 mg/m³, Skin, JUN2003
Occupational Exposure Limit-SWITZERLAND	MAK-week 5 ppm (20 mg/m³), KZG-week 10 ppm (40 mg/m³), skin, JAN2011
Occupational Exposure Limit-THE NETHERLANDS	MAC-TGG 60 mg/m³, 2003
Occupational Exposure Limit-TURKEY	time-weighted average 25 ppm (100 mg/m³), JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8H time-weighted average 25 ppm (100 mg/m³)	CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

Organization	Standard	Reference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MESITYL OXIDE-air	10H time-weighted average 10 ppm	NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983	Hazard Code 45360; Number of Industries 2; Total Number of Facilities 23; Number of Occupations 3; Total Number of Employees Exposed 362; Total Number of Female Employees Exposed 34
National Occupational Hazard Survey 1974	Hazard Code 45360; Number of Industries 9; Total Number of Facilities 1062; Number of Occupations 12; Total Number of Employees Exposed 6484

Status in Federal Agencies

Organization	Reference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301

Page last reviewed: November 16, 2018

Content source: National Institute for Occupational Safety and Health