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3 - Penten - 2 - one, 4 - methyl -

RTECS #: SB4200000

CAS #: 141-79-7


UPDATE: May 2009 MW: 98.16 MF: C6H10O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,2 - Dimethylvinyl methyl ketone
  2. 2 - Methyl - 2 - penten - 4 - one
  3. 2 - Methyl - 2 - pentenone - 4
  4. 4 - Methyl - 3 - penten - 2 - on (Dutch, German)
  5. 4 - Methyl - 3 - penten - 2 - one
  6. 4 - Methyl - 3 - pentene - 2 - one
  7. 4 - Metil - 3 - penten - 2 - one (Italian)
  8. Acetone, isopropylidene -
  9. Isobutenyl methyl ketone
  1. Isopropylidene acetone
  2. Mesityl oxide
  3. Mesityl oxide (ACGIH:OSHA)
  4. Mesityloxid (German)
  5. Mesityloxyde (Dutch)
  6. Methyl 2,2 - dimethylvinyl ketone
  7. Methyl isobutenyl ketone
  8. Ossido di mesitile (Italian)
  9. Oxyde de mesityle (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
human
25 ppm/15 minute N/R JIHTAB 28,262,1946
eye
rabbit
20 mg severe AJOPAA 29,1363,1946
skin
rabbit
430 mg open irritation test mild UCDS** 11/3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 500 ppm/8 hour Lung, Thorax, or Respiration: Other changes JIHTAB 24,46,1942
inhalation
human
lowest published toxic concentration: 25 ppm Eye: Conjunctiva irritation JIHTAB 28,262,1946
inhalation
human
lowest published toxic concentration: 100 mg/m3/15 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough
VCVGK* -,434,1994
inhalation
mouse
lethal concentration (50 percent kill): 10 gm/m3/2 hour N/R 85GMAT -,80,1982
inhalation
mouse
lowest published toxic concentration: 20,000 mg/m3 Behavioral: General anesthetic VCVGK* -,434,1994
inhalation
rat
lethal concentration (50 percent kill): 9 gm/m3/4 hour N/R 85GMAT -,80,1982
inhalation
rat
lethal concentration : 4,000 mg/m3/8 hour N/R VCVGK* -,434,1994
intraperitoneal
mouse
lethal dose (50 percent kill): 354 mg/kg N/R SCCUR* -,6,1961
oral
mammal (species unspecified)
lethal dose (50 percent kill): 710 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 710 mg/kg N/R 85GMAT -,80,1982
oral
rat
lethal dose (50 percent kill): 1,120 mg/kg N/R 85INA8 6,896,1991
oral
rabbit
lethal dose (50 percent kill): 1 gm/kg N/R 85INA8 6,896,1991
subcutaneous
frog
lowest published lethal dose: 1,400 mg/kg N/R AEXPBL 56,346,1906
subcutaneous
rabbit
lowest published lethal dose: 840 mg/kg N/R AEXPBL 56,346,1906
skin
rabbit
lethal dose (50 percent kill): 5,150 mg/kg N/R NPIRI* 1,71,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published toxic concentration: 500 ppm/8 hour/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 24,46,1942
inhalation
rat
lowest published toxic concentration: 500 ppm/8 hour/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
JIHTAB 24,46,1942
inhalation
rat
lowest published toxic concentration: 400 mg/m3/38 hour- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,435,1994
inhalation
rat
lowest published toxic concentration: 2,000 mg/m3/38 hour- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,435,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 15 ppm;short term exposure limit 25 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) DTLVS* 3,152,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 15 ppm (60 mg/m3), short term exposure limit 25 ppm (100 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 15 ppm (61 mg/m3), short term exposure limit 25 ppm (101 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 10 ppm (40 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (100 mg/m3), short term exposure limit 75 ppm (300 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 15 ppm (60 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 100 mg/m3 (25 mL/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 15 ppm (60 mg/m3), short term exposure limit 25 ppm (100 mg/m3), 2006
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 60 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 15 ppm (60 mg/m3);
short term exposure limit 25 ppm (100 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 100 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3),KZG- week 10 ppm (40 mg/m3), Skin, DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 15 ppm;
short term exposure limit 25 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 15 ppm;
short term exposure limit 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MESITYL OXIDE-air 10 hour time-weighted average 10 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 45360;
Number of Industries 9;
Total Number of Facilities 1,062;
Number of Occupations 12;
Total Number of Employees Exposed 6,484
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 45360;
Number of Industries 2;
Total Number of Facilities 23;
Number of Occupations 3;
Total Number of Employees Exposed 362;
Total Number of Female Employees Exposed 34


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones II, 1301


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Human Data
   Primary Irritant

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