CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Pentane, 2,2,4 - trimethyl -

RTECS #: SA3320000

CAS #: 540-84-1


UPDATE: May 2009 MW: 114.26 MF: C8H18


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,2,4 - Trimethylpentane
  2. 2,4,4 - Trimethylpentane
  1. Isobutyltrimethylmethane
  2. Isooctane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
unscheduled DNA synthesis oral
mouse
500 mg/kg TXAPA9 85,11,1986
unscheduled DNA synthesis oral
rat
500 mg/kg TXAPA9 85,11,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 1,000 mg/m3/5 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
VCVGH* -,39,1990
inhalation
human
lowest published toxic concentration: 500 mg/m3/40 minute Behavioral: Muscle contraction or spasticity VCVGH* -,39,1990
inhalation
mouse
lethal concentration : 20,000 mg/m3/2 hour N/R VCVGH* -,39,1990
inhalation
rabbit
lowest published toxic concentration: 1,000 mg/m3 Brain and Coverings: Recordings from specific areas of CNS VCVGH* -,39,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 2,500 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 53,24,2000
oral
rat
lowest published toxic dose: 10 gm/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 1(3),67,1985
oral
rat
lowest published toxic dose: 8 mL/kg/2 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 5,58,1985
oral
rat
lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TOPADD 13,246,1985
oral
rat
lowest published toxic dose: 5 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOLED5 44,13,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 300 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JUL2008
Occupational Exposure Limit - HUNGARY time-weighted average 2350 mg/m3, short term exposure limit 9400 mg/m3, SEP2000
Occupational Exposure Limit - SWEDEN time-weighted average 200 ppm (900 mg/m3);
short term exposure limit 300 ppm (1400 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 300 ppm (1400 mg/m3),KZG- week 600 ppm (2800 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81210;
Number of Industries 14;
Total Number of Facilities 663;
Number of Occupations 18;
Total Number of Employees Exposed 31,908
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81210;
Number of Industries 7;
Total Number of Facilities 290;
Number of Occupations 6;
Total Number of Employees Exposed 7,206;
Total Number of Female Employees Exposed 2,337


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Mutagen
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us