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Registry of Toxic Effects of Chemical Substances (RTECS)

Pentane, 2,2,4-trimethyl-

RTECS #

SA3320000

CAS #

540-84-1

Updated

September 201

Molecular Weight

114.26

Molecular Formula

C8H18

Synonyms

2,2,4-Trimethylpentane
2,4,4-Trimethylpentane
Isobutyltrimethylmethane
Isooctane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Unscheduled DNA Synthesisoral/rat500 mg/kgTXAPA9 85,11,1986
Unscheduled DNA Synthesisoral/mouse500 mg/kgTXAPA9 85,11,1986

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 1000 mg/m3/5MEye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
VCVGH* -,39,1990
inhalation/human lowest published toxic concentration: 500 mg/m3/40MBehavioral: Muscle contraction or spasticityVCVGH* -,39,1990
inhalation/mouse Lowest published lethal concentration: 20000 mg/m3/2HVCVGH* -,39,1990
inhalation/rabbit lowest published toxic concentration: 1000 mg/m3Brain and Coverings: Recordings from specific areas of CNSVCVGH* -,39,1990
inhalation/rat lowest published toxic concentration: 500 ppm/1HBrain and Coverings: Recordings from specific areas of CNSNETEEC 32,525,2010
inhalation/rat lowest published toxic concentration: 2500 ppm/62MBehavioral: Alteration of operant conditioningNETEEC 32,525,2010

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 2500 mg/kg/5D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 53,24,2000
oral/rat lowest published toxic dose: 10 gm/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 1(3),67,1985
oral/rat lowest published toxic dose: 8 mL/kg/2W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 5,58,1985
oral/rat lowest published toxic dose: 2100 mg/kg/21D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TOPADD 13,246,1985
oral/rat lowest published toxic dose: 5 mg/kg/2W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOLED5 44,13,1988

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 300 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 300 ppm (1400 mg/m3), short term exposure limit 375 ppm (1750 mg/m3), JUL2008
Occupational Exposure Limit-HUNGARYtime-weighted average 2350 mg/m3, short term exposure limit 9400 mg/m3, SEP2000
Occupational Exposure Limit-SWEDENtime-weighted average 200 ppm (900 mg/m3);short term exposure limit 300 ppm (1400 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 300 ppm (1400 mg/m3),KZG-week 600 ppm (2800 mg/m3), DEC2006

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81210; Number of Industries 7; Total Number of Facilities 290; Number of Occupations 6; Total Number of Employees Exposed 7206; Total Number of Female Employees Exposed 2337
National Occupational Hazard Survey 1974Hazard Code 81210; Number of Industries 14; Total Number of Facilities 663; Number of Occupations 18; Total Number of Employees Exposed 31908

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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