Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

2,4-Pentanedione

RTECS #

SA1925000

CAS #

123-54-6

Updated

September 201

Molecular Weight

100.13

Molecular Formula

C5H8O2

Synonyms

Acetoacetone
Acetone, acetyl-
Acetyl 2-propanone
Acetyl-2-propaneone
Acetylaceetone
Acetylacetone
Diacetylmethane
Pentanedione
Pentanedione-2,4

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 20 mg severeAJOPAA 29,1363,1946
skin /rabbit 11.2 mL/6H- intermittent mildVHTODE 43,14,2001
skin /rabbit 33.6 mL/6H- intermittent moderateVHTODE 43,14,2001
skin /rabbit 11.2 mL/2D- intermittent moderateVHTODE 43,14,2001
skin /rabbit 10 mg/24H open irritation testJIHTAB 26,269,1944
skin /rabbit 488 mg open irritation test mildUCDS** 7/8/1971

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Dominant Lethal Testinhalation/rat694 ppm/6h/5DTIHEEC 5,463,1989
mutation in mammalian somatic cellsovary/hamster80 mg/LEPASR* 8EHQ-0386-0595

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 398 ppm/6H (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TIHEEC 6,461,1990

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 1000 ppm/4HJIHTAB 31,343,1949
intraperitoneal/mouse lethal dose (50 percent kill): 750 mg/kgNTIS** AD691-490
intraperitoneal/rat lowest published lethal dose: 400 mg/kgBCPCA6 13,285,1964
oral/mouse lethal dose (50 percent kill): 951 mg/kg38MKAJ 2C,4773,1982
oral/rat lethal dose (50 percent kill): 55 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Rigidity (includes catalepsy)
GISAAA 52(10),88,1987
oral/rat lethal dose (50 percent kill): 55 mg/kgBehavioral: General anesthetic

Behavioral: Tetany
VCVGK* -,448,1994
skin/guinea pig lowest published lethal dose: 20 mL/kgNTIS** OTS0533573
skin/rabbit lethal dose (50 percent kill): 810 µL/kgDCTODJ 9,133,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 805 ppm/6H/9D- intermittentEndocrine: Changes in thymus weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 7,329,1986
inhalation/rat lowest published toxic concentration: 650 ppm/6H/14W- intermittentBrain and Coverings: Other degenerative changes

Brain and Coverings: Changes in brain weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
FAATDF 7,329,1986
oral/rabbit lowest published toxic dose: 6 gm/kg/12D- intermittentBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0533573
oral/rat lowest published toxic dose: 10 gm/kg/2W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0533731
skin/rabbit lowest published toxic dose: 3900 mg/kg/4D- continuousBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0557686
skin/rabbit lowest published toxic dose: 8775 mg/kg/11D- intermittentBrain and Coverings: Other degenerative changes

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0510542-3
skin/rabbit lowest published toxic dose: 2925 mg/kg/3D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVHTODE 43,14,2001
skin/rabbit lowest published toxic dose: 2926 mg/kg/2D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVHTODE 43,14,2001
skin/rabbit lowest published toxic dose: 7315 mg/kg/5D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VHTODE 43,14,2001
skin/rabbit lowest published toxic dose: 1950 mg/kg/2D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake
VHTODE 43,14,2001
skin/rabbit lowest published toxic dose: 5852 mg/kg/4D- intermittentBrain and Coverings: Changes in circulation

Endocrine: Other changes

Blood: Changes in spleen
VHTODE 43,14,2001

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 25 ppm (skin)DTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWTOPADD 21,165,2001
TOXICOLOGY REVIEWFCTOD7 47,1287,2009
TOXICOLOGY REVIEWTXAPA9 243,180,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 20 ppm (83 mg/m3), skin, 2011
Occupational Exposure Limit-SWITZERLANDMAK-week 20 ppm (83 mg/m3), KZG-week 40 ppm (166 mg/m3), skin, JAN2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84754; Number of Industries 9; Total Number of Facilities 350; Number of Occupations 23; Total Number of Employees Exposed 6171; Total Number of Female Employees Exposed 1577
National Occupational Hazard Survey 1974Hazard Code 84754; Number of Industries 3; Total Number of Facilities 221; Number of Occupations 3; Total Number of Employees Exposed 3030

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP