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Pentane

RTECS #: RZ9450000

CAS #: 109-66-0


UPDATE: May 2009 MW: 72.17 MF: C5H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Amyl hydride
  2. Pentan (Polish)
  3. Pentanen (Dutch)
  1. Pentane (ACGIH:OSHA)
  2. Pentani (Italian)
  3. Skellysolve A


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 130 mg/m3 Brain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Behavioral: Headache
VCVGH* -,28,1990
inhalation
mouse
lowest published lethal concentration: 325 gm/m3/2 hour Behavioral: Excitement JPETAB 58,74,1936
inhalation
mouse
lowest published toxic concentration: 265,000 mg/m3/5 minute Behavioral: General anesthetic VCVGH* -,28,1990
inhalation
rat
lethal concentration (50 percent kill): 364 gm/m3/4 hour N/R GTPZAB 32(10),23,1988
intravenous
mouse
lethal dose (50 percent kill): 446 mg/kg N/R JPMSAE 67,566,1978
oral
rat
lethal dose (50 percent kill): >2,000 mg/kg N/R JTEHF8 58,35,1999


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 116 mg/m3/117 day- continuous Brain and Coverings: Other degenerative changes

Vascular: BP lowering not characterized in autonomic section
VCVGH* -,28,1990
inhalation
rat
lowest published toxic concentration: 8,800 mg/m3/12 hour/16 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve VCVGH* -,28,1990
oral
rat
lowest published toxic dose: 10 gm/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TIHEEC 1(3),67,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 600 ppm DTLVS* TLV/BEI,2007
TOXICOLOGY REVIEW
ENTOX* -,345,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (1475 mg/m3) DTLVS* 3,200,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (2950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 500 ppm (1500 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (1500 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (2950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 600 ppm (1770 mg/m3), short term exposure limit 750 ppm (2210 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 600 ppm (1800 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 750 ppm (2250 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1500 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 3000 mg/m3 (1000 ppm), FEB 2006
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (1500 mg/m3), short term exposure limit 625 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 600 ppm (1800 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 3000 mg/m3 (1000 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 2950 mg/m3, short term exposure limit 9400 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 300 ppm (880 mg/m3), APR2007
Occupational Exposure Limit - KOREA time-weighted average 600 ppm (1800 mg/m3), short term exposure limit 750 ppm (2250 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 600 ppm (1800 mg/m3);
short term exposure limit 760 ppm (2250 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1800 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 600 ppm (1770 mg/m3), short term exposure limit 750 ppm (2210 mg/m3),JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (2950 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1800 mg/m3, MAC(short term exposure limit) 2300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 300 mg/m3, short term exposure limit 900 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 600 ppm (1800 mg/m3);
short term exposure limit 750 ppm (2000 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 600 ppm (1800 mg/m3),KZG- week 1200 ppm (3600 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (2950 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 600 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 600 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PENTANE-air 10 hour time-weighted average 120 ppm;
ceiling concentration 610 ppm/15 minute
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 54243;
Number of Industries 31;
Total Number of Facilities 3,762;
Number of Occupations 22;
Total Number of Employees Exposed 34,548
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54243;
Number of Industries 24;
Total Number of Facilities 1,935;
Number of Occupations 47;
Total Number of Employees Exposed 38,465;
Total Number of Female Employees Exposed 10,889


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of ice, low-temperature thermometers and as a blowing agent for plastics
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Hydrocarbons, BP 36-126 degree C, 1500
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used in manufacture of ice, low-temperature thermometers and as a blowing agent for plastics

RTECS Compound Description:
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   Human Data

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