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Pentaerythritol, tetranitrate

RTECS #: RZ2620000

CAS #: 78-11-5


UPDATE: May 2008 MW: 316.17 MF: C5H8N4O12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,3 - Dinitrato - 2,2 - bis (nitratomethyl) propane
  2. 1,3 - Propanediol, 2,2 - bis ( (nitrooxy) methyl) - , dinitrate (ester)
  3. 2,2 - Bis ( (nitrooxy) methyl) - 1,3 - propanediol dinitrate (ester)
  4. 2,2 - Bis (hydroxymethyl) - 1,3 - propanediol tetranitrate
  5. Angicap
  6. Angitet
  7. Antora
  8. Arcotrate
  9. Baritrate
  10. C 2 (explosive)
  11. C Hot
  12. CHOT
  13. Cardiacap
  14. Deltrate - 20
  15. Dilcoran 80
  16. Dipentrate
  17. Duotrate
  18. El PETN
  19. Erinit
  20. Extex
  21. Hasethrol
  22. Kaytrate
  23. LX 02 - 1
  24. LX 08 - 0
  25. LX 16 (explosive)
  26. Lentrat
  27. Lowetrate
  28. Martrate - 45
  29. Metranil
  30. Mikardol
  31. Mycardol
  32. Myotrate 10
  33. NCI - C55743
  34. Neo - corovas
  35. Neopentanetetrayl nitrate
  36. Niperyt
  37. Niperyth
  1. Nitrinol
  2. Nitropenta
  3. Nitropentaerythrite
  4. Nitropentaerythritol
  5. PETN
  6. Pencard
  7. Pentafin
  8. Pentanitrine
  9. Pentarit
  10. Pentestan - 80
  11. Pentetrate unicelles
  12. Penthrit
  13. Penthrite
  14. Pentitrate
  15. Pentrate
  16. Pentriol
  17. Pentritol
  18. Pentryate
  19. Pentryate 80
  20. Pergitral
  21. Peridex - LA
  22. Peritrate
  23. Perityl
  24. Prevangor
  25. Quintrate
  26. Rythritol
  27. SDM No. 23
  28. SDM No. 35
  29. Subicard
  30. Tanipent
  31. Tentrate - 20
  32. Tetranitropentaerythrite
  33. Tetrasule
  34. Tranite D - lay
  35. Vasitol
  36. Vaso - 80 unicelies
  37. Vasodiatol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA inhibition cattle mammary gland 3 mol/L/24 hour MOCAE8 59,1044,2001
sister chromatid exchange hamster ovary 160 mg/L NTPTR* NTP-TR-365,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 12,875 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-365,1989
oral
rat
lowest published toxic dose: 1,092,000 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-219452/AS
oral
rat
lowest published toxic dose: 225,680 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-219452/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): >5 gm/kg Vascular: Regional or general arteriolar or venous dilation AIPTAK 131,187,1961
intravenous
rat
lethal dose (50 percent kill): 926 mg/kg N/R YAKUD5 9,759,1967
oral
man
lowest published toxic dose: 1,669 mg/kg/8 year- continuous Skin: After systemic exposure: Dermatitis, other BJDEAZ 87,498,1972
oral
mouse
lowest published lethal dose: 7 gm/kg N/R FRZKAP 16(2),63,1961
oral
rat
lethal dose (50 percent kill): 1,660 mg/kg N/R YAKUD5 9,759,1967
oral
rabbit
lowest published toxic dose: 50 mg/kg Vascular: BP lowering not characterized in autonomic section AEPPAE 364,269,2001
unreported route
rat
lowest published toxic dose: 15,120 g/kg Vascular: BP lowering not characterized in autonomic section NSAPCC 375(Suppl 1),64,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rabbit
lowest published toxic dose: 126 mg/kg/21 day- intermittent Vascular: Other changes AEPPAE 364,269,2001
unreported route
mouse
lowest published toxic dose: 168 mg/kg/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
NSAPCC 375(Suppl 1),29,2007
unreported route
rat
lowest published toxic dose: 45,360 g/kg/3 day- continuous Vascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
NSAPCC 375(Suppl 1),64,2007


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83538;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 6;
Total Number of Employees Exposed 2,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83538;
Number of Industries 4;
Total Number of Facilities 59;
Number of Occupations 8;
Total Number of Employees Exposed 2,650;
Total Number of Female Employees Exposed 1,267


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of detonators and explosive specialties
NTP Carcinogenesis Studies (feed);equivocal evidence:rat NTPTR* NTP-TR-365,1989
NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-365,1989


REFERENCES:

CODEN
REFERENCE

AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in manufacture of detonators and explosive specialties

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

ALT CAS #: 103842-90-6
ALT CAS #: 108736-71-6
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