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Registry of Toxic Effects of Chemical Substances (RTECS)

Pentaerythritol, tetranitrate

RTECS #

RZ2620000

CAS #

78-11-5; 103842-90-6; 108736-71-6

Updated

July 2010

Molecular Weight

316.17

Molecular Formula

C5H8N4O12

Synonyms

1,3-Dinitrato-2,2-bis(nitratomethyl)propane
1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, dinitrate (ester)
2,2-Bis((nitrooxy)methyl)-1,3-propanediol dinitrate (ester)
2,2-Bis(hydroxymethyl)-1,3-propanediol tetranitrate
Angicap
Angitet
Antora
Arcotrate
Baritrate
C 2 (explosive)
C Hot
Cardiacap
CHOT
Deltrate-20
Dilcoran 80
Dipentrate
Duotrate
El PETN
Erinit
Extex
Hasethrol
Kaytrate
Lentrat
Lowetrate
LX 02-1
LX 08-0
LX 16 (explosive)
Martrate-45
Metranil
Mikardol
Mycardol
Myotrate 10
NCI-C55743
Neo-corovas
Neopentanetetrayl nitrate
Niperyt
Niperyth
Nitrinol
Nitropenta
Nitropentaerythrite
Nitropentaerythritol
Pencard
Pentafin
Pentanitrine
Pentarit
Pentestan-80
Pentetrate unicelles
Penthrit
Penthrite
Pentitrate
Pentrate
Pentriol
Pentritol
Pentryate
Pentryate 80
Pergitral
Peridex-LA
Peritrate
Perityl
PETN
Prevangor
Quintrate
Rythritol
SDM No. 23
SDM No. 35
Subicard
Tanipent
Tentrate-20
Tetranitropentaerythrite
Tetrasule
Tranite D-lay
Vasitol
Vaso-80 unicelies
Vasodiatol

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA inhibitionmammary gland/cattle3 µmol/L/24HMOCAE8 59,1044,2001
sister chromatid exchangeovary/hamster160 mg/LNTPTR* NTP-TR-365,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 57000 mg/kg (14D pre-21D after birth)Reproductive: Other effects on femaleBDERB* 86,65,2009

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 12875 mg/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors
NTPTR* NTP-TR-365,1989
oral/rat lowest published toxic dose: 1092000 mg/kg/104W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-219452/AS
oral/rat lowest published toxic dose: 225680 mg/kg/104W- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
NTIS** PB90-219452/AS

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): >5 gm/kgVascular: Regional or general arteriolar or venous dilationAIPTAK 131,187,1961
intravenous/rat lethal dose (50 percent kill): 926 mg/kgYAKUD5 9,759,1967
oral/man lowest published toxic dose: 1669 mg/kg/8Y- continuousSkin: After systemic exposure: Dermatitis, otherBJDEAZ 87,498,1972
oral/mouse lowest published lethal dose: 7 gm/kgFRZKAP 16(2),63,1961
oral/rabbit lowest published toxic dose: 50 mg/kgVascular: BP lowering not characterized in autonomic sectionAEPPAE 364,269,2001
oral/rat lethal dose (50 percent kill): 1660 mg/kgYAKUD5 9,759,1967
unreported route/rat lowest published toxic dose: 15120 µg/kgVascular: BP lowering not characterized in autonomic sectionNSAPCC 375(Suppl 1),64,2007

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 126 mg/kg/21D- intermittentVascular: Other changesAEPPAE 364,269,2001
unreported route/mouse lowest published toxic dose: 168 mg/kg/4W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
NSAPCC 375(Suppl 1),29,2007
unreported route/rat lowest published toxic dose: 45360 µg/kg/3D- continuousVascular: BP lowering not characterized in autonomic section

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
NSAPCC 375(Suppl 1),64,2007

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 543,201,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 83538; Number of Industries 4; Total Number of Facilities 59; Number of Occupations 8; Total Number of Employees Exposed 2650; Total Number of Female Employees Exposed 1267
National Occupational Hazard Survey 1974Hazard Code 83538; Number of Industries 1; Total Number of Facilities 68; Number of Occupations 6; Total Number of Employees Exposed 2770

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (feed);equivocal evidence:rat NTPTR* NTP-TR-365,1989
NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-365,1989
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