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Registry of Toxic Effects of Chemical Substances (RTECS)

Palygorskite

RTECS #

RT6400000

CAS #

12174-11-7; 1337-76-4; 12174-28-6; 37189-50-7; 61180-55-0; 64418-16-2; 71396-54-8; 137546-91-9

Updated

April 2012

Molecular Weight

N/R

Molecular Formula

N/R

Synonyms

200U/P-Rvm
Activated attapulgite
Attaclay
Attaclay X 250
Attacote
Attagel
Attagel 150
Attagel 40
Attagel 50
Attapulgite
Attasorb
Diluex
Min-U-Gel 200
Min-U-Gel 400
Min-U-Gel FG
Palygorskit (German)
Permagel
Pharmasorb-colloidal
RVM-FG
X 250
Zeogel

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 200 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
JJIND8 67,965,1981
inhalation/rat lowest published toxic concentration: 10 mg/m3/6H/13W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
BJIMAG 44,749,1987
intraperitoneal/rat lowest published toxic dose: 338 mg/kg/2W- intermittentTumorigenic: Neoplastic by RTECS criteria

Tumorigenic: Tumors at site of application
ZHPMAT 162,467,1976

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 42,159,1987
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient (>5um)IMEMDT 68,245,1997
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 42,159,1987
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 68,245,1997
International Agency for Research on Cancer (IARC)Cancer Review:Animal Inadequate (<5um)IMEMDT 68,245,1997
International Agency for Research on Cancer (IARC)Cancer Review:Group 2B (fibre >5um)IMEMDT 68,245,1997
International Agency for Research on Cancer (IARC)Cancer Review:Group 3 (fibre >5um)IMEMDT 68,245,1997
TOXICOLOGY REVIEWIJTOFN 22,37,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-DENMARKtime-weighted average 1 f/cc, MAY2011
Occupational Exposure Limit-ICELANDtime-weighted average 1 f/cc, NOV2011

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X2204; Number of Industries 8; Total Number of Facilities 576; Number of Occupations 9; Total Number of Employees Exposed 8199

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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