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Registry of Toxic Effects of Chemical Substances (RTECS)

Palmitic acid

RTECS #

RT4550000

CAS #

57-10-3

Updated

July 2012

Molecular Weight

256.48

Molecular Formula

C16H32O2

Synonyms

1-Pentadecanecarboxylic acid
Cetylic acid
Emersol 140
Emersol 143
Hexadecanoic acid
Hexadecylic acid
Hydrofol
Hystrene 8016
Hystrene 9016
Industrene 4516
n-Hexadecanoic acid
n-Hexadecoic acid

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 75 mg/3D- intermittent mild85DKA8 -,127,1977

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageother cell types/rat50 µmol/l/16HMUREAV 530,27,2003
DNA Damagefibroblast/human1 mmol/l/16HMUREAV 530,27,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/mouse lowest published toxic dose: 1000 mg/kgTumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
CNREA8 26,105,1966

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, colon tumor Inhibitor Concentration (50 percent kill): 666.8 mg/L/72HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.JOETD7 131,363,2010
In Vitro/jtiInhibitor Concentration (50 percent kill): 75.5 mg/L/72HIn Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc.JOETD7 131,363,2010
In Vitro/mzxInhibitor Concentration Low: 20 µmol/L/5DIn Vitro Toxicity Studies: Other assaysJOETD7 132,274,2010
intravenous/mouse lethal dose (50 percent kill): 57 mg/kgBehavioral: Convulsions or effect on seizure thresholdAPTOA6 18,141,1961
oral/mouse lowest published toxic dose: 4.4 mg/kgEndocrine: Other changesPYTOEY 18,669,2011
oral/rat lethal dose (50 percent kill): >10 gm/kgAIHAAP 37,251,1976

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWAMIHAB 21,100,1960

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81460; Number of Industries 55; Total Number of Facilities 5543; Number of Occupations 61; Total Number of Employees Exposed 105420; Total Number of Female Employees Exposed 20470
National Occupational Hazard Survey 1974Hazard Code 81460; Number of Industries 23; Total Number of Facilities 1477; Number of Occupations 34; Total Number of Employees Exposed 20670

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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