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Registry of Toxic Effects of Chemical Substances (RTECS)

Oxygen

RTECS #

RS2060000

CAS #

7782-44-7

Updated

December 2013

Molecular Weight

32.00

Molecular Formula

O2

Synonyms

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human40 pph/4DHUGEDQ 74,438,1986
Cytogenetic Analysisovary/hamster20 pph/3D-continuousMUREAV 219,17,1989
Cytogenetic Analysislung/hamster80 pphMUREAV 57,27,1978
Cytogenetic Analysisembryo/chicken80 pphACATA5 94,520,1976
mutation in mammalian somatic cellslung/hamster95 pph/24HMUREAV 57,27,1978
sister chromatid exchangeovary/hamster20 pphMUREAV 219,17,1989

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/woman 12 pph/10M (26-39W pregnant)Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) systemAJOGAH 82,1055,1961
inhalation/rat 10 pph/12H (22D pregnant)Reproductive: Specific developmental abnormalities: Respiratory systemAJPHAP 257,L221,1989
inhalation/rat 10 pph/9H (22D pregnant)Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Effects on newborn: Physical
AJPHAP 257,L221,1989
inhalation/mouse 10 pph/24H (8D pregnant)Reproductive: Specific developmental abnormalities: Skin and skin appendagesNDKIA2 36,89,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 90 pphLung, Thorax, or Respiration: Other changes

Cardiac: Other changes

Blood: Normocytic anemia
VCVN5* -,156,1993
inhalation/guinea pig lowest published toxic concentration: 100 pph/17HLung, Thorax, or Respiration: Other changes

Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
JPHPH* 59,173,2008
inhalation/guinea pig Lowest published lethal concentration: 80 pphVCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 100 pph/6HLung, Thorax, or Respiration: Other changesVCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 30 pphVascular: Regional or general arteriolar constrictionVCVN5* -,159,1993
inhalation/human lowest published toxic concentration: 70 pph/55HLung, Thorax, or Respiration: Other changesVCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 90 pph/24HPeripheral Nerve and Sensation: ParesthesiaVCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 90 pph/60HCardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Nausea or vomiting
VCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 100 pph/15MGastrointestinal: Nausea or vomitingVCVN5* -,156,1993
inhalation/human lowest published toxic concentration: 100 pph/14HLung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Other changes
JAMAAP 128,710,1945
inhalation/man lowest published toxic concentration: 100 pph/45MCardiac: Pulse rate decreased with fall in BPFCLPH* 23(Suppl 1),17,2009
inhalation/monkey Lowest published lethal concentration: 80 pphLung, Thorax, or Respiration: Acute pulmonary edema

Behavioral: Aggression

Gastrointestinal: Nausea or vomiting
VCVN5* -,156,1993
inhalation/mouse Lowest published lethal concentration: 100 pph/24HBehavioral: Food intake (animal)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease
VCVN5* -,156,1993
inhalation/mouse lowest published toxic concentration: 85 pphLung, Thorax, or Respiration: Other changesTOXID9 78,199,2004
inhalation/rat lowest published toxic concentration: 80 pphLung, Thorax, or Respiration: Other changesVCVN5* -,156,1993
inhalation/rat lowest published toxic concentration: 95 pph/24HLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 66,124,2002
inhalation/rat lowest published toxic concentration: 95 pph/24HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 66,124,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lowest published toxic concentration: 90 pph/8H/90D- intermittentLiver: Other changesVCVN5* -,159,1989
inhalation/guinea pig lowest published toxic concentration: 100 pph/30M/3D- intermittentCardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other
AANEAB 45,119,2001
inhalation/guinea pig lowest published toxic concentration: 100 pph/60H/3D- continuousLung, Thorax, or Respiration: Other changes

Blood: Changes in leukocyte (WBC) count

Biochemical: Metabolism (intermediary): Lipids including transport
JPHPH* 59,173,2008
inhalation/mouse lowest published toxic concentration: 95 pph/4D- continuousLung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXAPA9 215,109,2006
inhalation/mouse lowest published toxic concentration: 95 pph/3D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
TXAPA9 215,109,2006
inhalation/mouse lowest published toxic concentration: >95 pph/3D- continuousLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TOXID9 -,240,2009
inhalation/mouse lowest published toxic concentration: 95 pph/2D- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,10,2003
inhalation/mouse lowest published toxic concentration: 95 pph/3D- continuousLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,10,2003
inhalation/mouse lowest published toxic concentration: 95 pph/4D- continuousLung, Thorax, or Respiration: Changes in lung weightTOXID9 72,11,2003
inhalation/mouse lowest published toxic concentration: 95 pph/3D- continuousLung, Thorax, or Respiration: Changes in lung weightTOXID9 72,11,2003
inhalation/rat lowest published toxic concentration: 95 pph/7D- continuousLung, Thorax, or Respiration: Changes in lung weight

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
TOXID9 72,110,2003
inhalation/rat lowest published toxic concentration: 85 pph/24H/5D- continuousLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
VCVN5* -,159,1989
inhalation/rat lowest published toxic concentration: 95 pph/8D- continuousLung, Thorax, or Respiration: Other changesJPETAB 299,90,2001
inhalation/rat lowest published toxic concentration: 100 pph/24H/3D- continuousLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** PB225-527
inhalation/rat lowest published toxic concentration: 95 pph/24H/2D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
ARTODN 73,540,2000
inhalation/rat lowest published toxic concentration: 70 pph/24H/20D- continuousLung, Thorax, or Respiration: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,159,1989
inhalation/rat lowest published toxic concentration: 95 pph/60H-continuousLung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 66,124,2002
inhalation/rat lowest published toxic concentration: 95 pph/2D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)TOXID9 66,124,2002
multiple/mouse lowest published toxic dose: 75 pph/5D- continuousEye: Retinal changes pigmentary deposition, retinitis, other)JPETAB 324,894,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWFEPRA7 35,89,1976
TOXICOLOGY REVIEWCEFYAD 23,513,1974
TOXICOLOGY REVIEWPTPBD7 1,731,1975
TOXICOLOGY REVIEW32RWA4 1,239,1976
TOXICOLOGY REVIEWANESAV 37,210,1972
TOXICOLOGY REVIEWTXAPA9 181,60,2002
TOXICOLOGY REVIEWDIMON* 40,258,1994
TOXICOLOGY REVIEWENTOX* -,324,2005
TOXICOLOGY REVIEWISMEA* 9,874,2007
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWMUREAV 733,83,2012
TOXICOLOGY REVIEWMUREAV 752,153,2012
TOXICOLOGY REVIEWMUTAEX 23,143,2008

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0006; Number of Industries 81; Total Number of Facilities 7113; Number of Occupations 90; Total Number of Employees Exposed 189129; Total Number of Female Employees Exposed 87473
National Occupational Hazard Survey 1974Hazard Code M0006; Number of Industries 23; Total Number of Facilities 917; Number of Occupations 33; Total Number of Employees Exposed 9677

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Oxygen, 6601
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