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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Oxetanone, 4-methylene-

RTECS #

RQ8225000

CAS #

674-82-8; 2130-41-8

Updated

August 2009

Molecular Weight

84.08

Molecular Formula

C4H4O2

Synonyms

3-Buteno-beta-lactone
4-Methylene-2-oxetanone
Diketene
Ketene, dimer

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 50 µg/24H severe85JCAE -,301,1986
eye /rabbit 25 mg severeUCDS** 2/20/1963
eye /rabbit 537 mgIHFCAY 6,1,1967
skin /rabbit 20 mg/24H moderate85JCAE -,301,1986
skin /rabbit 500 mg open irritation test mildUCDS** 2/20/1963
skin /rabbit 537 mgIHFCAY 6,1,1967

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): 3 gm/m3/2H85JCAE -,301,1986
inhalation/rat Lowest published lethal concentration: 20000 ppm/1HIHFCAY 6,1,1967
inhalation/rat lethal concentration (10 percent kill): 370 ppm/1HLung, Thorax, or Respiration: DyspneaHPV055 -,-,2003
oral/mouse lowest published lethal dose: 800 mg/kgKODAK* 21MAY1971
oral/mouse lethal dose (50 percent kill): 800 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Gastrointestinal: Hypermotility, diarrhea
HPV055 -,-,2003
oral/rat lethal dose (50 percent kill): 560 µL/kgTXAPA9 28,313,1974
oral/rat lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV055 -,-,2003
skin/guinea pig lowest published lethal dose: 10 mL/kgKODAK* 21MAY1971
skin/rabbit lethal dose (50 percent kill): 2830 µL/kgTXAPA9 28,313,1974
skin/rabbit lethal dose (50 percent kill): 6.73 gm/kgHPV055 -,-,2003

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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