CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






2H - 1,3,2 - Oxazaphosphorine, 2 - (bis (2 - chloroethyl) amino) tetrahydro - , 2 - oxide

RTECS #: RP5950000

CAS #: 50-18-0


UPDATE: May 2009 MW: 261.11 MF: C7H15Cl2N2O2P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - (Bis (2 - chloroethyl) amino) - 2H - 1,3,2 - oxazaphosphorine 2 - oxide
  2. 2 - H - 1,3,2 - Oxazaphosphorinane
  3. 2H - 1,3,2 - Oxazaphosphorin - 2 - amine, N,N - bis (2 - chloroethyl) tetrahydro - , 2 - oxide (9CI)
  4. ASTA B518
  5. B 518
  6. Bis (2 - chloroethyl) phosphoramide - cyclic propanolamide ester
  7. CB 4564
  8. CP
  9. CYP
  10. Clafen
  11. Claphene
  12. Cyclophosphamid
  13. Cyclophosphamide
  14. Cyclophosphamidum
  15. Cyclophosphan
  16. Cyclophosphane
  17. Cyclophosphanum
  18. Cyclophosphoramide
  19. Cyclostin
  20. Cyklofosfamid (Czech)
  21. Cytophosphan
  1. Cytoxan
  2. Endoxan
  3. Endoxan - asta
  4. Endoxana
  5. Endoxanal
  6. Endoxane
  7. Genoxal
  8. Genuxal
  9. N,N - Bis (2 - chloroethyl) - N',O - propylenephosphoric acid ester diamide
  10. N,N - Bis (2 - chloroethyl) tetrahydro - 2H - 1,3,2 - oxazaphosphorin - 2 - amine 2 - oxide
  11. N,N - Bis (beta - chloroethyl) - N',O - trimethylenephosphoric acid ester diamide
  12. N,N - Bis - (beta - chloraethyl) - N',O - propylen - phosphorsaeure - ester - diamid (German)
  13. N,N - Di (2 - chloroethyl) - N,O - propylene - phosphoric acid ester diamide
  14. NCI - C04900
  15. NSC 26271
  16. Phosphorodiamidic acid, N,N - bis (2 - chloroethyl) - N' - (3 - hydroxypropyl) - , intramol. ester
  17. Procytox
  18. RCRA waste number U058
  19. SK 20501
  20. Sendoxan
  21. Zyklophosphamid (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay human
Saccharomyes cerevisiae
6,200 g/kg MUREAV 21,257,1973
body fluid assay human
Salmonella typhimurium
14 mg/kg CANCAR 38,1253,1976
body fluid assay mouse
Salmonella typhimurium
50 mg/kg ENMUDM 2,521,1980
body fluid assay mouse
lymphocyte
1 gm/kg SOGEBZ 12,1425,1976
body fluid assay rat
Salmonella typhimurium
50 mg/kg ENMUDM 1,155,1979
body fluid assay rat
embryo
100 mg/kg TOLED5 28,23,1985
body fluid assay rabbit
lymphocyte
20 mg/kg BEBMAE 101,461,1986
cytogenetic analysis unreported route
child
4 mg/kg/4 week HUMAA7 22,221,1974
cytogenetic analysis parenteral
chicken
8 g/kg 47JMAE -,137,1982
cytogenetic analysis intraperitoneal
guinea pig
25 mg/kg MUREAV 268,211,1992
cytogenetic analysis grasshopper embryo 200 mol/L MUREAV 119,71,1983
cytogenetic analysis grasshopper other cell types 20 mol/L CGCGBR 33,114,1982
cytogenetic analysis inhalation
hamster
1 mg/m3/2 hour- continuous MUREAV 203,1,1988
cytogenetic analysis hamster lung 100 mol/L ARGEAR 52,97,1982
cytogenetic analysis hamster ovary 20 mg/L MUREAV 223,191,1989
cytogenetic analysis oral
hamster
320 mg/kg/2 week- intermittent MUREAV 7,99,1969
cytogenetic analysis hamster other cell types 10 mg/L CNREA8 38,2922,1978
cytogenetic analysis hamster fibroblast 10 mmol/L MUREAV 51,397,1978
cytogenetic analysis intraperitoneal
hamster
3,300 g/kg ARTODN 38,35,1977
cytogenetic analysis hamster other cell types 10 gm/L/2 hour (+enzymatic activation step) MUREAV 472,75,2000
cytogenetic analysis hamster ovary 25 mg/L/4 hour (+enzymatic activation step) MUREAV 494,41,2001
cytogenetic analysis hamster ovary 20 mg/L/4 hour EMMUEG 36,13,2000
cytogenetic analysis hamster ovary 0.9 mmol/L/3 hour (+enzymatic activation step) MUREAV 498,117,2001
cytogenetic analysis hamster lung 5 mg/L/18 hour (+enzymatic activation step) JTSCDR 26,243,2001
cytogenetic analysis oral
hamster
30 mg/kg MUREAV 537,183,2003
cytogenetic analysis hamster lung 42.9 mol/L/2 hour (+enzymatic activation step) MUREAV 540,29,2003
cytogenetic analysis hamster ovary 0.66 mg/L/3 hour (+enzymatic activation step) TOLED5 136,87,2002
cytogenetic analysis hamster ovary 50 mg/L/2 hour (+enzymatic activation step) TCMUD8 23,137,2003
cytogenetic analysis hamster lung 1.4 mg/L/4 hour (+enzymatic activation step) RTOPDW 36,69,2002
cytogenetic analysis hamster ovary 50 mg/L/24 hour (+enzymatic activation step) TCMUD8 23(Suppl 1),137,2003
cytogenetic analysis hamster lung 5 mg/L/6 hour (+enzymatic activation step) FCTOD7 44,354,2006
cytogenetic analysis unreported route
human
60 mg/kg/8 week- intermittent HUHEAS 29,100,1979
cytogenetic analysis human leukocyte 1 mmol/L MUREAV 56,101,1977
cytogenetic analysis human HeLa cell 210 mg/L/48 hour HUMAA7 4,362,1967
cytogenetic analysis human lymphocyte 10 g/L/72 hour ARTODN 46,61,1980
cytogenetic analysis human other cell types 50 g/L MUREAV 11,258,1971
cytogenetic analysis human lymphocyte 10 mg/L/18 hour IJTOFN 19,69,2000
cytogenetic analysis human lymphocyte 50 nmol/L/6 hour (+enzymatic activation step) MUREAV 494,13,2001
cytogenetic analysis human lymphocyte 28 mg/L/2 hour (+enzymatic activation step) MUREAV 497,89,2001
cytogenetic analysis human sperm 20 mg/L/120 minute (+enzymatic activation step) MUTAEX 504,183,2002
cytogenetic analysis human lymphocyte 0.15 mmol/L/3 hour (+enzymatic activation step) MUREAV 536,27,2003
cytogenetic analysis human lymphocyte 28 mg/L/2 hour MUREAV 535,161,2003
cytogenetic analysis human lymphocyte 0.2 mmol/L/2 hour (+enzymatic activation step) MUREAV 542,117,2003
cytogenetic analysis human lymphocyte 5 mg/L/22 hour (+enzymatic activation step) MUREAV 558,93,2004
cytogenetic analysis human lymphocyte 10 mg/L/4 hour (+enzymatic activation step) MUREAV 560,147,2004
cytogenetic analysis human lymphocyte 6.25 mg/L/3 hour (+enzymatic activation step) RTOPDW 39,256,2004
cytogenetic analysis human lymphocyte 0.25 mg/L/20 hour (+enzymatic activation step) RTOPDW 35,255,2002
cytogenetic analysis human lymphocyte 30 mg/L/48 hour (+enzymatic activation step) TXCYAC 200,39,2004
cytogenetic analysis human other cell types 50 mol/L/2 hour MUREAV 649,45,2008
cytogenetic analysis oral
mammal (species unspecified)
25 mg/kg JANSAG 39,142,1974
cytogenetic analysis intraperitoneal
mammal (species unspecified)
50 mg/kg GNKAA5 17,1639,1981
cytogenetic analysis intravenous
monkey
18,400 g/kg GNKAA5 22,1213,1986
cytogenetic analysis mouse lymphocyte 35 mg/L MUREAV 252,221,1991
cytogenetic analysis inhalation
mouse
1 mg/m3/2 hour- continuous MUREAV 203,1,1988
cytogenetic analysis unreported route
mouse
150 mg/kg GNTKDF 11,203,1979
cytogenetic analysis intraperitoneal
mouse
10 mg/kg MUREAV 140,49,1984
cytogenetic analysis mouse embryo 50 mg/L CNREA8 38,2922,1978
cytogenetic analysis intravenous
mouse
45 mg/kg MUREAV 60,329,1979
cytogenetic analysis oral
mouse
20 mg/kg CALEDQ 144,137,1999
cytogenetic analysis intraperitoneal
mouse
270 mg/kg/10 day- intermittent FATOAO 55,49,1992
cytogenetic analysis mouse other cell types 2 mg/L/4 hour (+enzymatic activation step) TCMUD8 23,137,2003
cytogenetic analysis intraperitoneal
non-mammalian species
15,600 g/kg MUREAV 172,165,1986
cytogenetic analysis multiple
non-mammalian species
500 g/L MUREAV 319,223,1993
cytogenetic analysis intraperitoneal
other insects
2 gm/L MUREAV 520,141,2002
cytogenetic analysis rat liver 2 gm/L MUREAV 64,329,1979
cytogenetic analysis intraperitoneal
rat
3,300 g/kg ARTODN 38,35,1977
cytogenetic analysis oral
rat
9 mg/kg ARZNAD 29,1871,1979
cytogenetic analysis intravenous
rat
3,300 g/kg GISAAA 42(8),27,1977
cytogenetic analysis intraperitoneal
rat
30 mg/kg (+enzymatic activation step) JAPTO* 21,449,2001
cytogenetic analysis unreported route
rat
6 mg/kg MUREAV 577S,1,2005
cytogenetic analysis intravenous
rabbit
20 mg/kg BEBMAE 101,461,1986
dominant lethal test oral
mouse
160 mg/kg MUREAV 26,427,1974
dominant lethal test unreported route
mouse
40 mg/kg EESADV 3,122,1979
dominant lethal test intraperitoneal
mouse
100 mg/kg TXCYAC 206,169,2005
dominant lethal test oral
rat
50 mg/kg MUREAV 48,267,1977
DNA adduct oral
dog
6,600 g/kg CRNGDP 12,1483,1991
DNA adduct mouse Ascites tumor 120 mol/kg CNREA8 33,1048,1973
DNA damage Bacillus subtilis 2 mg/disc PMRSDJ 1,175,1981
DNA damage hamster ovary 10 mg/L/3 hour (+enzymatic activation step) MUREAV 605,7,2006
DNA damage intravenous
human
750 mg/kg CNREA8 49,3452,1989
DNA damage human leukocyte 500 mol/L MUREAV 346,49,1995
DNA damage human other cell types 900 mol/L MUREAV 468,213,2000
DNA damage human lymphocyte 0.25 mmol/L/3 hour (+enzymatic activation step) MUREAV 540,43,2003
DNA damage human ovary 1 mmol/L MUREAV 575,17,2005
DNA damage subcutaneous
mouse
15 mg/kg CRNGDP 10,83,1989
DNA damage intravenous
mouse
160 mg/kg CNREA8 49,3452,1989
DNA damage mouse lymphocyte 500 mol/L MUREAV 203,155,1988
DNA damage intraperitoneal
mouse
20 mg/kg TCMUD8 2,47,1982
DNA damage unreported route
mouse
60 mg/kg PACHAS 42,209,1975
DNA damage mouse leukocyte 1 mmol/L CTRRDO 62,23,1978
DNA damage oral
mouse
25 mg/kg MUTAEX 20,279,2005
DNA damage intraperitoneal
mouse
120 mg/kg/3 day- intermittent INJPD2 39,265,2007
DNA damage other microorganisms 300 mol/L MUREAV 368,235,1996
DNA damage oral
rat
150 mg/kg/10 week TXCYAC 217,71,2006
DNA damage intraperitoneal
rat
40 mg/kg MUREAV 606,85,2006
DNA inhibition human HeLa cell 600 mol/L/1 hour- continuous JEPTDQ 2(1),65,1978
DNA inhibition human other cell types 200 mg/L CNREA8 42,3676,1982
DNA inhibition intraperitoneal
mouse
150 mg/kg BJDEAZ 94,1,1976
DNA inhibition subcutaneous
mouse
80 mg/kg BCPCA6 22,3181,1973
DNA inhibition intravenous
rat
75 mg/kg MUREAV 68,275,1979
DNA repair Bacillus subtilis 1 gm/L EVSRBT 24,19,1981
DNA repair Escherichia coli 1,250 g/plate NULSAK 28,159,1985
DNA repair Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,502,1981
unscheduled DNA synthesis human HeLa cell 100 nmol/L CNREA8 38,2621,1978
unscheduled DNA synthesis human lymphocyte 1 mol/L JTEHD6 6,1059,1980
unscheduled DNA synthesis human other cell types 300 mg/L MUREAV 271,201,1992
unscheduled DNA synthesis intraperitoneal
mouse
200 mg/kg MUREAV 50,229,1978
unscheduled DNA synthesis oral
mouse
100 mg/kg ATSUDG 7,174,1984
unscheduled DNA synthesis intraperitoneal
rat
25 mg/kg ENMUDM 2,278,1980
unscheduled DNA synthesis rat liver 500 mol/L ENMUDM 3,11,1981
unscheduled DNA synthesis oral
rat
25 mg/kg JJATDK 2,172,1982
unscheduled DNA synthesis intravenous
rabbit
20 mg/kg ARTODN 46,139,1980
unscheduled DNA synthesis Salmonella typhimurium 2 g ECEBDI 50,271,1982
host-mediated assay mouse
Ascites tumor
10 mg/kg TCMUD8 10,321,1990
host-mediated assay mouse
lung
1,600 g/kg MUREAV 64,259,1979
host-mediated assay mouse
Salmonella typhimurium
200 mg/kg BIZNAT 96,151,1977
host-mediated assay mouse
Serratia marcescens
870 mg/kg/2 hour MGGEAE 117,197,1972
host-mediated assay mouse
Saccharomyes cerevisiae
225 mg/kg MUREAV 111,295,1983
host-mediated assay mouse
lymphocyte
150 mg/kg ENVRAL 13,267,1977
host-mediated assay rat
Saccharomyes cerevisiae
2,611 mg/kg MUREAV 31,381,1975
mutation in microorganisms Aspergillus nidulans 20 mg/plate (-enzymatic activation step) MUREAV 80,265,1981
mutation in microorganisms Escherichia coli 5 mg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Escherichia coli 10 mmol/L (+enzymatic activation step) ARTODN 33,225,1975
mutation in microorganisms hamster lung 10 mg/L (+enzymatic activation step) MUREAV 157,189,1985
mutation in microorganisms human lymphocyte 7 mg/L (+enzymatic activation step) MUTAEX 4,335,1989
mutation in microorganisms human fibroblast 475 nmol/L (+enzymatic activation step) CNREA8 41,1873,1981
mutation in microorganisms mouse lymphocyte 250 g/L (+enzymatic activation step) MUREAV 223,295,1989
mutation in microorganisms Salmonella typhimurium 1 g/plate (-enzymatic activation step) ENMUDM 6(Suppl 2),1,1984
mutation in microorganisms Salmonella typhimurium 0.5 mg/plate (+enzymatic activation step) JOETD7 77,30,2001
mutation in microorganisms Salmonella typhimurium 100 g/plate/48 hour (+enzymatic activation step) MUTAEX 16,523,2001
mutation in microorganisms Salmonella typhimurium 500 g/plate/20 minute (+enzymatic activation step) MUREAV 514,19,2002
mutation in microorganisms Salmonella typhimurium 1,000 g/plate/72 hour (+enzymatic activation step) MUREAV 585,105,2005
mutation in microorganisms Saccharomyes cerevisiae 26,700 mol/L (+enzymatic activation step) MUREAV 45,309,1977
mutation in microorganisms Saccharomyes cerevisiae 2.5 mmol/plate (+enzymatic activation step) TOLED5 136,87,2002
mutation in microorganisms Saccharomyes cerevisiae 20,000 mg/L/17 hour (+/-enzymatic activation step) MUREAV 582,116,2005
mutation in microorganisms Saccharomyes cerevisiae 250 mg/L/18 hour (+enzymatic activation step) MUREAV 653,63,2008
mutation in microorganisms Schizosaccharomyces pombe 1 mmol/L (+enzymatic activation step) MUREAV 111,295,1983
micronucleus test hamster lung 2 mg/L MUREAV 222,63,1989
micronucleus test hamster other cell types 17.5 mol/L/3 hour (+/-enzymatic activation step) FCTOD7 39,843,2001
micronucleus test hamster fibroblast 10 mg/L/6 hour (+enzymatic activation step) MUREAV 493,75,2001
micronucleus test hamster fibroblast 2.5 mg/L/3 hour (+enzymatic activation step) MUREAV 514,133,2002
micronucleus test human lymphocyte 800 mol/L MUREAV 227,167,1989
micronucleus test human lymphocyte 28 mg/L/3 hour (+enzymatic activation step) MUREAV 497,177,2001
micronucleus test human lymphocyte 28 mg/L/2 hour (+enzymatic activation step) MUREAV 497,89,2001
micronucleus test human other cell types 12 mg/L/3 hour (+enzymatic activation step) MUREAV 517,39,2002
micronucleus test human lymphocyte 28 mg/L/2 hour MUREAV 535,161,2003
micronucleus test human lymphocyte 100 mol/L/2 hour (+enzymatic activation step) MUREAV 544,279,2003
micronucleus test human lymphocyte 5 mg/L/30 hour (+enzymatic activation step) MUREAV 558,93,2004
micronucleus test human lymphocyte 30 mg/L/48 hour (+enzymatic activation step) TXCYAC 200,39,2004
micronucleus test human lymphocyte 0.1 mmol/L/3 hour (+enzymatic activation step) MUTAEX 19,75,2004
micronucleus test human liver 800 mol/L/22 hour TOXIA6 49,1219,2007
micronucleus test mouse fibroblast 1 mg/L MUREAV 279,217,1992
micronucleus test intravenous
mouse
60 g/kg MUTAEX 4,6,1989
micronucleus test unreported route
mouse
20 mg/kg EESADV 3,122,1979
micronucleus test intraperitoneal
mouse
5 mg/kg MUREAV 56,311,1978
micronucleus test oral
mouse
30 mg/kg MUREAV 234,155,1990
micronucleus test subcutaneous
mouse
20 mg/kg/24 hour EXPEAM 36,297,1980
micronucleus test intraperitoneal
mouse
40 mg/kg/2 day TOLED5 121,159,2001
micronucleus test oral
mouse
40 mg/kg/2 day- intermittent (-enzymatic activation step) JAPTO* 20,491,2000
micronucleus test oral
mouse
20 mg/kg (-enzymatic activation step) JAPTO* 20,491,2000
micronucleus test intraperitoneal
mouse
120 mg/kg/3 day MUREAV 494,41,2001
micronucleus test oral
mouse
40 mg/kg/48 hour- intermittent JOETD7 77,30,2001
micronucleus test mouse mammary gland 2.5 mg/L/3 hour (+enzymatic activation step) MUREAV 540,153,2003
micronucleus test oral
mouse
100 mg/kg/2 day MUREAV 557,85,2004
micronucleus test oral
mouse
75 mg/kg/3 day- intermittent MUREAV 649,101,2008
micronucleus test intraperitoneal
mouse
120 mg/kg/3 day- intermittent INJPD2 39,265,2007
micronucleus test mouse other cell types 9.57 mol/L MUREAV 655,4,2008
micronucleus test non-mammalian species testis 1 mol/L MUREAV 203,125,1988
micronucleus test multiple
non-mammalian species
5 ppm MUREAV 298,25,1992
micronucleus test multiple
non-mammalian species
37.5 mg/L/24 hour- continuous EMMUEG 44,436,2004
micronucleus test multiple
other fish
5 mg/L MUREAV 438,155,1999
micronucleus test other fish other cell types 2 mg/L/3 day MUREAV 538,81,2003
micronucleus test intraperitoneal
rat
5 mg/kg MUREAV 58,79,1978
micronucleus test rat liver 10 mol/L MUREAV 292,213,1993
micronucleus test oral
rat
1.4 mg/kg MUREAV 478,211,2001
micronucleus test parenteral
rat
25 mg/kg MUREAV 560,147,2004
micronucleus test oral
rat
50 mg/kg/5 day- intermittent EMMUEG 44,174,2004
micronucleus test oral
rat
20 mg/kg/4 day MUREAV 577S,1,2005
micronucleus test oral
rat
11 mg/kg/11 day- intermittent MUREAV 626,26,2007
micronucleus test oral
rat
75 mg/kg/3 day- intermittent MUREAV 649,101,2008
gene conversion and mitotic recombination oral
Drosophila melanogaster
0.5 mmol/L/48 hour MUTAEX 16,385,2001
gene conversion and mitotic recombination Saccharomyes cerevisiae 500 mol/L MUREAV 111,295,1983
mutation in mammalian somatic cells hamster liver 5 mmol/L MUREAV 271,79,1992
mutation in mammalian somatic cells hamster ovary 30 mg/L/5 hour (+/-enzymatic activation step) RTOPDW 35,398,2002
mutation in mammalian somatic cells human lymphocyte 6.25 mg/L/3 hour (+enzymatic activation step) RTOPDW 37,11,2003
mutation in mammalian somatic cells mouse lymphocyte 80 mg/L DCTODJ 1,277,1978
morphological transform hamster kidney 80 g/L BJCAAI 37,873,1978
morphological transform hamster embryo 50 mg/L JJIND8 67,1303,1981
morphological transform mouse embryo 10 mg/L CNREA8 38,2922,1978
morphological transform mouse fibroblast 10 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform rat embryo 5 mg/L JJIND8 67,1303,1981
other mutation test systems chicken embryo 3 g ENMUDM 8,241,1986
other mutation test systems grasshopper embryo 200 mol/L MUREAV 119,71,1983
other mutation test systems human HeLa cell 840 mg/L HUMAA7 4,362,1967
other mutation test systems subcutaneous
mouse
80 mg/kg BCPCA6 22,3181,1973
other mutation test systems intraperitoneal
mouse
20 mg/kg MUREAV 224,105,1989
phage inhibition capacity Escherichia coli 100 g/plate CNREA8 43,2819,1983
sister chromatid exchange parenteral
chicken
8 g/kg 47JMAE -,137,1982
sister chromatid exchange intraperitoneal
hamster
1 mg/kg ARZNAD 29,1871,1979
sister chromatid exchange hamster ovary 100 mol/L/24 hour MUREAV 41,343,1976
sister chromatid exchange oral
hamster
5 mg/kg MUREAV 74,164,1980
sister chromatid exchange hamster lung 625 g/L CRNGDP 1,37,1980
sister chromatid exchange unreported route
hamster
1 mg/kg EESADV 3,122,1979
sister chromatid exchange hamster other cell types 10 mg/L CNREA8 38,2922,1978
sister chromatid exchange hamster fibroblast 3 mmol/L MUREAV 93,409,1982
sister chromatid exchange hamster liver 26 mg/L MUREAV 207,69,1988
sister chromatid exchange inhalation
hamster
1 mg/m3/2 hour- continuous MUREAV 203,1,1988
sister chromatid exchange hamster ovary 0.9 mmol/L/3 hour (+enzymatic activation step) MUREAV 498,117,2001
sister chromatid exchange human other cell types 500 mg/L ENMUDM 7(Suppl 3),26,1985
sister chromatid exchange oral
human
31 mg/kg MUREAV 67,289,1979
sister chromatid exchange human lymphocyte 10 mol/L PJABDW 56,568,1980
sister chromatid exchange human fibroblast 10 mol/L CNREA8 45,3626,1985
sister chromatid exchange human leukocyte 1 mol/L MUREAV 346,49,1995
sister chromatid exchange human lymphocyte 1.4 mg/L/3 hour (+enzymatic activation step) MUREAV 497,177,2001
sister chromatid exchange human lymphocyte 50 nmol/L/90 minute (+enzymatic activation step) MUREAV 494,13,2001
sister chromatid exchange human lymphocyte 28 mg/L/2 hour (+enzymatic activation step) MUREAV 497,89,2001
sister chromatid exchange human other cell types 12 mg/L/3 hour (+enzymatic activation step) MUREAV 517,39,2002
sister chromatid exchange human lymphocyte 5 mg/L/24 hour (+enzymatic activation step) MUREAV 558,93,2004
sister chromatid exchange human lymphocyte 0.5 mol/L/72 hour (+enzymatic activation step) TCMUD8 23,267,2003
sister chromatid exchange human lymphocyte 0.5 mol/L/3 hour (+enzymatic activation step) MUTAEX 19,75,2004
sister chromatid exchange intravenous
monkey
18,400 g/kg GNKAA5 22,1213,1986
sister chromatid exchange monkey kidney 100 mol/L CNREA8 45,3626,1985
sister chromatid exchange inhalation
mouse
1 mg/m3/2 hour- continuous MUREAV 203,1,1988
sister chromatid exchange parenteral
mouse
2,500 g/kg MUREAV 57,233,1978
sister chromatid exchange subcutaneous
mouse
5 mg/kg CGCGBR 18,231,1977
sister chromatid exchange intraperitoneal
mouse
3 mg/kg CNREA8 44,3820,1984
sister chromatid exchange intravenous
mouse
10 mg/kg ENMUDM 2,246,1980
sister chromatid exchange unreported route
mouse
12,500 g/kg NATUAS 260,448,1976
sister chromatid exchange mouse embryo 10 mg/L CNREA8 38,2922,1978
sister chromatid exchange mouse Ascites tumor 15 mg/kg ENMUDM 1,177,1979
sister chromatid exchange mouse other cell types 4 mg/L MUREAV 224,465,1989
sister chromatid exchange intraperitoneal
non-mammalian species
2,600 g/kg MUREAV 172,165,1986
sister chromatid exchange multiple
other fish
2,500 g/L MUREAV 97,35,1982
sister chromatid exchange rat lymphocyte 5 mol/L TOLED5 7,229,1981
sister chromatid exchange rat liver 1 mg/L TOLED5 13,95,1982
sister chromatid exchange rat other cell types 300 mol/L MUREAV 93,409,1982
sister chromatid exchange oral
rat
240 mg/kg/10 day- continuous ENMUDM 7(Suppl 3),79,1985
sister chromatid exchange intraperitoneal
rat
5 mg/kg TIHEEC 22,65,2006
sister chromatid exchange intraperitoneal
rabbit
35 mg/kg MUREAV 41,333,1976
sister chromatid exchange parenteral
rabbit
35 mg/kg ENMUDM 1,176,1979
sister chromatid exchange rabbit lymphocyte 5 mol/L TOLED5 7,229,1981
sister chromatid exchange intravenous
rabbit
20 mg/kg BEBMAE 101,461,1986
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
2 mmol/L/24 hour MUREAV 33,221,1975
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster
19,200 mol/L EVSRBT 24,175,1981
sex chromosome loss and nondisjunction hamster liver 2 gm/L PMRSDJ 5,397,1985
sex chromosome loss and nondisjunction intraperitoneal
mouse
50 mg/kg MUREAV 144,27,1985
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 100 mg/L PMRSDJ 1,468,1981
specific locus test oral
Drosophila melanogaster
100 mol/L MUREAV 252,305,1991
specific locus test intravenous
human
71.4 mg/kg MUTAEX 16,197,2001
specific locus test intraperitoneal
mouse
5 mg/kg ARTODN 38,87,1977
specific locus test intraperitoneal
mouse
200 mg/kg/5 day- intermittent MUREAV 535,35,2003
specific locus test mouse other cell types 5 mg/L/3 hour (+/-enzymatic activation step) MUREAV 537,183,2003
specific locus test intraperitoneal
rat
50 mg/kg EMMUEG 43,265,2004
sperm morphology oral
hamster
400 mg/kg/24 hour ARTODN 39,187,1978
sperm morphology intraperitoneal
hamster
200 mg/kg/5 day ARTODN 38,35,1977
sperm morphology human sperm 20 mg/L/2 hour (+enzymatic activation step) MUREAV 491,57,2001
sperm morphology intraperitoneal
mouse
100 mg/kg/5 day- continuous MUREAV 100,345,1982
sperm morphology unreported route
mouse
50 mg/kg GNKAA5 16,1397,1980
sperm morphology intraperitoneal
mouse
40 mg/kg ETOPFR 10,81,2001
sperm morphology oral
mouse
500 mg/kg/10 day MUREAV 492,1,2001
sperm morphology intraperitoneal
rat
100 mg/kg/5 day- intermittent ENMUDM 6,393,1984
sperm morphology intraperitoneal
rat
200 mg/kg/5 day MUREAV 513,193,2002
heritable translocation test oral
Drosophila melanogaster
8,000 ppm ENMUDM 7,349,1985
heritable translocation test intraperitoneal
mouse
350 mg/kg REBPAT 13,1,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lowest published toxic dose: 32 mg/kg (11-15 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NEOLA4 26,529,1979
intramuscular
mouse
lowest published toxic dose: 106 mg/kg (11-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
NEOLA4 26,529,1979
intraplacental
mouse
lowest published toxic dose: 80 g/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death 40YJAX -,207,1979
intraperitoneal
hamster
lowest published toxic dose: 1 gm/kg (4 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JTEHD6 22,29,1987
intraperitoneal
hamster
lowest published toxic dose: 5 mg/kg (17 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) ATSUDG 4,22,1980
intraperitoneal
hamster
lowest published toxic dose: 200 mg/kg (4 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JTEHD6 22,29,1987
intraperitoneal
hamster
lowest published toxic dose: 15 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JCGBDF 9,381,1989
intraperitoneal
hamster
lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
JCGBDF 9,381,1989
intraperitoneal
mammal (species unspecified)
lowest published toxic dose: 275 mg/kg (8-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JIDOAA 35,387,1986
intraperitoneal
mammal (species unspecified)
lowest published toxic dose: 550 mg/kg (8-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities
JIDOAA 35,387,1986
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
TCMUD8 7,7,1987
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 100,345,1982
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 42,473,1990
intraperitoneal
mouse
lowest published toxic dose: 1 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system JTEHD6 18,25,1986
intraperitoneal
mouse
lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TJADAB 4,141,1971
intraperitoneal
mouse
lowest published toxic dose: 5 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ARZNAD 22,122,1972
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Urogenital system
TJADAB 4,141,1971
intraperitoneal
mouse
lowest published toxic dose: 5 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) CNREA8 28,475,1968
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility REPTED 5,73,1991
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FATOAO 48,69,1985
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
FATOAO 48,69,1985
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FATOAO 48,69,1985
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg (1-5 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FCTOD7 46,567,2008
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg (5 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
FCTOD7 46,567,2008
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERE* 76,437,2006
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear
BDERE* 76,437,2006
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Gastrointestinal system
BDERE* 76,437,2006
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TERP2* -,317,2004
intraperitoneal
rat
lowest published toxic dose: 140 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) HIKYAJ 12,1339,1966
intraperitoneal
rat
lowest published toxic dose: 91 mg/kg (17-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Behavioral YACHDS 10,703,1982
intraperitoneal
rat
lowest published toxic dose: 7,500 g/kg (13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TJADAB 24,1,1981
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TCMUD8 10,417,1990
intraperitoneal
rat
lowest published toxic dose: 250 mg/kg (5 week prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) SCIEAS 211,80,1981
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 24,1,1981
intraperitoneal
rat
lowest published toxic dose: 20 mg/kg (13 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Body wall
TJADAB 24,1,1981
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JPETAB 45,79,1982
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg (3 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) CYLPDN 21,554,2000
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other effects to embryo or fetus
FCTOD7 41,89,2003
intravenous
mammal (species unspecified)
lowest published toxic dose: 50 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities
JIDOAA 35,387,1986
intravenous
mouse
lowest published toxic dose: 10 mg/kg (13 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) NATUAS 279,531,1979
intravenous
mouse
lowest published toxic dose: 5 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) JTEHD6 18,25,1986
intravenous
rat
lowest published toxic dose: 55 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system SEIJBO 20,143,1980
intravenous
rabbit
lowest published toxic dose: 30 mg/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Body wall
AGACBH 2,83,1971
intravenous
rabbit
lowest published toxic dose: 20 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ARZNAD 30,1585,1980
intravenous
rabbit
lowest published toxic dose: 30 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) AGACBH 2,83,1971
intravenous
rabbit
lowest published toxic dose: 65 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death
YACHDS 10,695,1982
intravenous
rabbit
lowest published toxic dose: 80 mg/kg (9 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TJADAB 24(2),36A,1981
multiple
woman
lowest published toxic dose: 382 mg/kg (1-39 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAMAAP 188,423,1964
multiple
woman
lowest published toxic dose: 502 mg/kg (1-37 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JAMAAP 188,423,1964
multiple
woman
lowest published toxic dose: 215 mg/kg (43-70 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
AIMEAS 74,87,1971
oral
domestic animal
lowest published toxic dose: 30 mg/kg (1 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) JANSAG 34,903,1972
oral
hamster
lowest published toxic dose: 16 mg/kg (2 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) ARZNAD 25,1889,1975
oral
mammal (species unspecified)
lowest published toxic dose: 528 mg/kg (8-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
JIDOAA 35,387,1986
oral
man
lowest published toxic dose: 107 mg/kg (21 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) LANCAO 2,156,1975
oral
mouse
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TXAPA9 45,344,1978
oral
mouse
lowest published toxic dose: 20 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system
JTEHD6 6,155,1980
oral
mouse
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
FCTXAV 13,317,1975
oral
mouse
lowest published toxic dose: 97 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AGACBH 2,180,1972
oral
rat
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) MUREAV 48,267,1977
oral
rat
lowest published toxic dose: 91,800 g/kg (18 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
BIREBV 37,317,1987
oral
rat
lowest published toxic dose: 168 mg/kg (4 week male) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) BIREBV 50,55,1994
oral
rat
lowest published toxic dose: 110 mg/kg (7-17 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
IYKEDH 7,367,1976
oral
rat
lowest published toxic dose: 110 mg/kg (7-17 day pregnant) Reproductive: Specific developmental abnormalities: Body wall

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
IYKEDH 7,367,1976
oral
rat
lowest published toxic dose: 5 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Gastrointestinal system TJADAB 28,11A,1983
oral
rat
lowest published toxic dose: 122 mg/kg (18 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
BIREBV 37,317,1987
oral
rat
lowest published toxic dose: 336 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TXAPA9 27,602,1974
oral
rat
lowest published toxic dose: 504 mg/kg (multigeneration) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
TXAPA9 27,602,1974
oral
rat
lowest published toxic dose: 61.2 mg/kg (3 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 8.4 mg/kg (1 week male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 40.8 mg/kg (2 week male) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetal death
BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 25.2 mg/kg (3 week male) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Fetal death
BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 91.8 mg/kg (3 week male) Reproductive: Other developmental abnormalities BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 214.2 mg/kg (7 week male) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 61.2 mg/kg (14 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NATUAS 316,144,1985
oral
rat
lowest published toxic dose: 91.8 mg/kg (21 day male) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Other developmental abnormalities
NATUAS 316,144,1985
oral
rat
lowest published toxic dose: 153 mg/kg (35 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) NATUAS 316,144,1985
oral
rat
lowest published toxic dose: 214.2 mg/kg (49 day male) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NATUAS 316,144,1985
oral
rat
lowest published toxic dose: 140 mg/kg (7 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
JTSCDR 26,75,2001
oral
rat
lowest published toxic dose: 100 mg/kg (16-20 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) EMMUEG 44,174,2004
oral
rabbit
lowest published toxic dose: 93 mg/kg (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NEOLA4 40,45,1993
oral
rabbit
lowest published toxic dose: 279 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
NEOLA4 40,45,1993
oral
woman
lowest published toxic dose: 60 mg/kg (60 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders NEJMAG 289,1159,1973
oral
woman
lowest published toxic dose: 980 mg/kg (2 week prior to copulation-33 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Gastrointestinal system
TCMUD8 13,139,1993
oral
woman
lowest published toxic dose: 168 g/kg (20 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders CANCAR 39,1403,1977
parenteral
mouse
lowest published toxic dose: 20 mg/kg (4 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TJADAB 24(2),49A,1981
parenteral
rat
lowest published toxic dose: 10 mg/kg (1 day male) Reproductive: Effects on newborn: Behavioral TJADAB 24(1),52A,1981
parenteral
rat
lowest published toxic dose: 20 mg/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
IJEBA6 20,838,1982
parenteral
rat
lowest published toxic dose: 20 mg/kg (14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Homeostasis
IJEBA6 20,838,1982
parenteral
rat
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TJADAB 30(1),42A,1984
parenteral
rabbit
lowest published toxic dose: 48 mg/kg (10-13 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear CRSBAW 164,1344,1970
parenteral
rabbit
lowest published toxic dose: 10 mg/kg (10-13 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system AAHEAF 58,147,1975
subcutaneous
mouse
lowest published toxic dose: 20 mg/kg (2 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ASBDD9 2,95,1979
subcutaneous
mouse
lowest published toxic dose: 20 mg/kg (3 day pregnant) Reproductive: Other effects to embryo or fetus TCMUD8 6,23,1986
subcutaneous
mouse
lowest published toxic dose: 200 mg/kg (11-14 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JFHZA8 15,662,1965
subcutaneous
mouse
lowest published toxic dose: 100 mg/kg (11-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death JFHZA8 15,662,1965
subcutaneous
mouse
lowest published toxic dose: 4 mg/kg (3 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TCMUD8 6,115,1986
subcutaneous
rat
lowest published toxic dose: 10 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 9,445,1966
subcutaneous
rat
lowest published toxic dose: 20 mg/kg (3 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other effects to embryo or fetus
ASBDD9 2,95,1979
subcutaneous
rat
lowest published toxic dose: 60 mg/kg (3 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina BIANA6 19,247,1981
subcutaneous
rat
lowest published toxic dose: 60 mg/kg (3 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus
JEEMAF 41,65,1977
subcutaneous
rat
lowest published toxic dose: 7.5 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TOLED5 138,205,2003
subcutaneous
rabbit
lowest published toxic dose: 4 mg/kg (10-13 day pregnant) Reproductive: Other effects to embryo or fetus COREAF 258,2899,1964
subcutaneous
rabbit
lowest published toxic dose: 60 mg/kg (10-13 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear AAHEAF 53,209,1970
unreported route
child
lowest published toxic dose: 180 mg/kg (90 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct LANCAO 2,426,1972
unreported route
child
lowest published toxic dose: 586 mg/kg (89 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) JOPDAB 88,206,1976
unreported route
hamster
lowest published toxic dose: 30 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system ANTDEV 7,204,1996
unreported route
man
lowest published toxic dose: 130 mg/kg (26 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
LANCAO 1,568,1972
unreported route
man
lowest published toxic dose: 24,286 g/kg (17 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) LANCAO 2,1290,1972
unreported route
man
lowest published toxic dose: 281 mg/kg (39 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
LANCAO 1,840,1972
unreported route
mouse
lowest published toxic dose: 20 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system APTOD9 19,A89,1980
unreported route
mouse
lowest published toxic dose: 20 mg/kg (11 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 28,46A,1983
unreported route
mouse
lowest published toxic dose: 65 mg/kg (6-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
IITOEF 11,193,1989
unreported route
rat
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system TJADAB 27,68A,1983
unreported route
rat
lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TJADAB 27,47A,1983
unreported route
rat
lowest published toxic dose: 15 mg/kg (13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AXVMAW 36,179,1982
unreported route
rat
lowest published toxic dose: 20 mg/kg (12 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 24(1),42A,1981
unreported route
woman
lowest published toxic dose: 24 mg/kg (30 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders LANCAO 1,693,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1,950 mg/kg/26 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Bladder tumors
RRCRBU 52,1,1975
intravenous
rat
lowest published toxic dose: 676 mg/kg/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Brain and Coverings: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
ARZNAD 20,1461,1970
oral
human
toxic dose : 920 mg/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
AIMEAS 91,221,1979
oral
man
lowest published toxic dose: 2,310 mg/kg/4.5 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
BMJOAE 280,524,1980
oral
man
toxic dose : 1,078 mg/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
RIHYAC 32,1073,1978
oral
man
toxic dose : 1,800 mg/kg/6 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
JOURAA 126,544,1981
oral
man
toxic dose : 1,190 mg/kg/4 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
MEDIAV 58,32,1979
oral
rat
lowest published toxic dose: 475 mg/kg/100 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Blood: Lymphoma including Hodgkin's disease
IJCNAW 23,706,1979
oral
rat
toxic dose : 1,270 mg/kg/87 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Blood: Lymphoma including Hodgkin's disease
IJCNAW 23,706,1979
oral
rat
toxic dose : 698 mg/kg/89 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Blood: Lymphoma including Hodgkin's disease
IJCNAW 23,706,1979
oral
rat
toxic dose : 1,075 mg/kg/86 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Blood: Tumors
CANCAR 51,606,1983
oral
woman
lowest published toxic dose: 1,890 mg/kg/3 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia
JHMJAX 142,211,1978
oral
woman
toxic dose : 2,700 mg/kg/6 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
URGABW 17,105,1978
oral
woman
toxic dose : 1,760 mg/kg/4 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors
SJRHAT 12,73,1983
subcutaneous
mouse
lowest published toxic dose: 1,352 mg/kg/1 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors
ARZNAD 20,1461,1970
subcutaneous
mouse
toxic dose : 3,600 mg/kg/76 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Lung, Thorax, or Respiration: Bronchogenic carcinoma
ARHEAW 22,1338,1979
unreported route
man
lowest published toxic dose: 857 mg/kg/3 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
JCPAAK 26,649,1973
unreported route
woman
lowest published toxic dose: 1,050 mg/kg/69 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors
JCPAAK 26,649,1973


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lethal dose (50 percent kill): >400 g/kg N/R JPPMAB 18,760,1966
intraperitoneal
cat
lowest published lethal dose: 50 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Body temperature decrease
KSRNAM 16,431,1982
intraperitoneal
dog
lowest published lethal dose: 50 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
KSRNAM 16,431,1982
intraperitoneal
guinea pig
lowest published lethal dose: 200 mg/kg Eye: Ptosis

Behavioral: Muscle weakness

Behavioral: Ataxia
KSRNAM 16,431,1982
intraperitoneal
hamster
lethal dose (50 percent kill): 429 mg/kg N/R CALEDQ 2,267,1977
intraperitoneal
mouse
lethal dose (50 percent kill): 110 mg/kg N/R FATOAO 41,90,1978
intraperitoneal
mouse
lowest published toxic dose: 75 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes REPTED 5,379,1991
intraperitoneal
mouse
lowest published toxic dose: 75 mg/kg Reproductive: Maternal effects: Oogenesis REPTED 6,411,1992
intraperitoneal
mouse
lowest published toxic dose: 500 mg/kg Endocrine: Estrogenic REPTED 6,411,1992
intraperitoneal
mouse
lowest published toxic dose: 20 mg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) PHMREP 35,457,1997
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg Behavioral: Altered sleep time (including change in righting reflex) FATOAO 53,52,1990
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Immunological Including Allergic: Decrease in humoral immune response FATOAO 51,60,1988
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Blood: Changes in spleen FATOAO 52,67,1989
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Blood: Luekopenia

Blood: Changes in bone marrow not included in above
EKFAE9 56,25,1993
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) EKFAE9 62,50,1999
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Blood: Changes in bone marrow not included in above TXCYAC 171,63,2002
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion)
BJMRDK 35,549,2002
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Tumorigenic: Active as anti-cancer agent EJCAAH 39,801,2003
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg Tumorigenic: Active as anti-cancer agent

Biochemical: Effect on specific coenzyme: NAD, NADP

Biochemical: Metabolism (intermediary): Glycolytic
CNREA8 63,8813,2003
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg Liver: Other changes

Blood: Changes in bone marrow not included in above

Biochemical: Metabolism (intermediary): Other proteins
ARTODN 79,482,2005
intraperitoneal
mouse
lowest published toxic dose: 120 mg/kg Skin and Appendages: Other: Hair EXPDE* 14,844,2005
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Endocrine: Diabetes mellitus

Endocrine: Hyperglycemia
JPETAB 320,1038,2007
intraperitoneal
mouse
lowest published toxic dose: 175 mg/kg Immunological Including Allergic: Increase in cellular immune response CNREA8 65,5027,2005
intraperitoneal
mouse
lowest published toxic dose: 160 mg/kg Tumorigenic: Protects against induction of experimental tumors BPBLEO 31,57,2008
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg Vascular: BP lowering not characterized in autonomic section

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
TOXID9 12,401,2008
intraperitoneal
rat
lethal dose (50 percent kill): 40 mg/kg N/R CPCHAO 18,307,1962
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in ovarian weight
REPTED 5,481,1991
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Skin and Appendages: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
VOONC* 45,650,1999
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 72,24,2003
intraperitoneal
rat
lowest published toxic dose: 12.5 mg/kg Blood: Luekopenia

Blood: Changes in spleen
TXCYAC 174,153,2002
intraperitoneal
rat
lowest published toxic dose: 50 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,89,2003
intraperitoneal
rat
lowest published toxic dose: 10 mg/kg Brain and Coverings: Recordings from specific areas of CNS TOLED5 145,143,2003
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg Cardiac: Other changes

Biochemical: Metabolism (intermediary): Other

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 44,374,2005
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
ARTODN 79,461,2005
intraperitoneal
rat
lowest published toxic dose: 25 mg/kg Blood: Changes in spleen TOXID9 66,298,2002
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg Cardiac: Cardiomyopathy including infarction

Biochemical: Metabolism (intermediary): TCS cycle

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXCYAC 215,108,2005
intraperitoneal
rat
lowest published toxic dose: 30 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 217,120,2006
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
EJPHAZ 543,92,2006
intraperitoneal
rat
lowest published toxic dose: 120 mg/kg Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EJPHAZ 554,34,2007
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg Behavioral: Food intake (animal) EJPHAZ 554,34,2007
intraperitoneal
rat
lowest published toxic dose: 150 mg/kg Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder

Blood: Hemorrhage

Biochemical: Metabolism (intermediary): Lipids including transport
CEXPB9 31,167,2004
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) MUREAV 549,101,2004
intraperitoneal
rabbit
lowest published lethal dose: 200 mg/kg Eye: Miosis (pupilliary constriction)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory depression
KSRNAM 16,431,1982
intratracheal
mouse
lowest published lethal dose: 200 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 30,63,1986
intravenous
dog
lowest published lethal dose: 11 mg/kg Behavioral: Somnolence (general depressed activity)

Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CCSUBJ 2,191,1965
intravenous
dog
lethal dose (50 percent kill): 40 mg/kg N/R ENTOX* -,709,2005
intravenous
domestic animal
lethal dose (50 percent kill): 45,100 g/kg Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
DNXUDW 34,56,1980
intravenous
guinea pig
lethal dose (50 percent kill): 400 mg/kg N/R ENTOX* -,709,2005
intravenous
monkey
lowest published lethal dose: 45 mg/kg Behavioral: Somnolence (general depressed activity)

Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CCSUBJ 2,191,1965
intravenous
monkey
lowest published toxic dose: 40 mg/kg Blood: Luekopenia TXCYAC 213,1,2005
intravenous
mouse
lethal dose (50 percent kill): 140 mg/kg N/R 17TVAO -,97,1969
intravenous
mouse
lethal dose : 200 mg/kg Blood: Luekopenia EJCAAH 39,801,2003
intravenous
rat
lethal dose (50 percent kill): 148 mg/kg Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
KSRNAM 16,431,1982
intravenous
rat
lowest published toxic dose: 100 mg/kg Behavioral: Food intake (animal)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 25,139,2000
intravenous
rat
lowest published toxic dose: 200 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
JPETAB 308,1204,2004
intravenous
rat
lethal dose (50 percent kill): 160 mg/kg N/R ENTOX* -,709,2005
intravenous
rabbit
lowest published lethal dose: 300 mg/kg N/R JTSCDR 34,308,1999
intravenous
woman
lowest published toxic dose: 60 mg/kg/9 week- intermittent Nutritional and Gross Metabolic: Other changes AIMDAP 145,548,1985
intravenous
woman
lowest published toxic dose: 13,500 g/kg Eye: Visual field changes AIMEAS 116,92,1992
multiple
man
lowest published lethal dose: 45 mg/kg/26 week- intermittent Blood: Other changes AJMSA9 254,48,1967
oral
child
lowest published toxic dose: 2,500 g/kg Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Other changes
AJDCAI 140,1094,1986
oral
hamster
lethal dose (50 percent kill): 763 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Behavioral: Ataxia
EXPEAM 37,401,1981
oral
human
lowest published toxic dose: 20 mg/kg Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin and Appendages: Other: Hair
ARHEAW 12,663,1969
oral
man
lowest published toxic dose: 579 mg/kg/2 year- intermittent Liver: Jaundice, other or unclassified

Liver: Liver function tests impaired

Liver: Other changes
AJGAAR 95,845,2000
oral
man
lowest published toxic dose: 56 mg/kg/26 day- intermittent Blood: Angranulocytosis AJMEAZ 81,1059,1986
oral
man
lowest published toxic dose: 56 mg/kg/4 week- intermittent Liver: Other changes SMJOAV 78,222,1985
oral
monkey
lowest published toxic dose: 40 mg/kg Blood: Luekopenia TXCYAC 213,1,2005
oral
mouse
lethal dose (50 percent kill): 137 mg/kg N/R RPTOAN 36,240,1973
oral
rat
lethal dose (50 percent kill): 100 mg/kg N/R NIIRDN -,516,1995
oral
rat
lowest published toxic dose: 100 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases FATOAO 49,51,1986
oral
rat
lowest published toxic dose: 10 mg/kg Lung, Thorax, or Respiration: Other changes

Liver: Change in gall bladder structure or function

Biochemical: Metabolism (intermediary): Other
FATOAO 49,51,1986
oral
rat
lowest published toxic dose: 200 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 30,195,2005
oral
woman
lowest published toxic dose: 45 mg/kg Kidney, Ureter, and Bladder: Other changes ARHEAW 15,530,1972
oral
woman
lowest published lethal dose: 16 mg/kg/4 day- intermittent Blood: Other changes AJMSA9 254,48,1967
parenteral
hamster
lethal dose (10 percent kill): 110 mg/kg Tumorigenic: Active as anti-cancer agent JSONAU 15,355,1980
parenteral
mouse
lethal dose (50 percent kill): 315 mg/kg N/R TRPLAU 13,316,1972
subcutaneous
mouse
lethal dose (50 percent kill): 200 mg/kg N/R ASBDD9 2,95,1979
subcutaneous
mouse
lowest published toxic dose: 25 mg/kg Immunological Including Allergic: Decreased immune response FATOAO 52,55,1989
subcutaneous
mouse
lowest published toxic dose: 35 mg/kg Immunological Including Allergic: Decrease in humoral immune response EKFAE9 61,34,1998
subcutaneous
rat
lethal dose (50 percent kill): 144 mg/kg Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
KSRNAM 16,431,1982
subcutaneous
rat
lowest published toxic dose: 7.5 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 138,205,2003
unreported route
human
lowest published toxic dose: 25.7 mg/kg Blood: Luekopenia

Blood: Changes in other cell count (unspecified)
EJCPAS (),A49,1999
unreported route
mouse
lethal dose (50 percent kill): 480 mg/kg N/R NYKZAU 64(4),157S,1968
unreported route
mouse
lowest published toxic dose: 10 mg/kg Immunological Including Allergic: Decrease in humoral immune response TOXID9 44,37,2005
unreported route
rat
lethal dose (50 percent kill): 190 mg/kg N/R NYKZAU 64(4),157S,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intramuscular
mouse
lowest published toxic dose: 200 mg/kg/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Tumorigenic: Active as anti-cancer agent
EKFAE9 63,59,2000
intraperitoneal
monkey
lowest published toxic dose: 120 mg/kg/3 day- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in leukocyte (WBC) count
INJPD2 36,175,2004
intraperitoneal
mouse
lowest published toxic dose: 875 mg/kg/35 day- intermittent Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in cellular immune response
JTSCDR 25,189,2000
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg/4 day- intermittent Endocrine: Changes in thymus weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 165,237,2000
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg/10 day- intermittent Immunological Including Allergic: Decrease in cellular immune response

Immunological Including Allergic: Decrease in humoral immune response
TOLED5 13,129,1982
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg/4 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Increased immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 39,1087,2001
intraperitoneal
mouse
lowest published toxic dose: 3,744 mg/kg/52 week- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility
PSEBAA 133,190,1970
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg/2 day- intermittent Skin and Appendages: Tumors

Tumorigenic: Active as anti-cancer agent

Tumorigenic: Protects against induction of experimental tumors
CALEDQ 147,17,1999
intraperitoneal
mouse
lowest published toxic dose: 120 mg/kg/5 day- intermittent Lung, Thorax, or Respiration: Tumors

Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
VOONC* 43,313,1997
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg/5 day- intermittent Tumorigenic: Protects against induction of experimental tumors

Tumorigenic: Active as anti-cancer agent
EXONC* 18,276,1996
intraperitoneal
mouse
lowest published toxic dose: 75 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 25,189,2000
intraperitoneal
mouse
lowest published toxic dose: 175 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Luekopenia
JTSCDR 25,189,2000
intraperitoneal
mouse
lowest published toxic dose: 350 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 25,189,2000
intraperitoneal
mouse
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Endocrine: Changes in thymus weight

Blood: Luekopenia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 25,189,2000
intraperitoneal
mouse
lowest published toxic dose: 270 mg/kg/10 day- intermittent Immunological Including Allergic: Decrease in humoral immune response FATOAO 52,67,1989
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg/8 day- intermittent Endocrine: Changes in thymus weight

Blood: Luekopenia

Immunological Including Allergic: Decrease in humoral immune response
FATOAO 52,74,1989
intraperitoneal
mouse
lowest published toxic dose: 200 mg/kg/4 day- intermittent Immunological Including Allergic: Decrease in humoral immune response EKFAE9 62,50,1999
intraperitoneal
mouse
lowest published toxic dose: 25 mg/kg/5 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TOXID9 72,104,2003
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg/4 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Increase in humoral response
TOSCF2 71,207,2003
intraperitoneal
mouse
lowest published toxic dose: 75 mg/kg/3 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TXCYAC 209,15,2005
intraperitoneal
mouse
lowest published toxic dose: 400 mg/kg/4 day- intermittent Tumorigenic: Active as anti-cancer agent TXAPA9 202,268,2005
intraperitoneal
mouse
lowest published toxic dose: 50 mg/kg/5 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in humoral immune response
INIMP* 4,1223,2004
intraperitoneal
mouse
lowest published toxic dose: 300 mg/kg/21 day- intermittent Tumorigenic: Active as anti-cancer agent ACPSI* 23,745,2002
intraperitoneal
mouse
lowest published toxic dose: 160 mg/kg/8 day- intermittent Tumorigenic: Active as anti-cancer agent ACPSI* 23,946,2002
intraperitoneal
mouse
lowest published toxic dose: 1,050 mg/kg/1 week- intermittent Tumorigenic: Active as anti-cancer agent CNREA8 65,5027,2005
intraperitoneal
mouse
lowest published toxic dose: 2,100 mg/kg/2 week- intermittent Tumorigenic: Active as anti-cancer agent CNREA8 65,5027,2005
intraperitoneal
mouse
lowest published toxic dose: 500 mg/kg/5 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXIA6 50,1116,2007
intraperitoneal
mouse
lowest published toxic dose: 150 mg/kg/5 day- intermittent Tumorigenic: Protects against induction of experimental tumors BMCPH* 4,32,2004
intraperitoneal
mouse
lowest published toxic dose: 980 mg/kg/42 day- intermittent Tumorigenic: Active as anti-cancer agent MOCAT* 5,541,2006
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg/5 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
TXCYAC 248,96,2008
intraperitoneal
mouse
lowest published toxic dose: 500 mg/kg/5 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 248,96,2008
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg/10 day- intermittent Tumorigenic: Active as anti-cancer agent FTRPAE 70,35,1999
intraperitoneal
mouse
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Tumorigenic: Active as anti-cancer agent CNREA8 66,7639,2006
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg/30 day- continuous Nutritional and Gross Metabolic: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
KSRNAM 16,439,1982
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg/30 day- intermittent Endocrine: Change in LH

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight
BJCAAI 61,861,1990
intraperitoneal
rat
lowest published toxic dose: 15 mg/kg/15 day- intermittent Endocrine: Effect on menstrual cycle CNREA8 47,2340,1987
intraperitoneal
rat
lowest published toxic dose: 750 mg/kg/15 day- intermittent Related to Chronic Data: Changes in uterine weight

Related to Chronic Data: Changes in ovarian weight

Reproductive: Maternal effects: Ovaries, fallopian tubes
CNREA8 47,2340,1987
intraperitoneal
rat
lowest published toxic dose: 1,500 mg/kg/15 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CNREA8 47,2340,1987
intraperitoneal
rat
lowest published toxic dose: 2,250 mg/kg/15 day- intermittent Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
CNREA8 47,2340,1987
intraperitoneal
rat
lowest published toxic dose: 60 mg/kg/6 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Blood: Luekopenia
FATOAO 52,74,1989
intraperitoneal
rat
lowest published toxic dose: 1,146 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CTSRCS 186,351,1978
intraperitoneal
rat
lowest published toxic dose: 1,528 mg/kg/4 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes CTSRCS 186,351,1978
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Cardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate increased without fall in BP
PCJOAU 36,1,2002
intraperitoneal
rat
lowest published toxic dose: 240 mg/kg/6 week- intermittent Cardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction)
PCJOAU 36,1,2002
intraperitoneal
rat
lowest published toxic dose: 300 mg/kg/10 day- intermittent Vascular: Structural changes in vessels

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other effects to embryo or fetus
ARTODN 78,397,2004
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg/4 week- intermittent Endocrine: Changes in spleen weight

Blood: Luekopenia

Immunological Including Allergic: Decreased immune response
TXCYAC 215,57,2005
intraperitoneal
rat
lowest published toxic dose: 84 mg/kg/14 day- intermittent Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
TOXID9 90,358,2006
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
HETOEA 24,67,2005
intraperitoneal
rat
lowest published toxic dose: 420 mg/kg/3 week- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FCLPH* 18(Suppl 1),107,2004
intraperitoneal
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Blood: Aplastic anemia INJPD2 38,285,2006
intraperitoneal
rat
lowest published toxic dose: 175 mg/kg/4 day- intermittent Immunological Including Allergic: Decrease in cellular immune response JCINAO 118,1065,2008
intravenous
dog
lowest published toxic dose: 140 mg/kg/35 day- intermittent Kidney, Ureter, and Bladder: Hematuria

Blood: Normocytic anemia

Blood: Changes in bone marrow not included in above
KSRNAM 16,462,1982
intravenous
monkey
lowest published toxic dose: 120 mg/kg/6 day- intermittent Behavioral: Food intake (animal)

Gastrointestinal: Nausea or vomiting

Blood: Luekopenia
TXCYAC 213,1,2005
intravenous
mouse
lowest published toxic dose: 80 mg/kg/8 day- intermittent Tumorigenic: Active as anti-cancer agent ACPSI* 23,946,2002
intravenous
rat
lowest published toxic dose: 87,500 g/kg/5 week- continuous Endocrine: Changes in spleen weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count
IYKEDH 5,444,1974
intravenous
rat
lowest published toxic dose: 21 mg/kg/7 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response
TXCYAC 107,47,1996
oral
child
lowest published toxic dose: 720 mg/kg/1 year- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in platelet count

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
APHRER 37,1618,2003
oral
dog
lowest published toxic dose: 150 mg/kg/6 week- intermittent Blood: Luekopenia TXAPA9 4,324,1962
oral
dog
lowest published toxic dose: 150 mg/kg/15 day- intermittent Blood: Luekopenia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 4,324,1962
oral
human
lowest published toxic dose: 42.8 mg/kg/30 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Endocrine: Change in gonadotropins
FESTAS 36,76,1981
oral
man
lowest published toxic dose: 210 mg/kg/12 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct AJDCAI 129,315,1975
oral
man
lowest published toxic dose: 430,180 mg/kg/274 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AJDCAI 129,315,1975
oral
man
lowest published toxic dose: 120 mg/kg/60 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AJDCAI 129,315,1975
oral
man
lowest published toxic dose: 338.6 mg/kg/60 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct AJDCAI 129,315,1975
oral
monkey
lowest published toxic dose: 80 mg/kg/8 day- intermittent Gastrointestinal: Nausea or vomiting

Blood: Luekopenia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 213,1,2005
oral
mouse
lowest published toxic dose: 150 mg/kg/3 day- intermittent Immunological Including Allergic: Decrease in humoral immune response JOETD7 78,133,2001
oral
mouse
lowest published toxic dose: 378 mg/kg/21 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
PHMREP 35,457,1997
oral
mouse
lowest published toxic dose: 70 mg/kg/7 day- intermittent Immunological Including Allergic: Decrease in cellular immune response CYLPDN 21,765,2000
oral
mouse
lowest published toxic dose: 300 mg/kg/3 day- intermittent Blood: Changes in bone marrow not included in above

Blood: Changes in leukocyte (WBC) count
CYLPDN 22,1121,2001
oral
mouse
lowest published toxic dose: 100 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) PHMREP 35,457,1997
oral
mouse
lowest published toxic dose: 800 mg/kg/40 day- continuous Tumorigenic: Active as anti-cancer agent CNREA8 66,3386,2006
oral
mouse
lowest published toxic dose: 200 mg/kg/10 day- continuous Vascular: Structural changes in vessels CNREA8 66,1664,2006
oral
mouse
lowest published toxic dose: 140 mg/kg/1 week- continuous Vascular: Structural changes in vessels

Tumorigenic: Active as anti-cancer agent
CNREA8 66,1664,2006
oral
mouse
lowest published toxic dose: 280 mg/kg/2 week- intermittent Tumorigenic: Active as anti-cancer agent CNREA8 67,3560,2007
oral
rat
lowest published toxic dose: 660 mg/kg/80 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 4,324,1962
oral
rat
lowest published toxic dose: 87,500 g/kg/5 week- continuous Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
IYKEDH 5,444,1974
oral
rat
lowest published toxic dose: 910 mg/kg/26 week- continuous Endocrine: Changes in spleen weight

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
IYKEDH 5,444,1974
oral
rat
lowest published toxic dose: 15 mg/kg/10 day- intermittent Endocrine: Changes in thymus weight

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decreased immune response
JTEHD6 15,561,1985
oral
rat
lowest published toxic dose: 168 mg/kg/56 day- intermittent Blood: Changes in leukocyte (WBC) count TXAPA9 27,602,1974
oral
rat
lowest published toxic dose: 26.1 mg/kg/10 day- intermittent Blood: Other changes JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 336.6 mg/kg/11 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct
BIREBV 34,275,1986
oral
rat
lowest published toxic dose: 140 mg/kg/1 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight
JTSCDR 26,75,2001
oral
rat
lowest published toxic dose: 510 mg/kg/30 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TOXID9 72,103,2003
oral
rat
lowest published toxic dose: 235 mg/kg/10 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 104.4 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Liver: Changes in liver weight
JESEDU A22,639,1987
oral
rat
lowest published toxic dose: 180 mg/kg/5 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) BIREBV 66,1024,2002
oral
rat
lowest published toxic dose: 150 mg/kg/10 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport

Related to Chronic Data: Changes in testicular weight
REPTED 19,163,2004
oral
rat
lowest published toxic dose: 150 mg/kg/10 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
REPTED 19,163,2004
oral
rat
lowest published toxic dose: 300 mg/kg/30 day- intermittent Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXCYAC 194,129,2003
oral
rat
lowest published toxic dose: 42 mg/kg/14 day- intermittent Immunological Including Allergic: Decreased immune response TOXID9 44,38,2005
oral
rat
lowest published toxic dose: 105 mg/kg/21 day- intermittent Immunological Including Allergic: Decrease in humoral immune response TOXID9 78,428,2004
oral
rat
lowest published toxic dose: 150 mg/kg/10 week- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) TXCYAC 217,71,2006
subcutaneous
guinea pig
lowest published toxic dose: 105 mg/kg/3 day- intermittent Immunological Including Allergic: Decrease in cellular immune response EKFAE9 61,34,1998
unreported route
woman
lowest published toxic dose: 120 mg/kg/18 week- intermittent Skin and Appendages: Other: Nails APHRER 38,1089,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 26,165,1981
International Agency for Research on Cancer (IARC) Cancer Review Human Sufficient Evidence IMEMDT 26,165,1981
International Agency for Research on Cancer (IARC) Cancer Review Group 1 IMSUDL 7,182,1987
TOXICOLOGY REVIEW
JJIND8 95,190,2003
TOXICOLOGY REVIEW
JJIND8 30,88,2001
TOXICOLOGY REVIEW
JJIND8 30,135,2001
TOXICOLOGY REVIEW
JPETAB 144,429,1964
TOXICOLOGY REVIEW
ARVPAX 5,447,1965
TOXICOLOGY REVIEW
ADVPA3 4,263,1966
TOXICOLOGY REVIEW
CRTXB2 2,159,1973
TOXICOLOGY REVIEW
BLFSBY 24,129,1983
TOXICOLOGY REVIEW
NEJMAG 342,1069,2000
TOXICOLOGY REVIEW
JTSCDR 25,1,2000
TOXICOLOGY REVIEW
TOLED5 135,167,2002
TOXICOLOGY REVIEW
TOLED5 140-141,281,2003
TOXICOLOGY REVIEW
EJCAAH 40,2274,2004
TOXICOLOGY REVIEW
TOLED5 144,383,2003
TOXICOLOGY REVIEW
REPTED 18,219,2004
TOXICOLOGY REVIEW
REPTED 19,421,2005
TOXICOLOGY REVIEW
TXAPA9 197,174,2004
TOXICOLOGY REVIEW
BDERE* 70,99,2004
TOXICOLOGY REVIEW
EOGRAL 117,10,2004
TOXICOLOGY REVIEW
TPHSDY 24,55,2003
TOXICOLOGY REVIEW
IMMPH* 46,103,2000
TOXICOLOGY REVIEW
TPHSDY 24,131,2003
TOXICOLOGY REVIEW
MUTAEX 15,431,2000
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
REPTED 22,126,2006
TOXICOLOGY REVIEW
MUTAEX 20,3,2005
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
DIMON* 40,258,1994
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
ENTOX* -,709,2005
TOXICOLOGY REVIEW
ENTOX* -,384,2005
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
MUREAV 658,124,2008
TOXICOLOGY REVIEW
CAINV* 23,537,2005
TOXICOLOGY REVIEW
CLLID* 11,641,2007
TOXICOLOGY REVIEW
MUREAV 658,154,2008
TOXICOLOGY REVIEW
MUREAV 659,68,2008
TOXICOLOGY REVIEW
JTPAE7 17,137,2004
TOXICOLOGY REVIEW
JAADDB 59,524,2008
TOXICOLOGY REVIEW
ITODC* -,327,2004
TOXICOLOGY REVIEW
MUREAV 544,403,2003
TOXICOLOGY REVIEW
HUTOX* -,439,1996
TOXICOLOGY REVIEW
MUREAV 608,136,2006
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3688;
Number of Industries 2;
Total Number of Facilities 991;
Number of Occupations 9;
Total Number of Employees Exposed 30,026;
Total Number of Female Employees Exposed 20,745


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Body fluid assay; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human bone marrow
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: Cytogenetics-male germ cell; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: Rodent heritable translocation
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Positive: Mouse spot test; E coli polA with S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; Mouse specific locus
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-rat; Sperm morphology-mouse F1
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-human; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal; UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Positive: TRP reversion; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-nonhuman; In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-human lymphocytes
EPA GENETOX PROGRAM 1988, Inconclusive: Sperm morphology-rabbit; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
Used as an immunosuppressive agent in non-malignant diseases
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (ipr);clear evidence:mouse,rat RRCRBU 52,1,1975
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

17TVAO "Radiation-Induced Cancer, Proceedings of a Symposium, Athens, 1969," Lanham, MD, Bernan-UNIPUB, 1969
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979
47JMAE "Cytogenetic Assays of Environmental Mutagens," Hsu, T.C., ed., Totowa, NJ, Allanheld, Osmun & Co., 1982
AAHEAF Archives d'Anatomie, d'Histologie & d'Embryologie. (Editions Alsatia, B.P. 9, 68001 Colmar, France) V.1- 1922-
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJGAAR American Journal of Gastroenterology. (American College of Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21- 1954-
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AJMSA9 American Journal of the Medical Sciences. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) New series: V.1- 1841-
ANTDEV Anti-Cancer Drugs. (Rapid Communications of Oxford Ltd., The Old Malthous, Paradise St., Oxford OX1 1LD, UK) V.1- 1990-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949-
ARHEAW Arthritis and Rheumatism. (Arthritis Foundation, 1314 Spring St., NW, Atlanta, GA 30309) V.1- 1958-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ASBDD9 Advances in the Study of Birth Defects. (Baltimore, MD) V.1-7, 1979-82. Discontinued.
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
AXVMAW Archiv fuer Experimentelle Veterinaermedizin. (S. Hirzel Verlag, Postfach 506, Leipzig DDR-7010, Ger. Dem. Rep.) V.6- 1952-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003-
BEBMAE Byulleten' Eksperimental'noi Biologii i Meditsiny. Bulletin of Experimental Biology and Medicine. For English translation, see BEXBAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
BIANA6 Bibliotheca Anatomica. (S. Karger AG, Postfach, CH-4009 Basel, Switzerland) No.1- 1961-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BIZNAT Biologisches Zentralblatt. (VEB Georg Thieme, Postfach 946, Leipzig DDR-7010, Ger. Dem. Rep.) V.1- 1881-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
BMCPH* BioMedCentral Pharmacology (Biomed Central Ltd) -
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CAINV* Cancer investigation (New York, N.Y. : Marcel Dekker) V.1- 1983-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CCSUBJ Cancer Chemotherapy Reports, Part 2. (Washington, DC) V.1-5, 1964-75. For publisher information, see CTRRDO.
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973-
CLLID*
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CPCHAO Clinical Proceedings of the Children's Hospital of the District of Columbia. (Washington, DC) V.1-27, 1971. For publisher information, see CPNMAQ.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ.
CTSRCS Cell and Tissue Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.148- 1974-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DNXUDW Dongbei Nongxueyuan Xuebao. Journal of Northeast Agricultural College. (Dongbei Nongxueyuan Xuebao Beinjibu, Majia Huayuan, Xiangfangqu Harbin, Peop. Rep. China) History not known.
ECEBDI Experimental Cell Biology. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.44- 1976-
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EOGRAL European Journal of Obstetrics, Gynecology and Reproductive Biology. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.3- 1973-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
EXONC* Experimental Oncology (Journal of ucrainian section of European institute of ecology and cancer, Kiev-22, Vaselkovskaya str., 25, Kiev-22) V.1- 1979-
EXPDE* Experimental dermatology (Copenhagen : Munksgaard) V.1- 1992-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GNKAA5 Genetika (Moscow). For English translation, see SOGEBZ. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1965-
GNTKDF Genetika (Zemun, Yugoslavia). (Unija Bioloskih Naucnih Drustava Jugoslavije, Postanski fah 12 7, Zemun, Yugoslavia) V.1- 1969-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HIKYAJ Hinyokika Kiyo. Journal of Urology. (Kyoto Daigaku Igakubu, Hinyokikagaku Kyoshitsu, 54 Kawara-machi, Shogain, Sakyo-ku, Kyoto 606, Japan) V.1- 1955-
HUHEAS Human Heredity. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.19- 1969-
HUMAA7 Humangenetik. (Heidelberg, Fed. Rep. Ger.) V.1-30, 1964-75. For publisher information, see HUGEDQ.
HUTOX*
IITOEF Immunopharmacology and Immunotoxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.9- 1987-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMMPH* Immunopharmacology. (New York, Elsevier/North-Holland) V. 1-49, 1978-2000
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
INIMP* International Immunopharmacology (http://www.elsevier.com/locate/intimp) V.1- 2001-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
ITODC*
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JCGBDF Journal of Craniofacial Genetics and Developmental Biology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JCPAAK Journal of Clinical Pathology. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1947-
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JESEDU Journal of Environmental Science and Health, Part A: Environmental Science and Engineering. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.A11- 1976-
JFHZA8 Journal of the Faculty of Science, Hokkaido University, Series 6: Zoology. (Hokkaido Univ., Faculty of Science, Nishi-8 chome, Kita-10jo, Kita-ku, Sapporo 060, Japan) V.1- 1930-
JHMJAX Johns Hopkins Medical Journal. (Baltimore, MD) V.120-151, 1967-82. Discontinued.
JIDOAA Experimental Animals. Jikken Dobutso Iho. (Nippon Jikken Dobutsu Gakkai, c/o Keio Gijuku Daigaku Igakubu Jikken Dobutsu Senta, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.1- 1952-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979-
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JOURAA Journal of Urology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1917-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JSONAU Journal of Surgical Oncology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1969-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MEDIAV Medicine. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1922-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MOCAT* Molecular Cancer Therapeutics (Philadelphia, PA : American Association for Cancer Research) V.1- 2001-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
PACHAS Pure and Applied Chemistry. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.1- 1960-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PHMREP Pharmacological Research. (Academic Press, 24-28 Oval Rd. London NW1 7DX, UK) V.21- 1989-
PJABDW Proceedings of the Japan Academy, Series B: Physical and Biological Sciences. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.53- 1977-
PMRSDJ Progress in Mutation Research. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1981-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
REBPAT Radiation and Environmental Biophysics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.11- 1974-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
RIHYAC Rinsho Hinyokika. Clinical Urology. (Igaku Shoin, 5-24-3 Hongo, Bunkyo-ku, Tokyo 113-91, Japan) V.21- 1967-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7.
SJRHAT Scandinavian Journal of Rheumatology. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) V.1- 1972-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
SOGEBZ Soviet Genetics. English translation of GNKAA5. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.2- 1966-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TERP2*
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TRPLAU Transplantation. (Williams & Wilkins, Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1963-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
URGABW Urologe Ausgabe A. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.9- 1970-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as an immunosuppressive agent in non-malignant diseases

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us