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Registry of Toxic Effects of Chemical Substances (RTECS)

Octanoic acid, pentadecafluoro-

RTECS #

RH0781000

CAS #

335-67-1

Updated

December 2013

Molecular Weight

414.09

Molecular Formula

C8HF15O2

Synonyms

Pentadecafluoro-n-octanoic acid
Pentadecafluorooctanoic acid
Perfluorocaprylic acid
Perfluoroctanoic acid
Perfluoroheptanecarboxylic acid
Perfluorooctanoic acid
PFOA

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adduct/Escherichia coli50 µmol/LMUREAV 89,95,1981
DNA Damageintraperitoneal/rat100 mg/kgCALEDQ 57,55,1991
DNA Damageoral/rat168 mg/kg/2W-continuousCALEDQ 57,55,1991
DNA Damageother cell types/human50 µmol/L/24HMUREAV 587,38,2005
micronucleus testother cell types/human100 µmol/L/24HMUREAV 587,38,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 9.9 mg/m3 (6-15D pregnant)Reproductive: Other effects on femaleFCTOD7 47,2557,2009
inhalation/rat 21 mg/m3 (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FCTOD7 47,2557,2009
oral/rabbit 650 mg/kg (6-18D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 47,2557,2009
oral/rat 92 mg/kg (multigeneration)Reproductive: Other effects on maleFCTOD7 47,2557,2009
oral/rat 2760 mg/kg (multigeneration)Reproductive: Other effects on male

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FCTOD7 47,2557,2009
oral/mouse 17 mg/kg (1-17D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
FCTOD7 47,2557,2009
oral/mouse 170 mg/kg (1-17D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
FCTOD7 47,2557,2009
oral/mouse 17 mg/kg (1-17D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
FCTOD7 47,2557,2009
oral/mouse 51 mg/kg (1-17D pregnant)Reproductive: Effects on newborn: Other postnatal measures or effectsFCTOD7 47,2557,2009
oral/mouse 85 mg/kg (1-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FCTOD7 47,2557,2009
oral/mouse 90 mg/kg (2-19D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 90,189,2006
oral/mouse 17 mg/kg (1-17D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TXCYAC 239,15,2007
oral/mouse 85 mg/kg (1-17D pregnant)Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral/mouse 50 mg/kg (8-17D pregnant)Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral/mouse 30 mg/kg (12-17D pregnant)Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral/mouse 340 mg/kg (1-17D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TERP2* -,312,2004
oral/mouse 340 mg/kg (1-17D pregnant)Reproductive: Effects on newborn: StillbirthTERP2* -,312,2004
oral/mouse 170 mg/kg (1-17D pregnant)Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical
TERP2* -,312,2004
oral/mouse 85 mg/kg (1-17D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TERP2* -,312,2004
oral/mouse 140 mg/kg (1-7D pregnant)Reproductive: Effects on embryo or fetus: Fetal deathTERP2* -,358,2005
oral/mouse 5.1 mg/kg (1-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,238,2008
oral/mouse 85 mg/kg (1-17D pregnant)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,238,2008
oral/mouse 17 mg/kg (1-17D pregnant)Reproductive: Effects on newborn: Delayed effectsTOXID9 -,238,2008
oral/rat 1000 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleFCTOD7 47,2557,2009
oral/mouse 17 mg/kg (2-18D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOXID9 44,58,2005
oral/mouse 340 mg/kg (2-18D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TOXID9 44,58,2005
oral/mouse 170 mg/kg (2-18D pregnant)Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical
TOXID9 44,58,2005
oral/mouse 55 mg/kg (8-18D pregnant)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)TOXID9 90,75,2006
unreported route/mouse 85 mg/kg (2-18D pregnant)Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 90,76,2006
unreported route/mouse 50 mg/kg (9-18D pregnant)Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 90,82,2006

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 10366 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Testicular tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
FCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 9928 mg/kg/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
FCTOD7 47,2557,2009

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 1 mg/L/24HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 250,108,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 1 mg/L/3HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 250,108,2011
In Vitro/Human, leukemia cells Inhibitor Concentration Low: 100 mg/L/30MBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 250,108,2011
intraperitoneal/rat lethal dose (50 percent kill): 189 mg/kgTXAPA9 70,362,1983
intraperitoneal/rat lethal dose (50 percent kill): 189 mg/kgLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 70,362,1983
intraperitoneal/rat lowest published toxic dose: 100 mg/kgLiver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 129,23,2002
intraperitoneal/rat lowest published toxic dose: 100 mg/kgLiver: Other changesTOXID9 66,362,2002
oral/mouse lowest published toxic dose: 0.58 mg/kgBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesteraseTOXID9 90,298,2006
oral/mouse lowest published toxic dose: 0.58 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NRTXDN 29,160,2008

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
implant/chicken lowest published toxic dose: 0.21 mg/kg/4W- continuousLiver: Other changesTXCYAC 237,111,2007
inhalation/rat lowest published toxic concentration: 8 mg/m3/10D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
FCTOD7 47,2557,2009
inhalation/rat lowest published toxic concentration: 84 mg/m3/10D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/monkey lowest published toxic dose: 2700 mg/kg/90D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above
FCTOD7 47,2557,2009
oral/monkey lowest published toxic dose: 14700 mg/kg/49D- intermittentEndocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/monkey lowest published toxic dose: 504 mg/kg/24W- intermittentLiver: Changes in liver weightFCTOD7 47,2557,2009
oral/monkey lowest published toxic dose: 3360 mg/kg/24W- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 12 mg/kg/10D- continuousLiver: Changes in liver weightTXCYAC 260,68,2009
oral/mouse lowest published toxic dose: 240 mg/kg/10D- continuousEndocrine: Changes in spleen weight

Endocrine: Changes in thymus weight
TXCYAC 260,68,2009
oral/mouse lowest published toxic dose: 370.23 mg/kg/21D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
ARTODN 82,239,2008
oral/mouse lowest published toxic dose: 50.4 mg/kg/14D- intermittentLiver: Changes in liver weightFCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 1680 mg/kg/14D- intermittentLiver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 7.56 mg/kg/21D- intermittentLiver: Changes in liver weightFCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 100.8 mg/kg/28D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 1008 mg/kg/28D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/mouse lowest published toxic dose: 450 mg/kg/15D- continuousLiver: Changes in liver weightTOXID9 -,35,2008
oral/mouse lowest published toxic dose: 450 mg/kg/15D- continuousLiver: Changes in liver weight

Immunological Including Allergic: Increased immune response
TOXID9 -,35,2008
oral/mouse lowest published toxic dose: 450 mg/kg/15D- continuousLiver: Changes in liver weight

Immunological Including Allergic: Decreased immune response
TOXID9 -,35,2008
oral/mouse lowest published toxic dose: 450 mg/kg/15D- continuousImmunological Including Allergic: Decreased immune responseTOXID9 -,35,2008
oral/mouse lowest published toxic dose: 8.4 mg/kg/21D- intermittentBlood: Changes in spleen

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
TOXID9 -,163,2008
oral/mouse lowest published toxic dose: 210 mg/kg/21D- intermittentEndocrine: Changes in thymus weight

Immunological Including Allergic: Uncharacterized (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,163,2008
oral/mouse lowest published toxic dose: 1050 mg/kg/21D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,163,2008
oral/mouse lowest published toxic dose: 450 mg/kg/15D- continuousLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decreased immune response
TOXID9 -,268,2009
oral/mouse lowest published toxic dose: 75 mg/kg/10D- continuousImmunological Including Allergic: Decreased immune responseTOXID9 -,268,2009
oral/mouse lowest published toxic dose: 0.03 mg/kg/3D- intermittentReproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight
TOXID9 -,297,2009
oral/mouse lowest published toxic dose: 6 mg/kg/10D- continuousLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
XENOBH 23,761,1993
oral/mouse lowest published toxic dose: 120 mg/kg/10D- continuousLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
XENOBH 23,761,1993
oral/mouse lowest published toxic dose: 204.4 mg/kg/7D- continuousLiver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
BCPCA6 63,1893,2002
oral/mouse lowest published toxic dose: 161.7 mg/kg/7D- continuousBehavioral: Fluid intake

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCPCA6 66,749,2003
oral/mouse lowest published toxic dose: 161.7 mg/kg/7D- continuousBiochemical: Metabolism (intermediary): Lipids including transportBCPCA6 66,749,2003
oral/mouse lowest published toxic dose: 46.2 mg/kg/2D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)BCPCA6 66,749,2003
oral/mouse lowest published toxic dose: 340 mg/kg/17D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 44,58,2005
oral/mouse lowest published toxic dose: 17 mg/kg/17D- intermittentLiver: Other changesTOXID9 44,58,2005
oral/mouse lowest published toxic dose: 450 mg/kg/15D- intermittentEndocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 90,52,2006
oral/mouse lowest published toxic dose: 240 mg/kg/10D- intermittentBlood: Luekopenia

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXCYAC 262,207,2009
oral/mouse lowest published toxic dose: 235 mg/kg/10D- continuousEndocrine: Changes in thymus weight

Blood: Changes in bone marrow not included in above

Blood: Changes in spleen
FCTOD7 50,2955,2012
oral/mouse lowest published toxic dose: 31 mg/kg/10D- continuousLiver: Changes in liver weight

Blood: Changes in bone marrow not included in above
FCTOD7 50,2955,2012
oral/rat lowest published toxic dose: 840 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TXCYAC 264,10,2009
oral/rat lowest published toxic dose: 42 mg/kg/7D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 99,169,1995
oral/rat lowest published toxic dose: 84 mg/kg/2W- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 93,85,1994
oral/rat lowest published toxic dose: 1092 mg/kg/26W- continuousLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 93,85,1994
oral/rat lowest published toxic dose: 1000 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 10.5 mg/kg/7D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 50.4 mg/kg/28D- intermittentLiver: Changes in liver weightFCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 1680 mg/kg/28D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 16800 mg/kg/28D- intermittentLiver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 47,2557,2009
oral/rat lowest published toxic dose: 1620 mg/kg/90D- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
skin/rabbit lowest published toxic dose: 1000 mg/kg/2W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
skin/rat lowest published toxic dose: 200 mg/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
FCTOD7 47,2557,2009
skin/rat lowest published toxic dose: 2000 mg/kg/2W- intermittentLiver: Hepatitis (hepatocellular necrosis), diffuse

Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 47,2557,2009
unreported route/rat lowest published toxic dose: 840 mg/kg/28D- intermittentLiver: Other changes

Biochemical: Metabolism (intermediary): Effect on mitochondrial function
TOXID9 -,418,2009

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,355,2005
TOXICOLOGY REVIEWJTSCDR 28,49,2003
TOXICOLOGY REVIEWCRTXB2 34,351,2004
TOXICOLOGY REVIEWMUREAV 658,124,2008
TOXICOLOGY REVIEWREPTED 27,246,2009
TOXICOLOGY REVIEWFCTOD7 47,1577,2009
TOXICOLOGY REVIEWREPTED 27,266,2009
TOXICOLOGY REVIEWTXCYAC 285,83,2011
TOXICOLOGY REVIEWREPTED 33,269,2012
TOXICOLOGY REVIEWREPTED 38,1,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-GERMANYMAK 0.005 mg/m3, inhal, 2011
Occupational Exposure Limit-GERMANYMAK 0.005 mg/m3, inhal, skin, 2011
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.005 mg/m3, MAY2012
Occupational Exposure Limit-SWITZERLANDMAK-week 0.005 mg/m3, KZG-week 0.04 mg/m3, inhal, skin, JAN2011

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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