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Octanoic acid, pentadecafluoro -

RTECS #: RH0781000

CAS #: 335-67-1


UPDATE: February 2009 MW: 414.09 MF: C8HF15O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. PFOA
  2. Pentadecafluorooctanoic acid
  3. Pentadecafluoro - n - octanoic acid
  4. Perfluorocaprylic acid
  1. Perfluoroheptanecarboxylic acid
  2. Perfluoroctanoic acid
  3. Perfluorooctanoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct Escherichia coli 50 Ámol/L MUREAV 89,95,1981
DNA damage human other cell types 50 Ámol/L/24 hour MUREAV 587,38,2005
DNA damage intraperitoneal
rat
100 mg/kg CALEDQ 57,55,1991
DNA damage oral
rat
168 mg/kg/2 week- continuous CALEDQ 57,55,1991
micronucleus test human other cell types 100 Ámol/L/24 hour MUREAV 587,38,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 17 mg/kg (2-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOXID9 44,58,2005
oral
mouse
lowest published toxic dose: 340 mg/kg (2-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TOXID9 44,58,2005
oral
mouse
lowest published toxic dose: 170 mg/kg (2-18 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical
TOXID9 44,58,2005
oral
mouse
lowest published toxic dose: 55 mg/kg (8-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TOXID9 90,75,2006
oral
mouse
lowest published toxic dose: 90 mg/kg (2-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Biochemical and metabolic
TOXID9 90,189,2006
oral
mouse
lowest published toxic dose: 17 mg/kg (1-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 239,15,2007
oral
mouse
lowest published toxic dose: 85 mg/kg (1-17 day pregnant) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral
mouse
lowest published toxic dose: 50 mg/kg (8-17 day pregnant) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral
mouse
lowest published toxic dose: 30 mg/kg (12-17 day pregnant) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical
TOSCF2 96,133,2007
oral
mouse
lowest published toxic dose: 340 mg/kg (1-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
TERP2* -,312,2004
oral
mouse
lowest published toxic dose: 340 mg/kg (1-17 day pregnant) Reproductive: Effects on newborn: Stillbirth TERP2* -,312,2004
oral
mouse
lowest published toxic dose: 170 mg/kg (1-17 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Physical
TERP2* -,312,2004
oral
mouse
lowest published toxic dose: 85 mg/kg (1-17 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TERP2* -,312,2004
oral
mouse
lowest published toxic dose: 340 mg/kg (1-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TERP2* -,358,2005
oral
mouse
lowest published toxic dose: 140 mg/kg (1-7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death TERP2* -,358,2005
oral
mouse
lowest published toxic dose: 5.1 mg/kg (1-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,238,2008
oral
mouse
lowest published toxic dose: 85 mg/kg (1-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects
TOXID9 -,238,2008
oral
mouse
lowest published toxic dose: 17 mg/kg (1-17 day pregnant) Reproductive: Effects on newborn: Delayed effects TOXID9 -,238,2008
unreported route
mouse
lowest published toxic dose: 85 mg/kg (2-18 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 90,76,2006
unreported route
mouse
lowest published toxic dose: 50 mg/kg (9-18 day pregnant) Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy)

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 90,82,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lethal dose (50 percent kill): 189 mg/kg N/R TXAPA9 70,362,1983
intraperitoneal
rat
lethal dose (50 percent kill): 189 mg/kg Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport
TXAPA9 70,362,1983
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 129,23,2002
intraperitoneal
rat
lowest published toxic dose: 100 mg/kg Liver: Other changes TOXID9 66,362,2002
oral
mouse
lowest published toxic dose: 0.58 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TOXID9 90,298,2006
oral
mouse
lowest published toxic dose: 0.58 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning
NRTXDN 29,160,2008


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
implant
chicken
lowest published toxic dose: 0.21 mg/kg/4 week- continuous Liver: Other changes TXCYAC 237,111,2007
oral
mouse
lowest published toxic dose: 6 mg/kg/10 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
XENOBH 23,761,1993
oral
mouse
lowest published toxic dose: 120 mg/kg/10 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
XENOBH 23,761,1993
oral
mouse
lowest published toxic dose: 204.4 mg/kg/7 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thymus weight

Blood: Changes in spleen
BCPCA6 63,1893,2002
oral
mouse
lowest published toxic dose: 161.7 mg/kg/7 day- continuous Behavioral: Fluid intake

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
BCPCA6 66,749,2003
oral
mouse
lowest published toxic dose: 161.7 mg/kg/7 day- continuous Biochemical: Metabolism (intermediary): Lipids including transport BCPCA6 66,749,2003
oral
mouse
lowest published toxic dose: 46.2 mg/kg/2 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) BCPCA6 66,749,2003
oral
mouse
lowest published toxic dose: 340 mg/kg/17 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 44,58,2005
oral
mouse
lowest published toxic dose: 17 mg/kg/17 day- intermittent Liver: Other changes TOXID9 44,58,2005
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- intermittent Endocrine: Changes in spleen weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 90,52,2006
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- continuous Liver: Changes in liver weight TOXID9 -,35,2008
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- continuous Liver: Changes in liver weight

Immunological Including Allergic: Increased immune response
TOXID9 -,35,2008
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Immunological Including Allergic: Decreased immune response
TOXID9 -,35,2008
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- continuous Liver: Changes in liver weight

Immunological Including Allergic: Decreased immune response
TOXID9 -,35,2008
oral
mouse
lowest published toxic dose: 450 mg/kg/15 day- continuous Immunological Including Allergic: Decreased immune response TOXID9 -,35,2008
oral
mouse
lowest published toxic dose: 8.4 mg/kg/21 day- intermittent Blood: Changes in spleen

Immunological Including Allergic: Uncharacterized (multiple organ involvement)
TOXID9 -,163,2008
oral
mouse
lowest published toxic dose: 210 mg/kg/21 day- intermittent Endocrine: Changes in thymus weight

Immunological Including Allergic: Uncharacterized (multiple organ involvement)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 -,163,2008
oral
mouse
lowest published toxic dose: 1,050 mg/kg/21 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 -,163,2008
oral
rat
lowest published toxic dose: 42 mg/kg/7 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 99,169,1995
oral
rat
lowest published toxic dose: 84 mg/kg/2 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 93,85,1994
oral
rat
lowest published toxic dose: 1,092 mg/kg/26 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TXCYAC 93,85,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,355,2005
TOXICOLOGY REVIEW
JTSCDR 28,49,2003
TOXICOLOGY REVIEW
CRTXB2 34,351,2004
TOXICOLOGY REVIEW
MUREAV 658,124,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - GERMANY MAK 0.005 mg/m3, 2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.005 mg/m3,KZG- week 0.04 mg/m3, Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
TERP2*
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
XENOBH Xenobiotica. (Taylor & Francis Ltd., 4 John St., London WC1N 2ET, UK) V.1- 1971-

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