CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Octyl alcohol

RTECS #: RH6550000

CAS #: 111-87-5


UPDATE: February 2008 MW: 130.26 MF: C8H18O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Hydroxyoctane
  2. 1 - Octanol
  3. Alcohol C - 8
  4. Alfol 8
  5. Caprylic alcohol
  6. Dytol M - 83
  7. EPAL 8
  8. Heptyl carbinol
  1. Lorol 20
  2. Octanol
  3. Octilin
  4. Octyl alcohol, normal - primary
  5. Primary octyl alcohol
  6. Sipol L8
  7. n - Octanol
  8. n - Octyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
500 mg/24 hour mild FCTXAV 11,1079,1973


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
sex chromosome loss and nondisjunction hamster lung 800 Ámol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 0.1 ppm/4 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
inhalation
mouse
lowest published toxic concentration: 4.5 gm/m3/2 hour N/R TPKVAL 5,51,1963
inhalation
rat
lowest published lethal concentration: 5,600 mg/m3/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
EPASR* 8EHQ-1088-0762
intraperitoneal
rat
lowest published toxic dose: 2,000 mg/kg Behavioral: Ataxia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
intravenous
mouse
lethal dose (50 percent kill): 69 mg/kg N/R AIPTAK 135,330,1962
ocular
rabbit
lowest published toxic dose: 100 pph Eye: Conjunctiva irritation TPKVAL 5,51,1963
oral
human
lowest published lethal dose: 428.6 mg/kg N/R VCVGK* -,116,1984
oral
mouse
lethal dose (50 percent kill): 1,790 mg/kg N/R HYSAAV 31(1-3),310,1966
oral
mouse
lethal dose (50 percent kill): 15,000 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
oral
mouse
lethal dose (50 percent kill): 3.91 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral
mouse
lowest published lethal dose: 1.95 gm/kg Brain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral
rat
lethal dose (50 percent kill): >3,200 mg/kg N/R FCTXAV 11,95,1973
oral
rat
lethal dose (50 percent kill): 20,000 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
parenteral
frog
lowest published lethal dose: 1,240 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin
guinea pig
lethal dose (50 percent kill): >1 gm/kg N/R FCTXAV 11,95,1973
skin
mouse
lowest published lethal dose: 100 pph/3 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Corrosive
TPKVAL 5,51,1963
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TPKVAL 5,51,1963
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 4 gm/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.27 gm/m3/107 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 5,51,1963
inhalation
rat
lowest published toxic concentration: 0.27 gm/m3/137 day- intermittent Brain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 140-141,261,2003
TOXICOLOGY REVIEW
MUREAV 628,67,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,292,1998
Occupational Exposure Limit - AUSTRIA MAK 106 mg/m3 (20 ppm), JAN 2006
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80235;
Number of Industries 29;
Total Number of Facilities 1,071;
Number of Occupations 32;
Total Number of Employees Exposed 13,905
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80235;
Number of Industries 133;
Total Number of Facilities 9,310;
Number of Occupations 93;
Total Number of Employees Exposed 287,737;
Total Number of Female Employees Exposed 72,792


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us