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Registry of Toxic Effects of Chemical Substances (RTECS)

Octyl alcohol

RTECS #

RH6550000

CAS #

111-87-5

Updated

July 2011

Molecular Weight

130.26

Molecular Formula

C8H18O

Synonyms

1-Hydroxyoctane
1-Octanol
Alcohol C-8
Alfol 8
Caprylic alcohol
Dytol M-83
EPAL 8
Heptyl carbinol
Lorol 20
n-Octanol
n-Octyl alcohol
Octanol
Octilin
Octyl alcohol, normal-primary
Primary octyl alcohol
Sipol L8

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 0.1 mLHPV112 -,-,2008
skin /rabbit 500 mg/24H mildFCTXAV 11,1079,1973
skin /rabbit 0.5 mL/4H mildHPV112 -,-,2008

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctionlung/hamster800 µmol/LMUREAV 182,135,1987

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 6500 mg/kg (6-15D pregnant)Reproductive: Other effects on femaleHPV112 -,-,2008

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Hamster, lung fibroblast Inhibitor Concentration Low: >5.1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration Low: >9.6 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 1.8 mmol/L/24HIn Vitro Toxicity Studies: Cell protein synthesisTIVIEQ 3,189,1989
In Vitro/Mouse, fibroblast Inhibitor Concentration (50 percent kill): 170 µmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 17,717,2003
In Vitro/Mouse, fibroblast Inhibitor Concentration Low: >6.4 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
In Vitro/Mouse, macrophage Inhibitor Concentration Low: >5.1 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 1,3,1987
inhalation/human lowest published toxic concentration: 0.1 ppm/4HCardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
inhalation/mouse lowest published toxic concentration: 4.5 gm/m3/2HTPKVAL 5,51,1963
inhalation/rat Lowest published lethal concentration: 5600 mg/m3/4HLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Hemorrhage
EPASR* 8EHQ-1088-0762
inhalation/rat lowest published toxic concentration: 1203 ppm/1HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands
HPV112 -,-,2008
inhalation/rat Lowest published lethal concentration: 1053 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Endocrine: Differential effect of sex or castration on observed toxicity
HPV112 -,-,2008
intraperitoneal/rat lowest published toxic dose: 2000 mg/kgBehavioral: Ataxia

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
intravenous/mouse lethal dose (50 percent kill): 69 mg/kgAIPTAK 135,330,1962
ocular/rabbit lowest published toxic dose: 100 pphEye: Conjunctiva irritationTPKVAL 5,51,1963
oral/human lowest published lethal dose: 428.6 mg/kgVCVGK* -,116,1984
oral/mouse lethal dose (50 percent kill): 15000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
oral/mouse lethal dose (50 percent kill): 1790 mg/kgHPV112 -,-,2008
oral/mouse lethal dose (50 percent kill): 3.91 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/mouse lowest published lethal dose: 1.95 gm/kgBrain and Coverings: Changes in circulation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 5,51,1963
oral/rat lethal dose (50 percent kill): >3200 mg/kgFCTXAV 11,95,1973
oral/rat lethal dose (50 percent kill): 18240 mg/kgVascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Gastritis
HPV112 -,-,2008
oral/rat lethal dose (50 percent kill): 20000 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
parenteral/frog lowest published lethal dose: 1240 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
skin/guinea pig lethal dose (50 percent kill): >1 gm/kgFCTXAV 11,95,1973
skin/rabbit lowest published lethal dose: 2 gm/kgGastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Hematuria

Skin: After topical application: Corrosive
HPV112 -,-,2008
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 4 gm/kgGISAAA 51(5),61,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/107D- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerveTPKVAL 5,51,1963
inhalation/rat lowest published toxic concentration: 0.27 gm/m3/137D- intermittentBrain and Coverings: Changes in circulation

Lung, Thorax, or Respiration: Emphysema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 5,51,1963

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 140-141,261,2003
TOXICOLOGY REVIEWMUREAV 628,67,2007

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,292,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 80235; Number of Industries 133; Total Number of Facilities 9310; Number of Occupations 93; Total Number of Employees Exposed 287737; Total Number of Female Employees Exposed 72792
National Occupational Hazard Survey 1974Hazard Code 80235; Number of Industries 29; Total Number of Facilities 1071; Number of Occupations 32; Total Number of Employees Exposed 13905

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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