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Registry of Toxic Effects of Chemical Substances (RTECS)

1,6-Octadien-3-ol, 3,7-dimethyl-

RTECS #

RG5775000

CAS #

78-70-6

Updated

September 201

Molecular Weight

154.28

Molecular Formula

C10H18O

Synonyms

2,6-Dimethylocta-2,7-dien-6-ol
3,7-Dimethyl-1,6-octadien-3-ol
3,7-Dimethylocta-1,6-dien-3-ol
allo-Ocimenol
Linalool
Linalyl alcohol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL moderateNTIS** OTS0543729
eye /rabbit 0.1 mL/1H moderateFCTOD7 46,S1,2008
skin /guinea pig 100 mg/24H moderateCTOIDG 94(8),41,1979
skin /human 32%/72H mildFCTOD7 46,S1,2008
skin /human 10%/2DCODEDG 61,217,2009
skin /man 16 mg/48H mildCTOIDG 94(8),41,1979
skin /rabbit 500 mg/24H mildFCTXAV 14,673,1976
skin /rabbit 100 mg/24H severeCTOIDG 94(8),41,1979

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Bacillus subtilis8622 µg/discOIGZDE 34,267,1985
mutation in mammalian somatic cellsother cell types/mouse0.1 mL/L (+enzymatic activation step)HPV397 ,,2001
mutation in microorganisms/Salmonella typhimurium3000 µg/plate (-enzymatic activation step)HPV397 ,,2001

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 19500 mg/kg (7D pre-10D after birth)Reproductive: Other effects on femaleHPV397 -,-,2001
oral/rat 39000 mg/kg (7D pre-10D after birth)Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
HPV397 -,-,2001

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, monocyte Inhibitor Concentration Low: 1000 µg/LIn Vitro Toxicity Studies: Cell viability (mitochondrial reductase assays): MTT, XTT, MTS, WSTs assays etc.FCTOD7 50,3079,2012
inhalation/mouse lowest published toxic dose: 1 pph/1HBehavioral: Altered sleep time (including change in righting reflex)

Nutritional and Gross Metabolic: Body temperature decrease
PYTOEY 16,303,2009
inhalation/mouse lowest published toxic dose: 3 pph/1HBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease
PYTOEY 16,303,2009
intramuscular/mouse lethal dose (50 percent kill): 8000 mg/kgFCTOD7 46,S1,2008
intraperitoneal/mouse lethal dose (50 percent kill): 200 mg/kgFCTOD7 46,S1,2008
intraperitoneal/mouse lethal dose (50 percent kill): 340 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
IIFBA4 15,149,1973
intraperitoneal/rat lethal dose (50 percent kill): 307 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia
IIFBA4 15,149,1973
intraperitoneal/rat lethal dose (50 percent kill): 307 mg/kgFCTOD7 46,S1,2008
oral/mouse lethal dose (50 percent kill): 3 gm/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0543729
oral/mouse lethal dose (50 percent kill): 2200 mg/kgFCTOD7 46,S1,2008
oral/rat lethal dose (50 percent kill): >2.79 gm/kgBehavioral: AtaxiaFCTOD7 47,22,2009
oral/rat lethal dose (50 percent kill): 2790 mg/kgHPV397 -,-,2001
skin/rabbit lethal dose (50 percent kill): 5610 mg/kgBehavioral: Somnolence (general depressed activity)HPV397 -,-,2001
skin/rabbit lethal dose (50 percent kill): 5610 mg/kgFCTOD7 46,S1,2008
skin/rat lethal dose (50 percent kill): 5610 mg/kg85JCAE -,202,1986
subcutaneous/mouse lethal dose (50 percent kill): 1470 mg/kgFCTOD7 46,S1,2008
subcutaneous/mouse lethal dose (50 percent kill): 1470 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory changeSIZSAR 3,73,1952
subcutaneous/rat lowest published toxic dose: 25 mg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationPYTOEY 9,721,2002

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 11200 mg/kg/28D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
FCTOD7 46,S1,2008
oral/rat lowest published toxic dose: 11200 mg/kg/28D- intermittentGastrointestinal: Other changesFCTOD7 46,S1,2008
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca
FCTOD7 46,S1,2008
oral/rat lowest published toxic dose: 28000 mg/kg/28D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation
FCTOD7 46,S1,2008
oral/rat lowest published toxic dose: 39000 mg/kg/39D- intermittentBehavioral: Food intake (animal)

Behavioral: Ataxia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,S1,2008
oral/rat lowest published toxic dose: 11000 mg/kg/11D- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,S1,2008
skin/rat lowest published toxic dose: 92 gm/kg/13W- intermittentSkin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 46,S1,2008
skin/rat lowest published toxic dose: 364 gm/kg/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 46,S1,2008
skin/rat lowest published toxic dose: 364 gm/kg/13W- intermittentBehavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
FCTOD7 46,S1,2008
skin/rat lowest published toxic dose: 3625 mg/kg/29D- intermittentBehavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Skin: After topical application: Primary irritation
FCTOD7 46,S1,2008

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWFCTOD7 41,919,2003
TOXICOLOGY REVIEWFCTOD7 46,S1,2008
TOXICOLOGY REVIEWFCTOD7 46,S190,2008

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESActive registrationRBREV* -,379,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 5 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M4982; Number of Industries 106; Total Number of Facilities 16058; Number of Occupations 118; Total Number of Employees Exposed 245476; Total Number of Female Employees Exposed 109311
National Occupational Hazard Survey 1974Hazard Code M4982; Number of Industries 2; Total Number of Facilities 37; Number of Occupations 16; Total Number of Employees Exposed 2301

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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