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9 - Octadecenoic acid, (Z) -

RTECS #: RG2275000

CAS #: 112-80-1


UPDATE: May 2009 MW: 282.52 MF: C18H34O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 9 - Octadecenoic acid, cis -
  2. Acide oleique (French)
  3. Emersol 210
  4. Emersol 213
  5. Emersol 6321
  6. Emersol 233LL
  7. Emersol 221 low titer white oleic acid
  8. Emersol 220 white oleic acid
  9. Glycon RO
  10. Glycon WO
  11. Groco 2
  12. Groco 4
  13. Groco 5L
  14. Groco 6
  15. HY - Phi 1055
  16. HY - Phi 1088
  1. HY - Phi 2066
  2. HY - Phi 2088
  3. HY - Phi 2102
  4. Industrene 105
  5. Industrene 205
  6. Industrene 206
  7. Oleic acid
  8. Oleinic acid
  9. Pamolyn
  10. Tego - oleic 130
  11. Vopcolene 27
  12. Wecoline OO
  13. Wochem No. 320
  14. cis - 9 - Octadecenoic acid
  15. cis - Octadec - 9 - enoic acid
  16. cis - delta (sup 9) - Octadecenoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg mild JACTDZ 6(3),321,1987
skin
human
15 mg/3 day- intermittent moderate 85DKA8 -,127,1977
skin
rabbit
500 mg open irritation test mild UCDS** 11/29/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster fibroblast 2,500 g/L CRNGDP 3,499,1982
cytogenetic analysis Saccharomyes cerevisiae 100 mg/L NATUAS 294,263,1981
unscheduled DNA synthesis rectal
mouse
35 mg/kg CALEDQ 23,253,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
subcutaneous
rabbit
lowest published toxic dose: 390 mg/kg/17 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CRSBAW 137,760,1943
skin
mouse
lowest published toxic dose: 6 mL/kg/10 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens
PBBHAU 21,17,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intradermal
guinea pig
lowest published toxic dose: 400 g/kg Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) TOVEFN (1),42,2000
inhalation
rat
lowest published toxic concentration: 30 mg/m3/4 hour Behavioral: Alteration of classical conditioning

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)
TOVEFN (1),42,2000
intraperitoneal
mouse
lethal dose (50 percent kill): 282 mg/kg N/R YKKZAJ 104,793,1984
intravenous
guinea pig
lowest published toxic dose: 15 L/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Respiratory depression
BPBLEO 27,1451,2004
intravenous
monkey
lethal dose : >40 L/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
LUNGD9 164,259,1986
intravenous
monkey
lowest published toxic dose: 0.8 mg/kg Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Other proteins
TOXID9 90,347,2006
intravenous
mouse
lethal dose (50 percent kill): 230 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
intravenous
rat
lethal dose (50 percent kill): 2,400 g/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
AJPAA4 103,376,1981
intravenous
rat
lowest published toxic dose: 0.15 mL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
JPETAB 313,379,2005
intravenous
rat
lowest published toxic dose: 100 mg/kg Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Other changes
EJPHAZ 510,135,2005
intravenous
rat
lowest published toxic dose: 100 mg/kg Blood: Hemorrhage

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
EJPHAZ 510,135,2005
intravenous
rabbit
lethal dose : >55 mg/kg Lung, Thorax, or Respiration: Other changes ARDSBL 137(Suppl),226,1988
oral
mouse
lethal dose (50 percent kill): 28,000 mg/kg N/R TOVEFN (1),42,2000
oral
rat
lethal dose (50 percent kill): 25,000 mg/kg N/R TOVEFN (1),42,2000
skin
rabbit
lowest published toxic dose: 100 pph Skin: After topical application: Primary irritation TOVEFN (1),42,2000
skin
rabbit
lowest published toxic dose: 100 pph/2 hour Skin: After topical application: Primary irritation TPKVAL 3,120,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 2,712 mg/kg/6 week- intermittent Immunological Including Allergic: Autoimmune (multiple organ involvement) TOXID9 44,187,2005
skin
mouse
lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Blood: Other changes FCTOD7 46,1896,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,336,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52190;
Number of Industries 312;
Total Number of Facilities 65,952;
Number of Occupations 196;
Total Number of Employees Exposed 796,897
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52190;
Number of Industries 256;
Total Number of Facilities 49,332;
Number of Occupations 181;
Total Number of Employees Exposed 1,078,478;
Total Number of Female Employees Exposed 410,362


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for inks, alkyds, adhesives, soaps, soluble cutting oils, rubber compounding, cleaners
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
LUNGD9 Lung. (Springer-Verlag New York, POB 2485, Secaucus, NJ 07096) V.154- 1976-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used for inks, alkyds, adhesives, soaps, soluble cutting oils, rubber compounding, cleaners

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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