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1 - Octadecanol

RTECS #: RG2010000

CAS #: 112-92-5

UPDATE: August 2006 MW: 270.56 MF: C18H38O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Adol 68
  2. Alfol 18
  3. Atalco S
  4. CO - 1895
  5. CO - 1897
  6. Crodacol - S
  7. Decyl octyl alcohol
  8. Dytol E - 46
  9. Lorol 28
  10. Octadecanol
  1. Octadecyl alcohol
  2. Polaax
  3. Sipol S
  4. Siponol S
  5. Stearol
  6. Stearyl alcohol
  7. Steraffine
  8. USP XIII stearyl alcohol
  9. n - Octadecanol
  10. n - Octadecyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg/24 hour mild JACTDZ 4(5),1,1985
skin
rabbit 		500 mg/24 hour mild JACTDZ 4(5),1,1985


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		CNREA8 26,105,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 20 gm/kg N/R 37ASAA 1,722,1978


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA MAK 224 mg/m3 (20 ppm), JAN 2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80705;
Number of Industries 37;
Total Number of Facilities 3,948;
Number of Occupations 44;
Total Number of Employees Exposed 60,590
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80705;
Number of Industries 177;
Total Number of Facilities 22,262;
Number of Occupations 127;
Total Number of Employees Exposed 508,141;
Total Number of Female Employees Exposed 181,509


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in various drug, cosmetic and derivative chemistry applications
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
37ASAA "Kirk-Othmer Encyclopedia of Chemical Technology," 3rd ed., Grayson, M., and D. Eckroth, eds., New York, John Wiley & Sons, Inc., 1978
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.

Used in various drug, cosmetic and derivative chemistry applications

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Primary Irritant

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