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Registry of Toxic Effects of Chemical Substances (RTECS)

5-Norbornene-2,3-dicarboxylic anhydride, 1,4,5,6,7,7-hexachloro-

RTECS #

RB9080000

CAS #

115-27-5

Updated

November 2009

Molecular Weight

370.81

Molecular Formula

C9H2Cl6O3

Synonyms

4,7-Methanoisobenzofuran-1,3-dione, 4,5,6,7,8,8-hexachloro-3a,4,7,7a-tetrahydro-
Chloran 542
Chlorendic anhydride
HET anhydride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeNTIS** OTS0537102

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/cat lethal concentration (50 percent kill): >1 gm/m3GTPZAB 26(4),49,1982
inhalation/rabbit lethal concentration (50 percent kill): >1 gm/m3GTPZAB 26(4),49,1982
inhalation/rat lethal concentration (50 percent kill): >1 gm/m3GTPZAB 26(4),49,1982
oral/mouse lethal dose (50 percent kill): 2400 mg/kgGTPZAB 26(4),49,1982
oral/rat lethal dose (50 percent kill): 2336 mg/kgLung, Thorax, or Respiration: Consolidation

Gastrointestinal: Gastritis

Gastrointestinal: Hypermotility, diarrhea
HPV167 -,-,2001
oral/rat lethal dose (50 percent kill): 2300 mg/kgGTPZAB 26(4),49,1982
skin/rabbit lowest published toxic dose: 10000 mg/kgSkin: After topical application: Primary irritationHPV167 -,-,2001
skin/rabbit lowest published lethal dose: 20000 mg/kgLung, Thorax, or Respiration: Consolidation

Kidney, Ureter, and Bladder: Other changes

Skin: After topical application: Primary irritation
HPV167 -,-,2001
skin/rabbit lethal dose (50 percent kill): >3 gm/kgNTIS** OTS0537102

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 51500 µg/m3/30D- intermittentBrain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Blood: Other changes
GTPZAB 26(4),49,1982

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3595; Number of Industries 2; Total Number of Facilities 57; Number of Occupations 3; Total Number of Employees Exposed 686; Total Number of Female Employees Exposed 237

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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