Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Nitrous acid, sodium salt

RTECS #

RA1225000

CAS #

7632-00-0

Updated

December 2013

Molecular Weight

69.00

Molecular Formula

NO2·Na

Synonyms

Anti-rust
Azotyn sodowy (Polish)
Diazotizing salts
Dusitan sodny (Czech)
Erinitrit
Filmerine
Natrium nitrit (German)
NCI-C02084
Nitrite de sodium (French)
Sodium nitrite

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 500 mg/24H mild28ZPAK -,15,1972

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assaySalmonella typhimurium/other fish450 µg/LCALEDQ 20,147,1983
body fluid assayEscherichia coli/other fish450 µg/LCALEDQ 20,147,1983
body fluid assaySalmonella typhimurium/human200 mmol/LCANCAR 47,889,1981
Cytogenetic AnalysisHeLa cell/hamster265 mg/LMUREAV 189,333,1987
Cytogenetic Analysisparenteral/rat100 mg/kg/5D- intermittentPRKHDK 4,151,1979
Cytogenetic Analysisoral/rat2730 mg/kg/13D-continuousJTEHD6 13,643,1984
Cytogenetic Analysisintraperitoneal/rat69 mg/kgMUREAV 240,281,1990
Cytogenetic Analysisoral/mouse60 mg/kg/30D-continuousCALEDQ 30,315,1986
Cytogenetic Analysismammary gland/mouse10 mmol/L/24HMUREAV 40,119,1976
Cytogenetic Analysisfibroblast/hamster530 mg/L/34HMUREAV 48,337,1977
Cytogenetic Analysisembryo/hamster20 mmol/LMUREAV 56,69,1977
Cytogenetic Analysislung/hamster400 mg/LGMCRDC 27,95,1981
Cytogenetic Analysisliver/monkey265 mg/LMUREAV 189,333,1987
DNA Damagelymphocyte/mammal (species unspecified)1 moleJCPBAN 58,1005,1961
DNA Damageother cell types/human150 µmol/L/12HMUTAEX 28,515,2013
DNA Damagelymphocyte/mouse105 mmol/LMUREAV 203,155,1988
DNA Damage/Other microorganisms1 mole/LJCPBAN 58,1005,1961
DNA Damage/Other microorganisms1 mole/LMUREAV 25,235,1974
DNA Damage/Other microorganisms100 mmol/LJMOBAK 116,31,1977
DNA inhibitionfibroblast/human2000 ppmNEOLA4 32,341,1985
DNA inhibitionother cell types/human725 µmol/LIJCNAW 47,396,1991
DNA inhibitionlung/hamster100 ppmNEOLA4 32,341,1985
DNA repairother cell types/human150 µmol/L/12HMUTAEX 28,515,2013
DNA repair/Escherichia coli625 µg/wellMUREAV 133,161,1984
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 µmol/LMGGEAE 168,125,1979
gene conversion and mitotic recombinationoral/Drosophila melanogaster36 mmol/L/48HMUREAV 518,95,2002
host-mediated assaySchizosaccharomyces pombe/mouse362 µmol/kgMUREAV 113,21,1983
micronucleus testoral/hamster500 mg/kgIJCNAW 24,365,1979
morphological transformoral/hamster100 mg/kgBBRCA9 81,310,1978
morphological transformother cell types/hamster100 mmol/L/24HBBRCA9 55,1117,1973
morphological transformfibroblast/hamster50 mmol/L/3HGANNA2 67,165,1976
morphological transformfibroblast/mouse10 mmol/LCRNGDP 11,595,1990
mutation in mammalian somatic cellslymphocyte/mouse70400 µmol/LMUTAEX 3,193,1988
mutation in mammalian somatic cellsmammary gland/mouse1 mmol/L/2DMUREAV 40,119,1976
mutation in mammalian somatic cellsoral/hamster100 mg/kgIAPUDO 41,585,1982
mutation in mammalian somatic cellslung/hamster1000 ppmNEOLA4 32,341,1985
mutation in microorganisms/Salmonella typhimurium5 mg/plateEXONC* 15,25,1992
mutation in microorganisms/Salmonella typhimurium5000 µg/plate/48H (-enzymatic activation step)RTOPDW 35,255,2002
mutation in microorganisms/Salmonella typhimurium4000 µg/plate/20M (-enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Salmonella typhimurium4000 µg/plate/20M (+enzymatic activation step)MUTAEX 20,217,2005
mutation in microorganisms/Schizosaccharomyces pombe34 mmol/L (-enzymatic activation step)ADWMAX -,193,1962
mutation in microorganisms/Neurospora crassa5 µmol/L/2H (-enzymatic activation step)MGGEAE 111,159,1971
mutation in microorganisms/Saccharomyes cerevisiae72500 µmol/L (-enzymatic activation step)MGGEAE 102,290,1968
mutation in microorganisms/Other microorganisms5 mole/L (-enzymatic activation step)MGGEAE 141,207,1975
mutation in microorganisms/Other microorganisms200 mg/kg (-enzymatic activation step)JOVIAM 37,936,1981
mutation in microorganisms/Salmonella typhimurium250 µg/plate (+enzymatic activation step)MUREAV 28,31,1975
mutation in microorganisms/Salmonella typhimurium1 mg/plate (-enzymatic activation step)MIBUBI 25,94,1991
mutation in microorganisms/Bacillus subtilis400 mole (-enzymatic activation step)MOPMA3 4,411,1968
mutation in microorganisms/Escherichia coli50 mmol/L (-enzymatic activation step)GENTAE 61,376,1969
mutation in microorganisms/Other microorganisms2 mole/L (-enzymatic activation step)VIRLAX 37,335,1969
mutation in microorganisms/Other microorganisms17 mmol/L (-enzymatic activation step)FOMIAZ 15,48,1970
mutation in microorganisms/Other microorganisms4 pph (-enzymatic activation step)ZAPOAK 16,279,1976
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)BBRCA9 2,324,1960
mutation in microorganisms/Other microorganisms50 mmol/L (-enzymatic activation step)TGANAK 3,87,1968
mutation in microorganisms/Other microorganisms3350 mmol/L (-enzymatic activation step)VIRLAX 81,192,1977
mutation in microorganisms/Other microorganisms50 mmol/L (-enzymatic activation step)AMICCW 103,141,1975
mutation in microorganisms/Other microorganisms2 mole/L (-enzymatic activation step)VIRLAX 74,154,1976
mutation in microorganisms/Other microorganisms50 mole/L (-enzymatic activation step)ZBPIA9 128,678,1974
mutation in microorganisms/Other microorganisms700 mmol/L (-enzymatic activation step)JOVIAM 15,1,1975
mutation in microorganisms/Other microorganisms1 mmol/L (-enzymatic activation step)JOVIAM 15,41,1975
mutation in microorganisms/Other microorganisms10 mmol/L (-enzymatic activation step)FOMIAZ 23,177,1978
mutation in microorganisms/Other microorganisms4 mole/L (-enzymatic activation step)JOVIAM 7,295,1971
mutation in microorganisms/Other microorganisms1 mole/L (-enzymatic activation step)AVIRA2 21,397,1977
mutation in microorganisms/Other microorganisms50 mmol/L (-enzymatic activation step)JGMIAN 128,1401,1982
other mutation test systems/Haemophilus influenzae100 mmol/LMUREAV 61,129,1979
other mutation test systems/Salmonella typhimurium2200 mg/LMUREAV 192,239,1987
other mutation test systems/Other microorganisms1 mole/LJCPBAN 58,1005,1961
phage inhibition capacity/Escherichia coli215 µg/wellANYAA9 463,347,1986
sex chromosome loss and nondisjunction/Aspergillus nidulans500 mmol/LMUREAV 10,111,1970
sister chromatid exchangeintraperitoneal/mouse5 mg/kgCALEDQ 31,299,1986
sister chromatid exchangefibroblast/hamster3 mmol/LPJACAW 53,46,1977
specific locus testoral/Drosophila melanogaster72500 µmol/L/48HMUREAV 222,359,1989
sperm morphologyoral/mouse840 mg/kg/2WMUREAV 204,689,1988
Unscheduled DNA SynthesisHeLa cell/human6 mmol/LFCTOD7 21,551,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat 400 mg/kg (10-19D pregnant)Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Behavioral
ZVNDAM 43,613,1993
intravenous/cattle 36 mg/kg (30-31W pregnant)Reproductive: Other effects to embryo or fetusTHGNBO 33,1075,1990
oral/rat 110 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
VCVN5* -,42,1989
oral/mouse 480 mg/kg (multigenerations)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)NTIS** #PB91132027
oral/mouse 480 mg/kg (multigenerations)Reproductive: Specific developmental abnormalities: Urogenital systemNTIS** #PB91132027
oral/mouse 280 mg/kg (1-14D pregnant)Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)TJADAB 18,367,1978
oral/mouse 1200 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
NEZAAQ 42,836,1987
oral/mouse 1680 mg/kg (14D male)Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)MUREAV 204,689,1988
oral/mouse 840 mg/kg (14D male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)MUREAV 204,689,1988
oral/rat 660 mg/kg (1-22D pregnant)Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
AJHEAA 62,1045,1972
oral/rat 11 gm/kg (1-22D preg/21D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOXID9 4,89,1984
oral/rat 10280 mg/kg (1-22D preg/20D after birth)Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)FAATDF 9,668,1987
oral/rat 6080 mg/kg (20D after birth)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
FAATDF 9,668,1987
subcutaneous/pig 1890 mg/kg (15-105D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVN5* -,41,1989

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 2149 mg/kg (2W male/2W pre-3W after birth)Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
CNREA8 45,3561,1985
oral/mouse lowest published toxic dose: 118965 mg/kg/103W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB2001-107676
oral/rat lowest published toxic dose: 27300 mg/kg/273D- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens
VOONC* 37,203,1991
oral/rat lowest published toxic dose: 2856.42 mg/kg/6W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
JTPAE7 18,99,2005
oral/rat lowest published toxic dose: 2190 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
HKXUDL 6,246,1986
oral/rat toxic dose: 63 gm/kg/95W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
JJIND8 64,1435,1980
oral/rat toxic dose: 91 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982
oral/rat toxic dose: 183 gm/kg/2Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982
oral/rat toxic dose: 100 gm/kg/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CRNGDP 4,1189,1983
oral/rat toxic dose: 40 gm/kg/56W- continuousTumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
ZKKOBW 90,87,1977
oral/rat toxic dose: 365 gm/kg/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
TCMUD8 8,35,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/phaInhibitor Concentration Low: 1 mmol/LVascular: Relaxation (isolated tissue)JOETD7 134,637,2011
inhalation/rat lethal concentration (50 percent kill): 5.5 mg/m3/4HVCVN5* -,40,1993
inhalation/rat lowest published toxic concentration: 1.2 mg/m3/4HBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
VCVN5* -,40,1993
intramuscular/mouse lowest published toxic dose: 100 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
ETOPFR 7,237,1999
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
ETOPFR 7,237,1999
intraperitoneal/mouse lethal dose (50 percent kill): 158 mg/kgJPETAB 165,30,1969
intraperitoneal/mouse lowest published toxic dose: 250 mg/kgBrain and Coverings: Other degenerative changesCYLPDN 23,225,2002
intraperitoneal/mouse lowest published toxic dose: 120 mg/kgBehavioral: Alteration of classical conditioningPYTOEY 15,587,2008
intraperitoneal/rat lethal dose (50 percent kill): 90 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
TOVEFN (4),27,2006
intraperitoneal/rat lethal dose (50 percent kill): 90 mg/kgBlood: Normocytic anemia

Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
TOVEFN (1),7,2004
intraperitoneal/rat lowest published toxic dose: 21 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTOXID9 72,32,2003
intravenous/Dog lowest published toxic dose: 150 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
intravenous/Dog lowest published lethal dose: 15 mg/kg27ZIAQ -,245,1973
intravenous/rabbit lowest published lethal dose: 80 mg/kgPeripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Coma

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 41,121,1931
intravenous/rat lethal dose (50 percent kill): 65 mg/kgARZNAD 13,320,1963
oral/cat lowest published lethal dose: 1500 mg/kgHBAMAK 4,1372,1935
oral/chicken lethal dose (50 percent kill): 28944 µg/kgAJVRAH 30,2185,1969
oral/child lowest published lethal dose: 22 mg/kgVascular: Other changesLANCAO 2,162,1917
oral/Dog lowest published lethal dose: 330 mg/kg27ZIAQ -,245,1973
oral/Dog lowest published toxic dose: 150 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
oral/human lowest published lethal dose: 71 mg/kgBehavioral: Coma

Gastrointestinal: Nausea or vomiting

Blood: Methemoglobinemia- Carboxhemoglobinemia
34ZIAG -,543,1969
oral/human lowest published toxic dose: 14 mg/kgBehavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Nausea or vomiting
DMWOAX 74,961,1949
oral/man lowest published lethal dose: 321 mg/kgBehavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
IJMDAI 28,289,1992
oral/man lowest published toxic dose: 1714 µg/kg/70MCardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section
JCINAO 16,73,1937
oral/mouse lethal dose (50 percent kill): 175 mg/kgVascular: BP lowering not characterized in autonomic section

Vascular: Regional or general arteriolar or venous dilation
FAONAU 53A,97,1974
oral/mouse lowest published toxic dose: 25 mg/kgImmunological Including Allergic: Decrease in cellular immune responseFCTOD7 39,119,2001
oral/mouse lowest published toxic dose: 100 mg/kgBlood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
FCTOD7 39,119,2001
oral/rabbit lethal dose (50 percent kill): 186 mg/kgSOVEA7 27,246,1974
oral/rat lethal dose (50 percent kill): 157.9 mg/kgTOVEFN (5),22,1996
oral/rat lowest published toxic dose: 15 mg/kgBlood: Methemoglobinemia- CarboxhemoglobinemiaTOVEFN (5),22,1996
subcutaneous/cat lowest published lethal dose: 100 mg/kgBrain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above
FATOAO 44,210,1981
subcutaneous/cat lowest published lethal dose: 35 mg/kgLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
AEPPAE 126,209,1927
subcutaneous/Dog lowest published lethal dose: 60 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AIPTAK 21,425,1911
subcutaneous/Dog lowest published toxic dose: 150 mg/kgBlood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
subcutaneous/frog lowest published lethal dose: 1 gm/kgHBAMAK 4,1372,1935
subcutaneous/mouse lowest published lethal dose: 150 mg/kgBehavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
AIPTAK 35,480,1929
subcutaneous/mouse lowest published toxic dose: 300 mg/kgNutritional and Gross Metabolic: Other changesFATOAO 50,74,1987
subcutaneous/mouse lowest published lethal dose: 100 mg/kgFATOAO 44,210,1981
subcutaneous/mouse lowest published toxic dose: 120 mg/kgBehavioral: Alteration of classical conditioningACPSI* 24,1137,2003
subcutaneous/rabbit lowest published lethal dose: 60 mg/kgHBAMAK 4,1372,1935
subcutaneous/rat lethal dose (50 percent kill): 96600 µg/kgATSUDG 14,231,1991
subcutaneous/rat lowest published lethal dose: 100 mg/kgFATOAO 44,210,1981
subcutaneous/rat lowest published toxic dose: 60 mg/kgBrain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
INJPD2 38,414,2006
subcutaneous/rat lowest published lethal dose: 120 mg/kgLung, Thorax, or Respiration: Dyspnea

Blood: Other changes
FATOAO 45,76,1982
unreported route/human lowest published lethal dose: 0.036 gm/kgBehavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia
VCVN5* -,41,1993

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 300 µg/m3/4H/30D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 37(3),41,1972
inhalation/rat lowest published toxic concentration: 125 µg/m3/22W- intermittentBrain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GTPZAB 16(10),36,1972
inhalation/rat lowest published toxic concentration: 0.3 mg/m3/4H/30D- intermittentBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,41,1989
inhalation/rat lowest published toxic concentration: 0.125 mg/m3/4H/22W- intermittentPeripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVN5* -,42,1989
intraperitoneal/rat lowest published toxic dose: 960 mg/kg/30D- intermittentLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 34(6),29,1990
oral/guinea pig lowest published toxic dose: 53.5 gm/kg/9W- continuousCardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,42,1989
oral/mouse lowest published toxic dose: 16800 mg/kg/35D- continuousBehavioral: Fluid intakeNTIS** #PB91132027
oral/mouse lowest published toxic dose: 3600 mg/kg/90D- intermittentGastrointestinal: Other changesBECTA6 60,185,1998
oral/mouse lowest published toxic dose: 175 mg/kg/1W- continuousImmunological Including Allergic: Decrease in cellular immune responseFCTOD7 39,119,2001
oral/mouse lowest published toxic dose: 700 mg/kg/1W- continuousImmunological Including Allergic: Decrease in humoral immune responseFCTOD7 39,119,2001
oral/rat lowest published toxic dose: 27 mg/kg/10D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
VCVN5* -,41,1989
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentLiver: Liver function tests impairedVCVN5* -,41,1989
oral/rat lowest published toxic dose: 110 mg/kg/22D- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Metabolism (intermediary): Glycolytic
VCVN5* -,42,1989
oral/rat lowest published toxic dose: 185 gm/kg/61W- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 6,199,1980
oral/rat lowest published toxic dose: 180 mg/kg/8D- intermittentLiver: Other changesKHZDAN 25,558,1982
oral/rat lowest published toxic dose: 22500 mg/kg/90D- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BCTKAG 13,41,1980
oral/rat lowest published toxic dose: 17080 mg/kg/61D- continuousBrain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Blood: Methemoglobinemia- Carboxhemoglobinemia
ENVRAL 5,409,1972
oral/rat lowest published toxic dose: 4477 mg/kg/26W- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 44(7),8,1979
oral/rat lowest published toxic dose: 134 gm/kg/64W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainJEPTDQ 2(3),687,1979
oral/rat lowest published toxic dose: 912.5 mg/kg/26W- intermittentBehavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVN5* -,42,1989
oral/rat lowest published toxic dose: 3083.64 mg/kg/6W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 18,99,2005
oral/rat lowest published toxic dose: 7200 mg/kg/90D- intermittentBrain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FCTOD7 48,1980,2010
subcutaneous/pig lowest published toxic dose: 1890 mg/kg/90D- intermittentBlood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,41,1989
subcutaneous/rat lowest published toxic dose: 150 mg/kg/3D- intermittentBehavioral: Alteration of classical conditioningJPHSC* 101,199,2006

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJSFAAE 26,1761,1975
TOXICOLOGY REVIEWFNSCA6 2,67,1973
TOXICOLOGY REVIEWENTOX* -,232,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 654,114,2008
TOXICOLOGY REVIEWMUREAV 566,49,2004
TOXICOLOGY REVIEWHUTOX* -,259,1996

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,318,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 69230; Number of Industries 250; Total Number of Facilities 47686; Number of Occupations 169; Total Number of Employees Exposed 928532; Total Number of Female Employees Exposed 274167
National Occupational Hazard Survey 1974Hazard Code 69230; Number of Industries 229; Total Number of Facilities 40763; Number of Occupations 127; Total Number of Employees Exposed 389731

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent heritable translocation; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; In vivo cytogenetics-mammalian oocyte
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);equivocal evidence:mouse
NCI Carcinogenesis Studies (water);no evidence:rat
NTP Carcinogenesis studies; test completed (post peer review), October 2000
TOP