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Nitrous acid, sodium salt

RTECS #: RA1225000

CAS #: 7632-00-0


UPDATE: May 2009 MW: 69.00 MF: NO2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Anti - rust
  2. Azotyn sodowy (Polish)
  3. Diazotizing salts
  4. Dusitan sodny (Czech)
  5. Erinitrit
  1. Filmerine
  2. NCI - C02084
  3. Natrium nitrit (German)
  4. Nitrite de sodium (French)
  5. Sodium nitrite


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
500 mg/24 hour mild 28ZPAK -,15,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay human
Salmonella typhimurium
200 mmol/L CANCAR 47,889,1981
body fluid assay other fish
Salmonella typhimurium
450 g/L CALEDQ 20,147,1983
body fluid assay other fish
Escherichia coli
450 g/L CALEDQ 20,147,1983
cytogenetic analysis hamster HeLa cell 265 mg/L MUREAV 189,333,1987
cytogenetic analysis hamster fibroblast 530 mg/L/34 hour MUREAV 48,337,1977
cytogenetic analysis hamster embryo 20 mmol/L MUREAV 56,69,1977
cytogenetic analysis hamster lung 400 mg/L GMCRDC 27,95,1981
cytogenetic analysis monkey liver 265 mg/L MUREAV 189,333,1987
cytogenetic analysis oral
mouse
60 mg/kg/30 day- continuous CALEDQ 30,315,1986
cytogenetic analysis mouse mammary gland 10 mmol/L/24 hour MUREAV 40,119,1976
cytogenetic analysis parenteral
rat
100 mg/kg/5 day- intermittent PRKHDK 4,151,1979
cytogenetic analysis oral
rat
2,730 mg/kg/13 day- continuous JTEHD6 13,643,1984
cytogenetic analysis intraperitoneal
rat
69 mg/kg MUREAV 240,281,1990
DNA damage mammal (species unspecified) lymphocyte 1 mole JCPBAN 58,1005,1961
DNA damage mouse lymphocyte 105 mmol/L MUREAV 203,155,1988
DNA damage other microorganisms 100 mmol/L JMOBAK 116,31,1977
DNA damage other microorganisms 1 mole/L JCPBAN 58,1005,1961
DNA damage other microorganisms 1 mole/L MUREAV 25,235,1974
DNA inhibition hamster lung 100 ppm NEOLA4 32,341,1985
DNA inhibition human fibroblast 2,000 ppm NEOLA4 32,341,1985
DNA inhibition human other cell types 725 mol/L IJCNAW 47,396,1991
DNA repair Escherichia coli 625 g/well MUREAV 133,161,1984
unscheduled DNA synthesis human HeLa cell 6 mmol/L FCTOD7 21,551,1983
host-mediated assay mouse
Schizosaccharomyces pombe
362 mol/kg MUREAV 113,21,1983
mutation in microorganisms Bacillus subtilis 400 mole (-enzymatic activation step) MOPMA3 4,411,1968
mutation in microorganisms Escherichia coli 50 mmol/L (-enzymatic activation step) GENTAE 61,376,1969
mutation in microorganisms Neurospora crassa 5 mol/L/2 hour (-enzymatic activation step) MGGEAE 111,159,1971
mutation in microorganisms other microorganisms 2 mole/L (-enzymatic activation step) VIRLAX 37,335,1969
mutation in microorganisms other microorganisms 17 mmol/L (-enzymatic activation step) FOMIAZ 15,48,1970
mutation in microorganisms other microorganisms 4 pph (-enzymatic activation step) ZAPOAK 16,279,1976
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) BBRCA9 2,324,1960
mutation in microorganisms other microorganisms 50 mmol/L (-enzymatic activation step) TGANAK 3,87,1968
mutation in microorganisms other microorganisms 3,350 mmol/L (-enzymatic activation step) VIRLAX 81,192,1977
mutation in microorganisms other microorganisms 50 mmol/L (-enzymatic activation step) AMICCW 103,141,1975
mutation in microorganisms other microorganisms 2 mole/L (-enzymatic activation step) VIRLAX 74,154,1976
mutation in microorganisms other microorganisms 50 mole/L (-enzymatic activation step) ZBPIA9 128,678,1974
mutation in microorganisms other microorganisms 700 mmol/L (-enzymatic activation step) JOVIAM 15,1,1975
mutation in microorganisms other microorganisms 1 mmol/L (-enzymatic activation step) JOVIAM 15,41,1975
mutation in microorganisms other microorganisms 10 mmol/L (-enzymatic activation step) FOMIAZ 23,177,1978
mutation in microorganisms other microorganisms 4 mole/L (-enzymatic activation step) JOVIAM 7,295,1971
mutation in microorganisms other microorganisms 1 mole/L (-enzymatic activation step) AVIRA2 21,397,1977
mutation in microorganisms other microorganisms 50 mmol/L (-enzymatic activation step) JGMIAN 128,1401,1982
mutation in microorganisms other microorganisms 5 mole/L (-enzymatic activation step) MGGEAE 141,207,1975
mutation in microorganisms other microorganisms 200 mg/kg (-enzymatic activation step) JOVIAM 37,936,1981
mutation in microorganisms Salmonella typhimurium 250 g/plate (+enzymatic activation step) MUREAV 28,31,1975
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) MIBUBI 25,94,1991
mutation in microorganisms Salmonella typhimurium 5 mg/plate EXONC* 15,25,1992
mutation in microorganisms Salmonella typhimurium 5,000 g/plate/48 hour (-enzymatic activation step) RTOPDW 35,255,2002
mutation in microorganisms Salmonella typhimurium 4,000 g/plate/20 minute (-enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Salmonella typhimurium 4,000 g/plate/20 minute (+enzymatic activation step) MUTAEX 20,217,2005
mutation in microorganisms Saccharomyes cerevisiae 72,500 mol/L (-enzymatic activation step) MGGEAE 102,290,1968
mutation in microorganisms Schizosaccharomyces pombe 34 mmol/L (-enzymatic activation step) ADWMAX -,193,1962
micronucleus test oral
hamster
500 mg/kg IJCNAW 24,365,1979
gene conversion and mitotic recombination oral
Drosophila melanogaster
36 mmol/L/48 hour MUREAV 518,95,2002
gene conversion and mitotic recombination Saccharomyes cerevisiae 100 mol/L MGGEAE 168,125,1979
mutation in mammalian somatic cells oral
hamster
100 mg/kg IAPUDO 41,585,1982
mutation in mammalian somatic cells hamster lung 1,000 ppm NEOLA4 32,341,1985
mutation in mammalian somatic cells mouse lymphocyte 70,400 mol/L MUTAEX 3,193,1988
mutation in mammalian somatic cells mouse mammary gland 1 mmol/L/2 day MUREAV 40,119,1976
morphological transform oral
hamster
100 mg/kg BBRCA9 81,310,1978
morphological transform hamster other cell types 100 mmol/L/24 hour BBRCA9 55,1117,1973
morphological transform hamster fibroblast 50 mmol/L/3 hour GANNA2 67,165,1976
morphological transform mouse fibroblast 10 mmol/L CRNGDP 11,595,1990
other mutation test systems Haemophilus influenzae 100 mmol/L MUREAV 61,129,1979
other mutation test systems other microorganisms 1 mole/L JCPBAN 58,1005,1961
other mutation test systems Salmonella typhimurium 2,200 mg/L MUREAV 192,239,1987
phage inhibition capacity Escherichia coli 215 g/well ANYAA9 463,347,1986
sister chromatid exchange hamster fibroblast 3 mmol/L PJACAW 53,46,1977
sister chromatid exchange intraperitoneal
mouse
5 mg/kg CALEDQ 31,299,1986
sex chromosome loss and nondisjunction Aspergillus nidulans 500 mmol/L MUREAV 10,111,1970
specific locus test oral
Drosophila melanogaster
72,500 mol/L/48 hour MUREAV 222,359,1989
sperm morphology oral
mouse
840 mg/kg/2 week MUREAV 204,689,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 400 mg/kg (10-19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Effects on newborn: Behavioral
ZVNDAM 43,613,1993
intravenous
cattle
lowest published toxic dose: 36 mg/kg (30-31 week pregnant) Reproductive: Other effects to embryo or fetus THGNBO 33,1075,1990
oral
mouse
lowest published toxic dose: 280 mg/kg (1-14 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) TJADAB 18,367,1978
oral
mouse
lowest published toxic dose: 1,200 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death
NEZAAQ 42,836,1987
oral
mouse
lowest published toxic dose: 1,680 mg/kg (14 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) MUREAV 204,689,1988
oral
mouse
lowest published toxic dose: 840 mg/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 204,689,1988
oral
mouse
lowest published toxic dose: 480 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB91132027
oral
mouse
lowest published toxic dose: 480 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB91132027
oral
rat
lowest published toxic dose: 660 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
AJHEAA 62,1045,1972
oral
rat
lowest published toxic dose: 11 gm/kg (1-22 day pregnant/21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects
TOXID9 4,89,1984
oral
rat
lowest published toxic dose: 10,280 mg/kg (1-22 day pregnant/20 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FAATDF 9,668,1987
oral
rat
lowest published toxic dose: 6,080 mg/kg (20 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
FAATDF 9,668,1987
oral
rat
lowest published toxic dose: 110 mg/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
VCVN5* -,42,1989
subcutaneous
pig
lowest published toxic dose: 1,890 mg/kg (15-105 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVN5* -,41,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 2,149 mg/kg (2 week male/2 week prior to copulation-3 week after birth) Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Lung, Thorax, or Respiration: Tumors
CNREA8 45,3561,1985
oral
mouse
lowest published toxic dose: 118,965 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
NTIS** PB2001-107676
oral
rat
lowest published toxic dose: 2,190 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
HKXUDL 6,246,1986
oral
rat
toxic dose : 63 gm/kg/95 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors
JJIND8 64,1435,1980
oral
rat
toxic dose : 91 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982
oral
rat
toxic dose : 183 gm/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Reproductive: Tumorigenic effects: Testicular tumors
FCTOD7 20,25,1982
oral
rat
toxic dose : 100 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
CRNGDP 4,1189,1983
oral
rat
toxic dose : 40 gm/kg/56 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors
ZKKOBW 90,87,1977
oral
rat
toxic dose : 365 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors
TCMUD8 8,35,1988
oral
rat
lowest published toxic dose: 27,300 mg/kg/273 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Facilitates action of known carcinogens
VOONC* 37,203,1991
oral
rat
lowest published toxic dose: 2,856.42 mg/kg/6 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens
JTPAE7 18,99,2005


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 5.5 mg/m3/4 hour N/R VCVN5* -,40,1993
inhalation
rat
lowest published toxic concentration: 1.2 mg/m3/4 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
VCVN5* -,40,1993
intramuscular
mouse
lowest published toxic dose: 100 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
ETOPFR 7,237,1999
intraperitoneal
mouse
lethal dose (50 percent kill): 158 mg/kg N/R JPETAB 165,30,1969
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Other changes
ETOPFR 7,237,1999
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Brain and Coverings: Other degenerative changes CYLPDN 23,225,2002
intraperitoneal
rat
lowest published toxic dose: 21 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TOXID9 72,32,2003
intravenous
dog
lowest published lethal dose: 15 mg/kg N/R 27ZIAQ -,245,1973
intravenous
dog
lowest published toxic dose: 150 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
intravenous
rat
lethal dose (50 percent kill): 65 mg/kg N/R ARZNAD 13,320,1963
intravenous
rabbit
lowest published lethal dose: 80 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Coma

Kidney, Ureter, and Bladder: Urine volume increased
JPETAB 41,121,1931
oral
cat
lowest published lethal dose: 1,500 mg/kg N/R HBAMAK 4,1372,1935
oral
child
lowest published lethal dose: 22 mg/kg Vascular: Other changes LANCAO 2,162,1917
oral
chicken
lethal dose (50 percent kill): 28,944 g/kg N/R AJVRAH 30,2185,1969
oral
dog
lowest published lethal dose: 330 mg/kg N/R 27ZIAQ -,245,1973
oral
dog
lowest published toxic dose: 150 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
oral
human
lowest published toxic dose: 14 mg/kg Behavioral: Change in motor activity (specific assay)

Vascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Nausea or vomiting
DMWOAX 74,961,1949
oral
human
lowest published lethal dose: 71 mg/kg Behavioral: Coma

Gastrointestinal: Nausea or vomiting

Blood: Methemoglobinemia- Carboxhemoglobinemia
34ZIAG -,543,1969
oral
man
lowest published lethal dose: 321 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia
IJMDAI 28,289,1992
oral
man
lowest published toxic dose: 1,714 g/kg/70 minute Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section
JCINAO 16,73,1937
oral
mouse
lethal dose (50 percent kill): 175 mg/kg Vascular: BP lowering not characterized in autonomic section

Vascular: Regional or general arteriolar or venous dilation
FAONAU 53A,97,1974
oral
mouse
lowest published toxic dose: 25 mg/kg Immunological Including Allergic: Decrease in cellular immune response FCTOD7 39,119,2001
oral
mouse
lowest published toxic dose: 100 mg/kg Blood: Changes in other cell count (unspecified)

Immunological Including Allergic: Decrease in cellular immune response
FCTOD7 39,119,2001
oral
rat
lethal dose (50 percent kill): 157.9 mg/kg N/R TOVEFN (5),22,1996
oral
rat
lowest published toxic dose: 15 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia TOVEFN (5),22,1996
oral
rabbit
lethal dose (50 percent kill): 186 mg/kg N/R SOVEA7 27,246,1974
subcutaneous
cat
lowest published lethal dose: 35 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Changes in structure or function of salivary glands
AEPPAE 126,209,1927
subcutaneous
cat
lowest published lethal dose: 100 mg/kg Brain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above
FATOAO 44,210,1981
subcutaneous
dog
lowest published lethal dose: 60 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Gastrointestinal: Nausea or vomiting
AIPTAK 21,425,1911
subcutaneous
dog
lowest published toxic dose: 150 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count
VCVN5* -,41,1993
subcutaneous
frog
lowest published lethal dose: 1 gm/kg N/R HBAMAK 4,1372,1935
subcutaneous
mouse
lowest published lethal dose: 150 mg/kg Behavioral: Excitement

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting
AIPTAK 35,480,1929
subcutaneous
mouse
lowest published toxic dose: 300 mg/kg Nutritional and Gross Metabolic: Other changes FATOAO 50,74,1987
subcutaneous
mouse
lowest published lethal dose: 100 mg/kg N/R FATOAO 44,210,1981
subcutaneous
mouse
lowest published toxic dose: 120 mg/kg Behavioral: Alteration of classical conditioning ACPSI* 24,1137,2003
subcutaneous
rat
lethal dose (50 percent kill): 96,600 g/kg N/R ATSUDG 14,231,1991
subcutaneous
rat
lethal dose : 120 mg/kg Lung, Thorax, or Respiration: Dyspnea

Blood: Other changes
FATOAO 45,76,1982
subcutaneous
rat
lowest published lethal dose: 100 mg/kg N/R FATOAO 44,210,1981
subcutaneous
rat
lowest published toxic dose: 60 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
INJPD2 38,414,2006
subcutaneous
rabbit
lowest published lethal dose: 60 mg/kg N/R HBAMAK 4,1372,1935
unreported route
human
lowest published lethal dose: 0.36 gm/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression

Blood: Methemoglobinemia- Carboxhemoglobinemia
VCVN5* -,41,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 300 g/m3/4 hour/30 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 37(3),41,1972
inhalation
rat
lowest published toxic concentration: 125 g/m3/22 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
GTPZAB 16(10),36,1972
inhalation
rat
lowest published toxic concentration: 0.3 mg/m3/4 hour/30 day- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cyanosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VCVN5* -,41,1989
inhalation
rat
lowest published toxic concentration: 0.125 mg/m3/4 hour/22 week- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
VCVN5* -,42,1989
intraperitoneal
rat
lowest published toxic dose: 960 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
GTPZAB 34(6),29,1990
oral
guinea pig
lowest published toxic dose: 53.5 gm/kg/9 week- continuous Cardiac: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
VCVN5* -,42,1989
oral
mouse
lowest published toxic dose: 3,600 mg/kg/90 day- intermittent Gastrointestinal: Other changes BECTA6 60,185,1998
oral
mouse
lowest published toxic dose: 175 mg/kg/1 week- continuous Immunological Including Allergic: Decrease in cellular immune response FCTOD7 39,119,2001
oral
mouse
lowest published toxic dose: 700 mg/kg/1 week- continuous Immunological Including Allergic: Decrease in humoral immune response FCTOD7 39,119,2001
oral
mouse
lowest published toxic dose: 16,800 mg/kg/35 day- continuous Behavioral: Fluid intake NTIS** #PB91132027
oral
rat
lowest published toxic dose: 180 mg/kg/8 day- intermittent Liver: Other changes KHZDAN 25,558,1982
oral
rat
lowest published toxic dose: 22,500 mg/kg/90 day- continuous Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
BCTKAG 13,41,1980
oral
rat
lowest published toxic dose: 17,080 mg/kg/61 day- continuous Brain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Blood: Methemoglobinemia- Carboxhemoglobinemia
ENVRAL 5,409,1972
oral
rat
lowest published toxic dose: 4,477 mg/kg/26 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 44(7),8,1979
oral
rat
lowest published toxic dose: 134 gm/kg/64 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JEPTDQ 2(3),687,1979
oral
rat
lowest published toxic dose: 185 gm/kg/61 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOLED5 6,199,1980
oral
rat
lowest published toxic dose: 27 mg/kg/10 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
VCVN5* -,41,1989
oral
rat
lowest published toxic dose: 100 mg/kg/10 day- intermittent Liver: Liver function tests impaired VCVN5* -,41,1989
oral
rat
lowest published toxic dose: 110 mg/kg/22 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Metabolism (intermediary): Glycolytic
VCVN5* -,42,1989
oral
rat
lowest published toxic dose: 912.5 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Methemoglobinemia- Carboxhemoglobinemia

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
VCVN5* -,42,1989
oral
rat
lowest published toxic dose: 3,083.64 mg/kg/6 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTPAE7 18,99,2005
subcutaneous
pig
lowest published toxic dose: 1,890 mg/kg/90 day- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,41,1989
subcutaneous
rat
lowest published toxic dose: 150 mg/kg/3 day- intermittent Behavioral: Alteration of classical conditioning JPHSC* 101,199,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JSFAAE 26,1761,1975
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
ENTOX* -,232,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 566,49,2004
TOXICOLOGY REVIEW
HUTOX* -,259,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,318,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69230;
Number of Industries 229;
Total Number of Facilities 40,763;
Number of Occupations 127;
Total Number of Employees Exposed 389,731
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69230;
Number of Industries 250;
Total Number of Facilities 47,686;
Number of Occupations 169;
Total Number of Employees Exposed 928,532;
Total Number of Female Employees Exposed 274,167


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: SHE-clonal assay; In vivo cytogenetics-mammalian oocyte
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent heritable translocation; Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a chemical intermediate, dye, pigment, printing ink, food and feed additive
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (water);equivocal evidence:mouse
NCI Carcinogenesis Studies (water);no evidence:rat
NTP Carcinogenesis studies; test completed (post peer review), October 2000


REFERENCES:

CODEN
REFERENCE

27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
ADWMAX Abhandlungen der Deutschen Akademie der Wissenschaften zu Berlin, Klasse fuer Medizin. (Berlin, Ger. Dem. Rep.) 1950-68. Discontinued.
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJHEAA American Journal of Public Health. (American Public Health Assoc., 1015 15th St., NW, Washington, DC 20005) V.2-17, 1912-27; V.61- 1971-
AJVRAH American Journal of Veterinary Research. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.1- 1940-
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
AVIRA2 Acta Virologica (English Edition). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1957-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DMWOAX Deutsche Medizinische Wochenschrift. (Stuttgart, Fed. Rep. Ger.) V.1-104, 1875-1979.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EXONC* Experimental Oncology (Journal of ucrainian section of European institute of ecology and cancer, Kiev-22, Vaselkovskaya str., 25, Kiev-22) V.1- 1979-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FNSCA6 Forensic Science. (Lausanne, Switzerland) V.1-11, 1972-78. For pub lisher information, see FSINDR.
FOMIAZ Folia Microbiologica (Prague). (Academia, Vodickova 40, 112 29 Prague 1, Czechoslavakia) V.4- 1959-
GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP.
GENTAE Genetics. (Genetics Business Office, POB 64025, Baltimore, MD 21264) V.1- 1916-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.)
HKXUDL Huanjing Kexue Xuebao. Environmental Sciences Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981-
HUTOX*
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IJMDAI Israel Journal of Medical Sciences. (POB 1435, Jerusalem 91013, Israel) V.1- 1965-
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JCPBAN Journal de Chimie Physique et de Physico-Chimie Biologique. (CDR-Centrale des Revues, 11, rue Gossin, F-92543 Montrouge Cedex, France) V.1- 1903-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JGMIAN Journal of General Microbiology. (Soc. for General Microbiology, Journal Sales, 62 London Rd., Reading, RG1 5AS, UK) V.1- 1947-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1967-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHSC*
JSFAAE Journal of the Science of Food and Agriculture. (Blackwell Scientific Pub. Inc., 52 Beacon St., Boston, MA 02108) V.1- 1950-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MIBUBI Mikrobiyoloji Bulteni. Bulletin of Microbiology. (c/o Dr. A. Tevfik Cenqiz, Ankara Universitesi Tip Fakultesi Mikrobiyoloji Ana Bilim Dah, Ankara, Turkey) V.1- 1967-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PJACAW Proceedings of the Japan Academy. (Tokyo, Japan) V.21-53, 1945-77. For publisher information, see PJABDW.
PRKHDK Problemi na Khigienata. Problems in Hygiene. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov 11, Sofia, Bulgaria) V.1- 1975-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RTOPDW Regulatory Toxicology and Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981-
SOVEA7 Southwestern Veterinarian. (College of Veterinary Medicine, Texas A & M Univ., College Station, TX 77843) V.1- 1948-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
THGNBO Theriogenology. (Geron-X, Inc., P.O. Box 1108, Los Altos, CA 94022) V.1- 1974-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VIRLAX Virology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1955-
VOONC* Voprosi oncologii (Questions of oncology. Journal of Petrov's Institute of Oncology, B. Zelenina str, 43a, Spb 197110, Russia) V.1- 1955-
ZAPOAK Zeitschrift fuer Allgemeine Mikrobiologie. (Akademie-Verlag GmbH, Postfach 1233, Berlin DDR-1086 Ger. Dem. Rep.) V.1- 1960-
ZBPIA9 Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene, Abteilung II. Naturwissenschaftliche: Allgemeine, Landwirtschaftliche und Technische Mikrobiologie. (Jena, Ger. Dem. Rep.) V.107-132, 1952-77.
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
ZVNDAM Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I. P. Pavlova. (Izdatelstvo Nauka, 21 Garibaldi Street, 117335 Moscow, Russia) V.1- 1951-

Used as a chemical intermediate, dye, pigment, printing ink, food and feed additive

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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