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Nicotinic acid

RTECS #: QT0525000

CAS #: 59-67-6


UPDATE: May 2009 MW: 123.12 MF: C6H5NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 3 - Carboxypyridine
  2. 3 - Pyridinecarboxylic acid
  3. Acide nicotinique (French)
  4. Acidum nicotinicum
  5. Akotin
  6. Anti - pellagra vitamin
  7. Apelagrin
  8. Bionic
  9. Daskil
  10. Davitamon PP
  11. Direktan
  12. Efacin
  13. Kyselina nikotinova (Czech)
  14. NAH
  15. NICO
  16. Niacin
  17. Nicacid
  18. Nicangin
  19. Nico - 400
  20. Nico - span
  21. Nicobid
  22. Nicocap
  23. Nicocidin
  24. Nicocrisina
  25. Nicodan
  26. Nicodelmine
  27. Nicolar
  28. Niconacid
  29. Niconat
  30. Niconazid
  1. Nicosan 3
  2. Nicosyl
  3. Nicotamin
  4. Nicotene
  5. Nicotil
  6. Nicotine acid
  7. Nicotinipca
  8. Nicotinoylhydrazine
  9. Nicotinsaure (German)
  10. Nicovasan
  11. Nicovasen
  12. Nicyl
  13. Nipellen
  14. P.P. factor - pellagra preventive factor
  15. PP factor
  16. Pellagramin
  17. Pellagra preventive factor
  18. Pellagrin
  19. Pelonin
  20. Peviton
  21. Pyridine - 3 - carbonic acid
  22. Pyridine - beta - carboxylic acid
  23. Pyridine - 3 - carboxylic acid
  24. Pyridine - carboxylique - 3 (French)
  25. S115
  26. SK - Niacin
  27. SR 4390
  28. Tinic
  29. Vitaplex N
  30. Wampocap


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 358 mg/kg N/R OYYAA2 14,741,1977
intraperitoneal
mouse
lowest published toxic dose: 100 mg/kg Vascular: Regional or general arteriolar or venous dilation

Vascular: Measurement of regional blood flow
JCINAO 115,3634,2005
intraperitoneal
rat
lethal dose (50 percent kill): 730 mg/kg N/R OYYAA2 14,741,1977
intravenous
guinea pig
lowest published lethal dose: 3,500 mg/kg Behavioral: Convulsions or effect on seizure threshold PSEBAA 38,241,1938
intravenous
man
lowest published toxic dose: 357 g/kg Cardiac: Cardiac output

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
AIMEAS 29,558,1948
intravenous
mouse
lethal dose (50 percent kill): 5 gm/kg N/R THERAP 26,831,1971
intravenous
rat
lowest published lethal dose: 3,500 mg/kg Behavioral: Convulsions or effect on seizure threshold PSEBAA 38,241,1938
oral
human
lowest published toxic dose: 7.14 mg/kg Vascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Nausea or vomiting
BMCCP* 3,4,2003
oral
man
lowest published toxic dose: 31,200 mg/kg/78 week- intermittent Eye: Visual field changes

Eye: Other eye effects
JAMAAP 279,1702,1998
oral
man
lowest published toxic dose: 2,571 mg/kg/90 day- intermittent Blood: Change in clotting factors

Blood: Changes in platelet count
AIMDAP 152,861,1992
oral
man
lowest published toxic dose: 9,713 mg/kg/58 week- intermittent Gastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
SMJOAV 84,496,1991
oral
man
lowest published toxic dose: 157.1 mg/kg Vascular: BP lowering not characterized in autonomic section CTOXAO 44,81,2006
oral
mouse
lethal dose (50 percent kill): 3,720 mg/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes
OYYAA2 7,149,1973
oral
rat
lethal dose (50 percent kill): 7 gm/kg N/R NIIRDN 6,544,1982
oral
rabbit
lethal dose (50 percent kill): 4,550 mg/kg N/R OYYAA2 14,741,1977
subcutaneous
mouse
lethal dose (50 percent kill): 3,500 mg/kg N/R OYYAA2 14,741,1977
subcutaneous
rat
lethal dose (50 percent kill): 5 gm/kg N/R NIIRDN 6,544,1982
unreported route
mouse
lethal dose (50 percent kill): 4 gm/kg N/R BAXXDU #2041937
unreported route
rat
lethal dose (50 percent kill): 4 gm/kg N/R USXXAM #4412998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
human
lowest published toxic dose: 800 mg/kg/16 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
BJMRDK 34,177,2001
oral
mouse
lowest published toxic dose: 9,000 mg/kg/3 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation JPETAB 293,82,2000
oral
mouse
lowest published toxic dose: 24.7 gm/kg/3 week- continuous Lung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
BCPCA6 64,41,2002
oral
mouse
lowest published toxic dose: 23.1 gm/kg/3 week- continuous Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
BCPCA6 64,41,2002
oral
mouse
lowest published toxic dose: 25.2 gm/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
BCPCA6 64,41,2002
oral
mouse
lowest published toxic dose: 25,200 mg/kg/3 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain BCPCA6 66,393,2003
skin
mouse
lowest published toxic dose: 250 mg/kg/10 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation FATOAO 47,84,1984


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
AJOPAA 138,639,2004
TOXICOLOGY REVIEW
TPHSDY 24,228,2003
TOXICOLOGY REVIEW
APHRER 39,523,2005
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
JPETAB 318,1,2006
TOXICOLOGY REVIEW
ENTOX* -,218,2005
TOXICOLOGY REVIEW
IJTOFN 24,1,2005
TOXICOLOGY REVIEW
HTOPA* 1,595,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81908;
Number of Industries 10;
Total Number of Facilities 1,815;
Number of Occupations 19;
Total Number of Employees Exposed 13,494
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81908;
Number of Industries 15;
Total Number of Facilities 3,028;
Number of Occupations 46;
Total Number of Employees Exposed 61,057;
Total Number of Female Employees Exposed 26,152


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antipellagra agent
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BMCCP*
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HTOPA*
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446, Birmingham, AL 35205) V.1- 1908-
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as an antipellagra agent

FDA-proprietary drug

RTECS Compound Description:
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   Human Data

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