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Registry of Toxic Effects of Chemical Substances (RTECS)

Nicotinic acid

RTECS #

QT0525000

CAS #

59-67-6

Updated

December 2013

Molecular Weight

123.12

Molecular Formula

C6H5NO2

Synonyms

3-Carboxypyridine
3-Pyridinecarboxylic acid
Acide nicotinique (French)
Acidum nicotinicum
Akotin
Anti-pellagra vitamin
Apelagrin
Bionic
Daskil
Davitamon PP
Direktan
Efacin
Kyselina nikotinova (Czech)
NAH
Niacin
Niaspan
Nicacid
Nicangin
NICO
Nico-400
Nicobid
Nicocap
Nicocidin
Nicocrisina
Nicodan
Nicodelmine
Nicolar
Niconacid
Niconat
Niconazid
Nicosan 3
Nico-span
Nicosyl
Nicotamin
Nicotene
Nicotil
Nicotine acid
Nicotinipca
Nicotinoylhydrazine
Nicotinsaure (German)
Nicovasan
Nicovasen
Nicyl
Nipellen
P.P. factor-pellagra preventive factor
Pellagra preventive factor
Pellagramin
Pellagrin
Pelonin
Peviton
PP factor
Pyridine-3-carbonic acid
Pyridine-3-carboxylic acid
Pyridine-beta-carboxylic acid
Pyridine-carboxylique-3 (French)
S115
SK-Niacin
SR 4390
Tinic
Vitaplex N
Wampocap

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endothelium Inhibitor Concentration (50 percent kill): 52 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, fibroblast Inhibitor Concentration (50 percent kill): 80 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 82 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 90 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 70 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/mzxInhibitor Concentration Low: 80 µmol/L/5DIn Vitro Toxicity Studies: Other assaysJOETD7 132,274,2010
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgVascular: Regional or general arteriolar or venous dilation

Vascular: Measurement of regional blood flow
JCINAO 115,3634,2005
intraperitoneal/mouse lowest published toxic dose: 10 mg/kgBiochemical: Metabolism (intermediary): Lipids including transportJCINAO 119,1312,2009
intraperitoneal/mouse lowest published toxic dose: 100 mg/kgVascular: Measurement of regional blood flow

Biochemical: Metabolism (intermediary): Lipids including transport
JCINAO 119,1312,2009
intraperitoneal/mouse lethal dose (50 percent kill): 358 mg/kgOYYAA2 14,741,1977
intraperitoneal/rat lethal dose (50 percent kill): 730 mg/kgOYYAA2 14,741,1977
intraperitoneal/rat lowest published toxic dose: 24.75 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Body temperature increase

Biochemical: Metabolism (intermediary): Other
JPETAB 327,665,2008
intraperitoneal/rat lowest published toxic dose: 16.5 mg/kgNutritional and Gross Metabolic: Body temperature increaseJPETAB 327,665,2008
intravenous/guinea pig lowest published lethal dose: 3500 mg/kgBehavioral: Convulsions or effect on seizure thresholdPSEBAA 38,241,1938
intravenous/man lowest published toxic dose: 357 µg/kgCardiac: Cardiac output

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Respiratory depression
AIMEAS 29,558,1948
intravenous/mouse lethal dose (50 percent kill): 5 gm/kgTHERAP 26,831,1971
intravenous/rat lowest published lethal dose: 3500 mg/kgBehavioral: Convulsions or effect on seizure thresholdPSEBAA 38,241,1938
oral/human lowest published toxic dose: 7.14 mg/kgVascular: Regional or general arteriolar or venous dilation

Gastrointestinal: Nausea or vomiting
BMCCP* 3,4,2003
oral/man lowest published toxic dose: 7.143 mg/kgBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
FCLPH* 23(Suppl 1),112,2009
oral/man lowest published toxic dose: 31200 mg/kg/78W- intermittentEye: Visual field changes

Eye: Other eye effects
JAMAAP 279,1702,1998
oral/man lowest published toxic dose: 2571 mg/kg/90D- intermittentBlood: Change in clotting factors

Blood: Changes in platelet count
AIMDAP 152,861,1992
oral/man lowest published toxic dose: 9713 mg/kg/58W- intermittentGastrointestinal: Nausea or vomiting

Skin and Appendages: Other: Sweating

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
SMJOAV 84,496,1991
oral/man lowest published toxic dose: 157.1 mg/kgVascular: BP lowering not characterized in autonomic sectionJTCTDW 44,81,2006
oral/mouse lethal dose (50 percent kill): 3720 mg/kgBehavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes
OYYAA2 7,149,1973
oral/rabbit lethal dose (50 percent kill): 4550 mg/kgOYYAA2 14,741,1977
oral/rat lethal dose (50 percent kill): 7 gm/kgNIIRDN 6,544,1982
subcutaneous/man lowest published toxic dose: 175.94 µg/kgBiochemical: Metabolism (intermediary): Lipids including transportFCLPH* 23(Suppl 1),57,2009
subcutaneous/mouse lethal dose (50 percent kill): 3500 mg/kgOYYAA2 14,741,1977
subcutaneous/rat lethal dose (50 percent kill): 5 gm/kgNIIRDN 6,544,1982
unreported route/mouse lethal dose (50 percent kill): 4 gm/kgBAXXDU #2041937
unreported route/rat lethal dose (50 percent kill): 4 gm/kgUSXXAM #4412998

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/human lowest published toxic dose: 800 mg/kg/16W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
BJMRDK 34,177,2001
oral/human lowest published toxic dose: 150 mg/kg/3W- intermittentVascular: Regional or general arteriolar or venous dilationJCLIP* (3),101,2009
oral/mouse lowest published toxic dose: 9000 mg/kg/3D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationJPETAB 293,82,2000
oral/mouse lowest published toxic dose: 24.7 gm/kg/3W- continuousLung, Thorax, or Respiration: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
BCPCA6 64,41,2002
oral/mouse lowest published toxic dose: 23.1 gm/kg/3W- continuousLung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins
BCPCA6 64,41,2002
oral/mouse lowest published toxic dose: 25.2 gm/kg/3W- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
BCPCA6 64,41,2002
oral/mouse lowest published toxic dose: 25200 mg/kg/3W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainBCPCA6 66,393,2003
oral/mouse lowest published toxic dose: 2000 mg/kg/20D- continuousLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport
CBINA8 171,363,2008
skin/mouse lowest published toxic dose: 250 mg/kg/10D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationFATOAO 47,84,1984

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 488,151,2001
TOXICOLOGY REVIEWAJOPAA 138,639,2004
TOXICOLOGY REVIEWTPHSDY 24,228,2003
TOXICOLOGY REVIEWAPHRER 39,523,2005
TOXICOLOGY REVIEWDIMON* 39,678,1993
TOXICOLOGY REVIEWJPETAB 318,1,2006
TOXICOLOGY REVIEWENTOX* -,218,2005
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWHTOPA* 1,595,2002
TOXICOLOGY REVIEWBPRCR* 17,877,2003
TOXICOLOGY REVIEWCOCPH* -,701,2008
TOXICOLOGY REVIEWCLLID* 11,597,2007
TOXICOLOGY REVIEWCLLID* 13,277,2009
TOXICOLOGY REVIEWJCLIP* (1),191,2007
TOXICOLOGY REVIEWNEUCL* 18,695,2000
TOXICOLOGY REVIEWNCLNA* 16,107,1998
TOXICOLOGY REVIEWNEUCL* 23,397,2005
TOXICOLOGY REVIEWNBREV* 5,1,1981
TOXICOLOGY REVIEWFCLPH* 21(Suppl 2),5,2007
TOXICOLOGY REVIEWMUREAV 750,1,2012

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81908; Number of Industries 15; Total Number of Facilities 3028; Number of Occupations 46; Total Number of Employees Exposed 61057; Total Number of Female Employees Exposed 26152
National Occupational Hazard Survey 1974Hazard Code 81908; Number of Industries 10; Total Number of Facilities 1815; Number of Occupations 19; Total Number of Employees Exposed 13494

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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