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Registry of Toxic Effects of Chemical Substances (RTECS)

Nicotine, sulfate (2:1)

RTECS #

QS9625000

CAS #

65-30-5

Updated

December 2013

Molecular Weight

420.58

Molecular Formula

C20H28N4·O4S

Synonyms

(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine sulfate (2:1)
ENT 2,435
l-1-Methyl-2-(3-pyridyl)-pyrrolidine sulfate
l-3-(1-Methyl-2-pyrrolidyl)pyridine sulfate
Nicotine sulfate
Nikotinsulfat (German)
Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-, sulfate (2:1)
Pyrrolidine, 1-methyl-2-(3-pyridyl)-, sulfate
Sulfate de nicotine (French)

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse 1670 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BSTME2 3,31,1990/1991

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 22 mg/m385GMAT -,86,1982
intraperitoneal/cat lethal dose (50 percent kill): 20 mg/kg85GMAT -,86,1982
intraperitoneal/mouse lethal dose (50 percent kill): 10200 µg/kgJPPMAB 38,54,1986
intraperitoneal/rat lethal dose (90 percent kill): 29 mg/kgBehavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NURIBL 23,43,1981
oral/duck lethal dose (50 percent kill): 75 mg/kgTXAPA9 21,315,1972
oral/mouse lethal dose (50 percent kill): 8550 µg/kgBehavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 34(4-6),187,1969
oral/pigeon lethal dose (50 percent kill): 75 mg/kgTXAPA9 21,315,1972
oral/quail lethal dose (50 percent kill): 316 mg/kgAECTCV 12,355,1983
oral/rat lethal dose (50 percent kill): 50 mg/kgARSIM* 20,16,1966
oral/wild bird lethal dose (50 percent kill): 32 mg/kgTXAPA9 21,315,1972
skin/rabbit lethal dose (50 percent kill): 50 mg/kg85GYAV -,141,1971
skin/rat lethal dose (50 percent kill): 285 mg/kgBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intracerebral/rat lowest published toxic dose: 38 µg/kg/4D- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
NRTXDN 33,44,2012
oral/rat lowest published toxic dose: 571 mg/kg/8W- intermittentBehavioral: Alteration of classical conditioningGISAAA 34(5),30,1969

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWJEMME* 26,169,2004

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,194,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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