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Nicotine, sulfate (2:1)

RTECS #: QS9625000

CAS #: 65-30-5


UPDATE: August 2006 MW: 420.58 MF: C20H28N4O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. (S) - 3 - (1 - Methyl - 2 - pyrrolidinyl) pyridine sulfate (2:1)
  2. ENT 2,435
  3. Nicotine sulfate
  4. Nikotinsulfat (German)
  5. Pyridine, 3 - (1 - methyl - 2 - pyrrolidinyl) - , (S) - , sulfate (2:1)
  1. Pyrrolidine, 1 - methyl - 2 - (3 - pyridyl) - , sulfate
  2. Sulfate de nicotine (French)
  3. l - 1 - Methyl - 2 - (3 - pyridyl) - pyrrolidine sulfate
  4. l - 3 - (1 - Methyl - 2 - pyrrolidyl) pyridine sulfate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 1,670 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
BSTME2 3,31,1990/1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 22 mg/m3 N/R 85GMAT -,86,1982
intraperitoneal
cat
lethal dose (50 percent kill): 20 mg/kg N/R 85GMAT -,86,1982
intraperitoneal
mouse
lethal dose (50 percent kill): 10,200 g/kg N/R JPPMAB 38,54,1986
intraperitoneal
rat
lethal dose (90 percent kill): 29 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold
NURIBL 23,43,1981
oral
wild bird
lethal dose (50 percent kill): 32 mg/kg N/R TXAPA9 21,315,1972
oral
duck
lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
mouse
lethal dose (50 percent kill): 8,550 g/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea
HYSAAV 34(4-6),187,1969
oral
pigeon
lethal dose (50 percent kill): 75 mg/kg N/R TXAPA9 21,315,1972
oral
quail
lethal dose (50 percent kill): 316 mg/kg N/R AECTCV 12,355,1983
oral
rat
lethal dose (50 percent kill): 50 mg/kg N/R ARSIM* 20,16,1966
skin
rat
lethal dose (50 percent kill): 285 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement
TXAPA9 2,88,1960
skin
rabbit
lethal dose (50 percent kill): 50 mg/kg N/R 85GYAV -,141,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 571 mg/kg/8 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 34(5),30,1969


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
JEMME* 26,169,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,194,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARSIM* Agricultural Research Service, USDA Information Memorandum. (Beltsville, MD 20705)
BSTME2 Biological Structures and Morphogenesis. (Paris, Francs) V.1- 1988-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
JEMME* The Journal of emergency medicine (New York : Pergamon Press) V.1- 1983-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NURIBL Nutrition Reports International. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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