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Nicotinamide

RTECS #: QS3675000

CAS #: 98-92-0


UPDATE: November 2008 MW: 122.14 MF: C6H6N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 3 - Carbamoylpyridine
  2. 3 - Pyridinecarboxamide
  3. 3 - Pyridinecarboxylic acid amide
  4. Acid amide
  5. Amid kyseliny nikotinove (Czech)
  6. Amide PP
  7. Aminicotin
  8. Amixicotyn
  9. Amnicotin
  10. Austrovit PP
  11. Benicot
  12. Delonin amide
  13. Dipegyl
  14. Endobion
  15. Factor PP
  16. Hansamid
  17. Inovitan PP
  18. NAM
  19. Niacevit
  20. Niacinamide
  21. Niavit PP
  22. Nicamindon
  23. Nicasir
  24. Nicobion
  25. Nicofort
  26. Nicogen
  1. Nicomidol
  2. Nicosan 2
  3. Nicotamide
  4. Nicotilamide
  5. Nicotinic acid amide
  6. Nicotinic amide
  7. Nicotinsaureamid (German)
  8. Nicotylamide
  9. Nicovit
  10. Nicovitol
  11. Nicozymin
  12. Niko - Tamin
  13. Nikotinsaeureamid (German)
  14. Niocinamide
  15. Niozymin
  16. PP - Faktor
  17. Pelmine
  18. Pelonin amide
  19. Pyridine - 3 - carboxylic acid amide
  20. Savacotyl
  21. VI - Nicotyl
  22. Vitamin B
  23. Vitamin B3
  24. Vitamin PP
  25. Witamina PP
  26. m - (Aminocarbonyl) pyridine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
body fluid assay rat
ovary
25 mg/kg MUREAV 143,263,1985
cytogenetic analysis intraperitoneal
mouse
1,200 mg/kg MUTAEX 17,1,2002
DNA inhibition rat liver 20 mmol/L JJIND8 69,1353,1982
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) TRENAF 37,447,1986
sister chromatid exchange hamster ovary 5 mmol/L MUREAV 126,63,1984
sister chromatid exchange human lymphocyte 10 mmol/L NULSAK 28,198,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 2,050 mg/kg N/R RAREAE 109,479,1987
intraperitoneal
mouse
lowest published toxic dose: 250 mg/kg Behavioral: Anticonvulsant FATOAO 48,21,1985
intraperitoneal
mouse
lowest published lethal dose: 1,800 mg/kg N/R MUTAEX 17,1,2002
oral
human
lowest published toxic dose: 35.7 mg/kg Gastrointestinal: Nausea or vomiting

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AEMED3 50,587,2007
oral
mouse
lethal dose (50 percent kill): 2,500 mg/kg N/R USXXAM #6365129
oral
rat
lethal dose (50 percent kill): 3,500 mg/kg N/R USXXAM #6365129
subcutaneous
mouse
lethal dose (50 percent kill): 2 gm/kg N/R QJPPAL 19,48,1946
subcutaneous
mouse
lowest published toxic dose: 62.5 mg/kg Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FATOAO 51,51,1988
subcutaneous
rat
lethal dose (50 percent kill): 1,680 mg/kg Lung, Thorax, or Respiration: Other changes PSEBAA 62,19,1946
subcutaneous
rabbit
lowest published toxic dose: 62.5 mg/kg Endocrine: Hypoglycemia FATOAO 51,51,1988
skin
mouse
lowest published toxic dose: 5,128 g/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation WOPOF* #2004000333
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 2,500 mg/kg N/R PCJOAU 20,29,1986
unreported route
mouse
lowest published toxic dose: 820 mg/kg Behavioral: Anticonvulsant FATOAO 55,27,1992
unreported route
mouse
lowest published toxic dose: 1,600 mg/kg Behavioral: Ataxia FATOAO 55,27,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lowest published toxic dose: 480 mg/kg/2 day- intermittent Endocrine: Other changes BPBLEO 29,1167,2006
intraperitoneal
mouse
lowest published toxic dose: 960 mg/kg/2 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation BPBLEO 29,1167,2006
intraperitoneal
rat
lowest published toxic dose: 4,200 mg/kg/2 week- intermittent Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPETAB 320,458,2007
intraperitoneal
rat
lowest published toxic dose: 2,800 mg/kg/2 week- intermittent Vascular: BP elevation not characterized in autonomic section JPETAB 320,458,2007
intraperitoneal
rat
lowest published toxic dose: 5,600 mg/kg/2 week- intermittent Vascular: BP elevation not characterized in autonomic section

Behavioral: Analgesia
JPETAB 320,458,2007
oral
rat
lowest published toxic dose: 0.56 mg/kg/40 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOVEFN (3),36,1997
oral
rat
lowest published toxic dose: 16.8 mg/kg/5 week- continuous Gastrointestinal: Other changes CRNGDP 24,81,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
TPHSDY 24,228,2003
TOXICOLOGY REVIEW
IJTOFN 24,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0321;
Number of Industries 6;
Total Number of Facilities 1,142;
Number of Occupations 15;
Total Number of Employees Exposed 17,336
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0321;
Number of Industries 8;
Total Number of Facilities 2,791;
Number of Occupations 34;
Total Number of Employees Exposed 64,950;
Total Number of Female Employees Exposed 44,524


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE

AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038)
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RAREAE Radiation Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1954-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho. Annual Report of Tokyo Metropolitan Research Laboratory of Public Health. (Tokyo-toritsu Eisei Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1- 1949/50-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
WOPOF* Wold Intellectual Property Organization, International bureau; International Application Published Under The Patent Cooperation Treaty

Used as VITAMIN B3

FDA-over the counter drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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