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Registry of Toxic Effects of Chemical Substances (RTECS)

Nicotinamide

RTECS #

QS3675000

CAS #

98-92-0

Updated

October 2012

Molecular Weight

122.14

Molecular Formula

C6H6N2O

Synonyms

3-Carbamoylpyridine
3-Pyridinecarboxamide
3-Pyridinecarboxylic acid amide
Acid amide
Amid kyseliny nikotinove (Czech)
Amide PP
Aminicotin
Amixicotyn
Amnicotin
Austrovit PP
Benicot
Delonin amide
Dipegyl
Endobion
Factor PP
Hansamid
Inovitan PP
m-(Aminocarbonyl)pyridine
NAM
Niacevit
Niacinamide
Niavit PP
Nicamindon
Nicasir
Nicobion
Nicofort
Nicogen
Nicomidol
Nicosan 2
Nicotamide
Nicotilamide
Nicotinic acid amide
Nicotinic amide
Nicotinsaureamid (German)
Nicotylamide
Nicovit
Nicovitol
Nicozymin
Niko-Tamin
Nikotinsaeureamid (German)
Niocinamide
Niozymin
Pelmine
Pelonin amide
PP-Faktor
Pyridine-3-carboxylic acid amide
Savacotyl
VI-Nicotyl
Vitamin B
Vitamin B3
Vitamin PP
Witamina PP

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
body fluid assayovary/rat25 mg/kgMUREAV 143,263,1985
Cytogenetic Analysisintraperitoneal/mouse1200 mg/kgMUTAEX 17,1,2002
DNA inhibitionliver/rat20 mmol/LJJIND8 69,1353,1982
mutation in microorganisms/Salmonella typhimurium5 mg/plate (+enzymatic activation step)TRENAF 37,447,1986
sister chromatid exchangelymphocyte/human10 mmol/LNULSAK 28,198,1985
sister chromatid exchangeovary/hamster5 mmol/LMUREAV 126,63,1984

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, endothelium Inhibitor Concentration (50 percent kill): 50 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, fibroblast Inhibitor Concentration (50 percent kill): 88 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, liver tumor Inhibitor Concentration (50 percent kill): 65 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, melanoma Inhibitor Concentration (50 percent kill): 70 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
In Vitro/Human, skin Inhibitor Concentration (50 percent kill): 80 mmol/L/24HIn Vitro Toxicity Studies: Cell viability (lysosomal damage): neutral red assay etc.TIVIEQ 6,493,1992
intraperitoneal/mouse lowest published lethal dose: 1800 mg/kgMUTAEX 17,1,2002
intraperitoneal/mouse lowest published toxic dose: 250 mg/kgBehavioral: AnticonvulsantFATOAO 48,21,1985
intraperitoneal/mouse lethal dose (50 percent kill): 2050 mg/kgRAREAE 109,479,1987
oral/human lowest published toxic dose: 35.7 mg/kgGastrointestinal: Nausea or vomiting

Endocrine: Hypoglycemia

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis
AEMED3 50,587,2007
oral/mouse lethal dose (50 percent kill): 2500 mg/kgUSXXAM #6365129
oral/rat lethal dose (50 percent kill): 3500 mg/kgUSXXAM #6365129
skin/mouse lowest published toxic dose: 5128 µg/kgBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationWOPOF* #2004000333
subcutaneous/mouse lethal dose (50 percent kill): 2 gm/kgQJPPAL 19,48,1946
subcutaneous/mouse lowest published toxic dose: 62.5 mg/kgEndocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
FATOAO 51,51,1988
subcutaneous/rabbit lowest published toxic dose: 62.5 mg/kgEndocrine: HypoglycemiaFATOAO 51,51,1988
subcutaneous/rat lethal dose (50 percent kill): 1680 mg/kgLung, Thorax, or Respiration: Other changesPSEBAA 62,19,1946
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 2500 mg/kgPCJOAU 20,29,1986
unreported route/mouse lowest published toxic dose: 820 mg/kgBehavioral: AnticonvulsantFATOAO 55,27,1992
unreported route/mouse lowest published toxic dose: 1600 mg/kgBehavioral: AtaxiaFATOAO 55,27,1992

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 480 mg/kg/2D- intermittentEndocrine: Other changesBPBLEO 29,1167,2006
intraperitoneal/mouse lowest published toxic dose: 960 mg/kg/2D- intermittentBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationBPBLEO 29,1167,2006
intraperitoneal/rat lowest published toxic dose: 4200 mg/kg/2W- intermittentVascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JPETAB 320,458,2007
intraperitoneal/rat lowest published toxic dose: 2800 mg/kg/2W- intermittentVascular: BP elevation not characterized in autonomic sectionJPETAB 320,458,2007
intraperitoneal/rat lowest published toxic dose: 5600 mg/kg/2W- intermittentVascular: BP elevation not characterized in autonomic section

Behavioral: Analgesia
JPETAB 320,458,2007
oral/human lowest published toxic dose: 150 mg/kg/7D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Immunological Including Allergic: Increased immune response
CRNGDP 30,101,2009
oral/rat lowest published toxic dose: 0.56 mg/kg/40D- intermittentLiver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOVEFN (3),36,1997
oral/rat lowest published toxic dose: 16.8 mg/kg/5W- continuousGastrointestinal: Other changesCRNGDP 24,81,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 539,77,2003
TOXICOLOGY REVIEWTPHSDY 24,228,2003
TOXICOLOGY REVIEWIJTOFN 24,1,2005
TOXICOLOGY REVIEWJCLIP* (1),191,2007
TOXICOLOGY REVIEWTXCYAC 278,27,2010

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M0321; Number of Industries 8; Total Number of Facilities 2791; Number of Occupations 34; Total Number of Employees Exposed 64950; Total Number of Female Employees Exposed 44524
National Occupational Hazard Survey 1974Hazard Code M0321; Number of Industries 6; Total Number of Facilities 1142; Number of Occupations 15; Total Number of Employees Exposed 17336

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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