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Registry of Toxic Effects of Chemical Substances (RTECS)

Nickel(II) sulfate (1:1)

RTECS #

QR9350000

CAS #

7786-81-4

Updated

December 2013

Molecular Weight

154.77

Molecular Formula

O4S·Ni

Synonyms

NCI-C60344
Nickel sulfate
Nickel sulfate(1:1)
Nickel(2+)sulfate(1:1)
Nickel(II) sulfate
Nickelous sulfate
Sulfuric acid, nickel(2+) salt (1:1)
Sulfuric acid, nickel(2+)salt

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /child 5%/48HARDEAC 87,378,1963
skin /human 5%/48HCODEDG 58,51,2008
skin /man 5%CODEDG 61,236,2009
skin /rabbit 5%VCVN5* -,499,1989
skin /woman 5% open irritation testADVEA4 86,178,2006
skin /woman 5%/2D mildCODEDG 57,278,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysiskidney/human5 mg/LPAACA3 27,136,1986
Cytogenetic Analysisother cell types/hamster100 µmol/L/24HMUREAV 492,39,2001
Cytogenetic Analysisovary/hamster320 µmol/L/24HMOCAT* 18,133,2003
DNA adductintratracheal/rat5 mg/kgEVHPAZ 110,789,2002
DNA Damageparenteral/mouse0.5 mg/kgMUREAV 577S,1,2005
DNA Damageinhalation/rat0.03 µg/L/5D/3W- intermittentTOXID9 72,299,2003
gene conversion and mitotic recombination/Saccharomyes cerevisiae100 mmol/LMUREAV 117,149,1983
micronucleus testother cell types/hamster200 µmol/L/24HMUREAV 492,39,2001
micronucleus testfibroblast/human200 µmol/L/24HMUREAV 490,99,2001
morphological transformfibroblast/human10 µmol/LCNREA8 47,3815,1987
morphological transformkidney/human5 mg/LCNREA8 49,1829,1989
morphological transformembryo/hamster380 µmol/LCNREA8 39,193,1979
mutation in microorganisms/Saccharomyes cerevisiae100 mmol/L (-enzymatic activation step)MUREAV 117,149,1983
sex chromosome loss and nondisjunctionkidney/human5 mg/LCNREA8 49,1829,1989
sister chromatid exchangeleukocyte/human23 µmol/LDMBUAE 27,40,1980
specific locus testovary/hamster320 µmol/L/24HMOCAT* 18,133,2003
specific locus testparenteral/mouse1 mg/kgMUREAV 577S,1,2005

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/mouse 250 mg/kg (5W male)Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)BECTA6 64,161,2000

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 95 mg/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PAACA3 5,50,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
In Vitro/Human, lung fibroblast Inhibitor Concentration Low: 200 µmol/L/30HBiochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammationTXAPA9 247,146,2010
In Vitro/Human, lung fibroblast Inhibitor Concentration Low: 200 µmol/L/10MBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: PhosphokinaseTXAPA9 247,146,2010
In Vitro/Human, monocyte Inhibitor Concentration Low: 0.5 mmol/L/48HIn Vitro Toxicity Studies: Other assays

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TXAPA9 246,66,2010
intraperitoneal/mouse lethal dose (50 percent kill): 20894 µg/kgCOREAF 256,1043,1963
intraperitoneal/rat lethal dose (50 percent kill): 32 mg/kgVCVN5* -,489,1989
intraperitoneal/rat lethal dose (50 percent kill): 500 mg/kgBehavioral: Muscle contraction or spasticity

Gastrointestinal: Changes in structure or function of salivary glands

Nutritional and Gross Metabolic: Body temperature decrease
GTPZAB 23(6),48,1979
intravenous/Dog lowest published lethal dose: 38 mg/kgJOHYAY 8,565,1908
intravenous/mouse lowest published lethal dose: 7640 µg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Proteinuria
FATOAO 23,549,1960
intravenous/mouse lowest published lethal dose: 2.9 mg/kgVCVN5* -,491,1989
intravenous/rabbit lowest published lethal dose: 33 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease
JOHYAY 8,565,1908
oral/rat lowest published toxic dose: 250 mg/kgBehavioral: Change in motor activity (specific assay)VCVN5* -,491,1989
oral/rat lowest published lethal dose: 172 mg/kgVCVN5* -,491,1989
oral/rat lowest published toxic dose: 98 mg/kgEye: Lacrimation

Behavioral: Excitement

Behavioral: Change in motor activity (specific assay)
VCVN5* -,491,1989
subcutaneous/cat lowest published lethal dose: 24 mg/kgGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JOHYAY 8,565,1908
subcutaneous/Dog lowest published lethal dose: 38 mg/kgJOHYAY 8,565,1908
subcutaneous/rabbit lowest published lethal dose: 33 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease
JOHYAY 8,565,1908

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 10 mg/m3/4H/39W- intermittentLung, Thorax, or Respiration: Structural or functional change in trachea or bronchiGTPZAB 23(6),48,1979
inhalation/rat lowest published toxic concentration: 0.03 mg/m3/3W- intermittentLung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOXID9 72,299,2003
intramuscular/rat lowest published toxic dose: 271 mg/kg/26D- intermittentLung, Thorax, or Respiration: Acute pulmonary edema

Liver: Hepatitis (hepatocellular necrosis), diffuse

Endocrine: Other changes
ACLSCP 21,275,1991
oral/mouse lowest published toxic dose: 71226 mg/kg/26W- continuousKidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decreased immune response
JTEHD6 24,357,1988
oral/mouse lowest published toxic dose: 240 mg/kg/60D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
WDZAEK 8,1,1994
oral/rat lowest published toxic dose: 4798 mg/kg/26W- continuousKidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight
HETOEA 13,689,1994
oral/rat lowest published toxic dose: 14 mg/kg/2W- intermittentLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TOXID9 30,177,1996
oral/rat lowest published toxic dose: 2 gm/kg/20D- intermittentEndocrine: HyperglycemiaGTPZAB 23(6),48,1979
oral/rat lowest published toxic dose: 350 mg/kg/7D- intermittentGastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other hydrolases
JJATDK 26,397,2006

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.1 mg(Ni)/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Human Sufficient EvidenceIMEMDT 49,257,1990
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 49,257,1990
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEW85DHAX Ni,168,1975
TOXICOLOGY REVIEWCREOH* 42,35,2002
TOXICOLOGY REVIEWENTOX* -,220,2005
TOXICOLOGY REVIEWMUREAV 533,92,2003
TOXICOLOGY REVIEWHBTME* ,743,2007
TOXICOLOGY REVIEWHBTME* ,213,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWMUREAV 674,31,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Ni)/m3DTLVS* 3,178,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Ni)/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg(Ni)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 0.1 mg(Ni)/m3, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Ni)/m3, short term exposure limit 0.1 mg(Ni)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Ni)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit-KOREAtime-weighted average 1 mg/m3, carcinogen, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.25 mg(Ni)/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Ni)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Ni)/m3, sen, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg(Ni)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air10H Carcinogen time-weighted average 0.015 mg(Ni)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 50510; Number of Industries 67; Total Number of Facilities 3480; Number of Occupations 45; Total Number of Employees Exposed 56844; Total Number of Female Employees Exposed 12029
National Occupational Hazard Survey 1974Hazard Code 50510; Number of Industries 53; Total Number of Facilities 2205; Number of Occupations 26; Total Number of Employees Exposed 13210

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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