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Nickel (II) oxide (1:1)

RTECS #: QR8400000

CAS #: 1313-99-1


UPDATE: May 2009 MW: 74.71 MF: NiO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Black nickel oxide
  2. Bunsenite
  3. C.I. 77777
  4. Green nickel oxide
  5. Mononickel oxide
  6. Nickel monoxide
  1. Nickel oxide
  2. Nickel oxide sinter 75
  3. Nickel protoxide
  4. Nickel (II) oxide
  5. Nickelous oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
DNA adduct intratracheal
rat
5 mg/kg EVHPAZ 110,789,2002
DNA damage human lymphocyte 15 mol/L/2 hour MUREAV 586,124,2005
mutation in microorganisms other microorganisms 80 mmol/L/6 hour TOXID9 72,235,2003
morphological transform hamster kidney 100 mg/L IAPUDO 53,193,1984
morphological transform human fibroblast 50 mol/L CNREA8 47,3815,1987
morphological transform mouse embryo 500 mol/L PAACA3 24,100,1983
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform rat other cell types 50 mg/L MUREAV 300,179,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5 mg/m3/6 hour/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-451,1996
inhalation
rat
lowest published toxic concentration: 1,250 g/m3/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-451,1996
implant
rat
lowest published toxic dose: 95 mg/kg/78 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PAACA3 5,50,1964
intramuscular
mouse
lowest published toxic dose: 400 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 22,158,1962
intramuscular
rat
lowest published toxic dose: 71,264 g/kg Tumorigenic: Carcinogenic by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
IAPUDO 53,127,1984
intramuscular
rat
toxic dose : 180 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
CNREA8 22,158,1962
intrapleural
rat
lowest published toxic dose: 40 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
55DXAE -,37,1985
intratracheal
rat
lowest published toxic dose: 90 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONAW 24(4),44,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intratracheal
rat
lowest published lethal dose: 20 mg/kg N/R NTIS** AEC-TR-6710
intravenous
cat
lowest published lethal dose: 12,700 g/kg N/R EQSSDX 1,1,1975
intravenous
dog
lowest published lethal dose: 9 mg/kg N/R EQSSDX 1,1,1975
oral
rat
lowest published lethal dose: 5 gm/kg N/R FDRLI* 7684B,1983
subcutaneous
mouse
lethal dose (50 percent kill): 50 mg/kg N/R ZVKOA6 19,186,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,460 g/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Immunological Including Allergic: Increase in humoral response
FAATDF 15,476,1990
inhalation
mouse
lowest published toxic concentration: 30,032 g/m3/6 hour/12 day- intermittent Lung, Thorax, or Respiration: Other changes TXCYAC 50,145,1988
inhalation
rat
lowest published toxic concentration: 600 g/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 57,255,1989
inhalation
rat
lowest published toxic concentration: 30,032 g/m3/6 hour/12 day- intermittent Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TXCYAC 50,145,1988
inhalation
rat
lowest published toxic concentration: 200 mg/m3/24 hour/4 week- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response
EESADV 8,516,1984
inhalation
rat
lowest published toxic concentration: 25 mg/m3/24 hour/4 week- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response
EESADV 8,516,1984
inhalation
rat
lowest published toxic concentration: 200 g/m3/24 hour/17 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DTESD7 8,555,1980
inhalation
rat
lowest published toxic concentration: 50 g/m3/24 hour/6 week- continuous Lung, Thorax, or Respiration: Other changes VCVN5* -,493,1989
inhalation
rat
lowest published toxic concentration: 350 mg/m3/2 week- intermittent Lung, Thorax, or Respiration: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,495,1989
inhalation
rat
lowest published toxic concentration: 0.2 mg/m3/24 hour/17 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN5* -,495,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 mg(Ni)/m3 (inhalable) DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed human carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 11,75,1976
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 49,257,1990
TOXICOLOGY REVIEW
MUREAV 566,21,2004
TOXICOLOGY REVIEW
FCTXAV 9,105,1971
TOXICOLOGY REVIEW
85DHAX Ni,168,1975
TOXICOLOGY REVIEW
DICHAK 54,527,1968
TOXICOLOGY REVIEW
CREOH* 42,35,2002
TOXICOLOGY REVIEW
TOLED5 127,69,2002
TOXICOLOGY REVIEW
ENTOX* -,220,2005
TOXICOLOGY REVIEW
MUREAV 533,92,2003
TOXICOLOGY REVIEW
HBTME* ,743,2007
TOXICOLOGY REVIEW
HUTOX* -,515,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 mg(Ni)/m3 DTLVS* 3,178,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 mg(Ni)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Ni)/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - FRANCE VME 1 mg/m3, continuous1 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY ceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit - KOREA time-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.25 mg(Ni)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg(Ni)/m3, Carcinogen, DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed human carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air Carcinogen;
10 hour time-weighted average 0.015 mg(Ni)/m3
NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84269;
Number of Industries 11;
Total Number of Facilities 311;
Number of Occupations 14;
Total Number of Employees Exposed 4,916
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84269;
Number of Industries 22;
Total Number of Facilities 702;
Number of Occupations 31;
Total Number of Employees Exposed 18,166;
Total Number of Female Employees Exposed 5,820


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of stainless and alloy steels
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies (inhalation);some evidence:rat NTPTR* NTP-TR-451,1996
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE

55DXAE "Progress in Nickel Toxicology, Proceedings of the International Conference on Nickel Metabolism and Toxicology, 3rd, 1984," Brown, S.S., and F.W. Sunderman, Jr., eds., Oxford, UK, Blackwell Scientific Pub. Ltd., 1985
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CREOH* Critical Reviews in Oncology/Hematology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1983-
DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For publisher information, see CHETBF.
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EQSSDX Environmental Quality and Safety, Supplement. (Stuttgart, Fed. Rep. Ger.) V.1-5, 1975-76. Discontinued.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FDRLI* Food & Drug Research Laboratories, Inc., Papers. (P.O. Box 107, Rt. 17C, Waverly, NY 14892-0107)
HBTME*
HUTOX*
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.27- 1979-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955-
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

Used in the manufacture of stainless and alloy steels

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Natural Product

Click Here for Additional Information about RTECS

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