Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Nickel(II) oxide (1:1)

RTECS #

QR8400000

CAS #

1313-99-1

Updated

September 201

Molecular Weight

74.71

Molecular Formula

NiO

Synonyms

Black nickel oxide
Bunsenite
C.I. 77777
Green nickel oxide
Mononickel oxide
Nickel monoxide
Nickel oxide
Nickel oxide sinter 75
Nickel protoxide
Nickel(II) oxide
Nickelous oxide

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA adductintratracheal/rat5 mg/kgEVHPAZ 110,789,2002
DNA Damagelymphocyte/human15 µmol/L/2HMUREAV 586,124,2005
morphological transformfibroblast/human50 µmol/LCNREA8 47,3815,1987
morphological transformother cell types/rat50 mg/LMUREAV 300,179,1993
morphological transformembryo/mouse500 µmol/LPAACA3 24,100,1983
morphological transformkidney/hamster100 mg/LIAPUDO 53,193,1984
morphological transformfibroblast/mouse0.1 mg/L/21D (-enzymatic activation step)EMMUEG 37,231,2001
mutation in microorganisms/Other microorganisms80 mmol/L/6HTOXID9 72,235,2003

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 95 mg/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PAACA3 5,50,1964
inhalation/mouse lowest published toxic concentration: 5 mg/m3/6H/2Y- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-451,1996
inhalation/rat lowest published toxic concentration: 1250 µg/m3/6H/2Y- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-451,1996
intramuscular/mouse lowest published toxic dose: 400 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
CNREA8 22,158,1962
intramuscular/rat toxic dose: 180 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
CNREA8 22,158,1962
intramuscular/rat lowest published toxic dose: 71264 µg/kgTumorigenic: Carcinogenic by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Tumors at site of application
IAPUDO 53,127,1984
intrapleural/rat lowest published toxic dose: 40 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
55DXAE -,37,1985
intratracheal/rat lowest published toxic dose: 90 mg/kgTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
VOONAW 24(4),44,1978

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intratracheal/rat lowest published lethal dose: 20 mg/kgNTIS** AEC-TR-6710
intravenous/cat lowest published lethal dose: 12700 µg/kgEQSSDX 1,1,1975
intravenous/Dog lowest published lethal dose: 9 mg/kgEQSSDX 1,1,1975
oral/rat lowest published lethal dose: 5 gm/kgFDRLI* 7684B,1983
subcutaneous/mouse lethal dose (50 percent kill): 50 mg/kgZVKOA6 19,186,1974

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 2460 µg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Other changes

Immunological Including Allergic: Increase in humoral response
FAATDF 15,476,1990
inhalation/mouse lowest published toxic concentration: 30032 µg/m3/6H/12D- intermittentLung, Thorax, or Respiration: Other changesTXCYAC 50,145,1988
inhalation/rat lowest published toxic concentration: 50 µg/m3/24H/6W- continuousLung, Thorax, or Respiration: Other changesVCVN5* -,493,1989
inhalation/rat lowest published toxic concentration: 350 mg/m3/2W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVN5* -,495,1989
inhalation/rat lowest published toxic concentration: 0.2 mg/m3/24H/17W- continuousLung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN5* -,495,1989
inhalation/rat lowest published toxic concentration: 600 µg/m3/6H/13W- intermittentLung, Thorax, or Respiration: Other changes

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TXCYAC 57,255,1989
inhalation/rat lowest published toxic concentration: 30032 µg/m3/6H/12D- intermittentLung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight
TXCYAC 50,145,1988
inhalation/rat lowest published toxic concentration: 200 mg/m3/24H/4W- continuousLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response
EESADV 8,516,1984
inhalation/rat lowest published toxic concentration: 25 mg/m3/24H/4W- continuousLung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in humoral immune response
EESADV 8,516,1984
inhalation/rat lowest published toxic concentration: 200 µg/m3/24H/17W- continuousLung, Thorax, or Respiration: Changes in lung weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
DTESD7 8,555,1980

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg(Ni)/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 11,75,1976
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 49,257,1990
TOXICOLOGY REVIEWMUREAV 566,21,2004
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEW85DHAX Ni,168,1975
TOXICOLOGY REVIEWDICHAK 54,527,1968
TOXICOLOGY REVIEWCREOH* 42,35,2002
TOXICOLOGY REVIEWTOLED5 127,69,2002
TOXICOLOGY REVIEWENTOX* -,220,2005
TOXICOLOGY REVIEWMUREAV 533,92,2003
TOXICOLOGY REVIEWHBTME* ,743,2007
TOXICOLOGY REVIEWHUTOX* -,515,1996
TOXICOLOGY REVIEWMUREAV 674,31,2009
TOXICOLOGY REVIEWMUREAV 682,94,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Ni)/m3DTLVS* 3,178,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg(Ni)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg/m3, C1 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYceiling concentration 0.1 mg/m3, Carcinogen, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Ni)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.25 mg(Ni)/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.05 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Ni)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-THAILANDtime-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 1 mg(Ni)/m3, JAN1993
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Ni)/m3, carc, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg(Ni)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air10H Carcinogen time-weighted average 0.015 mg(Ni)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 84269; Number of Industries 22; Total Number of Facilities 702; Number of Occupations 31; Total Number of Employees Exposed 18166; Total Number of Female Employees Exposed 5820
National Occupational Hazard Survey 1974Hazard Code 84269; Number of Industries 11; Total Number of Facilities 311; Number of Occupations 14; Total Number of Employees Exposed 4916

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
NTP Carcinogenesis studies (inhalation);some evidence:rat NTPTR* NTP-TR-451,1996
TOP