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Registry of Toxic Effects of Chemical Substances (RTECS)

Nickel(II) carbonate (1:1)

RTECS #

QR6200000

CAS #

3333-67-3

Updated

September 201

Molecular Weight

118.72

Molecular Formula

CNiO3

Synonyms

C.I. 77779
Carbonic acid, nickel salt (1:1)
Nickel monocarbonate
Nickel(2+) carbonate
Nickelous carbonate

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA Damageintraperitoneal/rat10 mg/kg/3HCNREA8 42,3544,1982
other mutation test systemsintraperitoneal/rat40 mg/kgCNREA8 44,3892,1984

Tumorigenic Data and References

Route/OrganismDoseEffectReference
implant/rat lowest published toxic dose: 95 mg/kg/78W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application
PAACA3 5,50,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
subcutaneous/guinea pig lowest published lethal dose: 32 mg/kgPeripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes
JOHYAY 8,565,1908

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.2 mg(Ni)/m3 (inhal)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Confirmed human carcinogenDTLVS* TLV/BEI,2013
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 11,75,1976
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 49,257,1990
TOXICOLOGY REVIEWACLSCP 3,156,1973
TOXICOLOGY REVIEWFCTXAV 9,105,1971
TOXICOLOGY REVIEW85DHAX Ni,168,1975

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 1 mg(Ni)/m3DTLVS* 3,178,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.1 mg(Ni)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 1 mg(Ni)/m3, MAR2002
Occupational Exposure Limit-FINLANDtime-weighted average 0.1 mg(Ni)/m3, NOV2011
Occupational Exposure Limit-FRANCEVME 1 mg(Ni)/m3, C3 Carcinogen, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 0.1 mg(Ni)/m3, short term exposure limit 0.1 mg(Ni)/m3, SEP2000
Occupational Exposure Limit-JAPANOccupational Exposure Limit 0.1 mg(Ni)/m3, 2B carc, MAY2012
Occupational Exposure Limit-KOREAtime-weighted average 0.1 mg(Ni)/m3, 2006
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 0.1 mg(Ni)/m3, sen, JAN2002
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.005 mg(Ni)/m3, Carcinogen, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 0.1 mg(Ni)/m3 (total dust), Carcinogen, Sen, JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 0.05 mg(Ni)/m3, carc 1, inhal, sen, JAN2011
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 0.5 mg(Ni)/m3, skin, OCT2007
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 1 mg(Ni)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 1 mg(Ni)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NICKEL, INORGANIC-air10H Carcinogen time-weighted average 0.015 mg(Ni)/m3NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983Hazard Code 81905; Number of Industries 28; Total Number of Facilities 864; Number of Occupations 23; Total Number of Employees Exposed 13040; Total Number of Female Employees Exposed 2017
National Occupational Hazard Survey 1974Hazard Code 81905; Number of Industries 12; Total Number of Facilities 349; Number of Occupations 9; Total Number of Employees Exposed 4696

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
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