Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

1-Naphthylamine, N-phenyl-

RTECS #

QM4500000

CAS #

90-30-2

Updated

October 2011

Molecular Weight

219.30

Molecular Formula

C16H13N

Synonyms

1-Anilinonaphthalene
Aceto PAN
Additin 30
alpha-Phenylnaphthylamine
Amoco 32
Antigene PAN
Antioxidant PAN
C.I. 44050
Fenyl-alpha-naftylamin (Czech)
N-(1-Naphthyl)aniline
Neozone A
N-Fenyl-1-aminonaftalen (Czech)
N-Phenyl-1-naphthylamine
N-Phenyl-alpha-naphthylamine
PANA
Phenyl-alpha-naphthylamine
Phenylnaphthylamine
Vulkanox PAN

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /human 0.5%HPV314 -,-,2003
skin /man 1%CODEDG 58,93,2008
skin /rabbit 5%/6W- intermittent mildHPV314 -,-,2003
skin /rabbit 50% mildHPV314 -,-,2003
skin /rabbit 5%/4H mildHPV314 -,-,2003

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster60 mg/LMUREAV 241,175,1990
Dominant Lethal Testintraperitoneal/mouse830 mg/kg/5D- intermittentNTIS** AD-A041-973
morphological transformother cell types/human27500 µg/LITCSAF 17,719,1981
mutation in microorganisms/Salmonella typhimurium10 µg/plate (+enzymatic activation step)SYSWAE 12,41,1979
mutation in microorganisms/Salmonella typhimurium500 nL/well (-enzymatic activation step)NTIS** AD-A041-973
Unscheduled DNA Synthesislung/human50 mg/LNTIS** AD-A041-973

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 5400 mg/kg/9W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 44,3098,1984
oral/mouse toxic dose: 17280 mg/kg/9W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
CNREA8 44,3098,1984
subcutaneous/mouse lowest published toxic dose: 5400 mg/kg/290D- intermittentTumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
HPV314 -,-,2003

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 219 mg/kgHPV314 -,-,2003
oral/guinea pig lethal dose (50 percent kill): 4000 mg/kgHPV314 -,-,2003
oral/mouse lethal dose (50 percent kill): 500 mg/kgHPV314 -,-,2003
oral/rabbit lethal dose (50 percent kill): 4000 mg/kgHPV314 -,-,2003
oral/rat lethal dose (50 percent kill): 1625 mg/kgHPV314 -,-,2003
skin/rabbit lowest published lethal dose: 8 gm/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Skin: After systemic exposure: Dermatitis, other
NTIS** OTS0535072
skin/rabbit lethal dose (50 percent kill): >5000 mg/kgHPV314 -,-,2003
subcutaneous/rabbit lethal dose (50 percent kill): 200 mg/kgHPV314 -,-,2003
subcutaneous/rat lethal dose (50 percent kill): 500 mg/kgHPV314 -,-,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published toxic dose: 657 mg/kg/3D- continuousBlood: Methemoglobinemia- CarboxhemoglobinemiaHPV314 -,,2003
oral/rabbit lowest published toxic dose: 6000 mg/kg/6W- continuousGastrointestinal: Hypermotility, diarrhea

Liver: Fatty liver degeneration

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV314 -,,2003
oral/rabbit lowest published toxic dose: 1000 mg/kg/5D- continuousGastrointestinal: Hypermotility, diarrhea

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Other changes
HPV314 -,,2003
subcutaneous/rabbit lowest published toxic dose: 2100 mg/kg/7W- continuousLiver: Fatty liver degenerationHPV314 -,,2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82955; Number of Industries 127; Total Number of Facilities 13056; Number of Occupations 88; Total Number of Employees Exposed 184126; Total Number of Female Employees Exposed 16560
National Occupational Hazard Survey 1974Hazard Code 82955; Number of Industries 45; Total Number of Facilities 3583; Number of Occupations 46; Total Number of Employees Exposed 39803

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #96
TOP