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Registry of Toxic Effects of Chemical Substances (RTECS)

1,4-Naphthoquinone

RTECS #

QL7175000

CAS #

130-15-4

Updated

February 2006

Molecular Weight

158.16

Molecular Formula

C10H6O2

Synonyms

1,4-Dihydro-1,4-diketonaphthalene
1,4-Naftochinon (Czech)
1,4-Naphthalenedione
alpha-Naphthoquinone
RCRA waste number U166
USAF CY-10

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
micronucleus testlymphocyte/human100 µg/LMUREAV 393,23,1997
mutation in microorganisms/Escherichia coli16 µg/plate (-enzymatic activation step)MUREAV 467,41,2000

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
subcutaneous/rat 5 mg/kg (1D prior to copulation)Reproductive: Maternal effects: Ovaries, fallopian tubesENDOAO 57,466,1955

Tumorigenic Data and References

Route/OrganismDoseEffectReference
skin/mouse lowest published toxic dose: 800 mg/kg/29W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
PIATA8 16,309,1940

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 5500 µg/kgTumorigenic: Active as anti-cancer agentJMCMAR 26,570,1983
intraperitoneal/rat lowest published lethal dose: 50 mg/kg85GMAT -,91,1982
intravenous/mouse lowest published lethal dose: 10 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
JPETAB 71,210,1941
oral/guinea pig lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VKMGA7 6,37,1966
oral/guinea pig lethal dose (50 percent kill): 400 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,489,1994
oral/mouse lowest published lethal dose: 80 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
JPETAB 71,210,1941
oral/rat lethal dose (50 percent kill): 190 mg/kgBehavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VKMGA7 6,37,1966
oral/rat lethal dose (50 percent kill): 190 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,489,1994
oral/wild bird lethal dose (50 percent kill): 133 mg/kgAECTCV 12,355,1983
skin/rat lethal dose (50 percent kill): 202 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,489,1994
subcutaneous/mouse lowest published lethal dose: 40 mg/kgBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea
JPETAB 71,210,1941
subcutaneous/rat lethal dose (50 percent kill): 202 mg/kgGTPZAB 16(5),52,1972

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/guinea pig lowest published toxic dose: 72800 µg/kg/26W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 30(11),12,1965
oral/rat lowest published toxic dose: 72800 µg/kg/26W- intermittentLiver: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
GISAAA 30(11),12,1965
oral/rat lowest published toxic dose: 6 gm/kg/30D- intermittentLiver: Liver function tests impaired

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
VKMGA7 6,37,1966
subcutaneous/rat lowest published toxic dose: 300 mg/kg/10D- intermittentEndocrine: Changes in spleen weight

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Changes in: Fe
GTPZAB 16(5),52,1972
subcutaneous/rat lowest published toxic dose: 1300 mg/kg/13W- intermittentEndocrine: Changes in spleen weight

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Changes in: Fe
GTPZAB 16(5),52,1972
unreported route/rat lowest published toxic dose: 150 mg/kg/5D- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldVCVGK* -,489,1994

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, Skin, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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