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Registry of Toxic Effects of Chemical Substances (RTECS)

2-Naphthol

RTECS #

QL2975000

CAS #

135-19-3

Updated

December 2013

Molecular Weight

144.18

Molecular Formula

C10H8O

Synonyms

2-Hydroxynaphthalene
2-Naftol (Dutch)
2-Naftolo (Italian)
2-Naphthalenol
2-Naphtol (French)
Azogen developer A
beta-Hydroxynaphthalene
beta-Monoxynaphthalene
beta-Naftol (Dutch)
beta-Naftolo (Italian)
beta-Naphthol
beta-Naphthyl alcohol
beta-Naphthyl hydroxide
beta-Naphtol (German)
C.I. 37500
C.I. Azoic Coupling Component 1
C.I. Developer 5
Developer A
Developer AMS
Developer BN
Developer sodium
Isonaphthol
Naphthol
Naphthol B

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
DNA repair/Escherichia coli2 mg/discMUREAV 97,1,1982
DNA repair/Bacillus subtilis5 gm/LMUREAV 42,19,1977

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 0.5 mg/m3Behavioral: Headache

Kidney, Ureter, and Bladder: Hematuria

Nutritional and Gross Metabolic: Body temperature increase
VCVGK* -,220,1994
intraperitoneal/mouse lethal dose (50 percent kill): 97500 mg/kgEJMCA5 13,381,1978
oral/cat lowest published lethal dose: 100 mg/kgHBAMAK 4,1289,1935
oral/cat lethal dose (50 percent kill): 90 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
oral/guinea pig lethal dose (50 percent kill): 1300 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
oral/guinea pig lethal dose (50 percent kill): 1335 mg/kgGISAAA 30(9),22,1965
oral/mouse lethal dose (50 percent kill): 98 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
oral/mouse lowest published lethal dose: 100 mg/kgHBAMAK 4,1289,1935
oral/rabbit lethal dose (50 percent kill): 5400 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
oral/rabbit lowest published lethal dose: 3800 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
oral/rabbit lowest published lethal dose: 3800 mg/kgYKYUA6 31,1499,1980
oral/rat lethal dose (50 percent kill): 1960 mg/kgGTPPAF 8,145,1972
oral/rat lethal dose (50 percent kill): 1980 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
subcutaneous/guinea pig lowest published lethal dose: 2670 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
AEPPAE 186,195,1937
subcutaneous/mouse lowest published lethal dose: 100 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
subcutaneous/mouse lowest published lethal dose: 100 mg/kgZHINAV 64,113,1909
subcutaneous/rabbit lowest published lethal dose: 3 gm/kgHBAMAK 4,1289,1935
subcutaneous/rabbit lowest published lethal dose: 3000 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
subcutaneous/rat lowest published lethal dose: 2490 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen
VCVGK* -,220,1994
subcutaneous/rat lowest published lethal dose: 2940 mg/kgBehavioral: Sleep

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
AEPPAE 186,195,1937
unreported route/rabbit lowest published lethal dose: 3800 mg/kgYKYUA6 32,605,1981

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 1350 µg/m3/17W- intermittentBlood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
GISAAA 38(10),15,1973
inhalation/rat lowest published toxic concentration: 10 mg/m3/122D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
VCVGK* -,221,1994
oral/guinea pig lowest published toxic dose: 8008 mg/kg/26W- intermittentEye: Other eye effects

Kidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Decrease in cellular immune response
VCVGK* -,221,1994
oral/guinea pig lowest published toxic dose: 800.8 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells
VCVGK* -,221,1994
oral/rabbit lowest published toxic dose: 298 mg/kg/35W- intermittentLiver: Liver function tests impairedGISAAA 30(9),22,1965
oral/rat lowest published toxic dose: 20580 mg/kg/105D- intermittentBlood: Other hemolysis with or without anemiaVCVGK* -,221,1994
oral/rat lowest published toxic dose: 800.8 mg/kg/26W- intermittentBrain and Coverings: Other degenerative changes

Liver: Liver function tests impaired

Blood: Pigmented or nucleated red blood cells
VCVGK* -,221,1994
oral/rat lowest published toxic dose: 8008 mg/kg/26W- intermittentEye: Other eye effects

Kidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Decrease in cellular immune response
VCVGK* -,221,1994
oral/rat lowest published toxic dose: 107 mg/kg/35W- intermittentBrain and Coverings: Other degenerative changes

Behavioral: Alteration of classical conditioning
GISAAA 30(9),22,1965

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 47,75,1978
TOXICOLOGY REVIEWMUTAEX 28,485,2013

Standards and Regulations

OrganizationStandardReference
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATIONFEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDESCancelledRBREV* -,266,1998
Occupational Exposure Limit-RUSSIAshort term exposure limit 0.1 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X1957; Number of Industries 1; Total Number of Facilities 113; Number of Occupations 1; Total Number of Employees Exposed 453
National Occupational Exposure Survey 1983Hazard Code 84296; Number of Industries 11; Total Number of Facilities 199; Number of Occupations 26; Total Number of Employees Exposed 10985; Total Number of Female Employees Exposed 590
National Occupational Hazard Survey 1974Hazard Code 84296; Number of Industries 18; Total Number of Facilities 971; Number of Occupations 18; Total Number of Employees Exposed 6346

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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