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Registry of Toxic Effects of Chemical Substances (RTECS)

Naphthalene, 2-methyl-

RTECS #

QJ9635000

CAS #

91-57-6

Updated

September 201

Molecular Weight

142.21

Molecular Formula

C11H10

Synonyms

2-Methylnaphthalene
beta-Methylnaphthalene

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 0.05 mL/24H severeETOPFR 16,153,2004

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/human4 mmol/LMUREAV 208,155,1988
sister chromatid exchangelymphocyte/human250 µmol/LMUREAV 208,155,1988

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 28500 mg/kg/81W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors
FAATDF 36,90,1997

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 1 gm/kgLung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes
TXAPA9 61,185,1981
intraperitoneal/rat lethal dose (50 percent kill): 1.63 gm/kgBehavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Body temperature decrease
VCVGH* -,227,1990
oral/rat lethal dose (50 percent kill): 1630 mg/kg85GMAT -,85,1982
skin/rabbit lowest published toxic dose: 0.03 mL/kg/24HVascular: Measurement of regional blood flowETOPFR 16,153,2004

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 0.5 ppm (skin)DTLVS* TLV/BEI,2013
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-Not classifiable as a human carcinogenDTLVS* TLV/BEI,2013
TOXICOLOGY REVIEWMUREAV 636,95,2007
TOXICOLOGY REVIEWTXCYAC 260,16,2009

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code M1659; Number of Industries 5; Total Number of Facilities 376; Number of Occupations 5; Total Number of Employees Exposed 4359; Total Number of Female Employees Exposed 1608
National Occupational Hazard Survey 1974Hazard Code M1659; Number of Industries 10; Total Number of Facilities 633; Number of Occupations 15; Total Number of Employees Exposed 3498

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264362)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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