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Registry of Toxic Effects of Chemical Substances (RTECS)

1,5-Naphthalenediamine

RTECS #

QJ3400000

CAS #

2243-62-1

Updated

March 2011

Molecular Weight

158.22

Molecular Formula

C10H10N2

Synonyms

1,5-Diaminonaphthalene
1,5-Naphthylenediamine
NCI-C03021

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
morphological transformembryo/rat5200 ng/plateJJATDK 1,190,1981
mutation in microorganisms/Salmonella typhimurium33300 ng/plate (+/-enzymatic activation step)ENMUDM 7(Suppl 5),1,1985

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 120 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NCITR* NCI-TR-143,1978
oral/mouse toxic dose: 288 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
NCITR* NCI-TR-143,1978
oral/mouse toxic dose: 721 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
IMEMDT 27,127,1982
oral/mouse toxic dose: 1442 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors
IMEMDT 27,127,1982
oral/rat lowest published toxic dose: 721 gm/kg/1Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
IMEMDT 27,127,1982
oral/rat toxic dose: 18 gm/kg/88W- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NCITR* NCI-TR-143,1978
oral/rat toxic dose: 54 gm/kg/2Y- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NCITR* NCI-TR-143,1978
oral/rat toxic dose: 361 gm/kg/1Y- continuousTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors
IMEMDT 27,127,1982

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Limited EvidenceIMEMDT 27,127,1982
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 27,127,1982
International Agency for Research on Cancer (IARC)Cancer Review:Group 3IMSUDL 7,56,1987
TOXICOLOGY REVIEWARPTDI 43,309,2003
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWMUREAV 705,184,2010

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4423; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 28

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,ratNCITR* NCI-TR-143,1978
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