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Naphthalene, decahydro -

RTECS #: QJ3150000

CAS #: 91-17-8


UPDATE: May 2009 MW: 138.28 MF: C10H18


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. TUMORIGENIC DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Bicyclo (4.4.O) decane
  2. De - kalin
  3. Decalin
  4. Dekalina (Polish)
  1. Naphthalane
  2. Naphthane
  3. Perhydronaphthalene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 50 ppm/24 hour/90 day- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
FAATDF 5,785,1985
inhalation
rat
lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
FAATDF 5,785,1985
inhalation
rat
lowest published toxic concentration: 50 ppm ppm/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOSCF2 72,223,2003


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
guinea pig
lowest published lethal concentration: 319 ppm/8 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** AD-A086-341
inhalation
human
lowest published toxic concentration: 100 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
TGNCDL 2,40,1961
inhalation
mouse
lowest published lethal concentration: 993 ppm/4 hour N/R NTIS** AD-A062-138
inhalation
rat
lethal concentration (50 percent kill): 710 ppm/4 hour N/R ATDAEI 1,215,1992
oral
rat
lethal dose (50 percent kill): 4,170 mg/kg N/R AMIHBC 4,119,1951
skin
rabbit
lethal dose (50 percent kill): 5,900 ÁL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Endocrine: Evidence of thyroid hyperfunction
FAATDF 5,785,1985
inhalation
mouse
lowest published toxic concentration: 100 ppm/6 hour/17 day- intermittent Liver: Changes in liver weight NTPTR* TR-513
inhalation
mouse
lowest published toxic concentration: 200 ppm/14 week- continuous Liver: Changes in liver weight NTPTR* TR-513
inhalation
mouse
lowest published toxic concentration: 400 ppm/14 week- continuous Liver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
NTPTR* TR-513
inhalation
mouse
lowest published toxic concentration: 400 ppm/105 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse NTPTR* TR-513
inhalation
mouse
lowest published toxic concentration: 25 ppm/105 week- continuous Liver: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 5 ppm/24 hour/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 5,785,1985
inhalation
rat
lowest published toxic concentration: 125 ppm/22 hour/31 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,53,1987
inhalation
rat
lowest published toxic concentration: 50 ppm/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 400 ppm/13 week- intermittent Liver: Changes in liver weight TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 25 ppm/6 hour/16 day- intermittent Kidney, Ureter, and Bladder: Other changes NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 25 ppm/6 hour/16 day- intermittent Liver: Changes in liver weight NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 50 ppm/6 hour/16 day- intermittent Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 25 ppm/6 week- continuous Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 25 ppm/2 week- continuous Kidney, Ureter, and Bladder: Other changes NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 50 ppm/2 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 400 ppm/105 week- continuous Kidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Kidney tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-513
inhalation
rat
lowest published toxic concentration: 50 ppm/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 50 ppm/12 week- intermittent Kidney, Ureter, and Bladder: Proteinuria

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 25 ppm/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 50 ppm/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 100 ppm/12 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 200 ppm/12 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 100 ppm/6 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 100 ppm/13 week- intermittent Kidney, Ureter, and Bladder: Other changes TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 100 ppm/2 year- intermittent Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli TOSCF2 72,223,2003
inhalation
rat
lowest published toxic concentration: 25 ppm/2 year- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOSCF2 72,223,2003
oral
rat
lowest published toxic dose: 1,500 mg/kg/5 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,345,1987
oral
rat
lowest published toxic dose: 6 gm/kg/4 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,345,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (tentative), OCT 2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84339;
Number of Industries 3;
Total Number of Facilities 46;
Number of Occupations 3;
Total Number of Employees Exposed 934
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84339;
Number of Industries 2;
Total Number of Facilities 81;
Number of Occupations 2;
Total Number of Employees Exposed 249;
Total Number of Female Employees Exposed 74


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8815;8EHQ-0892-8816
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000


REFERENCES:

CODEN
REFERENCE

AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used as solvent and chemical intermediate

RTECS Compound Description:
   Tumorigen
   Human Data

Click Here for Additional Information about RTECS

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