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Registry of Toxic Effects of Chemical Substances (RTECS)

Naphthalene, decahydro-

RTECS #

QJ3150000

CAS #

91-17-8

Updated

May 2009

Molecular Weight

138.28

Molecular Formula

C10H18

Synonyms

Bicyclo(4.4.O)decane
Decalin
De-kalin
Dekalina (Polish)
Naphthalane
Naphthane
Perhydronaphthalene

Tumorigenic Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 50 ppm/24H/90D- continuousTumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
FAATDF 5,785,1985
inhalation/rat lowest published toxic concentration: 50 ppm/2Y- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 5 ppm/24H/90D- continuousTumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors
FAATDF 5,785,1985

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig Lowest published lethal concentration: 319 ppm/8HLung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTIS** AD-A086-341
inhalation/human lowest published toxic concentration: 100 ppmOlfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes
TGNCDL 2,40,1961
inhalation/mouse Lowest published lethal concentration: 993 ppm/4HNTIS** AD-A062-138
inhalation/rat lethal concentration (50 percent kill): 710 ppm/4HATDAEI 1,215,1992
oral/rat lethal dose (50 percent kill): 4170 mg/kgAMIHBC 4,119,1951
skin/rabbit lethal dose (50 percent kill): 5900 µL/kgAMIHBC 4,119,1951

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 5 ppm/24H/90D- continuousLung, Thorax, or Respiration: Other changes

Liver: Other changes

Endocrine: Evidence of thyroid hyperfunction
FAATDF 5,785,1985
inhalation/mouse lowest published toxic concentration: 400 ppm/105W- continuousLiver: Hepatitis (hepatocellular necrosis), diffuseNTPTR* TR-513
inhalation/mouse lowest published toxic concentration: 25 ppm/105W- continuousLiver: Tumors

Reproductive: Tumorigenic effects: Uterine tumors
NTPTR* TR-513
inhalation/mouse lowest published toxic concentration: 100 ppm/6H/17D- intermittentLiver: Changes in liver weightNTPTR* TR-513
inhalation/mouse lowest published toxic concentration: 200 ppm/14W- continuousLiver: Changes in liver weightNTPTR* TR-513
inhalation/mouse lowest published toxic concentration: 400 ppm/14W- continuousLiver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
NTPTR* TR-513
inhalation/rat lowest published toxic concentration: 400 ppm/105W- continuousKidney, Ureter, and Bladder: Interstitial nephritis

Kidney, Ureter, and Bladder: Kidney tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* TR-513
inhalation/rat lowest published toxic concentration: 25 ppm/6W- continuousKidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
NTPTR* TR-513
inhalation/rat lowest published toxic concentration: 25 ppm/2W- continuousKidney, Ureter, and Bladder: Other changesNTPTR* TR-513
inhalation/rat lowest published toxic concentration: 50 ppm/2W- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-513
inhalation/rat lowest published toxic concentration: 50 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 50 ppm/12W- intermittentKidney, Ureter, and Bladder: Proteinuria

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 25 ppm/12W- intermittentKidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 50 ppm/12W- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 100 ppm/12W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: DehydrogenasesTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 200 ppm/12W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: TransaminasesTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 100 ppm/6W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 100 ppm/13W- intermittentKidney, Ureter, and Bladder: Other changesTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 100 ppm/2Y- intermittentKidney, Ureter, and Bladder: Changes in both tubules and glomeruliTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 25 ppm/2Y- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 50 ppm/13W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Proteinuria
TOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 400 ppm/13W- intermittentLiver: Changes in liver weightTOSCF2 72,223,2003
inhalation/rat lowest published toxic concentration: 25 ppm/6H/16D- intermittentKidney, Ureter, and Bladder: Other changesNTPTR* TR-513
inhalation/rat lowest published toxic concentration: 25 ppm/6H/16D- intermittentLiver: Changes in liver weightNTPTR* TR-513
inhalation/rat lowest published toxic concentration: 50 ppm/6H/16D- intermittentKidney, Ureter, and Bladder: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight
NTPTR* TR-513
inhalation/rat lowest published toxic concentration: 5 ppm/24H/90D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FAATDF 5,785,1985
inhalation/rat lowest published toxic concentration: 125 ppm/22H/31D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,53,1987
oral/rat lowest published toxic dose: 1500 mg/kg/5D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,345,1987
oral/rat lowest published toxic dose: 6 gm/kg/4W- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
FCTOD7 25,345,1987

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 659,248,2008

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-POLANDMAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 300 mg/m3, JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 100 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84339; Number of Industries 2; Total Number of Facilities 81; Number of Occupations 2; Total Number of Employees Exposed 249; Total Number of Female Employees Exposed 74
National Occupational Hazard Survey 1974Hazard Code 84339; Number of Industries 3; Total Number of Facilities 46; Number of Occupations 3; Total Number of Employees Exposed 934

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8815;8EHQ-0892-8816
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis studies; on test (two year studies), October 2000
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