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Registry of Toxic Effects of Chemical Substances (RTECS)

Molybdic acid, disodium salt

RTECS #

QA5075000

CAS #

7631-95-0

Updated

July 2013

Molecular Weight

205.92

Molecular Formula

MoO4·2Na

Synonyms

Disodium molybdate
Natriummolybdat (German)
Sodium molybdate
Sodium molybdate(VI)

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
phage inhibition capacity/Escherichia coli16 mmol/LENMUDM 6,59,1984
sex chromosome loss and nondisjunction/Saccharomyes cerevisiae80 mmol/LMUTAEX 1,21,1986

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
intratesticular/mouse 16474 µg/kg (1D male)Reproductive: Paternal effects: Testes, epididymis, sperm ductJRPFA4 7,21,1964

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): >2080 mg/m3/4HPerDW# 18JUN1991
intraperitoneal/mouse lethal dose (50 percent kill): 303 mg/kgEQSSDX 1,1,1975
intraperitoneal/rat lethal dose (50 percent kill): 576 mg/kgEQSSDX 1,1,1975
intravenous/cat lethal dose (50 percent kill): 917 mg/kgVascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression
AGSOA6 8,51,1967
oral/Dog lethal dose (50 percent kill): 0.25 gm/kgGastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN5* -,316,1993
oral/guinea pig lethal dose (50 percent kill): 0.31 gm/kgGastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN5* -,316,1993
oral/rat lethal dose (50 percent kill): 4 gm/kgPerDW# 18JUN1991
oral/rat lethal dose (50 percent kill): 0.25 gm/kgGastrointestinal: Contraction (isolated tissue)

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
VCVN5* -,316,1993
subcutaneous/mouse lethal dose (50 percent kill): 570 mg/kgAEPPAE 244,17,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/domestic animal lowest published toxic dose: 484 mg/kg/21W- intermittentBlood: Other changes

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JANSAG 25,96,1966
oral/rabbit lowest published toxic dose: 3343 mg/kg/26D- continuousEndocrine: Evidence of thyroid hypofunction

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JOENAK 57,419,1973
oral/rat lowest published toxic dose: 5.25 gm/kg/21D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVN5* -,317,1989
oral/rat lowest published toxic dose: 1050 mg/kg/5W- intermittentBlood: Normocytic anemia

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
HBTME* -,731,2007
oral/rat lowest published toxic dose: 18200 mg/kg/13W- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
PHTOEH 73(Suppl 2),87,1993
oral/rat lowest published toxic dose: 3605 mg/kg/4W- continuousLiver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PSEBAA 91,638,1956

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWADTEAS 5,51,1972
TOXICOLOGY REVIEWENTOX* -,145,2005
TOXICOLOGY REVIEWHBTME* ,731,2007

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 5 mg(Mo)/m3DTLVS* 3,173,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-AUSTRALIAtime-weighted average 5 mg(Mo)/m3, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 10 mg(Mo)/m3, MAR2002
Occupational Exposure Limit-FRANCEVME 5 mg(Mo)/m3, VLE 10 mg(Mo)/m3, FEB2006
Occupational Exposure Limit-HUNGARYtime-weighted average 5 mg(Mo)/m3, short term exposure limit 20 mg(Mo)/m3, SEP2000
Occupational Exposure Limit-SWEDENtime-weighted average 10 mg(Mo)/m3 (total dust); time-weighted average 5 mg(Mo)/m3 (resp. dust), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 10 mg(Mo)/m3, inhal, JAN2011
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 5 mg(Mo)/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 5 mg(Mo)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 5 mg(Mo)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 5 mg(Mo)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 5 mg(Mo)/m3CFRGBR 29,1915.1000,1993

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81120; Number of Industries 55; Total Number of Facilities 2082; Number of Occupations 46; Total Number of Employees Exposed 33075; Total Number of Female Employees Exposed 6787
National Occupational Hazard Survey 1974Hazard Code 81120; Number of Industries 35; Total Number of Facilities 1540; Number of Occupations 33; Total Number of Employees Exposed 10443

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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