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Methyl sulfoxide

RTECS #: PV6210000

CAS #: 67-68-5


UPDATE: May 2009 MW: 78.14 MF: C2H6OS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. A 10846
  2. DMS - 70
  3. DMS - 90
  4. DMSO
  5. Deltan
  6. Demasorb
  7. Demavet
  8. Demeso
  9. Demsodrox
  10. Dermasorb
  11. Dimethyl sulfoxide
  12. Dimethyl sulphoxide
  13. Dimexide
  14. Dipirartril - tropico
  15. Dolicur
  16. Domoso
  1. Dromisol
  2. Durasorb
  3. Gamasol 90
  4. Hyadur
  5. Infiltrina
  6. M 176
  7. Methane, sulfinylbis -
  8. Methylsulfinylmethane
  9. NSC - 763
  10. Rimso - 50
  11. SQ 9453
  12. Somipront
  13. Sulfinylbis (methane)
  14. Syntexan
  15. Topsym


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
100 mg N/R TXAPA9 39,129,1977
eye
rabbit
500 mg/24 hour mild 85JCAE -,1044,1986
eye
rabbit
100 mg mild ENTOX* 51,-,2005
skin
rabbit
10 mg/24 hour open irritation test mild AIHAAP 23,95,1962
skin
rabbit
500 mg/24 hour mild 85JCAE -,1044,1986
skin
rabbit
100 mg mild ENTOX* 51,-,2005


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster ovary 19 pph MUREAV 88,397,1981
cytogenetic analysis hamster lung 1 pph MUREAV 42,109,1977
cytogenetic analysis mouse lymphocyte 93 gm/L MUREAV 222,191,1989
cytogenetic analysis intraperitoneal
rat
25 gm/kg/5 day TCMUD8 1,141,1980
DNA damage intraperitoneal
mouse
75 mmol/kg CRNGDP 5,319,1984
mutation in microorganisms Escherichia coli 551 gm/L (-enzymatic activation step) MUREAV 130,97,1984
mutation in microorganisms other microorganisms 111 gm/L (-enzymatic activation step) HEREAY 99,209,1983
mutation in microorganisms Salmonella typhimurium 25 pph (+enzymatic activation step) MUREAV 303,127,1993
mutation in microorganisms Saccharomyes cerevisiae 8 pph (-enzymatic activation step) BBRCA9 49,1336,1972
mutation in microorganisms Saccharomyes cerevisiae 1,400 mmol/L (+enzymatic activation step) MUREAV 45,309,1977
mutation in mammalian somatic cells mouse lymphocyte 1 mole/L MUTAEX 3,193,1988
other mutation test systems human lymphocyte 140 mmol/L PNASA6 79,1171,1982
other mutation test systems Salmonella typhimurium 70 gm/L MUREAV 192,239,1987
phage inhibition capacity Escherichia coli 6,200 ppm MUREAV 263,107,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
700 ppm MUREAV 259,147,1991
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 118 gm/L MUREAV 224,31,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 5,500 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
JEEMAF 16,49,1966
intraperitoneal
hamster
lowest published toxic dose: 4,400 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system
LANCAO 1,208,1966
intraperitoneal
mouse
lowest published toxic dose: 210 gm/kg (6-12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
ANYAA9 141,110,1967
intraperitoneal
mouse
lowest published toxic dose: 5,500 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
AUCMBJ 61,131,1973
intraperitoneal
mouse
lowest published toxic dose: 8,250 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AUCMBJ 61,131,1973
intraperitoneal
rat
lowest published toxic dose: 56 gm/kg (6-12 day pregnant) Reproductive: Effects on fertility: Abortion ANYAA9 141,110,1967
intraperitoneal
rat
lowest published toxic dose: 6,600 mg/kg (7-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ZPPLBF 116,131,1977
intravenous
hamster
lowest published toxic dose: 2,500 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
JEEMAF 16,49,1966
intravenous
hamster
lowest published toxic dose: 2,500 mg/kg (8 day pregnant) Reproductive: Other developmental abnormalities JEEMAF 16,49,1966
intravenous
mouse
lowest published toxic dose: 240 gm/kg (1-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) COREAF 260,327,1965
oral
hamster
lowest published toxic dose: 11 gm/kg (7 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system
TXAPA9 15,152,1969
oral
mouse
lowest published toxic dose: 16 mg/kg (5-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system
RCOCB8 82,371,1993
subcutaneous
rat
lowest published toxic dose: 30,750 mg/kg (8-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)
PSEBAA 125,567,1967


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 65,340 mg/kg/66 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Blood: Leukemia

Skin and Appendages: Tumors
GTPZAB 28(5),39,1984
oral
rat
lowest published toxic dose: 59 gm/kg/81 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
GTPZAB 28(5),39,1984
subcutaneous
mouse
lowest published toxic dose: 66 gm/kg/66 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Skin and Appendages: Tumors
GTPZAB 28(5),39,1984
subcutaneous
rat
lowest published toxic dose: 220 gm/kg/82 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors
GTPZAB 28(5),39,1984


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intracerebral
rat
lowest published toxic dose: 2,234.8 mg/kg Brain and Coverings: Other degenerative changes TXCYAC 218,75,2006
intraperitoneal
guinea pig
lowest published lethal dose: >5,500 mg/kg N/R JPPMAB 15,688,1963
intraperitoneal
mouse
lethal dose (50 percent kill): 2,500 mg/kg N/R RPTOAN 35,300,1972
intraperitoneal
mouse
lowest published toxic dose: 2.5 mL/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) JAPTO* 27,25,2007
intraperitoneal
mouse
lowest published toxic dose: 0.4 mL/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
BPBLEO 29,1618,2006
intraperitoneal
mouse
lowest published toxic dose: 2.5 mL/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BPBLEO 29,1618,2006
intraperitoneal
rat
lethal dose (50 percent kill): 8,200 mg/kg N/R FCTOD7 22,665,1984
intraperitoneal
rat
lowest published toxic dose: 200 mg/kg Endocrine: Other changes ANYAA9 -,325,1975
intraperitoneal
rat
lowest published toxic dose: 1,000 mg/kg Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other proteins
TOLED5 147,153,2004
intraperitoneal
rat
lowest published toxic dose: 750 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Changes in REM sleep (human)
TOLED5 157,221,2005
intraperitoneal
rat
lowest published toxic dose: 750 mg/kg Brain and Coverings: Changes in surface EEG TOLED5 157,221,2005
intraperitoneal
rat
lowest published toxic dose: 3.5 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Biochemical: Metabolism (intermediary): Other
NRTXDN 28,161,2007
intravenous
cat
lowest published lethal dose: 200 mg/kg Behavioral: Altered sleep time (including change in righting reflex) ARZNAD 28,1571,1978
intravenous
dog
lethal dose (50 percent kill): 2,500 mg/kg Cardiac: Other changes

Kidney, Ureter, and Bladder: Hematuria

Kidney, Ureter, and Bladder: Other changes
CNCRA6 31,7,1963
intravenous
man
lowest published toxic dose: 606 mg/kg Gastrointestinal: Nausea or vomiting

Liver: Jaundice, other or unclassified
LANCAO 2,1004,1980
intravenous
mouse
lethal dose (50 percent kill): 3,100 mg/kg Eye: Hemorrhage

Eye: Conjunctiva irritation
TXAPA9 15,74,1969
intravenous
rat
lethal dose (50 percent kill): 5,360 mg/kg Behavioral: Tremor

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea
TXAPA9 7,104,1965
oral
wild bird
lethal dose (50 percent kill): 100 mg/kg N/R TXAPA9 21,315,1972
oral
chicken
lethal dose (50 percent kill): 12 gm/kg N/R JPPMAB 15,688,1963
oral
dog
lethal dose (50 percent kill): >10 gm/kg N/R ANYAA9 141,96,1967
oral
guinea pig
lowest published lethal dose: >11 gm/kg N/R JPPMAB 15,688,1963
oral
mammal (species unspecified)
lethal dose (50 percent kill): 21,400 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse
lethal dose (50 percent kill): 7,920 mg/kg N/R CHTPBA 3,10,1968
oral
mouse
lowest published toxic dose: 10.91 mL/kg Endocrine: Hypoglycemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other
HETOEA 22,99,2003
oral
rat
lethal dose (50 percent kill): 14,500 mg/kg Eye: Hemorrhage

Eye: Conjunctiva irritation
TXAPA9 15,74,1969
oral
rat
lethal dose (50 percent kill): 17,400 mg/kg N/R USXXAM #6673157
subcutaneous
mouse
lethal dose (50 percent kill): 14 gm/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Hematuria
ANYAA9 141,96,1967
subcutaneous
rat
lethal dose (50 percent kill): 12 gm/kg Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Dyspnea
ARZNAD 14,1050,1964
skin
mouse
lethal dose (50 percent kill): 50 gm/kg N/R ANYAA9 141,96,1967
skin
rat
lethal dose (50 percent kill): 40 gm/kg N/R ANYAA9 141,96,1967
skin
woman
lowest published toxic dose: 1,800 mg/kg Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis

Blood: Other changes
VHTODE 40,87,1998
unreported route
mouse
lethal dose (50 percent kill): 12 gm/kg N/R USXXAM #4767763
unreported route
rat
lethal dose (50 percent kill): 1,300 mg/kg N/R NTIS** AD-A159-418


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 0.964 gm/m3/90 day- intermittent Skin: After systemic exposure: Dermatitis, irritative TOXID9 60,326,2001
inhalation
rat
lowest published toxic concentration: 2.783 gm/m3/90 day- intermittent Olfaction: Other olfaction effects TOXID9 60,326,2001
inhalation
rat
lowest published toxic concentration: 0.310 gm/m3/28 day- intermittent Blood: Changes in spleen TOXID9 60,326,2001
intraperitoneal
rat
lowest published toxic dose: 192 gm/kg/4 week- intermittent Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 7,104,1965
intraperitoneal
rat
lowest published toxic dose: 3,600 mg/kg/10 day- intermittent Peripheral Nerve and Sensation: Sensory change involving peripheral nerve TOLED5 132,117,2002
intraperitoneal
rat
lowest published toxic dose: 12 mL/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BJPCBM 139,787,2003
intravenous
dog
lowest published toxic dose: 57,600 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Hematuria

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXAPA9 7,104,1965
ocular
rabbit
lowest published toxic dose: 250 g/kg/30 day- intermittent Eye: Other eye effects JTOTDO 2,193,1983
oral
dog
lowest published toxic dose: 6,570 mL/kg/2 year- intermittent Eye: Other eye effects

Blood: Changes in erythrocyte (RBC) count

Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 3,143,1975
oral
monkey
lowest published toxic dose: 4,864 gm/kg/78 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TXAPA9 16,606,1970
oral
rat
lowest published toxic dose: 1,070 gm/kg/13 week- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
ARZNAD 14,1050,1964
skin
dog
lowest published toxic dose: 389 gm/kg/17 week- continuous Eye: Changes in refraction

Eye: Other eye effects
JPETAB 170,364,1969
skin
pig
lowest published toxic dose: 4,698 mL/kg/58 week- intermittent Eye: Changes in refraction

Behavioral: Fluid intake
TXCYAC 3,143,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ANYAA9 243,98,1975
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971
TOXICOLOGY REVIEW
ARZNAD 17,1553,1967
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
BCPCA6 64,1035,2002
TOXICOLOGY REVIEW
TOLED5 127,269,2002
TOXICOLOGY REVIEW
TPHSDY 23,504,2002
TOXICOLOGY REVIEW
AJOPAA 138,639,2004
TOXICOLOGY REVIEW
TPHSDY 24,355,2003
TOXICOLOGY REVIEW
EMCPT* 2,151,2005
TOXICOLOGY REVIEW
MUTAEX 19,251,2004
TOXICOLOGY REVIEW
ENTOX* -,51,2005
TOXICOLOGY REVIEW
HUTOX* -,577,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (tentative), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 150 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (150 mg/m3);
short term exposure limit 150 ppm (500 mg/m3), Skin, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (160 mg/m3), Skin, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80564;
Number of Industries 11;
Total Number of Facilities 476;
Number of Occupations 25;
Total Number of Employees Exposed 22,461
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80564;
Number of Industries 29;
Total Number of Facilities 3,507;
Number of Occupations 40;
Total Number of Employees Exposed 44,947;
Total Number of Female Employees Exposed 16,837


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA GENETOX PROGRAM 1988, Positive: Aspergillus-aneuploidy; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss; Host-mediated assay
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Inconclusive: Aspergillus-recombination; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Inconclusive: Rodent dominant lethal; B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent and in the preparation of VANILLIN from LIGNIN, also as an antifreeze
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
AUCMBJ Acta Universitatis Carolinae, Medica, Monographia. (Univerzita Karlova, Ovocny Trh. 3, 11636 Prague 1, Czechoslovakia) No.1- 1954-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5.
CNCRA6 Cancer Chemotherapy Reports. (Bethesda, MD) V.1-52, 1959-68. For publisher information, see CTRRDO.
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EMCPT* EMC-Toxicologie Pathologie (Elsevier) V.1- 2004-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
HUTOX*
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JEEMAF Journal of Embryology and Experimental Morphology. (Essex, UK) V.1-98, 1953-86. For Publisher information, see DEVPED
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
ZPPLBF Zentralblatt fuer Pharmazie, Pharmakotherapie und Laboratoriums-diagnostik. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, 102 Berlin, Ger. Dem. Rep.) V.109- 1970-

Used as solvent and in the preparation of VANILLIN from LIGNIN, also as an antifreeze

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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