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Methyl sulfide

RTECS #: PV5075000

CAS #: 75-18-3


UPDATE: February 2009 MW: 62.14 MF: C2H6S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2 - Thiapropane
  2. Dimethyl monosulfide
  3. Dimethylsulfid (Czech)
  4. Dimethyl sulphide
  5. Exact - S
  6. Methane, thiobis - (9CI)
  1. Methyl monosulfide
  2. Methyl sulphide
  3. Methyl thioether
  4. Sulfure de methyle (French)
  5. Thiobis (methane)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
250 g/24 hour severe 85JCAE -,990,1986
skin
rabbit
500 mg/24 hour mild FCTXAV 17,365,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 31,620 g/m3 N/R GTPZAB 16(6),46,1972
inhalation
rat
lethal concentration (50 percent kill): 40,250 ppm Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased
LacHB# 09JUN1978
intraperitoneal
mouse
lethal dose (50 percent kill): 8 gm/kg N/R IJRBA3 3,41,1961
oral
mouse
lethal dose (50 percent kill): 3,700 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Antipsychotic

Nutritional and Gross Metabolic: Other changes
FCTXAV 17,365,1979
oral
rat
lethal dose (50 percent kill): 3,300 mg/kg Behavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Irritability
GISAAA 32(3),3,1967
skin
rabbit
lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 17,365,1979
unreported route
mammal (species unspecified)
lethal dose (50 percent kill): 1,950 mg/kg N/R GTPZAB 16(6),46,1972
unreported route
mouse
lethal dose (50 percent kill): 3,700 mg/kg N/R HBPTO* 1,827,2001
unreported route
rat
lethal dose (50 percent kill): 3,300 mg/kg N/R HBPTO* 1,827,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 21 gm/kg/70 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases GISAAA 32(3),3,1967
oral
rat
lowest published toxic dose: 24,500 mg/kg/14 week- intermittent Gastrointestinal: Other changes

Endocrine: Changes in thyroid weight
FCTXAV 13,15,1975
oral
rabbit
lowest published toxic dose: 3,412 mg/kg/33 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 32(3),3,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (26 mg/m3), MAR2002
Occupational Exposure Limit - POLAND MAC(time-weighted average) 1 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, Skin, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84745;
Number of Industries 5;
Total Number of Facilities 265;
Number of Occupations 20;
Total Number of Employees Exposed 3,920;
Total Number of Female Employees Exposed 200


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as presulfiding agent for variety of catalysts used by petroleum industry
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
IJRBA3 International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine. (Taylor & Francis Inc., 242 Cherry St., Philadelphia, PA 19106) V.1- 1959-
LacHB# Personal Communication from H.B. Lackey, Chemical Products Div., Crown Zellerbach, Camas, WA 98607, June 9, 1978

Used as presulfiding agent for variety of catalysts used by petroleum industry

RTECS Compound Description:
   Primary Irritant

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