Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content

Registry of Toxic Effects of Chemical Substances (RTECS)

Methyl sulfide

RTECS #

PV5075000

CAS #

75-18-3

Updated

September 201

Molecular Weight

62.14

Molecular Formula

C2H6S

Synonyms

2-Thiapropane
Dimethyl monosulfide
Dimethyl sulphide
Dimethylsulfid (Czech)
Exact-S
Methane, thiobis- (9CI)
Methyl monosulfide
Methyl sulphide
Methyl thioether
Sulfure de methyle (French)
Thiobis(methane)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 250 µg/24H severe85JCAE -,990,1986
skin /rabbit 500 mg/24H mildFCTXAV 17,365,1979

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lethal concentration (50 percent kill): 31620 µg/m3GTPZAB 16(6),46,1972
inhalation/rat lethal concentration (50 percent kill): 40250 ppmLung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Urine volume increased
LacHB# 09JUN1978
intraperitoneal/mouse lethal dose (50 percent kill): 8 gm/kgIJRBA3 3,41,1961
oral/mouse lethal dose (50 percent kill): 3700 mg/kgBehavioral: Change in motor activity (specific assay)

Behavioral: Antipsychotic

Nutritional and Gross Metabolic: Other changes
FCTXAV 17,365,1979
oral/rat lethal dose (50 percent kill): 3300 mg/kgBehavioral: General anesthetic

Behavioral: Change in motor activity (specific assay)

Behavioral: Irritability
GISAAA 32(3),3,1967
skin/rabbit lethal dose (50 percent kill): >5 gm/kgFCTXAV 17,365,1979
unreported route/mammal (species unspecified) lethal dose (50 percent kill): 1950 mg/kgGTPZAB 16(6),46,1972
unreported route/mouse lethal dose (50 percent kill): 3700 mg/kgHBPTO* 1,827,2001
unreported route/rat lethal dose (50 percent kill): 3300 mg/kgHBPTO* 1,827,2001

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rabbit lowest published toxic dose: 3412 mg/kg/33W- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
GISAAA 32(3),3,1967
oral/rat lowest published toxic dose: 21 gm/kg/70D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: CatalasesGISAAA 32(3),3,1967
oral/rat lowest published toxic dose: 24500 mg/kg/14W- intermittentGastrointestinal: Other changes

Endocrine: Changes in thyroid weight
FCTXAV 13,15,1975

Reviews

OrganizationStandardReference
American Conference of Governmental Industrial Hygienists (ACGIH)Threshold Limit Value-time-weighted average 10 ppmDTLVS* TLV/BEI,2013

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-BELGIUMtime-weighted average 10 ppm (26 mg/m3), MAR2002
Occupational Exposure Limit-POLANDMAC(time-weighted average) 1 mg/m3, JAN1993
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, Skin, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 1 ppm, JUN2005

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 84745; Number of Industries 5; Total Number of Facilities 265; Number of Occupations 20; Total Number of Employees Exposed 3920; Total Number of Female Employees Exposed 200

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
TOP