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Methyl ether

RTECS #: PM4780000

CAS #: 115-10-6


UPDATE: May 2009 MW: 46.08 MF: C2H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. DME
  2. Demeon D
  3. Dimethyl oxide
  4. Dymel A
  5. Ether, dimethyl
  1. Ether, methyl
  2. Methane, oxybis - (9CI)
  3. Methoxymethane
  4. Wood ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
hamster
lowest published toxic dose: 200 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) VCVGK* -,263,1994


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 8.2 pph/21 minute Eye: Other eye effects

Behavioral: Ataxia
VCVGK* -,263,1994
inhalation
human
lowest published toxic concentration: 8.2 pph/30 minute Peripheral Nerve and Sensation: Sensory change involving peripheral nerve VCVGK* -,263,1994
inhalation
human
lowest published toxic concentration: 14 pph/26 minute Behavioral: General anesthetic VCVGK* -,263,1994
inhalation
mouse
lethal concentration (50 percent kill): 93,000 mg/m3/15 minute Behavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,263,1994
inhalation
mouse
lethal concentration (50 percent kill): 72,600 mg/m3/30 minute Behavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,263,1994
inhalation
rat
lethal concentration (50 percent kill): 308 gm/m3 Behavioral: General anesthetic TOXID9 1,79,1981
inhalation
rat
lethal concentration (50 percent kill): 309 gm/m3/4 hour N/R FEREAC 70,28436,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 2 pph/6 hour/30 week- intermittent Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 11,65,1978
inhalation
rat
lowest published toxic concentration: 5 pph/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0590013
inhalation
rat
lowest published toxic concentration: 0.2 pph/6 hour/24 week- intermittent Liver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,263,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,49,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (760 mg/m3), short term exposure limit 500 ppm (950 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (1920 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 1000 ppm (1885 mg/m3), OCT 2002
Occupational Exposure Limit - EC time-weighted average 1920 mg/m3 (1000 ppm), FEB 2006
Occupational Exposure Limit - FRANCE VME 1000 ppm (1920 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 1900 mg/m3 (1000 mL/m3), 2005
Occupational Exposure Limit - HUNGARY time-weighted average 1920 mg/m3, short term exposure limit 7680 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 950 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 400 ppm (766 mg/m3);
short term exposure limit 500 ppm (958 mg/m3), JAN2002
Occupational Exposure Limit - RUSSIA time-weighted average 200 mg/m3, short term exposure limit 600 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 500 ppm (950 mg/m3);
short term exposure limit 800 ppm (1500 mg/m3), JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (1910 mg/m3), DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 400 ppm (766 mg/m3);
short term exposure limit 500 ppm, 2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81811;
Number of Industries 7;
Total Number of Facilities 897;
Number of Occupations 12;
Total Number of Employees Exposed 50,005
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81811;
Number of Industries 3;
Total Number of Facilities 223;
Number of Occupations 8;
Total Number of Employees Exposed 2,282;
Total Number of Female Employees Exposed 75


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
   Reproductive Effector
   Human Data

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