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Registry of Toxic Effects of Chemical Substances (RTECS)

Methyl ether

RTECS #

PM4780000

CAS #

115-10-6

Updated

July 2013

Molecular Weight

46.08

Molecular Formula

C2H6O

Synonyms

Demeon D
Dimethyl oxide
DME
Dymel A
Ether, dimethyl
Ether, methyl
Methane, oxybis- (9CI)
Methoxymethane
Wood ether

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 20000 ppm (6-15D pregnant)Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
HPV210 -,-,2000
intraperitoneal/hamster 200 mg/kg (8D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)VCVGK* -,263,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog lowest published toxic concentration: 200000 ppm/5MCardiac: Other changesHPV210 -,-,2000
inhalation/human lowest published toxic concentration: 8.2 pph/21MEye: Other eye effects

Behavioral: Ataxia
VCVGK* -,263,1994
inhalation/human lowest published toxic concentration: 8.2 pph/30MPeripheral Nerve and Sensation: Sensory change involving peripheral nerveVCVGK* -,263,1994
inhalation/human lowest published toxic concentration: 14 pph/26MBehavioral: General anestheticVCVGK* -,263,1994
inhalation/human lowest published toxic concentration: 50000 ppm/60MBehavioral: Somnolence (general depressed activity)HPV210 -,-,2000
inhalation/human lowest published toxic concentration: 82000 ppm/60MEye: Other eye effects

Behavioral: Somnolence (general depressed activity)
HPV210 -,-,2000
inhalation/human lowest published toxic concentration: 100000 ppm/60MEye: Other eye effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in psychophysiological tests
HPV210 -,-,2000
inhalation/human lowest published toxic concentration: 200000 ppm/17MBehavioral: General anestheticHPV210 -,-,2000
inhalation/mouse lethal concentration (50 percent kill): 93000 mg/m3/15MBehavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,263,1994
inhalation/mouse lethal concentration (50 percent kill): 72600 mg/m3/30MBehavioral: Change in motor activity (specific assay)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
VCVGK* -,263,1994
inhalation/rat lethal concentration (50 percent kill): 308 gm/m3Behavioral: General anestheticTOXID9 1,79,1981
inhalation/rat lethal concentration (50 percent kill): 309 gm/m3/4HFEREAC 70,28436,2005
inhalation/rat lethal concentration (50 percent kill): 164000 ppm/4HBehavioral: Ataxia

Behavioral: Coma
HPV210 -,-,2000

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 2 pph/6H/30W- intermittentLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TXCYAC 11,65,1978
inhalation/rat lowest published toxic concentration: 5 pph/6H/2W- intermittentOlfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0590013
inhalation/rat lowest published toxic concentration: 0.02 pph/6H/24W- intermittentLiver: Hepatitis, fibrous (cirrhosis, post- necrotic scarring)

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
VCVGK* -,263,1994
inhalation/rat lowest published toxic concentration: 10000 ppm/2Y- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldHPV210 -,-,2000
inhalation/rat lowest published toxic concentration: 25000 ppm/0.5Y- intermittentBlood: Other hemolysis with or without anemia

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
HPV210 -,-,2000

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWENTOX* -,49,2005

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRALIAtime-weighted average 400 ppm (760 mg/m3), short term exposure limit 500 ppm (950 mg/m3), JUL2008
Occupational Exposure Limit-AUSTRIAMAK-TMW 1000 ppm (1910 mg/m3);KZW 2000 ppm (3820 mg/m3), 2007
Occupational Exposure Limit-BELGIUMtime-weighted average 1000 ppm (1920 mg/m3), MAR2002
Occupational Exposure Limit-DENMARKtime-weighted average 1000 ppm (1885 mg/m3), MAY2011
Occupational Exposure Limit-ECtime-weighted average 1920 mg/m3 (1000 ppm), JUN2000
Occupational Exposure Limit-FINLANDtime-weighted average 1000 ppm (2000 mg/m3), NOV2011
Occupational Exposure Limit-FRANCEVME 1000 ppm (1920 mg/m3), FEB2006
Occupational Exposure Limit-GERMANYMAK 1000 ppm (1900 mg/m3), 2011
Occupational Exposure Limit-HUNGARYtime-weighted average 1920 mg/m3, short term exposure limit 7680 mg/m3, SEP2000
Occupational Exposure Limit-ICELANDtime-weighted average 1000 ppm (1885 mg/m3), NOV2011
Occupational Exposure Limit-NEW ZEALANDtime-weighted average 400 ppm (766 mg/m3); short term exposure limit 500 ppm (958 mg/m3), JAN2002
Occupational Exposure Limit-PERUtime-weighted average 1000 ppm (1888 mg/m3), JUL2005
Occupational Exposure Limit-RUSSIAtime-weighted average 200 mg/m3, short term exposure limit 600 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 500 ppm (950 mg/m3);short term exposure limit 800 ppm (1500 mg/m3), JUN2005
Occupational Exposure Limit-SWITZERLANDMAK-week 1000 ppm (1910 mg/m3), JAN2011
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 950 mg/m3, 2003
Occupational Exposure Limit-UNITED KINGDOMtime-weighted average 400 ppm (766 mg/m3);short term exposure limit 500 ppm (958 mg/m3), OCT2007

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 81811; Number of Industries 3; Total Number of Facilities 223; Number of Occupations 8; Total Number of Employees Exposed 2282; Total Number of Female Employees Exposed 75
National Occupational Hazard Survey 1974Hazard Code 81811; Number of Industries 7; Total Number of Facilities 897; Number of Occupations 12; Total Number of Employees Exposed 50005

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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