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Registry of Toxic Effects of Chemical Substances (RTECS)

Methionine, DL-

RTECS #

PD0456000

CAS #

59-51-8

Updated

June 2000

Molecular Weight

149.23

Molecular Formula

C5H11NO2S

Synonyms

(+-)-Methionine
Acimetion
alpha-Amino-gamma-methylmercaptobutyric acid
Banthionine
Cynaron
DL-2-Amino-4-(methylthio)butyric acid
DL-Methionine (9CI)
Dyprin
Lactet
Lobamine
Meonine
Mertionin
Methilanin
Metione
Neston
Racemethionine

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 40 gm/kg (1-20D pregnant)Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
JRPFA4 33,109,1973

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lowest published lethal dose: 1500 mg/kgYACHDS 5,2041,1977
intraperitoneal/rat lowest published lethal dose: 2 gm/kgYACHDS 5,2041,1977
intravenous/mouse lowest published lethal dose: 300 mg/kgYACHDS 5,2041,1977
intravenous/rat Lethal dose: >400 mg/kgYACHDS 5,2041,1977
oral/mouse lowest published lethal dose: 4 gm/kgYACHDS 5,2041,1977
oral/rat Lethal dose: >5 gm/kgYACHDS 5,2041,1977

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 36 gm/kg/30D- continuousBlood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count
JONUAI 79,101,1963
oral/rat lowest published toxic dose: 21 gm/kg/13D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight
JONUAI 106,1714,1976
oral/rat lowest published toxic dose: 39 gm/kg/20D- continuousLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight
JONUAI 106,1714,1976
oral/turkey lowest published toxic dose: 33600 mg/kg/4W- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gainPOSCAL 57,699,1978

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X3271; Number of Industries 5; Total Number of Facilities 1272; Number of Occupations 27; Total Number of Employees Exposed 16781; Total Number of Female Employees Exposed 4397

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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