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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, trifluoro-

RTECS #

PB6900000

CAS #

75-46-7

Updated

July 2010

Molecular Weight

70.02

Molecular Formula

CHF3

Synonyms

Arcton 1
Carbon trifluoride
FC 23 (fluorocarbon)
Fluoroform
Fluoryl
Freon 23
Freon F-23
Freon R 23
Genetron-23
Halocarbon 23
Methyl trifluoride
R 23
R 23 (halocarbon)
Trifluoromethane

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
sex chromosome loss and nondisjunctioninhalation/Drosophila melanogaster98 pph/10MENVRAL 7,275,1974

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/guinea pig lethal concentration (50 percent kill): >200000 ppm/2HHPV412 -,-,2007
inhalation/rat lethal concentration (50 percent kill): >663000 ppm/4HBehavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression
HPV412 -,-,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3000 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code 82197; Number of Industries 2; Total Number of Facilities 14; Number of Occupations 4; Total Number of Employees Exposed 529; Total Number of Female Employees Exposed 353
National Occupational Hazard Survey 1974Hazard Code 82197; Number of Industries 1; Total Number of Facilities 11; Number of Occupations 3; Total Number of Employees Exposed 357

Status in Federal Agencies

OrganizationReference
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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