CDC logo, Safer Healthier People  CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us






Methanesulfenyl chloride, trichloro -

RTECS #: PB0370000

CAS #: 594-42-3


UPDATE: May 2009 MW: 185.87 MF: CCl4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Clairsit
  2. Mercaptan methylique perchlore (French)
  3. Perchlormethylmerkaptan (Czech)
  4. Perchloromethyl mercaptan
  5. Perchloromethyl mercaptan (ACGIH:OSHA)
  1. RCRA waste number P118
  2. Trichloromethane sulfenyl chloride
  3. Trichloromethanesulphenyl chloride
  4. Trichloromethylsulfenyl chloride
  5. Trichloromethylsulphenyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
50 g/24 hour severe 28ZPAK -,13,1972
skin
rabbit
500 mg/24 hour severe 28ZPAK -,13,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lethal concentration (50 percent kill): 296 mg/m3/2 hour N/R 85GMAT -,97,1982
inhalation
rat
lethal concentration (50 percent kill): 11 ppm/1 hour N/R TXAPA9 42,417,1977
intraperitoneal
mouse
lethal dose (50 percent kill): 10 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Skin and Appendages: Other: Hair
NTIS** OTS0533569
intraperitoneal
rat
lethal dose (50 percent kill): 25 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Skin and Appendages: Other: Hair
NTIS** OTS0533569
intravenous
mouse
lethal dose (50 percent kill): 56 mg/kg N/R CSLNX* NX#06768
oral
mouse
lethal dose (50 percent kill): 400 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Skin and Appendages: Other: Hair
NTIS** OTS0533569
oral
rat
lethal dose (50 percent kill): 82,600 g/kg N/R 28ZPAK -,13,1972
skin
guinea pig
lethal dose (50 percent kill): 500 L/kg Skin: After systemic exposure: Dermatitis, other NTIS** OTS0533569
skin
rabbit
lethal dose (50 percent kill): 1,410 mg/kg N/R TXAPA9 42,417,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Nausea or vomiting
NTIS** OTS0558749
inhalation
guinea pig
lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory stimulation

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** OTS0558749
inhalation
rat
lowest published toxic concentration: 1 ppm/8 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes NTIS** OTS0558749


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.8 mg/m3) DTLVS* 3,202,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.8 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.76 mg/m3), JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.77 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.8 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.8 mg/m3), FEB2006
Occupational Exposure Limit - KOREA time-weighted average 0.1 ppm (0.8 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.1 ppm (0.8 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.8 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.1 ppm (0.76 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JUN2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.8 mg/m3), DEC2006
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.8 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PERCHLOROMETHYL MERCAPTAN-air 10 hour time-weighted average 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 54800;
Number of Industries 6;
Total Number of Facilities 324;
Number of Occupations 17;
Total Number of Employees Exposed 9,112;
Total Number of Female Employees Exposed 1,677


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an intermediate for the synthesis of dyes and fungicides
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8978;8EHQ-0892-9092
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an intermediate for the synthesis of dyes and fungicides

RTECS Compound Description:
   Primary Irritant

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us