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Registry of Toxic Effects of Chemical Substances (RTECS)

Methanesulfonyl chloride

RTECS #

PB2790000

CAS #

124-63-0

Updated

February 2006

Molecular Weight

114.55

Molecular Formula

CH3ClO2S

Synonyms

Chloromethyl sulfone
Mesyl chloride
Methanesulfonic acid chloride
Methanesulphonyl chloride
Methyl sulfochloride
Methylsulfonyl chloride

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 mg severeNTIS** OTS0571119
skin /rabbit 500 mg severeNTIS** OTS0571119

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisovary/hamster32 µmol/LMUREAV 390,105,1997
mutation in microorganisms/Salmonella typhimurium250 µg/plate (+enzymatic activation step)MUREAV 320,165,1994

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat Lowest published lethal concentration: 620 mg/m3/6HLung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands

Skin and Appendages: Other: Hair
NTIS** OTS0571119
intraperitoneal/mouse lethal dose (50 percent kill): 10 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
NTIS** OTS0571119
intraperitoneal/rat lowest published lethal dose: 5 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0571119
oral/mouse lethal dose (50 percent kill): 200 mg/kgKidney, Ureter, and Bladder: HematuriaNTIS** OTS0571119
oral/rat lethal dose (50 percent kill): 50 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Kidney, Ureter, and Bladder: Hematuria
NTIS** OTS0571119
skin/guinea pig lethal dose (50 percent kill): 100 µL/kgSkin: After systemic exposure: Dermatitis, otherNTIS** OTS0571119

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 500 mg/kg/2W- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Changes in structure or function of esophagus

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0571119

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 4 mg/m3, Skin, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5012; Number of Industries 1; Total Number of Facilities 17; Number of Occupations 1; Total Number of Employees Exposed 851; Total Number of Female Employees Exposed 187

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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