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Methane, dichloro -

RTECS #: PA8050000

CAS #: 75-09-2


UPDATE: May 2009 MW: 84.93 MF: CH2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aerothene MM
  2. Chlorure de methylene (French)
  3. Dichloromethane
  4. Dichloromethane (DOT:OSHA)
  5. F 30 (chlorocarbon)
  6. Freon 30
  7. HCC 30
  8. Khladon 30
  9. Methane dichloride
  10. Methylene bichloride
  11. Methylene chloride
  1. Methylene chloride (ACGIH:OSHA)
  2. Methylene dichloride
  3. Metylenu chlorek (Polish)
  4. NCI - C50102
  5. Narkotil
  6. R 30
  7. R30 (refrigerant)
  8. RCRA waste number U080
  9. Solaesthin
  10. Soleana VDA
  11. Solmethine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
162 mg moderate EJTXAZ 9,171,1976
eye
rabbit
10 mg mild TXCYAC 6,173,1976
eye
rabbit
500 mg/24 hour mild 85JCAE -,88,1986
skin
rabbit
810 mg/24 hour severe EJTXAZ 9,171,1976
skin
rabbit
100 mg/24 hour moderate 85JCAE -,88,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 1 Ámol/L TECSDY 13,205,1987
cytogenetic analysis hamster ovary 6,628 mg/L MUREAV 116,361,1983
cytogenetic analysis inhalation
mouse
27,760 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
DNA damage hamster ovary 3,000 ppm MUREAV 367,143,1996
DNA damage hamster fibroblast 5 mmol/L/2 hour MUREAV 577S,1,2005
DNA damage human lung 1,000 Ámol/L/3 hour MUREAV 538,41,2003
DNA damage mouse liver 400 Ámol/L CRNGDP 15,991,1994
DNA damage inhalation
mouse
4,000 ppm/6 hour- continuous CRNGDP 15,991,1994
DNA damage oral
mouse
1,720 mg/kg MUREAV 419,13,1998
DNA damage oral
rat
1,275 mg/kg TCMUD8 9,61,1989
DNA damage rat liver 30 Ámol/L CRNGDP 15,991,1994
DNA inhibition hamster lung 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
DNA inhibition human fibroblast 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
mutation in microorganisms Escherichia coli 6,300 ppm (+/-enzymatic activation step) EMMUEG 20,211,1992
mutation in microorganisms Salmonella typhimurium 5,700 ppm (+/-enzymatic activation step) MUREAV 56,245,1978
micronucleus test inhalation
mouse
27,760 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
mutation in mammalian somatic cells hamster ovary 3,000 ppm MUREAV 367,143,1996
morphological transform hamster embryo 1,300 ÁL/plate EVSRBT 25,75,1982
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform rat embryo 160 Ámol/L ITCSAF 14,290,1978
other mutation test systems hamster ovary 6,628 mg/L MUREAV 116,361,1983
phage inhibition capacity Escherichia coli 8,250 Ág/well MUREAV 260,349,1991
sister chromatid exchange hamster lung 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
sister chromatid exchange inhalation
mouse
13,880 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
sex chromosome loss and nondisjunction oral
Drosophila melanogaster
125 mmol/L MUREAV 90,91,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 32,84,1975
inhalation
rat
lowest published toxic concentration: 4,500 ppm/24 hour (1-17 day pregnant) Reproductive: Effects on newborn: Behavioral TXAPA9 52,29,1980
inhalation
rat
lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system
TXAPA9 32,84,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 2,000 ppm/5 hour/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors
NTPTR* NTP-TR-306,1986
inhalation
mouse
lowest published toxic concentration: 122,400 mg/kg/102 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors
NTIS** PB86-187903/AS
inhalation
rat
lowest published toxic concentration: 3,500 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors
FAATDF 4,30,1984
inhalation
rat
lowest published toxic concentration: 122,400 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors
NTIS** PB86-187903/AS
inhalation
rat
lowest published toxic concentration: 102,000 mg/kg/102 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Blood: Leukemia
NTIS** PB86-187903/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
eye
rabbit
lowest published toxic dose: 0.25 mL/kg Eye: Increased intraocular pressure

Eye: Conjunctiva irritation

Eye: Corneal damage
VCVGH* -,323,1990
inhalation
cat
lowest published lethal concentration: 43,400 mg/m3/4.5 hour Behavioral: General anesthetic

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease
AHBAAM 116,131,1936
inhalation
dog
lowest published lethal concentration: 14,108 ppm/7 hour Eye: Miosis (pupilliary constriction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea
NIHBAZ 191,1,1949
inhalation
guinea pig
lowest published lethal concentration: 5,000 ppm/2 hour N/R FLCRAP 1,197,1967
inhalation
guinea pig
lethal concentration (50 percent kill): 40,200 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
guinea pig
lowest published toxic concentration: 21,000 mg/m3/45 minute Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
human
lowest published toxic concentration: 500 ppm/1 year- intermittent Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate
ABHYAE 43,1123,1968
inhalation
human
lowest published toxic concentration: 500 ppm/8 hour Behavioral: Euphoria SCIEAS 176,295,1972
inhalation
human
lowest published toxic concentration: 69,600 mg/m3/30 minute Behavioral: General anesthetic VCVGH* -,321,1990
inhalation
human
lowest published toxic concentration: 25,000 mg/m3/8 minute Peripheral Nerve and Sensation: Paresthesia

Eye: Conjunctiva irritation
VCVGH* -,321,1990
inhalation
human
lowest published toxic concentration: 8,000 mg/m3/30 minute Gastrointestinal: Nausea or vomiting VCVGH* -,321,1990
inhalation
mouse
lethal concentration (50 percent kill): 14,400 ppm/7 hour N/R NIHBAZ 191,1,1949
inhalation
mouse
lowest published toxic concentration: 32,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse
lethal concentration (50 percent kill): 49,100 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
mouse
lethal concentration (16 percent kill): 53,000 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
mouse
lethal concentration (50 percent kill): 54,000 mg/m3/2 hour N/R VCVGH* -,320,1990
inhalation
mouse
lethal concentration (84 percent kill): 75,000 mg/m3/2 hour N/R VCVGH* -,320,1990
inhalation
mouse
lethal concentration (50 percent kill): 56,220 mg/m3/7 hour N/R VCVGH* -,320,1990
inhalation
mouse
lowest published toxic concentration: 40,000 mg/m3 Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
mouse
lowest published toxic concentration: 17,000 mg/m3/2 hour Behavioral: Somnolence (general depressed activity) VCVGH* -,320,1990
inhalation
mouse
lowest published toxic concentration: 35 gm/m3/2 hour Brain and Coverings: Changes in circulation

Brain and Coverings: Other degenerative changes

Behavioral: General anesthetic
TPKVAL 1,96,1961
inhalation
mouse
lethal concentration : 50 gm/m3/2 hour Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory obstruction

Liver: Fatty liver degeneration
TPKVAL 1,96,1961
inhalation
mouse
lowest published toxic concentration: 15 gm/m3/2 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia
TPKVAL 1,96,1961
inhalation
mouse
lethal concentration (50 percent kill): 25 gm/m3/2 hour Behavioral: Alteration of classical conditioning

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)
TPKVAL 1,96,1961
inhalation
mouse
lethal concentration : 30 gm/m3/2 hour Skin: After systemic exposure: Dermatitis, other TPKVAL 1,96,1961
inhalation
mouse
lowest published toxic concentration: 10 gm/m3/2 hour N/R TPKVAL 1,96,1961
inhalation
rat
lethal concentration (50 percent kill): 76,000 mg/m3/4 hour N/R VCVGH* -,320,1990
inhalation
rat
lethal concentration (50 percent kill): 52,000 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
rat
lowest published toxic concentration: 50,000 mg/m3 Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/30 minute Endocrine: Adrenal cortex hyperplasia

Behavioral: Alteration of classical conditioning
VCVGH* -,320,1990
inhalation
rat
lethal concentration : 52,000 mg/m3 Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TPKVAL 15,64,1979
inhalation
rat
lowest published toxic concentration: 1 gm/m3/1 hour N/R TPKVAL 1,96,1961
inhalation
rabbit
lowest published lethal concentration: 10,000 ppm/7 hour N/R JIHTAB 26,8,1944
intraperitoneal
dog
lethal dose (50 percent kill): 1,274 mg/kg N/R TXAPA9 10,119,1967
intraperitoneal
mouse
lethal dose (50 percent kill): 437 mg/kg N/R AGGHAR 18,109,1960
intraperitoneal
mouse
lowest published toxic dose: 509.58 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia JAPTO* 27,25,2007
intraperitoneal
rat
lethal dose (50 percent kill): 916 mg/kg N/R ENVRAL 40,411,1986
intraperitoneal
rat
lowest published toxic dose: 510 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia VCVGH* -,320,1990
intratracheal
rat
lowest published lethal dose: 350 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema
NTIS** OTS0520615
intravenous
dog
lowest published lethal dose: 200 mg/kg N/R QJPPAL 7,205,1934
intravenous
mouse
lowest published toxic dose: 133 mg/kg Kidney, Ureter, and Bladder: Other changes VCVGH* -,320,1990
intravenous
rat
lowest published toxic dose: 1,000 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
VCVGH* -,320,1990
oral
dog
lowest published lethal dose: 3 gm/kg N/R QJPPAL 7,205,1934
oral
dog
lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGH* -,320,1990
oral
human
lowest published lethal dose: 357 mg/kg Peripheral Nerve and Sensation: Paresthesia

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold
34ZIAG -,390,1969
oral
man
lowest published toxic dose: 1,429 ÁL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Changes in: Fe
YAKUD5 36,575,1994
oral
mouse
lethal dose (50 percent kill): 873 mg/kg N/R EVHPAZ 106(Suppl 2),497,1998
oral
mouse
lethal dose (16 percent kill): 620 mg/kg N/R VCVGH* -,320,1990
oral
mouse
lethal dose (84 percent kill): 1,650 mg/kg N/R VCVGH* -,320,1990
oral
rat
lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Ataxia FAONAU 48A,94,1970
oral
rat
lethal dose (50 percent kill): 985 mg/kg N/R VCVGH* -,320,1990
oral
rat
lethal dose (16 percent kill): 800 mg/kg N/R VCVGH* -,320,1990
oral
rat
lethal dose (84 percent kill): 2,200 mg/kg N/R VCVGH* -,320,1990
oral
rat
lowest published toxic dose: 237.8 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVGH* -,321,1990
oral
rabbit
lowest published lethal dose: 1,900 mg/kg N/R HBTXAC 1,94,1955
oral
rabbit
lethal dose (50 percent kill): 2,000 mg/kg N/R VCVGH* -,320,1990
subcutaneous
mouse
lethal dose (50 percent kill): 6,460 mg/kg N/R TXAPA9 4,354,1962
subcutaneous
rabbit
lowest published lethal dose: 2,700 mg/kg N/R QJPPAL 7,205,1934
skin
mouse
lowest published lethal dose: 100 pph/30 minute Skin: After topical application: Corrosive TPKVAL 1,96,1961
unreported route
mouse
lethal dose (50 percent kill): 4,770 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from small intestine
ESKGA2 28,P31,1982
unreported route
rat
lethal dose (50 percent kill): 5,350 mg/kg N/R GISAAA 53(6),78,1988
unreported route
rabbit
lethal dose (50 percent kill): 1,225 mg/kg N/R GISAAA 53(6),78,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
dog
lowest published toxic concentration: 1,000 ppm/24 hour/7 week- continuous Behavioral: Food intake (animal)

Musculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD746-295
inhalation
dog
lowest published toxic concentration: 5,000 ppm/6 hour/12 week- intermittent Behavioral: Hallucinations, distorted perceptions

Behavioral: Ataxia

Behavioral: Antipsychotic
NTIS** OTS0555748
inhalation
dog
lowest published toxic concentration: 34 gm/m3/7 week- intermittent Behavioral: General anesthetic

Liver: Fatty liver degeneration
TPKVAL 1,96,1961
inhalation
guinea pig
lowest published toxic concentration: 552 ppm/6 hour/5 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport
AIHAAP 37,345,1976
inhalation
guinea pig
lowest published toxic concentration: 34 gm/m3/7 week- intermittent Behavioral: General anesthetic

Liver: Fatty liver degeneration
TPKVAL 1,96,1961
inhalation
monkey
lowest published toxic concentration: 5,000 ppm/24 hour/32 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTIS** AD746-295
inhalation
mouse
lowest published toxic concentration: 13,000 ppm/6 hour/19 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-306,1986
inhalation
mouse
lowest published toxic concentration: 150 ppm/24 hour/30 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
APTOA6 59,73,1986
inhalation
mouse
lowest published toxic concentration: 5,000 ppm/24 hour/7 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 23,660,1972
inhalation
mouse
lowest published toxic concentration: 300 ppm/24 hour/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases
APTOA6 59,73,1986
inhalation
mouse
lowest published toxic concentration: 1.04 gm/m3/5 day- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 66,62,2002
inhalation
rat
lowest published toxic concentration: 3,700 ppm/5 hour/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOLED5 7,41,1980
inhalation
rat
lowest published toxic concentration: 5,000 ppm/24 hour/14 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight
NTIS** AD746-295
inhalation
rat
lowest published toxic concentration: 8,400 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
NTPTR* NTP-TR-306,1986
inhalation
rat
lowest published toxic concentration: 500 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
RCOCB8 32,535,1981
inhalation
rat
lowest published toxic concentration: 1,000 ppm/2 hour/3 week- intermittent Behavioral: Food intake (animal)

Liver: Other changes

Blood: Other changes
HOCHE8 8,64,1990
inhalation
rat
lowest published toxic concentration: 1,000 ppm/6 hour/3 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
TXCYAC 29,293,1984
inhalation
rat
lowest published toxic concentration: 2,800 mg/m3/4 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes
TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 2,800 mg/m3/8 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 2,800 mg/m3/27 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 880 mg/m3/4 day- intermittent Peripheral Nerve and Sensation: Recording from peripheral motor nerve TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 880 mg/m3/15 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TPKVAL 15,76,1979
inhalation
rat
lowest published toxic concentration: 0.4 gm/m3/91 day- intermittent Brain and Coverings: Other degenerative changes TPKVAL 1,72,1961
inhalation
rat
lowest published toxic concentration: 0.45 gm/m3/91 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 1,96,1961
inhalation
rat
lowest published toxic concentration: 0.25 gm/m3/24 day- intermittent Behavioral: Alteration of classical conditioning TPKVAL 1,96,1961
inhalation
rat
lowest published toxic concentration: 5,000 ppm/28 day- intermittent Liver: Changes in liver weight

Endocrine: Differential effect of sex or castration on observed toxicity

Endocrine: Changes in spleen weight
JTEHF8 66,1207,2003
oral
mouse
lowest published toxic dose: 1,862 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) DCTODJ 6,563,1983
oral
mouse
lowest published toxic dose: 52,740 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
FCTOD7 24,943,1986
oral
rat
lowest published toxic dose: 14,940 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration
FCTOD7 24,943,1986
oral
rat
lowest published toxic dose: 91 gm/kg/2 year- continuous Behavioral: Fluid intake

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
FCTOD7 24,951,1986
skin
rat
lowest published toxic dose: 39,270 mg/kg/17 week- intermittent Liver: Other changes

Liver: Changes in liver weight
GTPZAB 26(5),41,1982
skin
rabbit
lowest published toxic dose: 100 pph/4 week- intermittent Skin: After topical application: Primary irritation TPKVAL 1,96,1961


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 41,43,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,251,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,43,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,251,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,251,1999
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004
TOXICOLOGY REVIEW
EMMUEG 39,69,2002
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
DIMON* 46,551,2000
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 628,67,2007
TOXICOLOGY REVIEW
ENTOX* -,92,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 636,242,2007
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HUTOX* -,661,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HUTOX* -,683,1996
TOXICOLOGY REVIEW
HUTOX* -,577,1996
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,263,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (1750 mg/m3) DTLVS* 3,171,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm;
ceiling concentration 1000 ppm;
peak concentration 2000 ppm/5 minute/2 hour
CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see 56 FR 57036 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (1740 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (1740 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (174 mg/m3), Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (177 mg/m3), MAR2002
Occupational Exposure Limit - DENMARK time-weighted average 35 ppm (122 mg/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (350 mg/m3), short term exposure limit 250 ppm (870 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (180 mg/m3), VLE 100 ppm, continuous3 Carcinogen, FEB2006
Occupational Exposure Limit - HUNGARY time-weighted average 10 mg/m3, short term exposure limit 10 mg/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 50 ppm (170 mg/m3), Occupational Exposure Limit- continuous 100 ppm (340 mg/m3), skin, 2B carc, APR2007
Occupational Exposure Limit - KOREA time-weighted average 50 ppm (175 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 100 ppm (330 mg/m3);
short term exposure limit 500 ppm (1740 mg/m3), 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 350 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 50 ppm (174 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 35 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (1740 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, short term exposure limit 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 50 mg/m3, short term exposure limit 100 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 35 ppm (120 mg/m3);
short term exposure limit 70 ppm (250 mg/m3), Skin, Carcinogen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (180 mg/m3), DEC2006
Occupational Exposure Limit - THAILAND time-weighted average 500 mg/m3, short term exposure limit 1000 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (1740 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 100 ppm (350 mg/m3);
short term exposure limit 300 ppm (skin), 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed animal carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed animal carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLENE CHLORIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47270;
Number of Industries 374;
Total Number of Facilities 89,025;
Number of Occupations 192;
Total Number of Employees Exposed 975,696
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47270;
Number of Industries 363;
Total Number of Facilities 87,086;
Number of Occupations 212;
Total Number of Employees Exposed 1,438,196;
Total Number of Female Employees Exposed 352,536


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108026)
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a paint remover, degreaser, solvent and in aerosol propellants
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 46, 1986
NIOSH Analytical Method, 1994: Methylene chloride, 1005
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #80


REFERENCES:

CODEN
REFERENCE

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABHYAE Abstracts on Hygiene. (Bureau of Hygiene and Tropical Diseases, Keppel St., London WC1E 7HT, UK) V.1- 1926-
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EVSRBT Environmental Science Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FLCRAP Fluorine Chemistry Reviews. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
HOCHE8 Hochudoku. (Nippon Hochudoku Gakkai, c/o Kyushu Daigaku Igakubu Hoigaku Kyoshitsu, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812, Japan) V.8- 1990-
HTOPA*
HUTOX*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
ITCSAF In Vitro. (Rockville, MD) V.1-20, 1965-85. For publisher information, see ICDBEO.
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIHBAZ National Institutes of Health, Bulletin. (Bethesda, MD)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as a paint remover, degreaser, solvent and in aerosol propellants

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

Click Here for Additional Information about RTECS

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