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Methane, dibromo -

RTECS #: PA7350000

CAS #: 74-95-3


UPDATE: May 2008 MW: 173.85 MF: CH2Br2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Methylene bromide
  2. Methylene dibromide
  1. RCRA waste number U068


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 1 µmol/L TECSDY 13,205,1987
mutation in microorganisms Escherichia coli 0.35 mmol/L/90 minute CRTOEC 17,742,2004
mutation in microorganisms Salmonella typhimurium 100 ng/plate (+enzymatic activation step) BECTA6 24,590,1980
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 13,205,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 40 gm/m3/2 hour N/R 85GMAT -,83,1982
inhalation
rat
lowest published toxic concentration: 1,000 mg/m3/2 hour Brain and Coverings: Changes in surface EEG VCVGH* -,579,1990
inhalation
rat
lethal concentration (50 percent kill): 40,000 mg/m3 N/R VCVGH* -,579,1990
oral
rat
lethal dose (50 percent kill): 108 mg/kg N/R NTIS** PB85-143766
oral
rabbit
lethal dose (50 percent kill): 1 gm/kg N/R DOWCC* MSD-472
rectal
rabbit
lowest published lethal dose: 5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 34,223,1928
subcutaneous
mouse
lethal dose (50 percent kill): 3,738 mg/kg N/R TXAPA9 4,354,1962
skin
rabbit
lethal dose (50 percent kill): >4 gm/kg N/R DOWCC* MSD-472


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
human
lowest published toxic concentration: 40 mg/m3/2 year- intermittent Behavioral: Anorexia (human)

Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea
VCVGH* -,579,1990
oral
rat
lowest published toxic dose: 333 mg/kg/28 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
BECTA6 41,515,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
MUREAV 636,242,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4051;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 2;
Total Number of Employees Exposed 1,065;
Total Number of Female Employees Exposed 452


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data

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