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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, dibromo-

RTECS #

PA7350000

CAS #

74-95-3

Updated

July 2010

Molecular Weight

173.85

Molecular Formula

CH2Br2

Synonyms

Methylene bromide
Methylene dibromide
RCRA waste number U068

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster1 µmol/LTECSDY 13,205,1987
mutation in microorganisms/Escherichia coli0.035 mmol/L/90MCRTOEC 17,742,2004
mutation in microorganisms/Salmonella typhimurium100 ng/plate (+enzymatic activation step)BECTA6 24,590,1980
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 13,205,1987
specific locus testovary/hamster0.1 mmol/L/2HMUREAV 684,35,2010

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 40 gm/m3/2H85GMAT -,83,1982
inhalation/rat lowest published toxic concentration: 1000 mg/m3/2HBrain and Coverings: Changes in surface EEGVCVGH* -,579,1990
inhalation/rat lethal concentration (50 percent kill): 40000 mg/m3VCVGH* -,579,1990
oral/rabbit lethal dose (50 percent kill): 1 gm/kgDOWCC* MSD-472
oral/rat lethal dose (50 percent kill): 108 mg/kgNTIS** PB85-143766
rectal/rabbit lowest published lethal dose: 5 gm/kgBehavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands
JPETAB 34,223,1928
skin/rabbit lethal dose (50 percent kill): >4 gm/kgDOWCC* MSD-472
subcutaneous/mouse lethal dose (50 percent kill): 3738 mg/kgTXAPA9 4,354,1962

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/human lowest published toxic concentration: 40 mg/m3/2Y- intermittentBehavioral: Anorexia (human)

Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea
VCVGH* -,579,1990
oral/rat lowest published toxic dose: 333 mg/kg/28D- continuousBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
BECTA6 41,515,1988

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 636,242,2007

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 10 mg/m3, JUN2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X4051; Number of Industries 2; Total Number of Facilities 33; Number of Occupations 2; Total Number of Employees Exposed 1065; Total Number of Female Employees Exposed 452

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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