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Methane, bromodichloro -

RTECS #: PA5310000

CAS #: 75-27-4


UPDATE: February 2009 MW: 163.83 MF: CHBrCl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. BDCM
  2. Bromo - dichloromethane
  3. Bromodichloromethane
  4. Dichlorobromomethane
  1. Dichloromonobromomethane
  2. Monobromodichloromethane
  3. NCI - C55243


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 µmol/L TECSDY 13,205,1987
cytogenetic analysis intraperitoneal
rat
164 mg/kg MUREAV 242,111,1990
DNA damage human lung 10 µmol/L/3 hour MUREAV 538,41,2003
DNA damage human kidney 0.5 mmol/L/20 hour TXCYAC 204,187,2004
DNA damage rat kidney 0.5 mmol/L/20 hour TXCYAC 204,187,2004
DNA damage oral
rat
458 mg/kg TXCYAC 204,187,2004
mutation in microorganisms mouse lymphocyte 180 mg/L (+enzymatic activation step) EMMUEG 11,91,1988
mutation in microorganisms Salmonella typhimurium 50 mg/plate (+enzymatic activation step) DHEFDK FDA-78-1046,1978
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 13,205,1987
micronucleus test human kidney 2 mmol/L/48 hour TXCYAC 204,187,2004
micronucleus test inhalation
mouse
100 ppm/6 hour/7 day MUREAV 520,171,2002
micronucleus test inhalation
mouse
15 ppm/6 hour/13 week MUREAV 520,171,2002
micronucleus test rat kidney 1 mmol/L/48 hour TXCYAC 204,187,2004
micronucleus test oral
rat
458 mg/kg TXCYAC 204,187,2004
mutation in mammalian somatic cells mouse lymphocyte 180 mg/L EMMUEG 11,91,1988
sister chromatid exchange human lymphocyte 400 µmol/L ENVRAL 32,72,1983
sister chromatid exchange oral
mouse
200 mg/kg/4 day- intermittent ENVRAL 32,72,1983
sister chromatid exchange rat leukocyte 200 µmol/L MUREAV 300,241,1993


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) FAATDF 40,30,1997
oral
rat
lowest published toxic dose: 200 mg/kg (6-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 1,627.6 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral
rat
lowest published toxic dose: 4,247 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral
rat
lowest published toxic dose: 375 mg/kg (6-10 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TOSCF2 77,101,2004
oral
rat
lowest published toxic dose: 1,890 mg/kg (1-21 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TOXID9 60,216,2001


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 25,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral
mouse
toxic dose : 38,250 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-321,1987
oral
mouse
lowest published toxic dose: 12,875 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral
mouse
lowest published toxic dose: 38,625 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB88-168687
oral
rat
lowest published toxic dose: 25,500 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral
rat
toxic dose : 51 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral
rat
lowest published toxic dose: 51,500 mg/kg/13 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral
rat
lowest published toxic dose: 8,400 mg/kg/16 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral
rat
lowest published toxic dose: 6,500 mg/kg/26 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
JTEHF8 67,23,2004


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published lethal concentration: 450 mg/m3 N/R VCVGH* -,629,1990
inhalation
rat
lowest published toxic concentration: 100 ppm/4 hour Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 161,67,2001
oral
mouse
lethal dose (50 percent kill): 450 mg/kg Brain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Blood: Hemorrhage
TXAPA9 44,213,1978
oral
mouse
lowest published toxic dose: 50 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral
rat
lethal dose (50 percent kill): 430 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Other changes
SRTCAC 36(1-4),10,1989
oral
rat
lowest published toxic dose: 40 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,77,2003
oral
rat
lowest published toxic dose: 35 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral
rat
lowest published toxic dose: 20.5 mg/kg Liver: Liver function tests impaired TOXID9 66,49,2002
oral
rat
lowest published toxic dose: 400 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,236,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
mouse
lowest published toxic concentration: 10 ppm/6 hour/3 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 54,221,2000
inhalation
mouse
lowest published toxic concentration: 30 ppm/3 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation
mouse
lowest published toxic concentration: 30 ppm/3 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 60,279,2001
inhalation
mouse
lowest published toxic concentration: 150 ppm/1 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation
mouse
lowest published toxic concentration: 150 ppm/1 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field TOXID9 60,279,2001
oral
mouse
lowest published toxic dose: 3,500 mg/kg/14 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 46,117,1982
oral
mouse
lowest published toxic dose: 750 mg/kg/5 day- intermittent Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 94,3,1994
oral
mouse
lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-321,1987
oral
mouse
lowest published toxic dose: 19.04 gm/kg/100 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight IJTOFN 21,219,2002
oral
mouse
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral
mouse
lowest published toxic dose: 1,960 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral
mouse
lowest published toxic dose: 1,960 mg/kg/28 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 66,62,2002
oral
mouse
lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Liver: Other changes

Liver: Changes in liver weight
TOXID9 66,184,2002
oral
mouse
lowest published toxic dose: 4,550 mg/kg/26 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 66,184,2002
oral
mouse
lowest published toxic dose: 1,000 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ARTODN 78,410,2004
oral
mouse
lowest published toxic dose: 2,548 mg/kg/0.5 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral
mouse
: 336 mg/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-532
oral
mouse
: 672 mg/kg/21 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-532
oral
mouse
: 672 mg/kg/21 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight NTPTR* NTP-TR-532
oral
mouse
: 252 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-532
oral
rat
lowest published toxic dose: 750 mg/kg/5 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 94,3,1994
oral
rat
lowest published toxic dose: 5,670 mg/kg/4 week- continuous Liver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 17,119,1992
oral
rat
lowest published toxic dose: 19,500 mg/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-321,1987
oral
rat
lowest published toxic dose: 9,828 mg/kg/9 week- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 50(4),80,1985
oral
rat
lowest published toxic dose: 20,075 mg/kg/2 year- continuous Liver: Fatty liver degeneration

Liver: Other changes

Liver: Changes in liver weight
JTSCDR 17,51,1992
oral
rat
lowest published toxic dose: 742 mg/kg/14 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
NTIS** PB97-111728
oral
rat
lowest published toxic dose: 1,232 mg/kg/14 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes NTIS** PB97-111728
oral
rat
lowest published toxic dose: 742 mg/kg/14 day- continuous Liver: Other changes NTIS** PB97-111728
oral
rat
lowest published toxic dose: 2,904.6 mg/kg/118 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
IJTOFN 21,115,2002
oral
rat
lowest published toxic dose: 5,366.9 mg/kg/118 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight

Skin and Appendages: Other: Hair
IJTOFN 21,115,2002
oral
rat
lowest published toxic dose: 3,127 mg/kg/106 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 21,115,2002
oral
rat
lowest published toxic dose: 2.84 gm/kg/104 week- continuous Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
IJTOFN 21,219,2002
oral
rat
lowest published toxic dose: 26.43 gm/kg/104 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
IJTOFN 21,219,2002
oral
rat
lowest published toxic dose: 375 mg/kg/5 day- intermittent Endocrine: Change in LH

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 77,101,2004
oral
rat
lowest published toxic dose: 1,000 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOXID9 78,91,2004
oral
rat
lowest published toxic dose: 2,000 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 78,91,2004
oral
rat
lowest published toxic dose: 1,400 mg/kg/28 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral
rat
lowest published toxic dose: 980 mg/kg/28 day- continuous Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral
rat
lowest published toxic dose: 1,225 mg/kg/28 day- continuous Liver: Other changes TOXID9 66,62,2002
oral
rat
lowest published toxic dose: 200 mg/kg/4 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition ARTODN 78,410,2004
oral
rat
lowest published toxic dose: 2,000 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
ARTODN 78,410,2004
oral
rat
lowest published toxic dose: 105 mg/kg/21 day- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake
TOXID9 60,216,2001
oral
rat
lowest published toxic dose: 375 mg/kg/5 day- intermittent Endocrine: Change in LH

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral
rat
lowest published toxic dose: 1,000 mg/kg/5 day- intermittent Endocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral
rat
lowest published toxic dose: 742 mg/kg/14 day- intermittent Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* RDGT94017
oral
rat
lowest published toxic dose: 1,232 mg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes NTPTR* RDGT94017
oral
rat
lowest published toxic dose: 742 mg/kg/14 day- intermittent Liver: Other changes NTPTR* RDGT94017
oral
rat
lowest published toxic dose: 1,232 mg/kg/14 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTPTR* RDGT94017
oral
rat
: 798 mg/kg/3 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-532
oral
rat
: 420 mg/kg/3 week- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight NTPTR* NTP-TR-532
oral
rat
: 126 mg/kg/3 week- intermittent Behavioral: Fluid intake NTPTR* NTP-TR-532
oral
rat
: 8,760 mg/kg/730 day- intermittent Liver: Other changes NTPTR* NTP-TR-532
oral
rabbit
lowest published toxic dose: 59.5 mg/kg/24 day- continuous Behavioral: Fluid intake TOXID9 60,216,2001
oral
rabbit
lowest published toxic dose: 1,783.2 mg/kg/24 day- continuous Behavioral: Food intake (animal) TOXID9 60,216,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 52,179,1991
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,179,1991
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1295,1999
TOXICOLOGY REVIEW
MUREAV 567,347,2004
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
TXCYAC 198,239,2004
TOXICOLOGY REVIEW
ENTOX* -,546,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BCLPT* 96,131,2005
TOXICOLOGY REVIEW
MUREAV 636,242,2007
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008
TOXICOLOGY REVIEW
MUREAV 659,248,2008
TOXICOLOGY REVIEW
MUREAV 659,202,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5772;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 3,266;
Total Number of Female Employees Exposed 502


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/167461/AS)
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical, chemical intermediate, solvent, emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (two year studies), October 2000
NTP Carcinogenesis studies; on test (prechronic studies), October 2000


REFERENCES:

CODEN
REFERENCE

ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
DHEFDK HEW Publication (FDA. United States). (Washington, DC) ?-1979(?). For publisher information, see HPFSDS.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

Used as an industrial chemical, chemical intermediate, solvent, emulsifier

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

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