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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromodichloro-

RTECS #

PA5310000

CAS #

75-27-4

Updated

December 2012

Molecular Weight

163.83

Molecular Formula

CHBrCl2

Synonyms

BDCM
Bromodichloromethane
Bromo-dichloromethane
Dichlorobromomethane
Dichloromonobromomethane
Monobromodichloromethane
NCI-C55243

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat164 mg/kgMUREAV 242,111,1990
Cytogenetic Analysislung/hamster10 µmol/LTECSDY 13,205,1987
DNA Damagelung/human10 µmol/L/3HMUREAV 538,41,2003
DNA Damagekidney/rat0.5 mmol/L/20HTXCYAC 204,187,2004
DNA Damageoral/rat458 mg/kgTXCYAC 204,187,2004
DNA Damagekidney/human0.5 mmol/L/20HTXCYAC 204,187,2004
DNA Damageother cell types/human1 µmol/L/4HMUREAV 741,89,2012
micronucleus testkidney/human2 mmol/L/48HTXCYAC 204,187,2004
micronucleus testkidney/rat1 mmol/L/48HTXCYAC 204,187,2004
micronucleus testoral/rat458 mg/kgTXCYAC 204,187,2004
micronucleus testinhalation/mouse100 ppm/6H/7DMUREAV 520,171,2002
micronucleus testinhalation/mouse15 ppm/6H/13WMUREAV 520,171,2002
mutation in mammalian somatic cellslymphocyte/mouse180 mg/LEMMUEG 11,91,1988
mutation in microorganismslymphocyte/mouse180 mg/L (+enzymatic activation step)EMMUEG 11,91,1988
mutation in microorganisms/Salmonella typhimurium50 mg/plate (+enzymatic activation step)DHEFDK FDA-78-1046,1978
mutation in microorganisms/Salmonella typhimurium10 µg/plate (-enzymatic activation step)TECSDY 13,205,1987
sister chromatid exchangelymphocyte/human400 µmol/LENVRAL 32,72,1983
sister chromatid exchangeleukocyte/rat200 µmol/LMUREAV 300,241,1993
sister chromatid exchangeoral/mouse200 mg/kg/4D- intermittentENVRAL 32,72,1983

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 750 mg/kg (6-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)FAATDF 40,30,1997
oral/rat 200 mg/kg (6-10D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)TOXID9 72,77,2003
oral/rat 1627.6 mg/kg (multigeneration)Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral/rat 4247 mg/kg (multigeneration)Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Other postnatal measures or effects
IJTOFN 21,115,2002
oral/rat 375 mg/kg (6-10D pregnant)Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
TOSCF2 77,101,2004
oral/rat 1890 mg/kg (1-21D pregnant)Reproductive: Specific developmental abnormalities: Musculoskeletal systemTOXID9 60,216,2001

Tumorigenic Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 25500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral/mouse toxic dose: 38250 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTPTR* NTP-TR-321,1987
oral/mouse lowest published toxic dose: 12875 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral/mouse lowest published toxic dose: 38625 mg/kg/103W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors
NTIS** PB88-168687
oral/rat lowest published toxic dose: 8400 mg/kg/16W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
TXCYAC 187,1,2003
oral/rat lowest published toxic dose: 6500 mg/kg/26W- intermittentTumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
JTEHF8 67,23,2004
oral/rat lowest published toxic dose: 51500 mg/kg/13W- intermittentTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTIS** PB88-168687
oral/rat toxic dose: 51 gm/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987
oral/rat lowest published toxic dose: 25500 mg/kg/2Y- continuousTumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Kidney, Ureter, and Bladder: Kidney tumors
NTPTR* NTP-TR-321,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/mouse Lowest published lethal concentration: 450 mg/m3VCVGH* -,629,1990
inhalation/rat lowest published toxic concentration: 100 ppm/4HLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TXCYAC 161,67,2001
oral/mouse lethal dose (50 percent kill): 450 mg/kgBrain and Coverings: Changes in circulation

Liver: Fatty liver degeneration

Blood: Hemorrhage
TXAPA9 44,213,1978
oral/mouse lowest published toxic dose: 50 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral/rat lowest published toxic dose: 35 mg/kgLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 72(Suppl 1),234,2003
oral/rat lowest published toxic dose: 20.5 mg/kgLiver: Liver function tests impairedTOXID9 66,49,2002
oral/rat lowest published toxic dose: 400 mg/kgLiver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TOXID9 60,236,2001
oral/rat lethal dose (50 percent kill): 430 mg/kgBehavioral: Somnolence (general depressed activity)

Behavioral: Tremor

Liver: Other changes
SRTCAC 36(1-4),10,1989
oral/rat lowest published toxic dose: 40 mg/kgNutritional and Gross Metabolic: Weight loss or decreased weight gainTOXID9 72,77,2003

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/mouse lowest published toxic concentration: 10 ppm/6H/3W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 54,221,2000
inhalation/mouse lowest published toxic concentration: 30 ppm/3W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 30 ppm/3W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 150 ppm/1W- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 60,279,2001
inhalation/mouse lowest published toxic concentration: 150 ppm/1W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldTOXID9 60,279,2001
oral/mouse lowest published toxic dose: 3500 mg/kg/14D- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
EVHPAZ 46,117,1982
oral/mouse lowest published toxic dose: 750 mg/kg/5D- intermittentLiver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TXCYAC 94,3,1994
oral/mouse lowest published toxic dose: 1400 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/mouse lowest published toxic dose: 4550 mg/kg/26W- intermittentLiver: Other changes

Liver: Changes in liver weight
TOXID9 66,184,2002
oral/mouse lowest published toxic dose: 4550 mg/kg/26W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
TOXID9 66,184,2002
oral/mouse lowest published toxic dose: 6500 mg/kg/13W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* NTP-TR-321,1987
oral/mouse lowest published toxic dose: 19.04 gm/kg/100W- continuousKidney, Ureter, and Bladder: Changes in kidney weightIJTOFN 21,219,2002
oral/mouse lowest published toxic dose: 1000 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Renal function tests depressed

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
ARTODN 78,410,2004
oral/mouse : 336 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/mouse : 672 mg/kg/21D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight
NTPTR* NTP-TR-532
oral/mouse : 672 mg/kg/21D- intermittentLung, Thorax, or Respiration: Changes in lung weightNTPTR* NTP-TR-532
oral/mouse lowest published toxic dose: 1960 mg/kg/28D- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/mouse lowest published toxic dose: 1960 mg/kg/28D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TOXID9 66,62,2002
oral/mouse lowest published toxic dose: 2548 mg/kg/0.5Y- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes
TOXID9 60,152,2001
oral/mouse : 252 mg/kg/4W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/rabbit lowest published toxic dose: 59.5 mg/kg/24D- continuousBehavioral: Fluid intakeTOXID9 60,216,2001
oral/rabbit lowest published toxic dose: 1783.2 mg/kg/24D- continuousBehavioral: Food intake (animal)TOXID9 60,216,2001
oral/rat lowest published toxic dose: 105 mg/kg/21D- continuousBehavioral: Food intake (animal)

Behavioral: Fluid intake
TOXID9 60,216,2001
oral/rat : 8760 mg/kg/730D- intermittentLiver: Other changesNTPTR* NTP-TR-532
oral/rat lowest published toxic dose: 1225 mg/kg/28D- continuousLiver: Other changesTOXID9 66,62,2002
oral/rat lowest published toxic dose: 2.84 gm/kg/104W- continuousLiver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains
IJTOFN 21,219,2002
oral/rat lowest published toxic dose: 26.43 gm/kg/104W- continuousKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight
IJTOFN 21,219,2002
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentEndocrine: Change in LH

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOSCF2 77,101,2004
oral/rat lowest published toxic dose: 1000 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionTOXID9 78,91,2004
oral/rat lowest published toxic dose: 2000 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
TOXID9 78,91,2004
oral/rat lowest published toxic dose: 1400 mg/kg/28D- intermittentKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/rat lowest published toxic dose: 750 mg/kg/5D- intermittentLiver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
TXCYAC 94,3,1994
oral/rat lowest published toxic dose: 5670 mg/kg/4W- continuousLiver: Changes in liver weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
JTSCDR 17,119,1992
oral/rat lowest published toxic dose: 19500 mg/kg/13W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldNTPTR* NTP-TR-321,1987
oral/rat lowest published toxic dose: 9828 mg/kg/9W- intermittentBlood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GISAAA 50(4),80,1985
oral/rat lowest published toxic dose: 20075 mg/kg/2Y- continuousLiver: Fatty liver degeneration

Liver: Other changes

Liver: Changes in liver weight
JTSCDR 17,51,1992
oral/rat lowest published toxic dose: 742 mg/kg/14D- continuousNutritional and Gross Metabolic: Weight loss or decreased weight gain

Behavioral: Food intake (animal)
NTIS** PB97-111728
oral/rat lowest published toxic dose: 1232 mg/kg/14D- continuousBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesNTIS** PB97-111728
oral/rat lowest published toxic dose: 742 mg/kg/14D- continuousLiver: Other changesNTIS** PB97-111728
oral/rat lowest published toxic dose: 2904.6 mg/kg/118D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Nutritional and Gross Metabolic: Dehydration
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 5366.9 mg/kg/118D- continuousKidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight

Skin and Appendages: Other: Hair
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 3127 mg/kg/106D- continuousBehavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
IJTOFN 21,115,2002
oral/rat lowest published toxic dose: 200 mg/kg/4D- intermittentKidney, Ureter, and Bladder: Other changes in urine compositionARTODN 78,410,2004
oral/rat lowest published toxic dose: 2000 mg/kg/4W- intermittentKidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes
ARTODN 78,410,2004
oral/rat lowest published toxic dose: 980 mg/kg/28D- continuousKidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other
TOXID9 44,365,2005
oral/rat lowest published toxic dose: 375 mg/kg/5D- intermittentEndocrine: Change in LH

Endocrine: Estrogenic

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral/rat lowest published toxic dose: 1000 mg/kg/5D- intermittentEndocrine: Change in LH

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 66,374,2002
oral/rat lowest published toxic dose: 742 mg/kg/14D- intermittentBehavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTPTR* RDGT94017
oral/rat lowest published toxic dose: 1232 mg/kg/14D- intermittentBiochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymesNTPTR* RDGT94017
oral/rat lowest published toxic dose: 742 mg/kg/14D- intermittentLiver: Other changesNTPTR* RDGT94017
oral/rat lowest published toxic dose: 1232 mg/kg/14D- intermittentLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
NTPTR* RDGT94017
oral/rat : 798 mg/kg/3W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTPTR* NTP-TR-532
oral/rat : 420 mg/kg/3W- intermittentKidney, Ureter, and Bladder: Changes in kidney weightNTPTR* NTP-TR-532
oral/rat : 126 mg/kg/3W- intermittentBehavioral: Fluid intakeNTPTR* NTP-TR-532

Reviews

OrganizationStandardReference
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 52,179,1991
International Agency for Research on Cancer (IARC)Cancer Review:Animal Sufficient EvidenceIMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC)Cancer Review:Human Inadequate EvidenceIMEMDT 52,179,1991
International Agency for Research on Cancer (IARC)Cancer Review:Human No Adequate DataIMEMDT 71,1295,1999
International Agency for Research on Cancer (IARC)Cancer Review:Group 2BIMEMDT 71,1295,1999
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWMUTAEX 14,5,1999
TOXICOLOGY REVIEWTXCYAC 198,239,2004
TOXICOLOGY REVIEWENTOX* -,546,2005
TOXICOLOGY REVIEWMUREAV 584,1,2005
TOXICOLOGY REVIEWBCLPT* 96,131,2005
TOXICOLOGY REVIEWMUREAV 636,242,2007
TOXICOLOGY REVIEWMUREAV 659,248,2008
TOXICOLOGY REVIEWMUREAV 659,202,2008
TOXICOLOGY REVIEWMUREAV 608,157,2006
TOXICOLOGY REVIEWMUREAV 721,27,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-JAPAN2B carc, MAY2012

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5772; Number of Industries 1; Total Number of Facilities 7; Number of Occupations 1; Total Number of Employees Exposed 3266; Total Number of Female Employees Exposed 502

Status in Federal Agencies

OrganizationReference
ATSDR TOXICOLOGY PROFILE (NTIS** PB/90/167461/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
NTP Carcinogenesis studies; on test (prechronic studies), October 2000
NTP Carcinogenesis studies; on test (two year studies), October 2000
On EPA IRIS database
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