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Registry of Toxic Effects of Chemical Substances (RTECS)

Methane, bromochlorodifluoro-

RTECS #

PA5270000

CAS #

353-59-3

Updated

December 2010

Molecular Weight

165.37

Molecular Formula

CBrClF2

Synonyms

BCF
Bromochlorodifluoromethane
Chlorodifluoromonobromomethane
Daiflon 12B1
Dwufluorochlorobromometan (Polish)
Flugex 12B1
Fluorocarbon 1211
Freon 12B1
Halon 1211

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
mutation in microorganisms/Salmonella typhimurium10 pph (+enzymatic activation step)MUREAV 142,187,1985

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 50000 ppm (6-15D pregnant)Reproductive: Other effects on femaleBJIMAG 45,755,1988

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 5 pph/30MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes
NTIS** OTS0571363
inhalation/guinea pig Lowest published lethal concentration: 30 pph/2HBehavioral: Convulsions or effect on seizure thresholdZAARAM 21,149,1971
inhalation/human lowest published toxic concentration: 295200 mg/m3/1MPeripheral Nerve and Sensation: ParesthesiaVCVGH* -,631,1990
inhalation/man lowest published toxic concentration: 4 pph/1MPeripheral Nerve and Sensation: Paresthesia

Behavioral: Hallucinations, distorted perceptions

Cardiac: EKG changes not diagnostic of above
NTIS** OTS0571363
inhalation/rat lethal concentration (50 percent kill): 20 pph/15MBehavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
inhalation/rat lethal concentration (50 percent kill): 2140000 mg/m3/5MVCVGH* -,631,1990
inhalation/rat lowest published toxic concentration: 396000 mg/m3/10MBehavioral: General anestheticVCVGH* -,631,1990

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rat lowest published toxic concentration: 210 µg/m3/4H/12W- intermittentBlood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in platelet count
BCTKAG 17,41,1984
inhalation/rat lowest published toxic concentration: 1 pph/6H/3W- intermittentBehavioral: Somnolence (general depressed activity)NTIS** OTS0571363

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWMUREAV 567,347,2004
TOXICOLOGY REVIEWHUTOX* -,577,1996
TOXICOLOGY REVIEWNCLNA* 16,503,1998

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 1000 mg/m3, JUN2003

Status in Federal Agencies

OrganizationReference
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9154
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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