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Methanearsonic acid

RTECS #: PA1575000

CAS #: 124-58-3


UPDATE: May 2009 MW: 139.98 MF: CH5AsO3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Kyselina methylarsonova (Czech)
  2. Methylarsenic acid
  3. Methylarsinic acid
  1. Methylarsonic acid
  2. Monomethylarsinic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis human fibroblast 1,400 Ámol/L MUREAV 357,123,1996
cytogenetic analysis human lymphocyte 3,000 Ámol/L/66 hour EMMUEG 42,192,2003
cytogenetic analysis mouse other cell types 5 mmol/L/4 hour MUREAV 634,40,2007
DNA damage human other cell types 2 Ámol/L/1 hour MUREAV 615,75,2007
sister chromatid exchange human lymphocyte 3,000 Ámol/L/66 hour EMMUEG 42,192,2003
specific locus test mouse other cell types 5 mmol/L/4 hour MUREAV 634,40,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 5,000 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) BDERB* 77,53,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lethal dose (50 percent kill): 1,800 mg/kg N/R JAFCAU 45,449,1997
oral
rat
lethal dose (50 percent kill): 961 mg/kg N/R FAATDF 7,299,1986
subcutaneous
mouse
lethal dose (50 percent kill): 794 mg/kg N/R 85JCAE -,1265,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
mouse
lowest published toxic dose: 13,440 mg/kg/4 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
TXCYAC 190,197,2003
oral
rat
lowest published toxic dose: 1,596 mg/kg/4 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
TXCYAC 190,197,2003
oral
rat
lowest published toxic dose: 19,110 mg/kg/42 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 190,197,2003
oral
rat
lowest published toxic dose: 400 mg/kg/20 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Other changes
TXAPA9 221,295,2007
oral
rat
lowest published toxic dose: 100 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,53,2006
oral
rat
lowest published toxic dose: 2,000 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,53,2006
oral
rat
lowest published toxic dose: 700 mg/kg/7 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,53,2006
oral
rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent Behavioral: Food intake (animal) BDERB* 77,53,2006
oral
rabbit
lowest published toxic dose: 156 mg/kg/13 day- intermittent Gastrointestinal: Hypermotility, diarrhea BDERB* 77,53,2006
oral
rabbit
lowest published toxic dose: 4 mg/kg/4 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,53,2006
oral
rabbit
lowest published toxic dose: 14 mg/kg/2 day- intermittent Behavioral: Food intake (animal) BDERB* 77,53,2006
oral
rabbit
lowest published toxic dose: 24 mg/kg/2 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain BDERB* 77,53,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
TOLED5 133,1,2002
TOXICOLOGY REVIEW
IMEMDT 84,39,2004
TOXICOLOGY REVIEW
EMMUEG 47,6,2006
TOXICOLOGY REVIEW
MUREAV 533,65,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg(As)/m3 DTLVS* 3,16,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg(As)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit - FINLAND Carcinogen, JAN1999
Occupational Exposure Limit - INDIA time-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit - THAILAND time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsenic, organo-, 5022


REFERENCES:

CODEN
REFERENCE

85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BDERB*
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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