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Registry of Toxic Effects of Chemical Substances (RTECS)

Methanearsonic acid

RTECS #

PA1575000

CAS #

124-58-3

Updated

July 2013

Molecular Weight

139.98

Molecular Formula

CH5AsO3

Synonyms

Kyselina methylarsonova (Czech)
Methylarsenic acid
Methylarsinic acid
Methylarsonic acid
Monomethylarsinic acid

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisfibroblast/human1400 µmol/LMUREAV 357,123,1996
Cytogenetic Analysisother cell types/mouse5 mmol/L/4HMUREAV 634,40,2007
Cytogenetic Analysislymphocyte/human3000 µmol/L/66HEMMUEG 42,192,2003
Cytogenetic Analysisother cell types/mouse214.3 µmol/L/10DMUREAV 675,66,2009
DNA Damageother cell types/human2 µmol/L/1HMUREAV 615,75,2007
micronucleus testlymphocyte/human100 µmol/L/20HMUTAEX 22,255,2007
micronucleus testlymphocyte/human100 µmol/L/48HMUTAEX 22,255,2007
morphological transformfibroblast/mouse7 mg/L/10DMUREAV 702,100,2010
sister chromatid exchangelymphocyte/human3000 µmol/L/66HEMMUEG 42,192,2003
specific locus testother cell types/mouse5 mmol/L/4HMUREAV 634,40,2007

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 5000 mg/kg (6-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)BDERB* 77,53,2006

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
oral/mouse lethal dose (50 percent kill): 1800 mg/kgJAFCAU 45,449,1997
oral/rat lethal dose (50 percent kill): 961 mg/kgFAATDF 7,299,1986
subcutaneous/mouse lethal dose (50 percent kill): 794 mg/kg85JCAE -,1265,1986

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/mouse lowest published toxic dose: 13440 mg/kg/4W- intermittentGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
TXCYAC 190,197,2003
oral/rabbit lowest published toxic dose: 156 mg/kg/13D- intermittentGastrointestinal: Hypermotility, diarrheaBDERB* 77,53,2006
oral/rabbit lowest published toxic dose: 4 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,53,2006
oral/rabbit lowest published toxic dose: 14 mg/kg/2D- intermittentBehavioral: Food intake (animal)BDERB* 77,53,2006
oral/rabbit lowest published toxic dose: 24 mg/kg/2D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,53,2006
oral/rat lowest published toxic dose: 400 mg/kg/20D- continuousLiver: Other changes

Kidney, Ureter, and Bladder: Other changes
TXAPA9 221,295,2007
oral/rat lowest published toxic dose: 100 mg/kg/10D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,53,2006
oral/rat lowest published toxic dose: 2000 mg/kg/4D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,53,2006
oral/rat lowest published toxic dose: 700 mg/kg/7D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainBDERB* 77,53,2006
oral/rat lowest published toxic dose: 400 mg/kg/4D- intermittentBehavioral: Food intake (animal)BDERB* 77,53,2006
oral/rat lowest published toxic dose: 1596 mg/kg/4W- intermittentGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes
TXCYAC 190,197,2003
oral/rat lowest published toxic dose: 19110 mg/kg/42W- intermittentGastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
TXCYAC 190,197,2003

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWTOLED5 133,1,2002
TOXICOLOGY REVIEWIMEMDT 84,39,2004
TOXICOLOGY REVIEWEMMUEG 47,6,2006
TOXICOLOGY REVIEWMUREAV 533,65,2003
TOXICOLOGY REVIEWMUREAV 674,85,2009

Standards and Regulations

OrganizationStandardReference
Mine Safety and Health Administration (MSHA) STANDARD-airtime-weighted average 0.5 mg(As)/m3DTLVS* 3,16,1971
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN check ACGIH TLV;
Occupational Exposure Limit IN SINGAPORE, VIETNAM check ACGIH TLV
Occupational Exposure Limit-ARAB Republic of Egypttime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-AUSTRALIAtime-weighted average 0.05 mg(As)/m3, Carcinogen, JUL2008
Occupational Exposure Limit-BELGIUMtime-weighted average 0.1 mg(As)/m3, Carcinogen, MAR2002
Occupational Exposure Limit-INDIAtime-weighted average 0.2 mg(As)/m3, JAN1993
Occupational Exposure Limit-POLANDMAC(time-weighted average) 0.3 mg(As)/m3, JAN1993
Occupational Exposure Limit-SWEDENtime-weighted average 0.01 mg(As)/m3, Carcinogen, JUN2005
Occupational Exposure Limit-THAILANDtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-THE PHILIPPINEStime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Exposure Limit-TURKEYtime-weighted average 0.5 mg(As)/m3, JAN1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)8H time-weighted average 0.5 mg(As)/m3CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)8H time-weighted average 0.5 mg(As)/m3CFRGBR 41,50-204.50,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)8H time-weighted average 0.5 mg(As)/m3CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)8H time-weighted average 0.5 mg(As)/m3CFRGBR 29,1915.1000,1993

Status in Federal Agencies

OrganizationReference
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Arsenic, organo-, 5022
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