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Methacrylic acid, 2 - hydroxyethyl ester

RTECS #: OZ4725000

CAS #: 868-77-9


UPDATE: November 2007 MW: 130.16 MF: C6H10O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Hydroxyethyl methacrylate
  2. Ethylene glycol methacrylate
  3. Ethylene glycol, monomethacrylate
  4. Glycol methacrylate
  5. Glycol monomethacrylate
  1. Hydroxyethyl methacrylate
  2. Mhoromer
  3. Monomer MG - 1
  4. Monomethacrylic ether of ethylene glycol
  5. beta - Hydroxyethyl methacrylate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis hamster lung 10 mmol/L/6 hour (+enzymatic activation step) MUREAV 517,187,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 3,062 mg/kg (35 week prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(11),81,1987
oral
rat
lowest published toxic dose: 3,062 mg/kg (35 week male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(11),81,1987


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
mouse
lethal dose (50 percent kill): 497 mg/kg N/R JPMSAE 62,778,1973
intraperitoneal
rat
lethal dose (50 percent kill): 1,250 mg/kg N/R AMPMAR 36,58,1975
intravenous
dog
lowest published lethal dose: 99,200 nL/kg N/R JPMSAE 63,376,1974
oral
guinea pig
lethal dose (50 percent kill): 4,680 mg/kg Behavioral: Coma GISAAA 54(9),75,1989
oral
mouse
lethal dose (50 percent kill): 3,275 mg/kg Behavioral: Coma GISAAA 54(9),75,1989
oral
rat
lethal dose (50 percent kill): 5,050 mg/kg Behavioral: Coma GISAAA 54(9),75,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
oral
rat
lowest published toxic dose: 612 mg/kg/35 week- intermittent Liver: Other changes

Blood: Changes in spleen
GISAAA 52(11),81,1987
oral
rat
lowest published toxic dose: 2,850 mg/kg/30 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 54(9),75,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
IJTOFN 24,53,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.24 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 20 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1338;
Number of Industries 5;
Total Number of Facilities 158;
Number of Occupations 8;
Total Number of Employees Exposed 2,245
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1338;
Number of Industries 17;
Total Number of Facilities 420;
Number of Occupations 20;
Total Number of Employees Exposed 16,031;
Total Number of Female Employees Exposed 5,273


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in optical and electronics chemical industries
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in optical and electronics chemical industries

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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