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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid, 2-hydroxyethyl ester

RTECS #

OZ4725000

CAS #

868-77-9

Updated

July 2013

Molecular Weight

130.16

Molecular Formula

C6H10O3

Synonyms

2-Hydroxyethyl methacrylate
beta-Hydroxyethyl methacrylate
Ethylene glycol methacrylate
Ethylene glycol, monomethacrylate
Glycol methacrylate
Glycol monomethacrylate
Hydroxyethyl methacrylate
Mhoromer
Monomer MG-1
Monomethacrylic ether of ethylene glycol

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /woman 2%/48HCODEDG 57,21,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislung/hamster10 mmol/L/6H (+enzymatic activation step)MUREAV 517,187,2002
DNA Damagelung/human5.4 mmol/L/24HMUREAV 723,158,2011

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
oral/rat 3062 mg/kg (35W prior to copulation)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(11),81,1987
oral/rat 3062 mg/kg (35W male)Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death
GISAAA 52(11),81,1987

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
intraperitoneal/mouse lethal dose (50 percent kill): 497 mg/kgJPMSAE 62,778,1973
intraperitoneal/rat lethal dose (50 percent kill): 1250 mg/kgAMPMAR 36,58,1975
intravenous/Dog lowest published lethal dose: 99200 nL/kgJPMSAE 63,376,1974
oral/guinea pig lethal dose (50 percent kill): 4680 mg/kgBehavioral: ComaGISAAA 54(9),75,1989
oral/mouse lethal dose (50 percent kill): 3275 mg/kgBehavioral: ComaGISAAA 54(9),75,1989
oral/rat lethal dose (50 percent kill): 5050 mg/kgBehavioral: ComaGISAAA 54(9),75,1989

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
oral/rat lowest published toxic dose: 612 mg/kg/35W- intermittentLiver: Other changes

Blood: Changes in spleen
GISAAA 52(11),81,1987
oral/rat lowest published toxic dose: 2850 mg/kg/30D- intermittentBlood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 54(9),75,1989

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWIJTOFN 24,53,2005
TOXICOLOGY REVIEWMUREAV 741,32,2012
TOXICOLOGY REVIEWFCTOD7 49,1877,2011

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 20 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.24 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code A1338; Number of Industries 17; Total Number of Facilities 420; Number of Occupations 20; Total Number of Employees Exposed 16031; Total Number of Female Employees Exposed 5273
National Occupational Hazard Survey 1974Hazard Code A1338; Number of Industries 5; Total Number of Facilities 158; Number of Occupations 8; Total Number of Employees Exposed 2245

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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