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Methacrylic acid, ethyl ester

RTECS #: OZ4550000

CAS #: 97-63-2


UPDATE: May 2008 MW: 114.16 MF: C6H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Propenoic acid, 2 - methyl - , ethyl ester
  2. Ethyl 2 - methyl - 2 - propenoate
  3. Ethyl 2 - methylacrylate
  4. Ethyl alpha - methyl acrylate
  1. Ethyl methacrylate
  2. Ethylester kyseliny methakrylove (Czech)
  3. RCRA waste number U118
  4. Rhoplex AC - 33 (rohm and haas)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
skin
rabbit
10 gm open irritation test N/R JIHTAB 23,343,1941


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE
DOSE REFERENCE
cytogenetic analysis mouse lymphocyte 900 mg/L EMMUEG 11,49,1988
mutation in mammalian somatic cells mouse lymphocyte 1,450 mg/L EMMUEG 11,49,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lowest published toxic concentration: 1,200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 50,136,1999
intraperitoneal
rat
lowest published toxic dose: 735 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JDREAF 51,1632,1972
intraperitoneal
rat
lowest published toxic dose: 366 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
JDREAF 51,1632,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
inhalation
rat
lethal concentration (50 percent kill): 8,300 ppm/4 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
intraperitoneal
mouse
lethal dose (50 percent kill): 1,369 mg/kg N/R JPMSAE 62,778,1973
intraperitoneal
rat
lethal dose (50 percent kill): 1,223 mg/kg N/R JDREAF 51,1632,1972
intraperitoneal
rat
lethal dose (50 percent kill): 1.2228 mL/kg N/R IJTOFN 21,63,2002
intravenous
dog
lowest published lethal dose: 137 ÁL/kg N/R JPMSAE 63,376,1974
oral
mouse
lethal dose (50 percent kill): 7.8 gm/kg N/R IJTOFN 21,63,2002
oral
rat
lethal dose (50 percent kill): 14,800 mg/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
oral
rat
lethal dose (50 percent kill): 12.7 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,63,2002
oral
rabbit
lowest published lethal dose: 3,630 mg/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
oral
rabbit
lethal dose (50 percent kill): 3.63 gm/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,63,2002
subcutaneous
rat
lowest published lethal dose: 25 gm/kg Behavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
skin
rabbit
lethal dose : >10 mL/kg N/R JIHTAB 23,343,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM
DOSE
EFFECT

REFERENCE
intraperitoneal
rat
lowest published toxic dose: 1,400 mg/kg/1 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTEHD6 59,97,2000
intraperitoneal
rat
lowest published toxic dose: 2,800 mg/kg/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTEHD6 59,97,2000
intraperitoneal
rat
lowest published toxic dose: 6,000 mg/kg/60 day- intermittent Behavioral: Change in motor activity (specific assay) JTEHD6 59,97,2000
intraperitoneal
rat
lowest published toxic dose: 12,000 mg/kg/60 day- intermittent Behavioral: Somnolence (general depressed activity) JTEHD6 59,97,2000
intraperitoneal
rat
lowest published toxic dose: 24,000 mg/kg/60 day- intermittent Behavioral: Sleep

Behavioral: Change in psychophysiological tests
JTEHD6 59,97,2000
intraperitoneal
rat
lowest published toxic dose: 48,000 mg/kg/60 day- intermittent Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea
JTEHD6 59,97,2000
oral
rat
lowest published toxic dose: 6 mL/kg/60 day- continuous Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
JTEHF8 59,97,2000
oral
rat
lowest published toxic dose: 600 mg/kg/60 day- continuous Brain and Coverings: Demyelination

Brain and Coverings: Other degenerative changes

Spinal Cord: Demyelination
JTEHD6 59,97,2000
oral
rat
lowest published toxic dose: 1,200 mg/kg/60 day- continuous Behavioral: Sleep JTEHD6 59,97,2000
oral
rat
lowest published toxic dose: 3,000 mg/kg/60 day- continuous Behavioral: Alteration of classical conditioning JTEHD6 59,97,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
IJTOFN 21,63,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE

Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (117 mg/m3), OCT 2002
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 48 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 50 ppm (250 mg/m3);
short term exposure limit 75 ppm (350 mg/m3), Sen, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5843;
Number of Industries 3;
Total Number of Facilities 259;
Number of Occupations 7;
Total Number of Employees Exposed 4,644;
Total Number of Female Employees Exposed 1,584


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in manufacture of coatings, resins and laquers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE

EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

Used in manufacture of coatings, resins and laquers

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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