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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid, ethyl ester

RTECS #

OZ4550000

CAS #

97-63-2

Updated

April 2012

Molecular Weight

114.16

Molecular Formula

C6H10O2

Synonyms

2-Propenoic acid, 2-methyl-, ethyl ester
Ethyl 2-methyl-2-propenoate
Ethyl 2-methylacrylate
Ethyl alpha-methyl acrylate
Ethyl methacrylate
Ethylester kyseliny methakrylove (Czech)
RCRA waste number U118
Rhoplex AC-33 (rohm and haas)

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
skin /rabbit 10 gm open irritation testJIHTAB 23,343,1941
skin /woman 2%/48HCODEDG 57,21,2007

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysislymphocyte/mouse900 mg/LEMMUEG 11,49,1988
mutation in mammalian somatic cellslymphocyte/mouse1450 mg/LEMMUEG 11,49,1988

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rat 1200 ppm/6H (6-20D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)TOSCF2 50,136,1999
intraperitoneal/rat 735 mg/kg (5-15D pregnant)Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)JDREAF 51,1632,1972
intraperitoneal/rat 366 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities
JDREAF 51,1632,1972

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/rat lethal concentration (50 percent kill): 8300 ppm/4HOlfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Dyspnea
JTEHD6 16,811,1985
intraperitoneal/mouse lethal dose (50 percent kill): 1369 mg/kgJPMSAE 62,778,1973
intraperitoneal/rat lethal dose (50 percent kill): 1223 mg/kgJDREAF 51,1632,1972
intraperitoneal/rat lethal dose (50 percent kill): 1.2228 mL/kgIJTOFN 21,63,2002
intravenous/Dog lowest published lethal dose: 137 µL/kgJPMSAE 63,376,1974
oral/mouse lethal dose (50 percent kill): 7.8 gm/kgIJTOFN 21,63,2002
oral/rabbit lowest published lethal dose: 3630 mg/kgBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
oral/rabbit lethal dose (50 percent kill): 3.63 gm/kgLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,63,2002
oral/rat lethal dose (50 percent kill): 14800 mg/kgBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941
oral/rat lethal dose (50 percent kill): 12.7 gm/kgLung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage

Kidney, Ureter, and Bladder: Hematuria
IJTOFN 21,63,2002
skin/rabbit Lethal dose: >10 mL/kgJIHTAB 23,343,1941
subcutaneous/rat lowest published lethal dose: 25 gm/kgBehavioral: Muscle weakness

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression
JIHTAB 23,343,1941

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
intraperitoneal/rat lowest published toxic dose: 1400 mg/kg/1W- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainJTEHD6 59,97,2000
intraperitoneal/rat lowest published toxic dose: 2800 mg/kg/2W- intermittentRelated to Chronic Data: Death in the "MULTIPLE DOSE" data type fieldJTEHD6 59,97,2000
intraperitoneal/rat lowest published toxic dose: 6000 mg/kg/60D- intermittentBehavioral: Change in motor activity (specific assay)JTEHD6 59,97,2000
intraperitoneal/rat lowest published toxic dose: 12000 mg/kg/60D- intermittentBehavioral: Somnolence (general depressed activity)JTEHD6 59,97,2000
intraperitoneal/rat lowest published toxic dose: 24000 mg/kg/60D- intermittentBehavioral: Sleep

Behavioral: Change in psychophysiological tests
JTEHD6 59,97,2000
intraperitoneal/rat lowest published toxic dose: 48000 mg/kg/60D- intermittentBehavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Hypermotility, diarrhea
JTEHD6 59,97,2000
oral/rat lowest published toxic dose: 3000 mg/kg/60D- continuousBehavioral: Alteration of classical conditioningJTEHD6 59,97,2000
oral/rat lowest published toxic dose: 6 mL/kg/60D- continuousBrain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Peripheral Nerve and Sensation: Structural change in nerve or sheath
JTEHF8 59,97,2000
oral/rat lowest published toxic dose: 600 mg/kg/60D- continuousBrain and Coverings: Demyelination

Brain and Coverings: Other degenerative changes

Spinal Cord: Demyelination
JTEHD6 59,97,2000
oral/rat lowest published toxic dose: 1200 mg/kg/60D- continuousBehavioral: SleepJTEHD6 59,97,2000

Reviews

OrganizationStandardReference
TOXICOLOGY REVIEWEVHPAZ 11,141,1975
TOXICOLOGY REVIEWIJTOFN 21,63,2002

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-AUSTRIAMAK-TMW 50 ppm (250 mg/m3);KZW 75 ppm (375 mg/m3), sen, 2007
Occupational Exposure Limit-DENMARKtime-weighted average 25 ppm (117 mg/m3), MAY2011
Occupational Exposure Limit-FINLANDtime-weighted average 10 ppm (47 mg/m3), short term exposure limit 20 ppm (95 mg/m3), NOV2011
Occupational Exposure Limit-ICELANDtime-weighted average 25 ppm (117 mg/m3), sen, NOV2011
Occupational Exposure Limit-NORWAYtime-weighted average 50 ppm (250 mg/m3), JAN1999
Occupational Exposure Limit-RUSSIAshort term exposure limit 50 mg/m3, JUN2003
Occupational Exposure Limit-SWEDENtime-weighted average 50 ppm (250 mg/m3);short term exposure limit 75 ppm (350 mg/m3), Sen, JUN2005
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 48 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Exposure Survey 1983Hazard Code X5843; Number of Industries 3; Total Number of Facilities 259; Number of Occupations 7; Total Number of Employees Exposed 4644; Total Number of Female Employees Exposed 1584

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
On EPA IRIS database
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