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Registry of Toxic Effects of Chemical Substances (RTECS)

Methacrylic acid, 2,3-epoxypropyl ester

RTECS #

OZ4375000

CAS #

106-91-2

Updated

October 2011

Molecular Weight

142.17

Molecular Formula

C7H10O3

Synonyms

1-Propanol, 2,3-epoxy-, methacrylate
2-((Methacryloxy)methyl)oxirane
2,3-Epoxypropyl methacrylate
2-Propenoic acid, 2-methyl-, oxiranylmethyl ester (9CI)
Acriester G
Blemmer G
Blemmer GMA
CP 105
Glycidyl alpha-methyl acrylate
Glycidyl methacrylate
Light Ester G
SR 379
SY-Monomer G

Skin and Eye Irritation and References

Route/OrganismDoseEffectReference
eye /rabbit 100 µL moderateNTIS** OTS0543732
skin /human 0.1%CODEDG 61,9,2009
skin /rabbit 500 µL/24H severeNTIS** OTS0543732
skin /woman 100%/6H severeCODEDG 59,316,2008

Mutation Data and Reference

System TestRoute/Organism/TissueDoseReference
Cytogenetic Analysisintraperitoneal/rat300 mg/kgBJPCAL 6,235,1951
Cytogenetic Analysislung/hamster10 mmol/L/6H (+/-enzymatic activation step)MUREAV 517,187,2002
DNA Damagelymphocyte/human1.2 mmol/L/1HCBINA8 180,69,2009
morphological transformembryo/hamster900 µg/LWEYAEM 25,261,1996
mutation in mammalian somatic cellslung/hamster200 µmol/LMUREAV 415,119,1998
mutation in microorganisms/Klebsiella pneumoniae200 µmol/L (-enzymatic activation step)MUREAV 89,269,1981
mutation in microorganisms/Salmonella typhimurium33 µg/plate (+enzymatic activation step)MUREAV 172,105,1986
other mutation test systems/Escherichia coli300 µmol/LMUREAV 231,205,1990
sister chromatid exchangelung/hamster78 µmol/LMUREAV 249,55,1991

Reproductive Effects Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit 50 ppm/6H (7-19D pregnant)Reproductive: Other effects on femaleNTIS** OTS0558852
oral/rat 110 mg/kg (5-15D pregnant)Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Stillbirth
NTIS** OTS0558852

Acute Toxicity Data and References

Route/OrganismDoseEffectReference
inhalation/Dog Lowest published lethal concentration: 1400 mg/m3/6HLung, Thorax, or Respiration: Other changesNTIS** OTS0530684
inhalation/guinea pig Lowest published lethal concentration: 1400 mg/m3/6HLung, Thorax, or Respiration: Other changesNTIS** OTS0530684
inhalation/rabbit Lowest published lethal concentration: 1400 mg/m3/6HLung, Thorax, or Respiration: Other changesNTIS** OTS0530684
inhalation/rat lethal concentration (50 percent kill): 45 ppm/4HLung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Other changes
NTIS** OTS0546546
oral/guinea pig lethal dose (50 percent kill): 697 mg/kgGISAAA 50(2),67,1985
oral/mouse lethal dose (50 percent kill): 390 mg/kgGISAAA 50(2),67,1985
oral/rat lethal dose (50 percent kill): 500 mg/kgWDZAEK 6,91,1992
skin/rabbit lethal dose (50 percent kill): 450 µL/kgAIHAAP 30,470,1969

Other Multiple Dose Data and References

Route/OrganismDoseEffectReference
inhalation/rabbit lowest published toxic concentration: 206 mg/m3/6H/26W- intermittentBrain and Coverings: Other degenerative changes

Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count
GWZHEW 16,1,1990
inhalation/rat lowest published toxic concentration: 206 mg/m3/6H/26W- intermittentLiver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
GWZHEW 16,1,1990
inhalation/rat lowest published toxic concentration: 40 ppm/6H/9D- intermittentOlfaction: Deviated nasal septum

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TOXID9 36(1 Pt2),331,1997
inhalation/rat lowest published toxic concentration: 15 ppm/6H/13W- intermittentOlfaction: Deviated nasal septumNTIS** OTS0558871
inhalation/rat lowest published toxic concentration: 160 ppm/6H/2W- intermittentOlfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0558852
oral/Dog lowest published toxic dose: 4500 mg/kg/90D- intermittentNutritional and Gross Metabolic: Weight loss or decreased weight gainNTIS** OTS0546568
oral/rat lowest published toxic dose: 2100 mg/kg/30D- intermittentBehavioral: Food intake (animal)

Gastrointestinal: Ulceration or bleeding from stomach

Kidney, Ureter, and Bladder: Changes primarily in glomeruli
GISAAA 50(2),67,1985

Standards and Regulations

OrganizationStandardReference
Occupational Exposure Limit-RUSSIAshort term exposure limit 3 mg/m3, JUN2003
Occupational Exposure Limit-THE NETHERLANDSMAC-TGG 0.24 mg/m3, 2003

NIOSH Documentation and Surveillance

OrganizationStandardReference
National Occupational Hazard Survey 1974Hazard Code A1341; Number of Industries 2; Total Number of Facilities 95; Number of Occupations 7; Total Number of Employees Exposed 4002

Status in Federal Agencies

OrganizationReference
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULEFEREAC 47,26992,82
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-1092-8813
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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